CY1107857T1 - Πολυανυδριτες με θεραπευτικα χρησιμα προϊοντα αποδομησης - Google Patents
Πολυανυδριτες με θεραπευτικα χρησιμα προϊοντα αποδομησηςInfo
- Publication number
- CY1107857T1 CY1107857T1 CY20081100048T CY081100048T CY1107857T1 CY 1107857 T1 CY1107857 T1 CY 1107857T1 CY 20081100048 T CY20081100048 T CY 20081100048T CY 081100048 T CY081100048 T CY 081100048T CY 1107857 T1 CY1107857 T1 CY 1107857T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ortho
- aromatic
- substituted
- polyhydrides
- dicarboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
- C08G67/04—Polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
Abstract
Ένας αρωματικός πολυανυδρίτης που έχει μια επαναλαμβανόμενη μονάδα με δομή (I) όπου Ar είναι ένας υποκατεστημένος ή μη υποκατεστημένος αρωματικός δακτύλιος και R είναι μια διλειτουργική οργανική ομάδα υποκατεστημένη επί εκάστου Ar ορθο προς την ομάδα του ανυδρίτη. Ορθο-υποκατεστημένα μονομερή ανυδριτών δις-αρωματικών δικαρβοξυλικών οξέων και ορθο-υποκατεστημένα δις-αρωματικών δικαρβοξυλικών οξέων ενδιάμεσα αυτών αποκαλύπτονται επίσης, όπως επίσης εμφυτεύσιμες ιατρικές συσκευές, όπως υποστηρικτικά εμφυτεύματα για επανακατασκευή ιστού, συστήματα απελευθέρωσης φαρμάκου παρασκευασμένα από αρωματικούς πολυανυδρίτες, όπως επίσης θεραπευτικές από του στόματος δοσολογικές μορφές και μέθοδοι θεραπείας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5832897P | 1997-09-10 | 1997-09-10 | |
EP98946004A EP1032605B1 (en) | 1997-09-10 | 1998-09-10 | Polyanhydrides with therapeutically useful degradation products |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107857T1 true CY1107857T1 (el) | 2013-06-19 |
Family
ID=22016145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100048T CY1107857T1 (el) | 1997-09-10 | 2008-01-14 | Πολυανυδριτες με θεραπευτικα χρησιμα προϊοντα αποδομησης |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1032605B1 (el) |
JP (2) | JP4130305B2 (el) |
KR (1) | KR20010023852A (el) |
CN (1) | CN1158325C (el) |
AT (1) | ATE378364T1 (el) |
AU (1) | AU750424C (el) |
CA (1) | CA2302508C (el) |
CY (1) | CY1107857T1 (el) |
DE (1) | DE69838731T2 (el) |
DK (1) | DK1032605T3 (el) |
ES (1) | ES2296344T3 (el) |
PT (1) | PT1032605E (el) |
WO (1) | WO1999012990A1 (el) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7985415B2 (en) | 1997-09-10 | 2011-07-26 | Rutgers, The State University Of New Jersey | Medical devices employing novel polymers |
US6486214B1 (en) * | 1997-09-10 | 2002-11-26 | Rutgers, The State University Of New Jersey | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby |
US6468519B1 (en) * | 1997-09-10 | 2002-10-22 | Rutgers, The State University Of New Jersey | Polyanhydrides with biologically active degradation products |
US7122615B1 (en) | 1998-09-10 | 2006-10-17 | Rutgers, The State University Of New Jersey | Polyanhydrides with therapeutically useful degradation products |
US6685928B2 (en) * | 1999-12-07 | 2004-02-03 | Rutgers, The State University Of New Jersey | Therapeutic compositions and methods |
DE60043075D1 (de) * | 1999-12-07 | 2009-11-12 | Univ Rutgers | Therapeutische zusammensetzungen und verfahren zur behandlung von periodontitis mit entzündunshemmenden mitteln |
US20040038948A1 (en) | 1999-12-07 | 2004-02-26 | Uhrich Kathryn E. | Therapeutic compositions and methods |
US8109994B2 (en) | 2003-01-10 | 2012-02-07 | Abbott Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
CA2417389C (en) | 2000-07-27 | 2012-05-29 | Rutgers, The State University | Therapeutic polyesters and polyamides |
WO2002009769A2 (en) | 2000-07-27 | 2002-02-07 | Rutgers, The State University Of New Jersey | Therapeutic azo-compounds for drug delivery |
IL140017A (en) * | 2000-11-30 | 2009-09-22 | Abraham J Domb | Polyhedra |
DE60231555D1 (de) | 2001-11-23 | 2009-04-23 | Theodore James Anastasiou | Verbesserte synthese von polyanhydriden |
AU2003225882A1 (en) * | 2002-03-20 | 2003-10-08 | Advanced Cardiovascular Systems, Inc. | Biodegradable hydrophobic polymer for stents |
CA2503841A1 (en) * | 2002-10-28 | 2004-05-13 | Polymerix Corporation | Therapeutic compositions |
JP4987232B2 (ja) * | 2002-11-18 | 2012-07-25 | ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー | 新規のポリマーを用いた医療用デバイス |
WO2005110485A1 (en) * | 2004-05-14 | 2005-11-24 | Interface Biologics Inc. | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
CA2467321A1 (en) | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
US8143368B2 (en) | 2004-12-23 | 2012-03-27 | Massachusetts Institute Of Technology | Disposable medical supplies from hydrolytically biodegradable plastics |
WO2006127667A1 (en) | 2005-05-23 | 2006-11-30 | Rutgers, The State University Of New Jersey | Fast degrading polymers |
EP1951260A4 (en) | 2005-10-21 | 2009-11-11 | Bezwada Biomedical Llc | FUNCTIONALIZED PHENOLIC COMPOUNDS AND POURABLE ARTICLES THEREOF |
US8007526B2 (en) | 2005-12-01 | 2011-08-30 | Bezwada Biomedical, Llc | Difunctionalized aromatic compounds and polymers therefrom |
AU2007256626A1 (en) * | 2006-06-06 | 2007-12-13 | Rutgers, The State University Of New Jersey | Iodinated polymers |
EP2102144A4 (en) | 2006-09-13 | 2011-03-23 | Univ Rutgers | ACTIVE SUBSTANCES AND THEIR OLIGOMERS AND POLYMERS |
CN101240065B (zh) * | 2007-02-07 | 2010-05-19 | 天津大学 | 癸二酸酐与十八烷二元酸酐共聚物及其制备方法和应用 |
EP2146701B1 (en) | 2007-04-12 | 2013-10-16 | Rutgers, The State University of New Jersey | Biodegradable polyanhydrides with natural bioactive molecules |
US8217134B2 (en) | 2007-08-30 | 2012-07-10 | Bezwada Biomedical, Llc | Controlled release of biologically active compounds |
US8048980B2 (en) | 2007-09-17 | 2011-11-01 | Bezwada Biomedical, Llc | Hydrolysable linkers and cross-linkers for absorbable polymers |
CN101357244B (zh) * | 2008-09-18 | 2011-06-01 | 复旦大学附属肿瘤医院 | 纳米粒子增强的光固化聚酸酐载药聚合物支架的制备方法 |
EP2569015A1 (en) | 2010-05-14 | 2013-03-20 | Iberhospitex S.A. | Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers |
EP2694079B1 (en) * | 2011-04-06 | 2018-01-17 | Rutgers, The State University of New Jersey | Polymers and methods for the treatment of pain |
AU2013232300B2 (en) * | 2012-03-16 | 2015-12-17 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
JP5883539B2 (ja) * | 2012-03-16 | 2016-03-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | Hif−1阻害剤の送達のための放出制御製剤 |
US9144579B2 (en) | 2012-08-17 | 2015-09-29 | Rutgers, The State University Of New Jersey | Polyesters and methods of use thereof |
US20140120057A1 (en) | 2012-10-25 | 2014-05-01 | Rutgers, The State University Of New Jersey | Polymers and methods thereof for wound healing |
CN103910875B (zh) * | 2012-12-31 | 2017-06-13 | 张雅珍 | 蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用 |
US9387250B2 (en) | 2013-03-15 | 2016-07-12 | Rutgers, The State University Of New Jersey | Therapeutic compositions for bone repair |
US9862672B2 (en) | 2013-05-29 | 2018-01-09 | Rutgers, The State University Of New Jersey | Antioxidant-based poly(anhydride-esters) |
US10023521B2 (en) | 2014-06-13 | 2018-07-17 | Rutgers, The State University Of New Jersey | Process and intermediates for preparing poly(anhydride-esters) |
AU2015365566B2 (en) | 2014-12-18 | 2020-02-27 | Dexcel Pharma Technologies Ltd. | Alternating and semi-alternating poly(ester-anhydride) copolymers |
WO2016164898A1 (en) | 2015-04-10 | 2016-10-13 | Rutgers, The State University Of New Jersey | Kojic acid polymers |
EP3600438A4 (en) | 2017-03-29 | 2020-10-28 | Dexcel Pharma Technologies Ltd. | COMPOSITIONS CONTAINING BIODEGRADABLE COPOLYMERS |
US20210113457A1 (en) | 2018-02-02 | 2021-04-22 | Ripple Therapeutics Corporation | Glass formulations and uses thereof |
JP2022539168A (ja) * | 2019-07-05 | 2022-09-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 好中球損傷用ポリマー粒子 |
MX2022013665A (es) | 2020-05-01 | 2022-11-30 | Ripple Therapeutics Corp | Composiciones y metodos heterodimeros para el tratamiento de trastornos oculares. |
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US2607799A (en) * | 1949-09-22 | 1952-08-19 | Monsanto Chemicals | Process for the preparation of glycol esters of benzyl acid phthalate |
JPS51134729A (en) * | 1975-05-20 | 1976-11-22 | Asahi Chem Ind Co Ltd | Powdered coating composition |
JPS5382743A (en) * | 1976-12-27 | 1978-07-21 | Okura Ind Co Ltd | Preparation of glycol trimellitic acid anhydrides |
JPS567716A (en) * | 1979-07-03 | 1981-01-27 | Chugai Pharmaceut Co Ltd | Preventive and remedy for cerebral angiospasm |
US4757128A (en) * | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
US4891225A (en) * | 1984-05-21 | 1990-01-02 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
US4886870A (en) * | 1984-05-21 | 1989-12-12 | Massachusetts Institute Of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
JPS6119649A (ja) * | 1984-07-06 | 1986-01-28 | Adeka Argus Chem Co Ltd | ポリ塩化ビニル系樹脂組成物 |
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DE246341T1 (de) * | 1986-05-20 | 1989-03-30 | Massachusetts Institute Of Technology, Cambridge, Mass., Us | Bioerodierbare erzeugnisse zur verwendung als implantate oder prothese mit einem voraussehbaren resorbierungsgrad. |
US4997904A (en) * | 1989-08-25 | 1991-03-05 | Nova Pharmaceutical Corporation | Aromatic polyanhydride compositions |
DD288387A5 (de) * | 1989-10-16 | 1991-03-28 | Friedrich-Schiller-Universitaet Jena,De | Verfahren zur herstellung von poly(esteranhydriden) |
DD288311A5 (de) * | 1989-10-16 | 1991-03-28 | Friedrich-Schiller-Universitaet Jena,De | Verfahren zur gesteuerten freisetzung von biologisch aktiven verbindungen |
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US5175235A (en) * | 1990-06-04 | 1992-12-29 | Nova Pharmaceutical Corporation | Branched polyanhydrides |
US5264540A (en) * | 1992-07-20 | 1993-11-23 | Ethicon, Inc. | Aromatic polyanhydrides |
JPH06172426A (ja) * | 1992-12-08 | 1994-06-21 | Shin Etsu Chem Co Ltd | 側鎖にアセチルサリチル酸基を有する重合体 |
US5364725A (en) * | 1993-03-15 | 1994-11-15 | Eastman Kodak Company | Toner and developer containing acyloxy-t-alkylated benzoic acids as charge-control agent |
JP3255197B2 (ja) * | 1993-05-26 | 2002-02-12 | 株式会社リコー | 感熱記録材料 |
JP3091366B2 (ja) * | 1993-06-25 | 2000-09-25 | 信越化学工業株式会社 | アセチルサリチル酸ビニル−ビニルアルコール系共重合体 |
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US6060212A (en) * | 1998-06-11 | 2000-05-09 | Clariant Finance (Bvi) Limited | 193 nm positive-working photoresist composition |
DE60043075D1 (de) * | 1999-12-07 | 2009-11-12 | Univ Rutgers | Therapeutische zusammensetzungen und verfahren zur behandlung von periodontitis mit entzündunshemmenden mitteln |
US6685928B2 (en) * | 1999-12-07 | 2004-02-03 | Rutgers, The State University Of New Jersey | Therapeutic compositions and methods |
NZ528994A (en) * | 2001-04-26 | 2006-02-24 | Control Delivery Sys Inc | Sustained release drug delivery system containing codrugs |
DE60231555D1 (de) * | 2001-11-23 | 2009-04-23 | Theodore James Anastasiou | Verbesserte synthese von polyanhydriden |
-
1998
- 1998-09-10 CN CNB988089629A patent/CN1158325C/zh not_active Expired - Fee Related
- 1998-09-10 WO PCT/US1998/018816 patent/WO1999012990A1/en active IP Right Grant
- 1998-09-10 AU AU93117/98A patent/AU750424C/en not_active Ceased
- 1998-09-10 ES ES98946004T patent/ES2296344T3/es not_active Expired - Lifetime
- 1998-09-10 CA CA2302508A patent/CA2302508C/en not_active Expired - Fee Related
- 1998-09-10 JP JP2000510791A patent/JP4130305B2/ja not_active Expired - Fee Related
- 1998-09-10 AT AT98946004T patent/ATE378364T1/de active
- 1998-09-10 DE DE69838731T patent/DE69838731T2/de not_active Expired - Lifetime
- 1998-09-10 DK DK98946004T patent/DK1032605T3/da active
- 1998-09-10 EP EP98946004A patent/EP1032605B1/en not_active Expired - Lifetime
- 1998-09-10 KR KR1020007002529A patent/KR20010023852A/ko not_active Application Discontinuation
- 1998-09-10 PT PT98946004T patent/PT1032605E/pt unknown
-
2007
- 2007-11-29 JP JP2007308503A patent/JP2008150367A/ja active Pending
-
2008
- 2008-01-14 CY CY20081100048T patent/CY1107857T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2296344T3 (es) | 2008-04-16 |
WO1999012990A1 (en) | 1999-03-18 |
AU750424B2 (en) | 2002-07-18 |
AU750424C (en) | 2003-05-15 |
EP1032605A4 (en) | 2002-03-13 |
KR20010023852A (ko) | 2001-03-26 |
PT1032605E (pt) | 2007-12-12 |
CA2302508C (en) | 2011-03-15 |
ATE378364T1 (de) | 2007-11-15 |
EP1032605B1 (en) | 2007-11-14 |
EP1032605A1 (en) | 2000-09-06 |
DE69838731T2 (de) | 2008-04-10 |
DK1032605T3 (da) | 2008-03-17 |
JP2001515934A (ja) | 2001-09-25 |
JP4130305B2 (ja) | 2008-08-06 |
JP2008150367A (ja) | 2008-07-03 |
AU9311798A (en) | 1999-03-29 |
CA2302508A1 (en) | 1999-03-18 |
DE69838731D1 (de) | 2007-12-27 |
CN1269811A (zh) | 2000-10-11 |
CN1158325C (zh) | 2004-07-21 |
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