CY1110665T1 - Αναστολεις hiv ιντεγκρασης - Google Patents
Αναστολεις hiv ιντεγκρασηςInfo
- Publication number
- CY1110665T1 CY1110665T1 CY20101100533T CY101100533T CY1110665T1 CY 1110665 T1 CY1110665 T1 CY 1110665T1 CY 20101100533 T CY20101100533 T CY 20101100533T CY 101100533 T CY101100533 T CY 101100533T CY 1110665 T1 CY1110665 T1 CY 1110665T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hiv
- inhibitions
- integration
- treatment
- hiv integration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση περιλαμβάνει σειρά δικυκλικών ενώσεων πυριμιδινόνης του τύπου I οι οποίες αναστέλλουν την HIV ιντεγκράση και εμποδίζουν την ιική ενωσμάτωση σε ανθρώπινο DNA. Η δράση αυτή καθιστά τις ενώσεις χρήσιμες για την αγωγή της HIV μόλυνσης και του AIDS. Η εφεύρεση επίσης περιλαμβάνει φαρμακευτικές συνθέσεις και μεθόδους για την αγωγή ατόμων μολυσμένων με HIV. [I].
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73778105P | 2005-11-17 | 2005-11-17 | |
US11/590,637 US8039458B2 (en) | 2005-11-17 | 2006-10-31 | HIV integrase inhibitors |
EP06837651A EP1948666B1 (en) | 2005-11-17 | 2006-11-15 | Hiv integrase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110665T1 true CY1110665T1 (el) | 2015-06-10 |
Family
ID=38041727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100533T CY1110665T1 (el) | 2005-11-17 | 2010-06-11 | Αναστολεις hiv ιντεγκρασης |
Country Status (20)
Country | Link |
---|---|
US (1) | US8039458B2 (el) |
EP (1) | EP1948666B1 (el) |
JP (1) | JP2009515981A (el) |
KR (1) | KR20080069254A (el) |
CN (1) | CN101360752B (el) |
AR (1) | AR057896A1 (el) |
AT (1) | ATE461202T1 (el) |
AU (1) | AU2006316582B2 (el) |
CY (1) | CY1110665T1 (el) |
DE (1) | DE602006013025D1 (el) |
DK (1) | DK1948666T3 (el) |
ES (1) | ES2341132T3 (el) |
HR (1) | HRP20100247T1 (el) |
NO (1) | NO20081935L (el) |
PE (1) | PE20071080A1 (el) |
PL (1) | PL1948666T3 (el) |
PT (1) | PT1948666E (el) |
SI (1) | SI1948666T1 (el) |
TW (1) | TW200738728A (el) |
WO (1) | WO2007061714A1 (el) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
CA2714033A1 (en) * | 2008-02-07 | 2009-08-13 | Bayer Cropscience Ag | Insecticidal arylpyrrolines |
US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
WO2010042391A2 (en) * | 2008-10-06 | 2010-04-15 | Merck Sharp & Dohme Corp. | Hiv integrase inhibitors |
US8143244B2 (en) | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
JP2012527414A (ja) | 2009-05-19 | 2012-11-08 | バイエル・クロップサイエンス・アーゲー | 殺虫性アリールピロリン |
CN102574854B (zh) * | 2009-10-13 | 2014-04-16 | 伊兰科动物健康爱尔兰有限公司 | 大环整合酶抑制剂 |
US8383639B2 (en) * | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
US8822471B2 (en) | 2011-03-14 | 2014-09-02 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
WO2012168315A1 (en) | 2011-06-09 | 2012-12-13 | Boehringer Ingelheim International Gmbh | Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders |
CN104185420B (zh) | 2011-11-30 | 2017-06-09 | 埃默里大学 | 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂 |
EP2880027B1 (en) | 2012-08-02 | 2016-09-28 | Boehringer Ingelheim International GmbH | N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof |
EP2931730B1 (en) | 2012-12-17 | 2019-08-07 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
WO2014172188A2 (en) | 2013-04-16 | 2014-10-23 | Merck Sharp & Dohme Corp. | 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors |
CA2909938A1 (en) * | 2013-04-22 | 2014-10-30 | Abbvie Inc. | Thiazoles and uses thereof |
WO2014183532A1 (en) | 2013-05-17 | 2014-11-20 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
WO2014200880A1 (en) | 2013-06-13 | 2014-12-18 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
PE20160501A1 (es) | 2013-09-27 | 2016-05-14 | Merck Sharp & Dohme | Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih |
KR102542097B1 (ko) * | 2015-01-16 | 2023-06-09 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 4-시아노피페리딘 하이드로클로라이드의 제조 방법 |
WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
WO2017087257A1 (en) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors |
US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
WO2018010163A1 (zh) * | 2016-07-15 | 2018-01-18 | 泸州东方农化有限公司 | 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体 |
CN110062627A (zh) | 2016-12-02 | 2019-07-26 | 默沙东公司 | 可用作hiv整合酶抑制剂的三环杂环化合物 |
JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
EP3573984A4 (en) | 2017-01-26 | 2020-07-29 | Merck Sharp & Dohme Corp. | USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS |
CN113795491A (zh) * | 2019-04-30 | 2021-12-14 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
CN113372335B (zh) * | 2021-07-05 | 2023-02-24 | 山东大学 | 一种含有1,2,4-三唑硫醚的苯丙氨酸衍生物及其制备方法与应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0317749A (pt) * | 2002-12-27 | 2005-11-22 | Angeletti P Ist Richerche Bio | Composto, composição farmacêutica, e, uso de um composto |
AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
US7981879B2 (en) * | 2005-03-31 | 2011-07-19 | Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. | HIV integrase inhibitors |
US7741315B2 (en) | 2005-05-10 | 2010-06-22 | Merck Sharp & Dohme Corp. | HIV integrase inhibitors |
-
2006
- 2006-10-31 US US11/590,637 patent/US8039458B2/en active Active
- 2006-11-15 JP JP2008541302A patent/JP2009515981A/ja active Pending
- 2006-11-15 KR KR1020087014533A patent/KR20080069254A/ko not_active Application Discontinuation
- 2006-11-15 CN CN2006800512376A patent/CN101360752B/zh not_active Expired - Fee Related
- 2006-11-15 AT AT06837651T patent/ATE461202T1/de active
- 2006-11-15 AU AU2006316582A patent/AU2006316582B2/en not_active Ceased
- 2006-11-15 PL PL06837651T patent/PL1948666T3/pl unknown
- 2006-11-15 SI SI200630642T patent/SI1948666T1/sl unknown
- 2006-11-15 ES ES06837651T patent/ES2341132T3/es active Active
- 2006-11-15 PT PT06837651T patent/PT1948666E/pt unknown
- 2006-11-15 DK DK06837651.6T patent/DK1948666T3/da active
- 2006-11-15 PE PE2006001455A patent/PE20071080A1/es not_active Application Discontinuation
- 2006-11-15 EP EP06837651A patent/EP1948666B1/en active Active
- 2006-11-15 WO PCT/US2006/044320 patent/WO2007061714A1/en active Application Filing
- 2006-11-15 DE DE602006013025T patent/DE602006013025D1/de active Active
- 2006-11-16 AR ARP060105027A patent/AR057896A1/es unknown
- 2006-11-17 TW TW095142505A patent/TW200738728A/zh unknown
-
2008
- 2008-04-23 NO NO20081935A patent/NO20081935L/no not_active Application Discontinuation
-
2010
- 2010-04-29 HR HR20100247T patent/HRP20100247T1/hr unknown
- 2010-06-11 CY CY20101100533T patent/CY1110665T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE602006013025D1 (de) | 2010-04-29 |
AR057896A1 (es) | 2007-12-26 |
SI1948666T1 (sl) | 2010-06-30 |
US20070111984A1 (en) | 2007-05-17 |
KR20080069254A (ko) | 2008-07-25 |
NO20081935L (no) | 2008-06-24 |
ATE461202T1 (de) | 2010-04-15 |
HRP20100247T1 (hr) | 2010-06-30 |
PE20071080A1 (es) | 2007-11-19 |
PL1948666T3 (pl) | 2010-08-31 |
AU2006316582B2 (en) | 2012-01-19 |
TW200738728A (en) | 2007-10-16 |
DK1948666T3 (da) | 2010-05-25 |
EP1948666B1 (en) | 2010-03-17 |
US8039458B2 (en) | 2011-10-18 |
CN101360752B (zh) | 2012-09-05 |
ES2341132T3 (es) | 2010-06-15 |
CN101360752A (zh) | 2009-02-04 |
PT1948666E (pt) | 2010-05-17 |
JP2009515981A (ja) | 2009-04-16 |
WO2007061714A1 (en) | 2007-05-31 |
EP1948666A1 (en) | 2008-07-30 |
AU2006316582A1 (en) | 2007-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1110665T1 (el) | Αναστολεις hiv ιντεγκρασης | |
CY1110266T1 (el) | Δικυκλικες ετεροκυκλικες ενωσεις ως αναστολεις της hiv ιντεγκρασης | |
CY1111613T1 (el) | Μεθοδοι για την αντιμετωπιση της μολυνσης απο hiv | |
NO20082135L (no) | HIV integrase inhibitorer | |
NO20065443L (no) | HIV-Integraseinhibitorer: Sykliske pyrimidinonforbindelser | |
CY1115580T1 (el) | Συνθεση και αντι-ιικη δραστηριοτητα των υποκατεστημενων παραγωγων αζαϊνδολοοξικης πιπεραζινης | |
WO2007059125A3 (en) | Hiv integrase inhibitors | |
WO2008002959A3 (en) | Hiv integrase inhibitors | |
CY1122841T1 (el) | Πολυαλκυλενικες πολυμερικες ενωσεις και χρησεις αυτων | |
EA201200631A1 (ru) | Ингибиторы репликации вируса иммунодефицита человека | |
NO20080797L (no) | Bicykliske heterocykler som HIV Integrase inhibitorer | |
EA200802203A1 (ru) | Дикетопиперазиновые и пиперидиновые производные в качестве противовирусных агентов | |
CY1118279T1 (el) | Φαρμακευτικeς συνθeσεις | |
CY1106207T1 (el) | Αντιιικα παραγωγα νουκλεοζιτων | |
CY1106476T1 (el) | Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες | |
CY1113103T1 (el) | Φωσφονικα νουκλεοσιδιων και αναλογα εξ αυτων για την αγωγη των λοιμωξεων-hpv | |
NO20083585L (no) | Hetero-bisykliske antivirale forbindelser | |
BRPI0508876A (pt) | pró medicamentos de agentes antivirais de piperazina e piperidina substituìda | |
DE60323133D1 (de) | Cyclohexylverbindungen als ccr5-antagonisten | |
DK1765337T3 (da) | Kombination af tenofovir, ritonavir og TMC114 | |
WO2008118849A3 (en) | Hiv-1 protease inhibitors | |
EA201101397A1 (ru) | Ингибиторы репликации вируса иммунодефицита человека | |
UY29189A1 (es) | Nonadepsipeptidos acilados ii | |
CY1109187T1 (el) | Νεα μακρολιδια | |
SE0302304D0 (sv) | Novel compounds |