NO20081935L - HIV-integraseinhibitorer - Google Patents
HIV-integraseinhibitorerInfo
- Publication number
- NO20081935L NO20081935L NO20081935A NO20081935A NO20081935L NO 20081935 L NO20081935 L NO 20081935L NO 20081935 A NO20081935 A NO 20081935A NO 20081935 A NO20081935 A NO 20081935A NO 20081935 L NO20081935 L NO 20081935L
- Authority
- NO
- Norway
- Prior art keywords
- hiv
- hiv integrase
- compounds
- aids
- series
- Prior art date
Links
- 108010002459 HIV Integrase Proteins 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- -1 bicyclic pyrimidinone compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73778105P | 2005-11-17 | 2005-11-17 | |
| US11/590,637 US8039458B2 (en) | 2005-11-17 | 2006-10-31 | HIV integrase inhibitors |
| PCT/US2006/044320 WO2007061714A1 (en) | 2005-11-17 | 2006-11-15 | Hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081935L true NO20081935L (no) | 2008-06-24 |
Family
ID=38041727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081935A NO20081935L (no) | 2005-11-17 | 2008-04-23 | HIV-integraseinhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8039458B2 (pl) |
| EP (1) | EP1948666B1 (pl) |
| JP (1) | JP2009515981A (pl) |
| KR (1) | KR20080069254A (pl) |
| CN (1) | CN101360752B (pl) |
| AR (1) | AR057896A1 (pl) |
| AT (1) | ATE461202T1 (pl) |
| AU (1) | AU2006316582B2 (pl) |
| CY (1) | CY1110665T1 (pl) |
| DE (1) | DE602006013025D1 (pl) |
| DK (1) | DK1948666T3 (pl) |
| ES (1) | ES2341132T3 (pl) |
| HR (1) | HRP20100247T1 (pl) |
| NO (1) | NO20081935L (pl) |
| PE (1) | PE20071080A1 (pl) |
| PL (1) | PL1948666T3 (pl) |
| PT (1) | PT1948666E (pl) |
| SI (1) | SI1948666T1 (pl) |
| TW (1) | TW200738728A (pl) |
| WO (1) | WO2007061714A1 (pl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| PE20091370A1 (es) * | 2008-02-07 | 2009-09-26 | Bayer Cropscience Ag | Arilpirrolinas insecticidas |
| US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| EP2349276B1 (en) * | 2008-10-06 | 2019-11-27 | Merck Sharp & Dohme Corp. | Hiv integrase inhibitors |
| US8143244B2 (en) | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| BRPI1010909A2 (pt) | 2009-05-19 | 2015-09-08 | Bayer Cropscience Ag | "inseticida arilpirrolinas" |
| ES2446720T3 (es) * | 2009-10-13 | 2014-03-10 | Elanco Animal Health Ireland Limited | Inhibidores de la integrasa macrocíclica |
| US8383639B2 (en) * | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| JP5935154B2 (ja) | 2011-03-14 | 2016-06-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｇｐｒ１１９モジュレーターとしてのｎ−シクロプロピル−ｎ−ピペリジニルベンズアミド |
| US8921398B2 (en) | 2011-06-09 | 2014-12-30 | Boehringer Ingelheim International Gmbh | N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof |
| US9089574B2 (en) | 2011-11-30 | 2015-07-28 | Emory University | Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections |
| EP2880027B1 (en) | 2012-08-02 | 2016-09-28 | Boehringer Ingelheim International GmbH | N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof |
| WO2014099586A1 (en) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
| EP2986291B1 (en) | 2013-04-16 | 2020-05-27 | Merck Sharp & Dohme Corp. | 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors |
| CN105307651A (zh) | 2013-04-22 | 2016-02-03 | 艾伯维公司 | 噻唑类化合物及其用途 |
| ES2656696T3 (es) | 2013-05-17 | 2018-02-28 | Merck Sharp & Dohme Corp. | Compuestos heterocíclicos tricíclicos condensados como inhibidores de la integrasa del VIH |
| US9951079B2 (en) | 2013-06-13 | 2018-04-24 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as HIV integrase inhibitors |
| MX367057B (es) | 2013-09-27 | 2019-08-02 | Merck Sharp & Dohme | Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih. |
| JP6660393B2 (ja) * | 2015-01-16 | 2020-03-11 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ４−シアノピペリジン塩酸塩を調製する方法 |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| US10548910B2 (en) | 2015-11-17 | 2020-02-04 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors |
| US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| CN109311823B (zh) * | 2016-07-15 | 2023-01-24 | 泸州东方农化有限公司 | 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体 |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| AU2017367714B2 (en) | 2016-12-02 | 2020-11-12 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as HIV integrase inhibitors |
| EP3573984A4 (en) | 2017-01-26 | 2020-07-29 | Merck Sharp & Dohme Corp. | USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS |
| CN113795491B (zh) * | 2019-04-30 | 2024-09-03 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| CN113372335B (zh) * | 2021-07-05 | 2023-02-24 | 山东大学 | 一种含有1,2,4-三唑硫醚的苯丙氨酸衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003292436B2 (en) * | 2002-12-27 | 2009-07-30 | Msd Italia S.R.L. | Tetrahydro-4H-pyrido[1,2-A]pyrimidines and related compounds useful as HIV integrase inhibitors |
| AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| EP1866313A1 (en) * | 2005-03-31 | 2007-12-19 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Hiv integrase inhibitors |
| WO2006121831A2 (en) | 2005-05-10 | 2006-11-16 | Merck & Co., Inc. | Hiv integrase inhibitors |
-
2006
- 2006-10-31 US US11/590,637 patent/US8039458B2/en active Active
- 2006-11-15 DE DE602006013025T patent/DE602006013025D1/de active Active
- 2006-11-15 PL PL06837651T patent/PL1948666T3/pl unknown
- 2006-11-15 ES ES06837651T patent/ES2341132T3/es active Active
- 2006-11-15 PT PT06837651T patent/PT1948666E/pt unknown
- 2006-11-15 SI SI200630642T patent/SI1948666T1/sl unknown
- 2006-11-15 HR HR20100247T patent/HRP20100247T1/hr unknown
- 2006-11-15 DK DK06837651.6T patent/DK1948666T3/da active
- 2006-11-15 AU AU2006316582A patent/AU2006316582B2/en not_active Ceased
- 2006-11-15 AT AT06837651T patent/ATE461202T1/de active
- 2006-11-15 WO PCT/US2006/044320 patent/WO2007061714A1/en not_active Ceased
- 2006-11-15 PE PE2006001455A patent/PE20071080A1/es not_active Application Discontinuation
- 2006-11-15 EP EP06837651A patent/EP1948666B1/en active Active
- 2006-11-15 KR KR1020087014533A patent/KR20080069254A/ko not_active Ceased
- 2006-11-15 CN CN2006800512376A patent/CN101360752B/zh not_active Expired - Fee Related
- 2006-11-15 JP JP2008541302A patent/JP2009515981A/ja active Pending
- 2006-11-16 AR ARP060105027A patent/AR057896A1/es unknown
- 2006-11-17 TW TW095142505A patent/TW200738728A/zh unknown
-
2008
- 2008-04-23 NO NO20081935A patent/NO20081935L/no not_active Application Discontinuation
-
2010
- 2010-06-11 CY CY20101100533T patent/CY1110665T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101360752A (zh) | 2009-02-04 |
| HRP20100247T1 (hr) | 2010-06-30 |
| KR20080069254A (ko) | 2008-07-25 |
| DK1948666T3 (da) | 2010-05-25 |
| CY1110665T1 (el) | 2015-06-10 |
| AU2006316582A1 (en) | 2007-05-31 |
| PE20071080A1 (es) | 2007-11-19 |
| DE602006013025D1 (de) | 2010-04-29 |
| US8039458B2 (en) | 2011-10-18 |
| ATE461202T1 (de) | 2010-04-15 |
| PT1948666E (pt) | 2010-05-17 |
| CN101360752B (zh) | 2012-09-05 |
| EP1948666B1 (en) | 2010-03-17 |
| AR057896A1 (es) | 2007-12-26 |
| US20070111984A1 (en) | 2007-05-17 |
| SI1948666T1 (sl) | 2010-06-30 |
| WO2007061714A1 (en) | 2007-05-31 |
| TW200738728A (en) | 2007-10-16 |
| ES2341132T3 (es) | 2010-06-15 |
| JP2009515981A (ja) | 2009-04-16 |
| PL1948666T3 (pl) | 2010-08-31 |
| EP1948666A1 (en) | 2008-07-30 |
| AU2006316582B2 (en) | 2012-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |