CY1111236T1 - Ανοσοτροποποιητικες ενωσεις που περιεχουν γαμμα-γλουταμυλο και βητα-ασπαρτυλο τμημα και μεθοδοι με αυτες - Google Patents

Ανοσοτροποποιητικες ενωσεις που περιεχουν γαμμα-γλουταμυλο και βητα-ασπαρτυλο τμημα και μεθοδοι με αυτες

Info

Publication number
CY1111236T1
CY1111236T1 CY20101101051T CY101101051T CY1111236T1 CY 1111236 T1 CY1111236 T1 CY 1111236T1 CY 20101101051 T CY20101101051 T CY 20101101051T CY 101101051 T CY101101051 T CY 101101051T CY 1111236 T1 CY1111236 T1 CY 1111236T1
Authority
CY
Cyprus
Prior art keywords
glutamyl
aspartyl
beta
sodium
methods
Prior art date
Application number
CY20101101051T
Other languages
English (en)
Inventor
Edward T Wei
Alexander A Kolobov
Andrey S Simbirtsev
Original Assignee
Cragmont Pharmaceuticals, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26653944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111236(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from RU97120940/04A external-priority patent/RU2142958C1/ru
Application filed by Cragmont Pharmaceuticals, Llc filed Critical Cragmont Pharmaceuticals, Llc
Publication of CY1111236T1 publication Critical patent/CY1111236T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/305—Mercury compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Παρέχονται συνθετικά ανοσοτροποποιητικά μόρια που έχουν γ-L-γλουταμυλο, γ-D-γλουταμυλο, β-L-ασπαρτυλο ή β-D-ασπαρτυλο μονάδα, όπως απεικονίζεται από το χημικό τύπο (Α). Στο χημικό τύπο (Α), το όπου το "n" είναι 1 ή 2, το R είναι υδρογόνο, ακυλο ή αλκυλο τμήμα και το Χ είναι αρωματικό ή ετεροκυκλικό αμινοξύ ή παράγωγο του. Ιδιαιτέρως προτιμώμενη εκδοχή είναι η γ-D-γλουταμυλο-L-τρυπτοφάνη, που έχει ανοσοτροποποιητική δράση.
CY20101101051T 1997-12-25 2010-11-23 Ανοσοτροποποιητικες ενωσεις που περιεχουν γαμμα-γλουταμυλο και βητα-ασπαρτυλο τμημα και μεθοδοι με αυτες CY1111236T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU97120940/04A RU2142958C1 (ru) 1997-12-25 1997-12-25 Пептид, обладающий иммуномодулирующей активностью, и препарат на его основе
US09/031,842 US5916878A (en) 1995-11-28 1998-02-27 γ-glutamyl and β-aspartyl containing immunomodulator compounds and methods therewith
EP98965445A EP1042286B1 (en) 1997-12-25 1998-12-22 Gamma-glutamyl and beta-aspartyl containing immunomodulator compounds and methods therewith

Publications (1)

Publication Number Publication Date
CY1111236T1 true CY1111236T1 (el) 2015-06-11

Family

ID=26653944

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101101051T CY1111236T1 (el) 1997-12-25 2010-11-23 Ανοσοτροποποιητικες ενωσεις που περιεχουν γαμμα-γλουταμυλο και βητα-ασπαρτυλο τμημα και μεθοδοι με αυτες

Country Status (14)

Country Link
US (1) US5916878A (el)
EP (1) EP1042286B1 (el)
JP (1) JP4536918B2 (el)
KR (2) KR100623104B1 (el)
CN (1) CN1155571C (el)
AU (1) AU754876B2 (el)
BR (1) BR9814472A (el)
CA (1) CA2316310C (el)
CY (1) CY1111236T1 (el)
IL (1) IL136937A0 (el)
MX (1) MXPA00006369A (el)
NO (1) NO317256B1 (el)
NZ (1) NZ505489A (el)
WO (1) WO1999033799A1 (el)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251857B1 (en) 1995-12-14 2001-06-26 Novelos Therapeutics, Inc. Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof
RU2089179C1 (ru) * 1995-12-14 1997-09-10 Закрытое акционерное общество "ВАМ" Стимулятор эндогенной продукции цитокинов и гепопоэтических факторов и способ его использования
US20070142267A1 (en) * 1998-11-23 2007-06-21 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
RU2144374C1 (ru) 1998-11-23 2000-01-20 Закрытое акционерное общество "ВАМ" Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток
WO2000063238A1 (en) * 1999-04-15 2000-10-26 Thymon, L.L.C. Nonextractive method of assaying thymopoietin
CA2417127A1 (en) * 2000-07-24 2002-01-31 The University Of Queensland Compounds and inhibitors of phospholipases
AU2001272234B2 (en) * 2000-07-24 2006-06-01 The University Of Queensland Compounds and inhibitors of phospholipases
RU2229892C2 (ru) * 2001-06-08 2004-06-10 Государственное учреждение "Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии" Способ лечения туберкулеза легких
US7173013B2 (en) * 2001-06-08 2007-02-06 Sciclone Pharmaceuticals, Inc. Treatment of tuberculosis using immunomodulator compounds
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
SG169362A1 (en) * 2004-05-14 2011-03-30 Sciclone Pharmaceuticals Inc Treatment or prevention of respiratory viral infections with immunomodulator compounds
DE602005022612D1 (de) * 2004-10-27 2010-09-09 Sciclone Pharmaceuticals Inc Behandlung oder prävention von hämorrhagischen virusinfektionen mit immunomodulatorischen verbindungen
US20090074815A1 (en) * 2005-04-22 2009-03-19 Sciclone Pharmaceuticals, Inc. Immunomodulator Compounds as Vaccine Enhancers
JP2009534383A (ja) * 2006-04-20 2009-09-24 サイクローン・ファーマシューティカルズ・インコーポレイテッド 黒色腫の治療
RU2301074C1 (ru) * 2006-05-30 2007-06-20 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Пептид, обладающий иммуногеропротекторным действием, фармацевтическая композиция на его основе и способ ее применения
CA2569204A1 (en) * 2006-11-28 2008-05-28 Apotex Technologies Inc. Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl-d-tryptophan
CA2571645A1 (en) * 2006-12-19 2008-06-19 Apotex Technologies Inc. Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
CN101657210A (zh) * 2007-02-13 2010-02-24 希克龙制药公司 粘膜疾病引起的组织退化、损伤或损害的治疗或预防方法
CA2579119C (en) 2007-02-16 2013-03-05 Apotex Technologies Inc. Crystalline forms of the mono-sodium salt of d-isoglutamyl-d-tryptophan
RU2007118237A (ru) * 2007-05-17 2008-11-27 ООО "Научно-производственна фирма Верта" (RU) Способ лечения аллергических заболеваний
EA201070295A1 (ru) * 2007-08-23 2010-10-29 Сиклоун Фармасьютикалз, Инк. Лечение рака легких
US20110256561A1 (en) * 2008-12-24 2011-10-20 The University Of Tokyo Liver disease marker, method and apparatus for measuring the same, and method for assaying pharmaceutical preparation
US20110064828A1 (en) * 2009-09-11 2011-03-17 Novelos Therapeutics, Incorporated Treatment of metastatic tumors and other conditions
WO2012040656A2 (en) * 2010-09-24 2012-03-29 Sciclone Pharmaceuticals, Inc. Biomarkers to track response to scv-07
CN102417474B (zh) * 2011-09-26 2014-07-02 深圳翰宇药业股份有限公司 D-异谷氨酰基-d-色氨酸制备的新方法
WO2013155592A1 (en) * 2012-04-18 2013-10-24 Apotex Technologies Inc. Crystal forms of golotimod and process for its manufacturing
WO2013155595A1 (en) * 2012-04-18 2013-10-24 Apotex Technologies Inc. Process for the preparation of a monosodium salt of h-d-glu-(l-trp-oh)-oh and a crystalline form thereof
RU2635968C1 (ru) * 2016-11-17 2017-11-17 Аллан Герович Бениашвили Способ лечения и профилактики состояний аллергического спектра

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125626A (en) * 1977-01-17 1978-11-14 Mt. Sinai School Of Medicine Of The City University Of New York Synthesis and use of L-γ-glutamyl-DOPA
US4568489A (en) * 1984-06-29 1986-02-04 E. R. Squibb & Sons, Inc. N-Acyl-γ-glutamyl imino and amino acids and esters
US4758551A (en) * 1986-07-08 1988-07-19 Cornell Research Foundation, Inc. Methods for combatting renal toxicity due to metals or nephrotoxic drugs and for selectively modulating in vivo formation of leukotriene types
US5206220A (en) * 1990-04-23 1993-04-27 Research Corporation Technologies, Inc. Soluble and stable sources of tyrosine, cysteine and glutamine for total parenteral nutrition
CA2107460A1 (en) * 1991-04-01 1992-10-02 Vladimir K. Khavinson Pharmaceutical dipeptide compositions and methods of use thereof
GB9113219D0 (en) * 1991-06-19 1991-08-07 Fujisawa Pharmaceutical Co Peptide compound,processes for preparation thereof and pharmaceutical composition comprising the same
WO1993008815A1 (en) * 1991-10-28 1993-05-13 Cytoven Pharmaceutical dipeptide compositions and methods of use thereof
WO1994020063A2 (en) * 1993-03-04 1994-09-15 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
RU2107692C1 (ru) * 1995-06-07 1998-03-27 Дейгин Владислав Исакович Пептид и способ его получения
WO1997019691A1 (en) * 1995-11-28 1997-06-05 Wei, Edward, T. Gamma-l-glutamyl containing immunomodulator compounds and methods therewith
US5744452A (en) * 1995-11-28 1998-04-28 Edward T. Wei γ-L-glutamyl containing immunomodulator compounds and methods therewith

Also Published As

Publication number Publication date
US5916878A (en) 1999-06-29
CA2316310C (en) 2008-02-19
KR100623104B1 (ko) 2006-09-15
NO317256B1 (no) 2004-09-27
BR9814472A (pt) 2001-10-23
NO20003312L (no) 2000-08-21
NZ505489A (en) 2003-02-28
AU754876B2 (en) 2002-11-28
KR20060057027A (ko) 2006-05-25
NO20003312D0 (no) 2000-06-23
KR100602529B1 (ko) 2006-07-19
WO1999033799A1 (en) 1999-07-08
CN1284943A (zh) 2001-02-21
MXPA00006369A (es) 2002-08-06
AU2090999A (en) 1999-07-19
JP4536918B2 (ja) 2010-09-01
CA2316310A1 (en) 1999-07-08
EP1042286A1 (en) 2000-10-11
CN1155571C (zh) 2004-06-30
IL136937A0 (en) 2001-06-14
JP2001527065A (ja) 2001-12-25
EP1042286B1 (en) 2010-08-25
KR20010033617A (ko) 2001-04-25

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