BR9712279A - Composto intermediário de depsipeptídeo e processo para produzir um derivado de depsipeptídeo - Google Patents
Composto intermediário de depsipeptídeo e processo para produzir um derivado de depsipeptídeoInfo
- Publication number
- BR9712279A BR9712279A BR9712279-3A BR9712279A BR9712279A BR 9712279 A BR9712279 A BR 9712279A BR 9712279 A BR9712279 A BR 9712279A BR 9712279 A BR9712279 A BR 9712279A
- Authority
- BR
- Brazil
- Prior art keywords
- depsipeptide
- producing
- derivative
- compound
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"COMPOSTO INTERMEDIáRIO DE DEPSIPEPTìDEO E PROCESSO PARA PRODUZIR UM DERIVADI DE DEPSIPEPTìDEO", sendo dito processo alternativo industrialmente excelente para a produção de derivados de ciclodepsipeptídeo, tal como representado pela fórmula (1), dito processo apresentado ainda excelente atividade vermicida como antelmítico em animais e em seres humanos, no qual R~ 1~ representa um hidrogênio ou um grupo protetor hidroxi; R~ 2~ representa um grupo carboxi opcionalmente protegido; R~ 3~, R~ 4~, R~ 7~ e R~ 8~ representam cada um um alquila inferior, arila ou aralquila substituído ou não substituído; e R~ 5~, R~ 6~, R~ 9~ e R~ 10~ representam cada um um alquila inferior. (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28604796 | 1996-10-07 | ||
PCT/JP1997/003417 WO1998015523A1 (fr) | 1996-10-07 | 1997-09-24 | Procede de production de derives de depsideptides et leurs nouveaux intermediaires |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712279A true BR9712279A (pt) | 1999-08-31 |
Family
ID=17699289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712279-3A BR9712279A (pt) | 1996-10-07 | 1997-09-24 | Composto intermediário de depsipeptídeo e processo para produzir um derivado de depsipeptídeo |
Country Status (12)
Country | Link |
---|---|
US (1) | US6235875B1 (pt) |
EP (1) | EP0953563B1 (pt) |
JP (1) | JP4035852B2 (pt) |
CN (1) | CN1205177C (pt) |
AT (1) | ATE237583T1 (pt) |
BR (1) | BR9712279A (pt) |
CA (1) | CA2267376C (pt) |
DE (1) | DE69721055T2 (pt) |
DK (1) | DK0953563T3 (pt) |
ES (1) | ES2191852T3 (pt) |
PT (1) | PT953563E (pt) |
WO (1) | WO1998015523A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU755709B2 (en) * | 1997-11-10 | 2002-12-19 | Astellas Pharma Inc. | Novel crystal of depsipeptide derivative and process for producing the same |
JP2008520682A (ja) * | 2004-11-17 | 2008-06-19 | ザ ユニヴァーシティー オヴ シカゴ | ヒストンデアセチラーゼ阻害剤およびその使用方法 |
PL3298027T3 (pl) | 2015-05-20 | 2021-11-08 | Boehringer Ingelheim Animal Health USA Inc. | Przeciwrobacze związki depsipeptydów |
AU2016380868B2 (en) | 2015-12-28 | 2019-11-28 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
US11382949B2 (en) | 2016-11-16 | 2022-07-12 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0634408T3 (da) | 1992-03-17 | 2002-04-22 | Fujisawa Pharmaceutical Co | Depsipeptidderivater, fremstilling og anvendelse deraf |
DE4317457A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
DE4317432A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
KR100392172B1 (ko) | 1993-09-06 | 2004-04-03 | 후지사와 야꾸힝 고교 가부시키가이샤 | 환상 뎁시펩티드 화합물 |
CN1071323C (zh) | 1995-06-30 | 2001-09-19 | 藤泽药品工业株式会社 | 缩肽衍生物或其盐的制造方法 |
-
1997
- 1997-09-24 CN CNB971985995A patent/CN1205177C/zh not_active Expired - Lifetime
- 1997-09-24 EP EP97941241A patent/EP0953563B1/en not_active Expired - Lifetime
- 1997-09-24 CA CA002267376A patent/CA2267376C/en not_active Expired - Lifetime
- 1997-09-24 DE DE69721055T patent/DE69721055T2/de not_active Expired - Lifetime
- 1997-09-24 DK DK97941241T patent/DK0953563T3/da active
- 1997-09-24 ES ES97941241T patent/ES2191852T3/es not_active Expired - Lifetime
- 1997-09-24 AT AT97941241T patent/ATE237583T1/de active
- 1997-09-24 PT PT97941241T patent/PT953563E/pt unknown
- 1997-09-24 JP JP51737098A patent/JP4035852B2/ja not_active Expired - Lifetime
- 1997-09-24 BR BR9712279-3A patent/BR9712279A/pt not_active Application Discontinuation
- 1997-09-24 US US09/269,743 patent/US6235875B1/en not_active Expired - Lifetime
- 1997-09-24 WO PCT/JP1997/003417 patent/WO1998015523A1/ja active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
PT953563E (pt) | 2003-08-29 |
CA2267376A1 (en) | 1998-04-16 |
JP4035852B2 (ja) | 2008-01-23 |
CA2267376C (en) | 2006-11-14 |
EP0953563A1 (en) | 1999-11-03 |
DE69721055T2 (de) | 2004-02-19 |
EP0953563B1 (en) | 2003-04-16 |
EP0953563A4 (en) | 2001-05-16 |
ATE237583T1 (de) | 2003-05-15 |
CN1205177C (zh) | 2005-06-08 |
DE69721055D1 (de) | 2003-05-22 |
US6235875B1 (en) | 2001-05-22 |
ES2191852T3 (es) | 2003-09-16 |
WO1998015523A1 (fr) | 1998-04-16 |
CN1232446A (zh) | 1999-10-20 |
DK0953563T3 (da) | 2003-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) Free format text: TRANSFERIDO POR FUSAO DE: FUJISAWA PHARMACEUTICAL CO., LTD. |
|
B25D | Requested change of name of applicant approved |
Owner name: ASTELLAS PHARMA INC. (JP) Free format text: ALTERADO DE: YAMANOUCHI PHARMACEUTICAL CO., LTD. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, POR INCIDENCIA NOS ARTIGOS 8O E 13 DA LPI, LEI DE NUMERO 9.279 DE 14/05/1996. |
|
B12B | Appeal against refusal [chapter 12.2 patent gazette] |