CY1110266T1 - Δικυκλικες ετεροκυκλικες ενωσεις ως αναστολεις της hiv ιντεγκρασης - Google Patents

Δικυκλικες ετεροκυκλικες ενωσεις ως αναστολεις της hiv ιντεγκρασης

Info

Publication number
CY1110266T1
CY1110266T1 CY20091100068T CY091100068T CY1110266T1 CY 1110266 T1 CY1110266 T1 CY 1110266T1 CY 20091100068 T CY20091100068 T CY 20091100068T CY 091100068 T CY091100068 T CY 091100068T CY 1110266 T1 CY1110266 T1 CY 1110266T1
Authority
CY
Cyprus
Prior art keywords
inhibitors
hiv
heterocyclic compounds
bicyclic heterocyclic
hiv integration
Prior art date
Application number
CY20091100068T
Other languages
English (en)
Inventor
B Narasimhulu Naidu
Jacques Banville
Francis Beaulieu
Timothy P Connolly
Mark R Krystal
John D Matiskella
Carl Ouellet
Serge Plamondon
Roger Remillard
Margaret E Sorenson
Yasutsugu Ueda
Michael A Walker
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1110266T1 publication Critical patent/CY1110266T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση περιλαμβάνει σειρά κυκλικών δικυκλικών ενώσεων πυριμιδινόνης του τύπου I οι οποίες αναστέλλουν την HIV ιντεγκράση και εμποδίζουν την ιική ολοκλήρωση στο ανθρώπινο DNA. Η δράση αυτή καθιστά τις ενώσεις χρήσιμες στην αντιμετώπιση της HIV μόλυνσης και του AIDS. Η εφεύρεση επίσης περιλαμβάνει φαρμακευτικές συνθέσεις και μεθόδους για τη θεραπεία ατόμων μολυσμένων με HIV.
CY20091100068T 2004-05-28 2009-01-19 Δικυκλικες ετεροκυκλικες ενωσεις ως αναστολεις της hiv ιντεγκρασης CY1110266T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57551304P 2004-05-28 2004-05-28
US60337104P 2004-08-20 2004-08-20
US11/126,891 US7176196B2 (en) 2004-05-28 2005-05-11 Bicyclic heterocycles as HIV integrase inhibitors
EP05750075A EP1749011B1 (en) 2004-05-28 2005-05-12 Bicyclic heterocycles as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
CY1110266T1 true CY1110266T1 (el) 2015-01-14

Family

ID=35456854

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100068T CY1110266T1 (el) 2004-05-28 2009-01-19 Δικυκλικες ετεροκυκλικες ενωσεις ως αναστολεις της hiv ιντεγκρασης

Country Status (27)

Country Link
US (2) US7176196B2 (el)
EP (1) EP1749011B1 (el)
JP (1) JP4874959B2 (el)
KR (1) KR101097623B1 (el)
AR (1) AR049124A1 (el)
AT (1) ATE412656T1 (el)
AU (1) AU2005250356C1 (el)
BR (1) BRPI0511623A (el)
CA (1) CA2568356C (el)
CY (1) CY1110266T1 (el)
DE (1) DE602005010690D1 (el)
DK (1) DK1749011T3 (el)
ES (1) ES2315875T3 (el)
HK (1) HK1107343A1 (el)
HR (1) HRP20090005T3 (el)
IL (1) IL179455A (el)
MX (1) MXPA06013835A (el)
NO (1) NO20065879L (el)
NZ (1) NZ551282A (el)
PE (1) PE20060242A1 (el)
PL (1) PL1749011T3 (el)
PT (1) PT1749011E (el)
RS (1) RS50700B (el)
RU (1) RU2381228C2 (el)
SI (1) SI1749011T1 (el)
TW (1) TWI366567B (el)
WO (1) WO2005118593A1 (el)

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US7115601B2 (en) 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
US7981879B2 (en) * 2005-03-31 2011-07-19 Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. HIV integrase inhibitors
US7494984B2 (en) * 2005-08-31 2009-02-24 Bristol-Myers Squibb Company Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
AU2006299042B8 (en) * 2005-10-04 2011-09-15 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa HIV integrase inhibitors
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064316A1 (en) * 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Bicyclic heterocycles as hiv integrase inhibitors
US20070129379A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Hiv integrase inhibitors
WO2007064502A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Forms of n-[(4-fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide
WO2007143446A1 (en) * 2006-05-30 2007-12-13 Bristol-Myers Squibb Company Spiro-condensed heterotricyclic compounds as hiv integrase inhibitors
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
EP2046328A4 (en) * 2006-07-19 2009-10-28 Univ Georgia Res Found PYRIDINONE DIKETOIC ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2009120841A1 (en) * 2008-03-27 2009-10-01 Bristol-Myers Squibb Company Crystalline form of n-[[4-fluoro-2-(5-methyl-1h-1,2,4-triazol-1-yl)phenyl]methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide, sodium salt monohydrate
CA2738814C (en) * 2008-10-06 2014-01-28 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
US8143244B2 (en) * 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
CN102574854B (zh) 2009-10-13 2014-04-16 伊兰科动物健康爱尔兰有限公司 大环整合酶抑制剂
US8383639B2 (en) 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
JP2013512957A (ja) 2009-12-07 2013-04-18 ユニバーシティ オブ ジョージア リサーチ ファウンデーション， インコーポレーテッド ピリジノンヒドロキシシクロペンチルカルボキサミド類：治療用途を備えたｈｉｖインテグラーゼ阻害剤
CA3003988C (en) 2010-01-27 2020-01-07 Viiv Healthcare Company Combinations for use in the inhibition of hiv-1
EP2552923B1 (en) 2010-04-02 2014-03-26 Janssen R&D Ireland Macrocyclic integrase inhibitors
BR112013000925A2 (pt) 2010-07-15 2020-12-01 Bayer Intellectual Property Gmbh compostos heterocíclicos como pesticidas
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP3750544A3 (en) 2011-11-30 2021-03-24 Emory University Jak inhibitors for use in the prevention or treatment of viral infection
EP2807149A2 (en) * 2012-01-26 2014-12-03 CRO Consulting Limited Agents for treating neurodegenerative disorders
WO2014099586A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
EP2986291B1 (en) 2013-04-16 2020-05-27 Merck Sharp & Dohme Corp. 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
RS56701B1 (sr) 2013-05-17 2018-03-30 Merck Sharp & Dohme Fuzionisana triciklična heterociklična jedinjenja kao inhibitori hiv integraze
EP3008044B1 (en) 2013-06-13 2018-11-21 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
KR101809392B1 (ko) 2013-09-27 2017-12-14 머크 샤프 앤드 돔 코포레이션 Hiv 인테그라제 억제제로서 유용한 치환된 퀴놀리진 유도체
WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
US10548910B2 (en) 2015-11-17 2020-02-04 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors
US10544155B2 (en) 2015-12-15 2020-01-28 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
CN110062627A (zh) 2016-12-02 2019-07-26 默沙东公司 可用作hiv整合酶抑制剂的三环杂环化合物
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
WO2018140368A1 (en) 2017-01-26 2018-08-02 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2021050555A1 (en) * 2019-09-10 2021-03-18 X-Chem, Inc. Compositions and uses thereof
CN113912622B (zh) * 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途

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PT1441734E (pt) 2001-10-26 2007-05-31 Isti Di Ric Di Bio Moleco P An Di-hidroxipirimidinocarboxamidas inibidoras da integrase do vih
ES2258668T3 (es) 2001-10-26 2006-09-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hidroxipirimidina carboxamidas n-sustituidas inhibidoras de hiv integrasa.
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TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
BRPI0518741A2 (pt) 2004-12-03 2008-12-02 Merck & Co Inc uso de uma combinaÇço de uma droga diretamente metabolizada por ugt1a1 ou um seu sal farmaceuticamente aceitÁvel e atazanavir ou um seu sal farmaceuticamente aceitÁvel, e, combinaÇço farmacÊutica para administraÇço oral a um mamÍfero
US7981879B2 (en) 2005-03-31 2011-07-19 Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. HIV integrase inhibitors

Also Published As

Publication number Publication date
ATE412656T1 (de) 2008-11-15
PL1749011T3 (pl) 2009-04-30
IL179455A0 (en) 2007-05-15
US20050267105A1 (en) 2005-12-01
KR20070039502A (ko) 2007-04-12
MXPA06013835A (es) 2007-02-02
NO20065879L (no) 2007-02-20
WO2005118593A1 (en) 2005-12-15
EP1749011B1 (en) 2008-10-29
KR101097623B1 (ko) 2011-12-22
PT1749011E (pt) 2008-11-27
US20060276466A1 (en) 2006-12-07
AU2005250356C1 (en) 2011-10-06
US7511037B2 (en) 2009-03-31
BRPI0511623A (pt) 2008-03-11
AU2005250356B2 (en) 2011-03-17
CA2568356C (en) 2012-07-03
SI1749011T1 (sl) 2009-08-31
HRP20090005T3 (en) 2009-02-28
RS50700B (sr) 2010-06-30
TW200600503A (en) 2006-01-01
PE20060242A1 (es) 2006-03-31
EP1749011A1 (en) 2007-02-07
JP4874959B2 (ja) 2012-02-15
AU2005250356A1 (en) 2005-12-15
HK1107343A1 (en) 2008-04-03
RU2006146970A (ru) 2008-07-10
JP2008501018A (ja) 2008-01-17
US7176196B2 (en) 2007-02-13
IL179455A (en) 2011-10-31
DE602005010690D1 (de) 2008-12-11
AR049124A1 (es) 2006-06-28
NZ551282A (en) 2009-05-31
RU2381228C2 (ru) 2010-02-10
TWI366567B (en) 2012-06-21
ES2315875T3 (es) 2009-04-01
DK1749011T3 (da) 2009-02-16
CA2568356A1 (en) 2005-12-15

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