PL1948666T3 - Inhibitory integrazy HIV - Google Patents
Inhibitory integrazy HIVInfo
- Publication number
- PL1948666T3 PL1948666T3 PL06837651T PL06837651T PL1948666T3 PL 1948666 T3 PL1948666 T3 PL 1948666T3 PL 06837651 T PL06837651 T PL 06837651T PL 06837651 T PL06837651 T PL 06837651T PL 1948666 T3 PL1948666 T3 PL 1948666T3
- Authority
- PL
- Poland
- Prior art keywords
- hiv integrase
- integrase inhibitors
- inhibitors
- hiv
- integrase
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73778105P | 2005-11-17 | 2005-11-17 | |
| US11/590,637 US8039458B2 (en) | 2005-11-17 | 2006-10-31 | HIV integrase inhibitors |
| PCT/US2006/044320 WO2007061714A1 (en) | 2005-11-17 | 2006-11-15 | Hiv integrase inhibitors |
| EP06837651A EP1948666B1 (en) | 2005-11-17 | 2006-11-15 | Hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1948666T3 true PL1948666T3 (pl) | 2010-08-31 |
Family
ID=38041727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06837651T PL1948666T3 (pl) | 2005-11-17 | 2006-11-15 | Inhibitory integrazy HIV |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8039458B2 (pl) |
| EP (1) | EP1948666B1 (pl) |
| JP (1) | JP2009515981A (pl) |
| KR (1) | KR20080069254A (pl) |
| CN (1) | CN101360752B (pl) |
| AR (1) | AR057896A1 (pl) |
| AT (1) | ATE461202T1 (pl) |
| AU (1) | AU2006316582B2 (pl) |
| CY (1) | CY1110665T1 (pl) |
| DE (1) | DE602006013025D1 (pl) |
| DK (1) | DK1948666T3 (pl) |
| ES (1) | ES2341132T3 (pl) |
| HR (1) | HRP20100247T1 (pl) |
| NO (1) | NO20081935L (pl) |
| PE (1) | PE20071080A1 (pl) |
| PL (1) | PL1948666T3 (pl) |
| PT (1) | PT1948666E (pl) |
| SI (1) | SI1948666T1 (pl) |
| TW (1) | TW200738728A (pl) |
| WO (1) | WO2007061714A1 (pl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| CN101939295B (zh) * | 2008-02-07 | 2013-04-24 | 拜尔农作物科学股份公司 | 杀虫的芳基吡咯啉 |
| US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| MX2011003637A (es) * | 2008-10-06 | 2011-04-27 | Merck Sharp & Dohme | Inhibidores de la integrasa del virus de inmunodeficiencia humana. |
| US8143244B2 (en) | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| CN102438984A (zh) | 2009-05-19 | 2012-05-02 | 拜耳作物科学公司 | 杀虫用芳基吡咯啉 |
| NZ598766A (en) * | 2009-10-13 | 2013-09-27 | Elanco Animal Health Ireland | Macrocyclic integrase inhibitors |
| US8383639B2 (en) * | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| US8822471B2 (en) | 2011-03-14 | 2014-09-02 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| WO2012168315A1 (en) | 2011-06-09 | 2012-12-13 | Boehringer Ingelheim International Gmbh | Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders |
| CN104185420B (zh) | 2011-11-30 | 2017-06-09 | 埃默里大学 | 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂 |
| EP2880027B1 (en) | 2012-08-02 | 2016-09-28 | Boehringer Ingelheim International GmbH | N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof |
| WO2014099586A1 (en) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
| WO2014172188A2 (en) | 2013-04-16 | 2014-10-23 | Merck Sharp & Dohme Corp. | 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors |
| JP6434496B2 (ja) * | 2013-04-22 | 2018-12-05 | アッヴィ・インコーポレイテッド | チアゾールおよびその使用 |
| HUE036384T2 (hu) | 2013-05-17 | 2018-07-30 | Merck Sharp & Dohme | Fúzionált triciklusos heterociklikus vegyületek mint HIV integráz inhibitorok |
| EP3008044B1 (en) | 2013-06-13 | 2018-11-21 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| AU2014324829B2 (en) | 2013-09-27 | 2017-09-07 | Merck Sharp & Dohme Corp. | Substituted Quinolizine Derivatives useful as HIV integrase inhibitors |
| JP6660393B2 (ja) * | 2015-01-16 | 2020-03-11 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ４−シアノピペリジン塩酸塩を調製する方法 |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| EP3377066B1 (en) | 2015-11-17 | 2021-04-07 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors |
| US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| EP3486235A4 (en) * | 2016-07-15 | 2020-02-12 | Oriental (Luzhou) Agrochemicals. Co., Ltd. | SYNTHETIC METHOD FOR 1,2,4-TRIAZOLE-3-THION COMPOUND AND INTERMEDIATE PRODUCT THEREOF |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| MX384729B (es) | 2016-12-02 | 2025-03-14 | Merck Sharp & Dohme | Compuestos heterocíclicos tricíclicos útiles como inhibidores de la integrasa del virus de inmunodeficiencia humana (vih). |
| WO2018140368A1 (en) | 2017-01-26 | 2018-08-02 | Merck Sharp & Dohme Corp. | Substituted quinolizine derivatives useful as hiv integrase inhibitors |
| WO2020221294A1 (zh) * | 2019-04-30 | 2020-11-05 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| CN113372335B (zh) * | 2021-07-05 | 2023-02-24 | 山东大学 | 一种含有1,2,4-三唑硫醚的苯丙氨酸衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05007010A (es) * | 2002-12-27 | 2005-08-18 | Angeletti P Ist Richerche Bio | Tetrahidro-4h-pirido[1,2-a]pirimidinas y compuestos relacionados utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana. |
| AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| JP5116660B2 (ja) * | 2005-03-31 | 2013-01-09 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ | Ｈｉｖインテグラーゼ阻害剤 |
| WO2006121831A2 (en) | 2005-05-10 | 2006-11-16 | Merck & Co., Inc. | Hiv integrase inhibitors |
-
2006
- 2006-10-31 US US11/590,637 patent/US8039458B2/en active Active
- 2006-11-15 AT AT06837651T patent/ATE461202T1/de active
- 2006-11-15 PE PE2006001455A patent/PE20071080A1/es not_active Application Discontinuation
- 2006-11-15 JP JP2008541302A patent/JP2009515981A/ja active Pending
- 2006-11-15 PT PT06837651T patent/PT1948666E/pt unknown
- 2006-11-15 CN CN2006800512376A patent/CN101360752B/zh not_active Expired - Fee Related
- 2006-11-15 PL PL06837651T patent/PL1948666T3/pl unknown
- 2006-11-15 DE DE602006013025T patent/DE602006013025D1/de active Active
- 2006-11-15 KR KR1020087014533A patent/KR20080069254A/ko not_active Ceased
- 2006-11-15 SI SI200630642T patent/SI1948666T1/sl unknown
- 2006-11-15 AU AU2006316582A patent/AU2006316582B2/en not_active Ceased
- 2006-11-15 HR HR20100247T patent/HRP20100247T1/hr unknown
- 2006-11-15 WO PCT/US2006/044320 patent/WO2007061714A1/en not_active Ceased
- 2006-11-15 EP EP06837651A patent/EP1948666B1/en active Active
- 2006-11-15 DK DK06837651.6T patent/DK1948666T3/da active
- 2006-11-15 ES ES06837651T patent/ES2341132T3/es active Active
- 2006-11-16 AR ARP060105027A patent/AR057896A1/es unknown
- 2006-11-17 TW TW095142505A patent/TW200738728A/zh unknown
-
2008
- 2008-04-23 NO NO20081935A patent/NO20081935L/no not_active Application Discontinuation
-
2010
- 2010-06-11 CY CY20101100533T patent/CY1110665T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101360752B (zh) | 2012-09-05 |
| PT1948666E (pt) | 2010-05-17 |
| SI1948666T1 (sl) | 2010-06-30 |
| HRP20100247T1 (hr) | 2010-06-30 |
| AU2006316582B2 (en) | 2012-01-19 |
| KR20080069254A (ko) | 2008-07-25 |
| EP1948666B1 (en) | 2010-03-17 |
| US8039458B2 (en) | 2011-10-18 |
| AU2006316582A1 (en) | 2007-05-31 |
| CN101360752A (zh) | 2009-02-04 |
| ATE461202T1 (de) | 2010-04-15 |
| JP2009515981A (ja) | 2009-04-16 |
| PE20071080A1 (es) | 2007-11-19 |
| NO20081935L (no) | 2008-06-24 |
| EP1948666A1 (en) | 2008-07-30 |
| ES2341132T3 (es) | 2010-06-15 |
| DE602006013025D1 (de) | 2010-04-29 |
| CY1110665T1 (el) | 2015-06-10 |
| WO2007061714A1 (en) | 2007-05-31 |
| DK1948666T3 (da) | 2010-05-25 |
| AR057896A1 (es) | 2007-12-26 |
| US20070111984A1 (en) | 2007-05-17 |
| TW200738728A (en) | 2007-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL1948666T3 (pl) | Inhibitory integrazy HIV | |
| EP1756069A4 (en) | HIV INTEGRASE INHIBITORS | |
| IL177189A0 (en) | Hiv integrase inhibitors | |
| IL177858A0 (en) | Hiv integrase inhibitors | |
| TWI366567B (en) | Bicyclic heterocycles as hiv integrase inhibitors | |
| IL179161A0 (en) | Hiv integrase inhibitors: cyclic pyrimidinone compounds | |
| IL192208A0 (en) | Methods for improving the pharmacokinetics of hiv integrase inhibitors | |
| IL188615A0 (en) | Hiv reverse transcriptase inhibitors | |
| EP1753767A4 (en) | BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS | |
| EP1749008A4 (en) | BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS | |
| ZA201102620B (en) | Hiv integrase inhibitors | |
| IL183850A0 (en) | Hiv protease inhibitors | |
| AP2005003451A0 (en) | HIV integrase inhibitors. | |
| EP1910363A4 (en) | INHIBITORS OF HIV INTEGRASE | |
| ZA200709605B (en) | HIV vaccine | |
| EP1855672A4 (en) | HIV PROTEASE INHIBITORS | |
| IL189939A0 (en) | Inhibitors of the hiv integrase enzyme | |
| EP1910356A4 (en) | HIV integrase | |
| ZA200706305B (en) | HIV protease inhibitors | |
| ZA200800185B (en) | Hiv reverse transcriptase inhibitors | |
| EP1909578A4 (en) | INHIBITORS OF HIV INTEGRASE | |
| EP1910355A4 (en) | HIV integrase | |
| ZA200606956B (en) | HIV integrase inhibitors | |
| ZA200806222B (en) | Methods for improving the pharmacokinetics of HIV integrase inhibitors | |
| GB0516967D0 (en) | Inhibitors |