CY1109842T1 - Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων i - Google Patents
Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων iInfo
- Publication number
- CY1109842T1 CY1109842T1 CY20101100164T CY101100164T CY1109842T1 CY 1109842 T1 CY1109842 T1 CY 1109842T1 CY 20101100164 T CY20101100164 T CY 20101100164T CY 101100164 T CY101100164 T CY 101100164T CY 1109842 T1 CY1109842 T1 CY 1109842T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- hydroxysteroids
- dehydrogenation
- inhibitors
- beta
- Prior art date
Links
- 238000006356 dehydrogenation reaction Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Steroid Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74556906P | 2006-04-25 | 2006-04-25 | |
| EP07761186A EP2021337B1 (en) | 2006-04-25 | 2007-04-24 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109842T1 true CY1109842T1 (el) | 2014-09-10 |
Family
ID=38564372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100164T CY1109842T1 (el) | 2006-04-25 | 2010-02-19 | Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων i |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7994176B2 (enExample) |
| EP (1) | EP2021337B1 (enExample) |
| JP (1) | JP5189079B2 (enExample) |
| CN (1) | CN101454310B (enExample) |
| AT (1) | ATE455110T1 (enExample) |
| AU (1) | AU2007244904B2 (enExample) |
| BR (1) | BRPI0710050A2 (enExample) |
| CA (1) | CA2648236C (enExample) |
| CY (1) | CY1109842T1 (enExample) |
| DE (1) | DE602007004324D1 (enExample) |
| DK (1) | DK2021337T3 (enExample) |
| EA (1) | EA015516B1 (enExample) |
| ES (1) | ES2336849T3 (enExample) |
| MX (1) | MX2008013651A (enExample) |
| PL (1) | PL2021337T3 (enExample) |
| PT (1) | PT2021337E (enExample) |
| SI (1) | SI2021337T1 (enExample) |
| WO (1) | WO2007127726A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0710273A2 (pt) | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
| KR101055576B1 (ko) * | 2006-04-21 | 2011-08-08 | 일라이 릴리 앤드 캄파니 | 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제로서의 시클로헥실피라졸-락탐 유도체 |
| JP5265521B2 (ja) * | 2006-04-21 | 2013-08-14 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤としてのビフェニルアミドラクタム誘導体 |
| WO2007127693A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP2021336B1 (en) * | 2006-04-24 | 2010-06-30 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| PL2049475T3 (pl) | 2006-04-24 | 2012-08-31 | Lilly Co Eli | Pirolidynony podstawione cykloheksylem jako inhibitory 11-betahydrokysterydu dehydrogenazy 1 |
| EP2016071B1 (en) * | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| DK2035379T3 (da) | 2006-04-25 | 2010-09-06 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| PT2049513E (pt) * | 2006-04-28 | 2012-03-20 | Lilly Co Eli | Pirrolidinonas substituídas com piperidinilo como inibidores de 11-beta-hidroxiesteróide desidrogenase i |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
| US8440710B2 (en) * | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2576600B1 (de) * | 2010-05-27 | 2018-01-24 | Pharmazell GmbH | Neuartige 7alpha-hydroxysteroid dehydrogenase-knockout-mutanten und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US9181266B2 (en) | 2011-07-13 | 2015-11-10 | Novartis Ag | 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
| AP2014007400A0 (en) | 2011-07-13 | 2014-01-31 | Novartis Ag | 4-Piperidinyl compounds for use as tankyrase inhibitors |
| US9227982B2 (en) | 2011-07-13 | 2016-01-05 | Novartis Ag | 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| MX344014B (es) | 2011-10-18 | 2016-12-02 | Astellas Pharma Inc | Compuesto heterocíclico bicíclico. |
| WO2015135461A1 (zh) * | 2014-03-10 | 2015-09-17 | 四川海思科制药有限公司 | 取代的二氢苯并呋喃-哌啶-甲酮衍生物、其制备及用途 |
| CN108046988B (zh) * | 2017-12-25 | 2021-04-16 | 云南民族大学 | 一种高效制备碘代醇的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| ES2525319T3 (es) * | 2004-05-07 | 2014-12-22 | Janssen Pharmaceutica Nv | Derivados de pirrolidin-2-ona y piperidin-2-ona como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa |
| MXPA06012929A (es) * | 2004-05-07 | 2007-01-26 | Janssen Pharmaceutica Nv | Derivados de adamantil pirrolidin-2-ona como inhibidores de 11-beta hidroxiesteroide deshidrogenasa. |
| WO2006040329A1 (en) | 2004-10-12 | 2006-04-20 | Novo Nordisk A/S | 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds |
| WO2006049952A1 (en) | 2004-10-29 | 2006-05-11 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| TWI400239B (zh) | 2004-11-10 | 2013-07-01 | Incyte Corp | 內醯胺化合物及其作為醫藥品之用途 |
| ES2308602T3 (es) | 2004-12-20 | 2008-12-01 | Eli Lilly And Company | Derivados de cicloalquil lactamas como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa 1. |
| WO2006068991A1 (en) | 2004-12-21 | 2006-06-29 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP1864971A4 (en) | 2005-03-31 | 2010-02-10 | Takeda Pharmaceutical | PROPHYLACTIC / THERAPEUTIC AGENT AGAINST DIABETES |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| BRPI0710273A2 (pt) | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
| KR101055576B1 (ko) | 2006-04-21 | 2011-08-08 | 일라이 릴리 앤드 캄파니 | 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제로서의 시클로헥실피라졸-락탐 유도체 |
| JP5265521B2 (ja) | 2006-04-21 | 2013-08-14 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤としてのビフェニルアミドラクタム誘導体 |
| PL2049475T3 (pl) | 2006-04-24 | 2012-08-31 | Lilly Co Eli | Pirolidynony podstawione cykloheksylem jako inhibitory 11-betahydrokysterydu dehydrogenazy 1 |
| EP2021336B1 (en) | 2006-04-24 | 2010-06-30 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127693A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| DK2035379T3 (da) | 2006-04-25 | 2010-09-06 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| EP2016071B1 (en) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| PT2049513E (pt) | 2006-04-28 | 2012-03-20 | Lilly Co Eli | Pirrolidinonas substituídas com piperidinilo como inibidores de 11-beta-hidroxiesteróide desidrogenase i |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-24 AT AT07761186T patent/ATE455110T1/de active
- 2007-04-24 EA EA200870474A patent/EA015516B1/ru not_active IP Right Cessation
- 2007-04-24 US US12/297,964 patent/US7994176B2/en not_active Expired - Fee Related
- 2007-04-24 JP JP2009507926A patent/JP5189079B2/ja not_active Expired - Fee Related
- 2007-04-24 PT PT07761186T patent/PT2021337E/pt unknown
- 2007-04-24 BR BRPI0710050-7A patent/BRPI0710050A2/pt not_active IP Right Cessation
- 2007-04-24 EP EP07761186A patent/EP2021337B1/en not_active Not-in-force
- 2007-04-24 SI SI200730213T patent/SI2021337T1/sl unknown
- 2007-04-24 ES ES07761186T patent/ES2336849T3/es active Active
- 2007-04-24 CN CN2007800148990A patent/CN101454310B/zh not_active Expired - Fee Related
- 2007-04-24 MX MX2008013651A patent/MX2008013651A/es active IP Right Grant
- 2007-04-24 DK DK07761186.1T patent/DK2021337T3/da active
- 2007-04-24 PL PL07761186T patent/PL2021337T3/pl unknown
- 2007-04-24 DE DE602007004324T patent/DE602007004324D1/de active Active
- 2007-04-24 CA CA2648236A patent/CA2648236C/en not_active Expired - Fee Related
- 2007-04-24 AU AU2007244904A patent/AU2007244904B2/en not_active Ceased
- 2007-04-24 WO PCT/US2007/067296 patent/WO2007127726A2/en not_active Ceased
-
2010
- 2010-02-19 CY CY20101100164T patent/CY1109842T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2336849T3 (es) | 2010-04-16 |
| WO2007127726A3 (en) | 2008-01-03 |
| EA015516B1 (ru) | 2011-08-30 |
| BRPI0710050A2 (pt) | 2011-08-02 |
| DE602007004324D1 (en) | 2010-03-04 |
| EP2021337B1 (en) | 2010-01-13 |
| EA200870474A1 (ru) | 2009-04-28 |
| PL2021337T3 (pl) | 2010-06-30 |
| WO2007127726A2 (en) | 2007-11-08 |
| MX2008013651A (es) | 2008-11-04 |
| SI2021337T1 (sl) | 2010-05-31 |
| ATE455110T1 (de) | 2010-01-15 |
| PT2021337E (pt) | 2010-02-22 |
| AU2007244904B2 (en) | 2012-05-31 |
| US20090099182A1 (en) | 2009-04-16 |
| CA2648236C (en) | 2013-05-28 |
| CN101454310B (zh) | 2013-07-17 |
| JP5189079B2 (ja) | 2013-04-24 |
| DK2021337T3 (da) | 2010-03-29 |
| US7994176B2 (en) | 2011-08-09 |
| EP2021337A2 (en) | 2009-02-11 |
| AU2007244904A1 (en) | 2007-11-08 |
| CA2648236A1 (en) | 2007-11-08 |
| CN101454310A (zh) | 2009-06-10 |
| JP2009535356A (ja) | 2009-10-01 |
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