CY1111236T1 - Ανοσοτροποποιητικες ενωσεις που περιεχουν γαμμα-γλουταμυλο και βητα-ασπαρτυλο τμημα και μεθοδοι με αυτες - Google Patents
Ανοσοτροποποιητικες ενωσεις που περιεχουν γαμμα-γλουταμυλο και βητα-ασπαρτυλο τμημα και μεθοδοι με αυτεςInfo
- Publication number
- CY1111236T1 CY1111236T1 CY20101101051T CY101101051T CY1111236T1 CY 1111236 T1 CY1111236 T1 CY 1111236T1 CY 20101101051 T CY20101101051 T CY 20101101051T CY 101101051 T CY101101051 T CY 101101051T CY 1111236 T1 CY1111236 T1 CY 1111236T1
- Authority
- CY
- Cyprus
- Prior art keywords
- glutamyl
- aspartyl
- beta
- sodium
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Παρέχονται συνθετικά ανοσοτροποποιητικά μόρια που έχουν γ-L-γλουταμυλο, γ-D-γλουταμυλο, β-L-ασπαρτυλο ή β-D-ασπαρτυλο μονάδα, όπως απεικονίζεται από το χημικό τύπο (Α). Στο χημικό τύπο (Α), το όπου το "n" είναι 1 ή 2, το R είναι υδρογόνο, ακυλο ή αλκυλο τμήμα και το Χ είναι αρωματικό ή ετεροκυκλικό αμινοξύ ή παράγωγο του. Ιδιαιτέρως προτιμώμενη εκδοχή είναι η γ-D-γλουταμυλο-L-τρυπτοφάνη, που έχει ανοσοτροποποιητική δράση.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU97120940/04A RU2142958C1 (ru) | 1997-12-25 | 1997-12-25 | Пептид, обладающий иммуномодулирующей активностью, и препарат на его основе |
US09/031,842 US5916878A (en) | 1995-11-28 | 1998-02-27 | γ-glutamyl and β-aspartyl containing immunomodulator compounds and methods therewith |
EP98965445A EP1042286B1 (en) | 1997-12-25 | 1998-12-22 | Gamma-glutamyl and beta-aspartyl containing immunomodulator compounds and methods therewith |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111236T1 true CY1111236T1 (el) | 2015-06-11 |
Family
ID=26653944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101101051T CY1111236T1 (el) | 1997-12-25 | 2010-11-23 | Ανοσοτροποποιητικες ενωσεις που περιεχουν γαμμα-γλουταμυλο και βητα-ασπαρτυλο τμημα και μεθοδοι με αυτες |
Country Status (14)
Country | Link |
---|---|
US (1) | US5916878A (el) |
EP (1) | EP1042286B1 (el) |
JP (1) | JP4536918B2 (el) |
KR (2) | KR100623104B1 (el) |
CN (1) | CN1155571C (el) |
AU (1) | AU754876B2 (el) |
BR (1) | BR9814472A (el) |
CA (1) | CA2316310C (el) |
CY (1) | CY1111236T1 (el) |
IL (1) | IL136937A0 (el) |
MX (1) | MXPA00006369A (el) |
NO (1) | NO317256B1 (el) |
NZ (1) | NZ505489A (el) |
WO (1) | WO1999033799A1 (el) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2089179C1 (ru) * | 1995-12-14 | 1997-09-10 | Закрытое акционерное общество "ВАМ" | Стимулятор эндогенной продукции цитокинов и гепопоэтических факторов и способ его использования |
US6251857B1 (en) | 1995-12-14 | 2001-06-26 | Novelos Therapeutics, Inc. | Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof |
RU2144374C1 (ru) | 1998-11-23 | 2000-01-20 | Закрытое акционерное общество "ВАМ" | Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток |
US20070142267A1 (en) * | 1998-11-23 | 2007-06-21 | Novelos Therapeutics, Inc. | Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells |
WO2000063238A1 (en) * | 1999-04-15 | 2000-10-26 | Thymon, L.L.C. | Nonextractive method of assaying thymopoietin |
AU2001272234B2 (en) * | 2000-07-24 | 2006-06-01 | The University Of Queensland | Compounds and inhibitors of phospholipases |
JP2004503604A (ja) * | 2000-07-24 | 2004-02-05 | ザ・ユニバーシティ・オブ・クイーンズランド | 化合物およびホスホリパーゼ阻害剤 |
US7173013B2 (en) * | 2001-06-08 | 2007-02-06 | Sciclone Pharmaceuticals, Inc. | Treatment of tuberculosis using immunomodulator compounds |
RU2229892C2 (ru) * | 2001-06-08 | 2004-06-10 | Государственное учреждение "Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии" | Способ лечения туберкулеза легких |
GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
BRPI0511107A (pt) * | 2004-05-14 | 2007-11-27 | Sciclone Pharmaceuticals Inc | tratamento ou prevenção de infecções virais respiratórias com compostos imunomoduladores |
KR20070070202A (ko) * | 2004-10-27 | 2007-07-03 | 사이클론 파아머슈티컬 인코오퍼레이티드 | 면역조절제 화합물로 출혈성 바이러스 감염의 치료 또는예방 |
US20090074815A1 (en) * | 2005-04-22 | 2009-03-19 | Sciclone Pharmaceuticals, Inc. | Immunomodulator Compounds as Vaccine Enhancers |
CN101448514A (zh) * | 2006-04-20 | 2009-06-03 | 希克龙制药公司 | 黑素瘤的治疗 |
RU2301074C1 (ru) * | 2006-05-30 | 2007-06-20 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Пептид, обладающий иммуногеропротекторным действием, фармацевтическая композиция на его основе и способ ее применения |
CA2569204A1 (en) | 2006-11-28 | 2008-05-28 | Apotex Technologies Inc. | Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl-d-tryptophan |
CA2571645A1 (en) | 2006-12-19 | 2008-06-19 | Apotex Technologies Inc. | Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture |
AU2008216799A1 (en) * | 2007-02-13 | 2008-08-21 | Sciclone Pharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa |
CA2579119C (en) | 2007-02-16 | 2013-03-05 | Apotex Technologies Inc. | Crystalline forms of the mono-sodium salt of d-isoglutamyl-d-tryptophan |
RU2007118237A (ru) * | 2007-05-17 | 2008-11-27 | ООО "Научно-производственна фирма Верта" (RU) | Способ лечения аллергических заболеваний |
MX2010002046A (es) * | 2007-08-23 | 2010-05-03 | Sciclone Pharmaceuticals Inc | Tratamiento de cancer de pulmon. |
CN102265160B (zh) * | 2008-12-24 | 2014-07-23 | 学校法人庆应义塾 | 肝病标记物、其测定方法、装置和医药品的检验方法 |
US20110064828A1 (en) * | 2009-09-11 | 2011-03-17 | Novelos Therapeutics, Incorporated | Treatment of metastatic tumors and other conditions |
WO2012040656A2 (en) * | 2010-09-24 | 2012-03-29 | Sciclone Pharmaceuticals, Inc. | Biomarkers to track response to scv-07 |
CN102417474B (zh) * | 2011-09-26 | 2014-07-02 | 深圳翰宇药业股份有限公司 | D-异谷氨酰基-d-色氨酸制备的新方法 |
WO2013155595A1 (en) * | 2012-04-18 | 2013-10-24 | Apotex Technologies Inc. | Process for the preparation of a monosodium salt of h-d-glu-(l-trp-oh)-oh and a crystalline form thereof |
WO2013155592A1 (en) * | 2012-04-18 | 2013-10-24 | Apotex Technologies Inc. | Crystal forms of golotimod and process for its manufacturing |
RU2635968C1 (ru) * | 2016-11-17 | 2017-11-17 | Аллан Герович Бениашвили | Способ лечения и профилактики состояний аллергического спектра |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US4125626A (en) * | 1977-01-17 | 1978-11-14 | Mt. Sinai School Of Medicine Of The City University Of New York | Synthesis and use of L-γ-glutamyl-DOPA |
US4568489A (en) * | 1984-06-29 | 1986-02-04 | E. R. Squibb & Sons, Inc. | N-Acyl-γ-glutamyl imino and amino acids and esters |
US4758551A (en) * | 1986-07-08 | 1988-07-19 | Cornell Research Foundation, Inc. | Methods for combatting renal toxicity due to metals or nephrotoxic drugs and for selectively modulating in vivo formation of leukotriene types |
US5206220A (en) * | 1990-04-23 | 1993-04-27 | Research Corporation Technologies, Inc. | Soluble and stable sources of tyrosine, cysteine and glutamine for total parenteral nutrition |
CA2107460A1 (en) * | 1991-04-01 | 1992-10-02 | Vladimir K. Khavinson | Pharmaceutical dipeptide compositions and methods of use thereof |
GB9113219D0 (en) * | 1991-06-19 | 1991-08-07 | Fujisawa Pharmaceutical Co | Peptide compound,processes for preparation thereof and pharmaceutical composition comprising the same |
AU2905092A (en) * | 1991-10-28 | 1993-06-07 | Cytoven | Pharmaceutical dipeptide compositions and methods of use thereof |
WO1994020063A2 (en) * | 1993-03-04 | 1994-09-15 | Cytoven International N.V. | Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof |
RU2107692C1 (ru) * | 1995-06-07 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
US5744452A (en) * | 1995-11-28 | 1998-04-28 | Edward T. Wei | γ-L-glutamyl containing immunomodulator compounds and methods therewith |
WO1997019691A1 (en) * | 1995-11-28 | 1997-06-05 | Wei, Edward, T. | Gamma-l-glutamyl containing immunomodulator compounds and methods therewith |
-
1998
- 1998-02-27 US US09/031,842 patent/US5916878A/en not_active Expired - Lifetime
- 1998-12-22 KR KR1020067008106A patent/KR100623104B1/ko not_active IP Right Cessation
- 1998-12-22 NZ NZ505489A patent/NZ505489A/xx not_active IP Right Cessation
- 1998-12-22 MX MXPA00006369A patent/MXPA00006369A/es unknown
- 1998-12-22 BR BR9814472-3A patent/BR9814472A/pt active Search and Examination
- 1998-12-22 CN CNB988137992A patent/CN1155571C/zh not_active Expired - Fee Related
- 1998-12-22 JP JP2000526483A patent/JP4536918B2/ja not_active Expired - Fee Related
- 1998-12-22 WO PCT/US1998/027291 patent/WO1999033799A1/en not_active Application Discontinuation
- 1998-12-22 CA CA002316310A patent/CA2316310C/en not_active Expired - Fee Related
- 1998-12-22 AU AU20909/99A patent/AU754876B2/en not_active Ceased
- 1998-12-22 IL IL13693798A patent/IL136937A0/xx not_active IP Right Cessation
- 1998-12-22 KR KR1020007007130A patent/KR100602529B1/ko not_active IP Right Cessation
- 1998-12-22 EP EP98965445A patent/EP1042286B1/en not_active Expired - Lifetime
-
2000
- 2000-06-23 NO NO20003312A patent/NO317256B1/no not_active IP Right Cessation
-
2010
- 2010-11-23 CY CY20101101051T patent/CY1111236T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2316310C (en) | 2008-02-19 |
CA2316310A1 (en) | 1999-07-08 |
US5916878A (en) | 1999-06-29 |
WO1999033799A1 (en) | 1999-07-08 |
KR100602529B1 (ko) | 2006-07-19 |
KR20060057027A (ko) | 2006-05-25 |
MXPA00006369A (es) | 2002-08-06 |
KR100623104B1 (ko) | 2006-09-15 |
JP2001527065A (ja) | 2001-12-25 |
AU2090999A (en) | 1999-07-19 |
CN1284943A (zh) | 2001-02-21 |
BR9814472A (pt) | 2001-10-23 |
AU754876B2 (en) | 2002-11-28 |
IL136937A0 (en) | 2001-06-14 |
NO20003312L (no) | 2000-08-21 |
KR20010033617A (ko) | 2001-04-25 |
NO20003312D0 (no) | 2000-06-23 |
CN1155571C (zh) | 2004-06-30 |
NO317256B1 (no) | 2004-09-27 |
JP4536918B2 (ja) | 2010-09-01 |
EP1042286B1 (en) | 2010-08-25 |
EP1042286A1 (en) | 2000-10-11 |
NZ505489A (en) | 2003-02-28 |
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