PL1948666T3 - Inhibitory integrazy HIV - Google Patents
Inhibitory integrazy HIVInfo
- Publication number
- PL1948666T3 PL1948666T3 PL06837651T PL06837651T PL1948666T3 PL 1948666 T3 PL1948666 T3 PL 1948666T3 PL 06837651 T PL06837651 T PL 06837651T PL 06837651 T PL06837651 T PL 06837651T PL 1948666 T3 PL1948666 T3 PL 1948666T3
- Authority
- PL
- Poland
- Prior art keywords
- hiv integrase
- integrase inhibitors
- inhibitors
- hiv
- integrase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73778105P | 2005-11-17 | 2005-11-17 | |
| US11/590,637 US8039458B2 (en) | 2005-11-17 | 2006-10-31 | HIV integrase inhibitors |
| PCT/US2006/044320 WO2007061714A1 (en) | 2005-11-17 | 2006-11-15 | Hiv integrase inhibitors |
| EP06837651A EP1948666B1 (en) | 2005-11-17 | 2006-11-15 | Hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1948666T3 true PL1948666T3 (pl) | 2010-08-31 |
Family
ID=38041727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06837651T PL1948666T3 (pl) | 2005-11-17 | 2006-11-15 | Inhibitory integrazy HIV |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8039458B2 (pl) |
| EP (1) | EP1948666B1 (pl) |
| JP (1) | JP2009515981A (pl) |
| KR (1) | KR20080069254A (pl) |
| CN (1) | CN101360752B (pl) |
| AR (1) | AR057896A1 (pl) |
| AT (1) | ATE461202T1 (pl) |
| AU (1) | AU2006316582B2 (pl) |
| CY (1) | CY1110665T1 (pl) |
| DE (1) | DE602006013025D1 (pl) |
| DK (1) | DK1948666T3 (pl) |
| ES (1) | ES2341132T3 (pl) |
| HR (1) | HRP20100247T1 (pl) |
| NO (1) | NO20081935L (pl) |
| PE (1) | PE20071080A1 (pl) |
| PL (1) | PL1948666T3 (pl) |
| PT (1) | PT1948666E (pl) |
| SI (1) | SI1948666T1 (pl) |
| TW (1) | TW200738728A (pl) |
| WO (1) | WO2007061714A1 (pl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| KR20100113598A (ko) * | 2008-02-07 | 2010-10-21 | 바이엘 크롭사이언스 아게 | 살충성 아릴피롤린 |
| US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| BRPI0920605A8 (pt) * | 2008-10-06 | 2016-04-26 | Merck Sharp & Dohme | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para o tratamento ou profilaxia de infecção pelo hiv ou para o tratamento, profilaxia, ou retardo no início ou progressão da aids em um paciente em necessidade deste. |
| US8143244B2 (en) | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| ES2536278T3 (es) | 2009-05-19 | 2015-05-22 | Bayer Intellectual Property Gmbh | Arilpirrolinas insecticidas |
| BR112012008586A2 (pt) * | 2009-10-13 | 2016-11-29 | Elanco Animal Health Ireland | inibidores da integrase macrocíclicos |
| US8383639B2 (en) * | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| US8822471B2 (en) | 2011-03-14 | 2014-09-02 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| EP2718288B1 (en) | 2011-06-09 | 2015-03-11 | Boehringer Ingelheim International GmbH | Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders |
| MX2014006479A (es) | 2011-11-30 | 2015-01-22 | Univ Emory | Inhibidores antivirales de la janus cinasa utiles en el tratamiento o prevencion de infecciones retrovirales y otras infecciones virales. |
| JP2015523404A (ja) | 2012-08-02 | 2015-08-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｎ−シクロプロピル−ｎ−ピペリジニル−アミド、これらを含有する医薬組成物およびその使用 |
| EP2931730B1 (en) | 2012-12-17 | 2019-08-07 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
| US9493479B2 (en) | 2013-04-16 | 2016-11-15 | Merck Sharp & Dohme Corp. | Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors |
| BR112015026847A2 (pt) | 2013-04-22 | 2017-07-25 | Abbvie Inc | tiazóis e usos dos mesmos |
| EP3330272B1 (en) | 2013-05-17 | 2021-02-17 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| WO2014200880A1 (en) | 2013-06-13 | 2014-12-18 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| MX367057B (es) | 2013-09-27 | 2019-08-02 | Merck Sharp & Dohme | Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih. |
| KR102542097B1 (ko) * | 2015-01-16 | 2023-06-09 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 4-시아노피페리딘 하이드로클로라이드의 제조 방법 |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| WO2017087257A1 (en) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors |
| EP3389380B1 (en) | 2015-12-15 | 2021-07-21 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| CN109311823B (zh) * | 2016-07-15 | 2023-01-24 | 泸州东方农化有限公司 | 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体 |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| CA3042314A1 (en) | 2016-12-02 | 2018-06-07 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| WO2018140368A1 (en) | 2017-01-26 | 2018-08-02 | Merck Sharp & Dohme Corp. | Substituted quinolizine derivatives useful as hiv integrase inhibitors |
| WO2020221294A1 (zh) * | 2019-04-30 | 2020-11-05 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| CN113372335B (zh) * | 2021-07-05 | 2023-02-24 | 山东大学 | 一种含有1,2,4-三唑硫醚的苯丙氨酸衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ540729A (en) * | 2002-12-27 | 2008-03-28 | Angeletti P Ist Richerche Bio | Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds useful as HIV integrase inhibitors |
| AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| WO2006103399A1 (en) | 2005-03-31 | 2006-10-05 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv integrase inhibitors |
| AU2006244424B2 (en) | 2005-05-10 | 2011-09-22 | Merck Sharp & Dohme Corp. | HIV integrase inhibitors |
-
2006
- 2006-10-31 US US11/590,637 patent/US8039458B2/en active Active
- 2006-11-15 AU AU2006316582A patent/AU2006316582B2/en not_active Ceased
- 2006-11-15 WO PCT/US2006/044320 patent/WO2007061714A1/en active Application Filing
- 2006-11-15 DE DE602006013025T patent/DE602006013025D1/de active Active
- 2006-11-15 AT AT06837651T patent/ATE461202T1/de active
- 2006-11-15 DK DK06837651.6T patent/DK1948666T3/da active
- 2006-11-15 SI SI200630642T patent/SI1948666T1/sl unknown
- 2006-11-15 EP EP06837651A patent/EP1948666B1/en active Active
- 2006-11-15 ES ES06837651T patent/ES2341132T3/es active Active
- 2006-11-15 CN CN2006800512376A patent/CN101360752B/zh not_active Expired - Fee Related
- 2006-11-15 PT PT06837651T patent/PT1948666E/pt unknown
- 2006-11-15 JP JP2008541302A patent/JP2009515981A/ja active Pending
- 2006-11-15 KR KR1020087014533A patent/KR20080069254A/ko not_active Application Discontinuation
- 2006-11-15 PE PE2006001455A patent/PE20071080A1/es not_active Application Discontinuation
- 2006-11-15 PL PL06837651T patent/PL1948666T3/pl unknown
- 2006-11-16 AR ARP060105027A patent/AR057896A1/es unknown
- 2006-11-17 TW TW095142505A patent/TW200738728A/zh unknown
-
2008
- 2008-04-23 NO NO20081935A patent/NO20081935L/no not_active Application Discontinuation
-
2010
- 2010-04-29 HR HR20100247T patent/HRP20100247T1/hr unknown
- 2010-06-11 CY CY20101100533T patent/CY1110665T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20100247T1 (hr) | 2010-06-30 |
| SI1948666T1 (sl) | 2010-06-30 |
| AU2006316582B2 (en) | 2012-01-19 |
| JP2009515981A (ja) | 2009-04-16 |
| NO20081935L (no) | 2008-06-24 |
| CN101360752A (zh) | 2009-02-04 |
| PE20071080A1 (es) | 2007-11-19 |
| CN101360752B (zh) | 2012-09-05 |
| EP1948666B1 (en) | 2010-03-17 |
| US8039458B2 (en) | 2011-10-18 |
| AR057896A1 (es) | 2007-12-26 |
| US20070111984A1 (en) | 2007-05-17 |
| AU2006316582A1 (en) | 2007-05-31 |
| KR20080069254A (ko) | 2008-07-25 |
| PT1948666E (pt) | 2010-05-17 |
| CY1110665T1 (el) | 2015-06-10 |
| ES2341132T3 (es) | 2010-06-15 |
| ATE461202T1 (de) | 2010-04-15 |
| TW200738728A (en) | 2007-10-16 |
| DE602006013025D1 (de) | 2010-04-29 |
| DK1948666T3 (da) | 2010-05-25 |
| WO2007061714A1 (en) | 2007-05-31 |
| EP1948666A1 (en) | 2008-07-30 |
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