PL1948666T3 - Inhibitory integrazy HIV - Google Patents

Inhibitory integrazy HIV

Info

Publication number
PL1948666T3
PL1948666T3 PL06837651T PL06837651T PL1948666T3 PL 1948666 T3 PL1948666 T3 PL 1948666T3 PL 06837651 T PL06837651 T PL 06837651T PL 06837651 T PL06837651 T PL 06837651T PL 1948666 T3 PL1948666 T3 PL 1948666T3
Authority
PL
Poland
Prior art keywords
hiv integrase
integrase inhibitors
inhibitors
hiv
integrase
Prior art date
Application number
PL06837651T
Other languages
English (en)
Inventor
B Narasimhulu Naidu
Yasutsugu Ueda
John D Matiskella
Michael A Walker
Jacques Banville
Francis Beaulieu
Carl Ouellet
Serge Plamondon
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PL1948666T3 publication Critical patent/PL1948666T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL06837651T 2005-11-17 2006-11-15 Inhibitory integrazy HIV PL1948666T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73778105P 2005-11-17 2005-11-17
US11/590,637 US8039458B2 (en) 2005-11-17 2006-10-31 HIV integrase inhibitors
PCT/US2006/044320 WO2007061714A1 (en) 2005-11-17 2006-11-15 Hiv integrase inhibitors
EP06837651A EP1948666B1 (en) 2005-11-17 2006-11-15 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
PL1948666T3 true PL1948666T3 (pl) 2010-08-31

Family

ID=38041727

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06837651T PL1948666T3 (pl) 2005-11-17 2006-11-15 Inhibitory integrazy HIV

Country Status (20)

Country Link
US (1) US8039458B2 (pl)
EP (1) EP1948666B1 (pl)
JP (1) JP2009515981A (pl)
KR (1) KR20080069254A (pl)
CN (1) CN101360752B (pl)
AR (1) AR057896A1 (pl)
AT (1) ATE461202T1 (pl)
AU (1) AU2006316582B2 (pl)
CY (1) CY1110665T1 (pl)
DE (1) DE602006013025D1 (pl)
DK (1) DK1948666T3 (pl)
ES (1) ES2341132T3 (pl)
HR (1) HRP20100247T1 (pl)
NO (1) NO20081935L (pl)
PE (1) PE20071080A1 (pl)
PL (1) PL1948666T3 (pl)
PT (1) PT1948666E (pl)
SI (1) SI1948666T1 (pl)
TW (1) TW200738728A (pl)
WO (1) WO2007061714A1 (pl)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
PE20091370A1 (es) * 2008-02-07 2009-09-26 Bayer Cropscience Ag Arilpirrolinas insecticidas
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
BRPI0920605A8 (pt) * 2008-10-06 2016-04-26 Merck Sharp & Dohme Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para o tratamento ou profilaxia de infecção pelo hiv ou para o tratamento, profilaxia, ou retardo no início ou progressão da aids em um paciente em necessidade deste.
US8143244B2 (en) 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
JP2012527414A (ja) 2009-05-19 2012-11-08 バイエル・クロップサイエンス・アーゲー 殺虫性アリールピロリン
CA2777664C (en) * 2009-10-13 2014-06-10 Johannes Wilhelmus J. Thuring Macrocyclic integrase inhibitors
US8383639B2 (en) * 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
JP5935154B2 (ja) 2011-03-14 2016-06-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Gpr119モジュレーターとしてのn−シクロプロピル−n−ピペリジニルベンズアミド
US8921398B2 (en) 2011-06-09 2014-12-30 Boehringer Ingelheim International Gmbh N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof
AU2012345732B2 (en) 2011-11-30 2016-07-14 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
JP2015523404A (ja) 2012-08-02 2015-08-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング N−シクロプロピル−n−ピペリジニル−アミド、これらを含有する医薬組成物およびその使用
EP2931730B1 (en) 2012-12-17 2019-08-07 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
EP2986291B1 (en) 2013-04-16 2020-05-27 Merck Sharp & Dohme Corp. 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
WO2014176268A1 (en) * 2013-04-22 2014-10-30 Abbvie Inc. Thiazoles and uses thereof
AU2014267951A1 (en) 2013-05-17 2015-11-19 Merck Sharp & Dohme Corp. Fused Tricyclic Heterocyclic compounds as HIV integrase inhibitors
WO2014200880A1 (en) 2013-06-13 2014-12-18 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
MA38922A3 (fr) 2013-09-27 2018-11-30 Merck Sharp & Dohme Dérivés de quinolizine substitués utiles en tant qu'inhibiteurs de l'integrase du vih
KR102542097B1 (ko) * 2015-01-16 2023-06-09 바이엘 크롭사이언스 악티엔게젤샤프트 4-시아노피페리딘 하이드로클로라이드의 제조 방법
WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
EP3377066B1 (en) 2015-11-17 2021-04-07 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors
US10544155B2 (en) 2015-12-15 2020-01-28 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
WO2018010163A1 (zh) * 2016-07-15 2018-01-18 泸州东方农化有限公司 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
JP2020500866A (ja) 2016-12-02 2020-01-16 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. Hivインテグラーゼ阻害剤として有用な三環式複素環化合物
WO2018140368A1 (en) 2017-01-26 2018-08-02 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2020221294A1 (zh) * 2019-04-30 2020-11-05 上海拓界生物医药科技有限公司 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途
CN114426540B (zh) * 2020-10-29 2024-04-26 上海拓界生物医药科技有限公司 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用
CN113372335B (zh) * 2021-07-05 2023-02-24 山东大学 一种含有1,2,4-三唑硫醚的苯丙氨酸衍生物及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2509554C (en) * 2002-12-27 2011-02-01 Benedetta Crescenzi Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
AR046938A1 (es) 2003-12-12 2006-01-04 Merck & Co Inc Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
AU2006228278C1 (en) * 2005-03-31 2011-06-23 Msd Italia S.R.L. HIV integrase inhibitors
AU2006244424B2 (en) 2005-05-10 2011-09-22 Merck Sharp & Dohme Corp. HIV integrase inhibitors

Also Published As

Publication number Publication date
SI1948666T1 (sl) 2010-06-30
HRP20100247T1 (hr) 2010-06-30
PT1948666E (pt) 2010-05-17
DK1948666T3 (da) 2010-05-25
EP1948666B1 (en) 2010-03-17
AU2006316582B2 (en) 2012-01-19
AR057896A1 (es) 2007-12-26
ES2341132T3 (es) 2010-06-15
WO2007061714A1 (en) 2007-05-31
CN101360752B (zh) 2012-09-05
KR20080069254A (ko) 2008-07-25
NO20081935L (no) 2008-06-24
ATE461202T1 (de) 2010-04-15
EP1948666A1 (en) 2008-07-30
JP2009515981A (ja) 2009-04-16
AU2006316582A1 (en) 2007-05-31
CY1110665T1 (el) 2015-06-10
US8039458B2 (en) 2011-10-18
DE602006013025D1 (de) 2010-04-29
PE20071080A1 (es) 2007-11-19
CN101360752A (zh) 2009-02-04
TW200738728A (en) 2007-10-16
US20070111984A1 (en) 2007-05-17

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