CY1109452T1 - Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i - Google Patents
Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)iInfo
- Publication number
- CY1109452T1 CY1109452T1 CY20091101024T CY091101024T CY1109452T1 CY 1109452 T1 CY1109452 T1 CY 1109452T1 CY 20091101024 T CY20091101024 T CY 20091101024T CY 091101024 T CY091101024 T CY 091101024T CY 1109452 T1 CY1109452 T1 CY 1109452T1
- Authority
- CY
- Cyprus
- Prior art keywords
- igf
- methods
- growth factor
- insulin growth
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 239000003102 growth factor Substances 0.000 title 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 2
- 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 abstract 1
- 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 abstract 1
- 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 abstract 1
- 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P37/02—Immunomodulators
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- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11501099P | 1999-01-06 | 1999-01-06 | |
| EP00905535A EP1141015B1 (en) | 1999-01-06 | 2000-01-05 | Insulin-like growth factor (igf) i mutant variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109452T1 true CY1109452T1 (el) | 2014-08-13 |
Family
ID=22358799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091101024T CY1109452T1 (el) | 1999-01-06 | 2009-10-02 | Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US6506874B1 (https=) |
| EP (1) | EP1141015B1 (https=) |
| JP (3) | JP2002535967A (https=) |
| AU (1) | AU762047B2 (https=) |
| CA (1) | CA2356257C (https=) |
| CY (1) | CY1109452T1 (https=) |
| DE (1) | DE60042550D1 (https=) |
| DK (1) | DK1141015T3 (https=) |
| ES (1) | ES2329220T3 (https=) |
| IL (3) | IL143834A0 (https=) |
| PT (1) | PT1141015E (https=) |
| WO (1) | WO2000040612A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU762351B2 (en) | 1999-01-06 | 2003-06-26 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
| AUPQ585500A0 (en) * | 2000-02-25 | 2000-03-16 | Gropep Pty Ltd | Treatment for peripheral sensory neuropathy |
| ATE389416T1 (de) | 2000-05-16 | 2008-04-15 | Genentech Inc | Behandlung von knorpelerkrankungen |
| AUPR030900A0 (en) | 2000-09-22 | 2000-10-12 | Queensland University Of Technology | Growth factor complex |
| ES2207387B1 (es) * | 2002-02-28 | 2005-07-16 | Consejo Sup. Investig. Cientificas | Composicion quimica de igf-i para el tratamiento y prevencion de enfermedades neurodegenerativas. |
| KR20050071498A (ko) * | 2002-09-18 | 2005-07-07 | 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 | 성장 호르몬 방출 호르몬 유사체 |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| EP2274978B1 (en) | 2003-09-12 | 2015-05-20 | Tercica, Inc. | Methods for treatment of insulin-like growth factor-I(IGF-I) deficiency |
| US7355018B2 (en) * | 2003-09-30 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Modified IGF1 polypeptides with increased stability and potency |
| WO2005047327A2 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
| GB0426154D0 (en) * | 2004-11-29 | 2004-12-29 | European Molecular Biology Lab Embl | IGF-1 novel peptides |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| EP1674113A1 (en) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
| EP1838736B1 (en) | 2005-01-05 | 2013-03-06 | Biogen Idec MA Inc. | Cripto binding molecules |
| EP1841443A4 (en) * | 2005-01-11 | 2012-05-02 | Heart Failure Technologies Inc | METHOD AND SYSTEM FOR TREATING HEART ERRORS |
| TWI406870B (zh) * | 2005-02-21 | 2013-09-01 | Chugai Pharmaceutical Co Ltd | A method of making a protein using hamster IGF-1 |
| FR2892174B1 (fr) | 2005-10-14 | 2007-12-28 | Vallourec Mannesmann Oil Gas F | Element filete tubulaire muni d'un revetement protecteur sec |
| CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| JP4958975B2 (ja) * | 2006-08-31 | 2012-06-20 | エフ.ホフマン−ラ ロシュ アーゲー | インスリン様増殖因子iの製造方法 |
| US20110045510A1 (en) * | 2008-04-03 | 2011-02-24 | Kurt Lang | Pegylated insulin-like-growth-factor assay |
| JP5173018B2 (ja) * | 2008-04-03 | 2013-03-27 | エフ.ホフマン−ラ ロシュ アーゲー | 神経筋障害の処置のためのpeg化igf−i変異体の使用 |
| WO2010094906A1 (en) * | 2009-07-16 | 2010-08-26 | Arecor Limited | The stabilisation of proteins |
| EP2341940A1 (en) * | 2008-07-16 | 2011-07-13 | Arecor Limited | The stabilisation of proteins |
| EP2328607A1 (en) * | 2008-07-16 | 2011-06-08 | Arecor Limited | Stable formulation of a therapeutic protein |
| WO2011011072A2 (en) * | 2009-07-22 | 2011-01-27 | Ipsen Pharma S.A.S. | Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59 |
| US8906231B2 (en) * | 2009-09-10 | 2014-12-09 | Lonza Biologics Plc | Method and system for polypeptide purification |
| US20110152188A1 (en) * | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
| EP2571992B1 (en) | 2010-05-21 | 2018-04-25 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
| TW201217527A (en) | 2010-07-09 | 2012-05-01 | Biogen Idec Hemophilia Inc | Processable single chain molecules and polypeptides made using same |
| WO2013012733A1 (en) | 2011-07-15 | 2013-01-24 | Biogen Idec Ma Inc. | Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto |
| US9676849B2 (en) | 2012-01-10 | 2017-06-13 | Biogen Ma Inc. | Enhancement of transport of therapeutic molecules across the blood brain barrier |
| PL2935320T3 (pl) * | 2012-12-18 | 2020-03-31 | Novartis Ag | Stabilizowane polipeptydy insulinopodobnego czynnika wzrostu |
| WO2014144549A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Factor ix polypeptide formulations |
| CN115181778A (zh) | 2015-02-04 | 2022-10-14 | 百时美施贵宝公司 | 选择治疗性分子的方法 |
| US11077132B2 (en) | 2015-02-04 | 2021-08-03 | F. Hoffmann-La Roche Ag | Tau antisense oligomers and uses thereof |
| CN108367048B (zh) | 2015-10-02 | 2022-08-12 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
| EP3453722A1 (en) * | 2017-09-06 | 2019-03-13 | Julius-Maximilians-Universität Würzburg | Pharmaceuticals and devices for the covalent immobilization to the extracellular matrix by transglutaminase |
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-
2000
- 2000-01-05 JP JP2000592320A patent/JP2002535967A/ja not_active Withdrawn
- 2000-01-05 AU AU27194/00A patent/AU762047B2/en not_active Expired
- 2000-01-05 CA CA2356257A patent/CA2356257C/en not_active Expired - Lifetime
- 2000-01-05 EP EP00905535A patent/EP1141015B1/en not_active Expired - Lifetime
- 2000-01-05 WO PCT/US2000/000151 patent/WO2000040612A1/en not_active Ceased
- 2000-01-05 IL IL14383400A patent/IL143834A0/xx unknown
- 2000-01-05 ES ES00905535T patent/ES2329220T3/es not_active Expired - Lifetime
- 2000-01-05 DK DK00905535.1T patent/DK1141015T3/da active
- 2000-01-05 PT PT00905535T patent/PT1141015E/pt unknown
- 2000-01-05 DE DE60042550T patent/DE60042550D1/de not_active Expired - Lifetime
- 2000-11-28 US US09/723,981 patent/US6506874B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/723,896 patent/US6509443B1/en not_active Expired - Lifetime
-
2001
- 2001-06-19 IL IL143834A patent/IL143834A/en not_active IP Right Cessation
-
2003
- 2003-05-22 US US10/444,701 patent/US20040033952A1/en not_active Abandoned
- 2003-05-22 US US10/444,649 patent/US20040033951A1/en not_active Abandoned
- 2003-05-22 US US10/444,326 patent/US20030191065A1/en not_active Abandoned
- 2003-05-22 US US10/444,262 patent/US20040023883A1/en not_active Abandoned
-
2005
- 2005-02-16 JP JP2005038688A patent/JP2005139203A/ja not_active Withdrawn
-
2006
- 2006-08-25 JP JP2006229517A patent/JP4467549B2/ja not_active Expired - Lifetime
-
2007
- 2007-10-11 IL IL186608A patent/IL186608A/en not_active IP Right Cessation
-
2009
- 2009-10-02 CY CY20091101024T patent/CY1109452T1/el unknown
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|---|---|
| AU762047B2 (en) | 2003-06-19 |
| WO2000040612A1 (en) | 2000-07-13 |
| IL143834A0 (en) | 2002-04-21 |
| US6509443B1 (en) | 2003-01-21 |
| IL186608A0 (en) | 2008-01-20 |
| ES2329220T3 (es) | 2009-11-24 |
| JP2002535967A (ja) | 2002-10-29 |
| EP1141015B1 (en) | 2009-07-15 |
| DK1141015T3 (da) | 2010-01-25 |
| WO2000040612A9 (en) | 2001-03-22 |
| JP2005139203A (ja) | 2005-06-02 |
| US20030191065A1 (en) | 2003-10-09 |
| JP4467549B2 (ja) | 2010-05-26 |
| AU2719400A (en) | 2000-07-24 |
| IL186608A (en) | 2014-06-30 |
| EP1141015A1 (en) | 2001-10-10 |
| US6506874B1 (en) | 2003-01-14 |
| PT1141015E (pt) | 2009-10-13 |
| JP2007045829A (ja) | 2007-02-22 |
| US20040033952A1 (en) | 2004-02-19 |
| CA2356257C (en) | 2012-10-16 |
| US20040033951A1 (en) | 2004-02-19 |
| US20040023883A1 (en) | 2004-02-05 |
| IL143834A (en) | 2008-07-08 |
| CA2356257A1 (en) | 2000-07-13 |
| DE60042550D1 (de) | 2009-08-27 |
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