CY1107632T1 - Διαδικασια για την παρασκευη μιας θρομβινης στην οποια εχουν αδρανοποιηθει οι ιοι - Google Patents
Διαδικασια για την παρασκευη μιας θρομβινης στην οποια εχουν αδρανοποιηθει οι ιοιInfo
- Publication number
- CY1107632T1 CY1107632T1 CY20071100677T CY071100677T CY1107632T1 CY 1107632 T1 CY1107632 T1 CY 1107632T1 CY 20071100677 T CY20071100677 T CY 20071100677T CY 071100677 T CY071100677 T CY 071100677T CY 1107632 T1 CY1107632 T1 CY 1107632T1
- Authority
- CY
- Cyprus
- Prior art keywords
- thrombine
- incredible
- viruses
- preparing
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Μία μέθοδος για την παρασκευή θρομβίνης στην οποία έχουν αδρανοποιηθεί οι ιοί που περιλαμβάνει αδρανοποίηση των ιών ενός διαλύματος που συνιστάται σε προθρομβίνη και παράγοντα Χ με τη χρήση επεξεργασίας διαλύτη - απορρυπαντικού, τοποθέτηση της προθρομβίνης και του παράγοντα Χ σε ένα μέσο ανταλλαγής ανιόντων πλύση του μέσου προκειμένου να απομακρυνθούν τα αντιδραστήρια που χρησιμοποιήθηκαν για την αδρανοποίηση ιών με επεξεργασία διαλύτη-απορρυπαντικού και ενεργοποίηση της προθρομβίνης στο μέσο προκειμένου να σχηματίσει θρομβίνη με την προσθήκη ιόντων μετάλλου, κατά προτίμηση ιόντων ασβεστίου. Η θρομβίνη είναι τότε, κατά προτίμηση, επιλεκτικά εκλούσα από το μέσο ανταλλαγής ανιόντων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0216002.6A GB0216002D0 (en) | 2002-07-10 | 2002-07-10 | Process and composition |
EP03738334A EP1520018B1 (en) | 2002-07-10 | 2003-07-07 | Process for producing a virus-inactivated thrombin preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107632T1 true CY1107632T1 (el) | 2013-04-18 |
Family
ID=9940204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100677T CY1107632T1 (el) | 2002-07-10 | 2007-05-18 | Διαδικασια για την παρασκευη μιας θρομβινης στην οποια εχουν αδρανοποιηθει οι ιοι |
Country Status (19)
Country | Link |
---|---|
US (1) | US8435779B2 (el) |
EP (1) | EP1520018B1 (el) |
JP (1) | JP4445386B2 (el) |
AT (1) | ATE354648T1 (el) |
AU (1) | AU2003244858B2 (el) |
BR (1) | BRPI0312522B8 (el) |
CA (1) | CA2491718C (el) |
CY (1) | CY1107632T1 (el) |
DE (1) | DE60311990T2 (el) |
EC (1) | ECSP055586A (el) |
ES (1) | ES2282644T3 (el) |
GB (1) | GB0216002D0 (el) |
IL (3) | IL165989A0 (el) |
MX (1) | MXPA05000393A (el) |
NO (1) | NO20050090L (el) |
NZ (1) | NZ537502A (el) |
PL (1) | PL208219B1 (el) |
PT (1) | PT1520018E (el) |
WO (1) | WO2004007707A1 (el) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2572327A1 (en) * | 2004-06-29 | 2006-02-02 | Reliance Life Sciences Pvt. Ltd. | Process for the preparation of virus-safe biological fluids |
EP1685852A1 (en) * | 2005-02-01 | 2006-08-02 | Fondation pour la Recherche Diagnostique | Set of disposable bags for viral inactivation of biological fluids |
US20060270015A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
US20070148151A1 (en) | 2005-07-29 | 2007-06-28 | Martin Frink | Processes for the manufacture and use of pancreatin |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
PL2027263T3 (pl) * | 2006-05-22 | 2013-01-31 | Abbott Laboratories Gmbh | Sposób separacji i określenia wiremii w próbce pankreatyny |
US7774628B2 (en) * | 2006-05-25 | 2010-08-10 | Foundry Networks, Inc. | Enabling/disabling power-over-ethernet software subsystem in response to power supply status |
KR20100134078A (ko) * | 2008-04-16 | 2010-12-22 | 잇빤 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 트롬빈 고정화 생체 흡수성 시트 제제의 제조방법 |
JP5442310B2 (ja) * | 2009-04-23 | 2014-03-12 | 旭化成メディカル株式会社 | トロンビン溶液の調製方法 |
US8945895B2 (en) * | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
AU2015252061A1 (en) * | 2009-07-31 | 2015-11-19 | Baxalta GmbH | Method for Purifying Recombinant ADAMTS13 and Other Proteins and Compositions Thereof |
SE1050124A1 (sv) * | 2010-02-08 | 2011-08-09 | Linkoping Biocontrols Ab | Stabil lösning |
CN102357259A (zh) * | 2011-07-28 | 2012-02-22 | 王珊珊 | 一种生物蛋白海绵及其制备方法 |
JP6297029B2 (ja) * | 2012-05-31 | 2018-03-20 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ | 多様な官能基を有する粒子による免疫グロブリンg調製物のクロマトグラフィー精製 |
US9932388B2 (en) | 2014-11-13 | 2018-04-03 | Hemarus Therapeutics Limited | Chromatographic process for producing high purity fibrinogen and thrombin |
CN113754757A (zh) * | 2021-07-01 | 2021-12-07 | 华兰生物工程股份有限公司 | 一种人纤维蛋白原的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3336631A1 (de) * | 1983-10-08 | 1985-04-18 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x |
DE3843126C3 (de) * | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
EP0443724B1 (en) * | 1990-02-20 | 1999-03-17 | Baxter International Inc. | Viral-safe purified human thrombin |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
DE4137996A1 (de) * | 1991-11-19 | 1993-05-27 | Behringwerke Ag | Verfahren zur herstellung eines virussicheren thrombinkonzentrates |
AT397390B (de) * | 1992-04-06 | 1994-03-25 | Immuno Ag | Verfahren zur spaltung von proteinen |
GB9503750D0 (en) * | 1995-02-24 | 1995-04-12 | Common Services Agency | Thrombin preparation |
AT500670A1 (de) * | 1999-05-19 | 2006-02-15 | Bio & Bio Licensing Sa | Arzneimittel zur lokalen anwendung |
US6245548B1 (en) * | 2000-03-09 | 2001-06-12 | American National Red Cross | Activation of pure prothrombin to thrombin with about 30% to about 40% sodium citrate |
DE10012732A1 (de) * | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
IL136552A (en) | 2000-06-05 | 2005-05-17 | Omrix Biopharmaceuticals Ltd | Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration |
US20030133829A1 (en) * | 2001-12-21 | 2003-07-17 | Baxter Healthcare Corporation | Process for inactivating pathogens in a biological material |
-
2002
- 2002-07-10 GB GBGB0216002.6A patent/GB0216002D0/en not_active Ceased
-
2003
- 2003-07-07 NZ NZ537502A patent/NZ537502A/en unknown
- 2003-07-07 PL PL374747A patent/PL208219B1/pl unknown
- 2003-07-07 CA CA2491718A patent/CA2491718C/en not_active Expired - Lifetime
- 2003-07-07 BR BRPI0312522A patent/BRPI0312522B8/pt not_active IP Right Cessation
- 2003-07-07 IL IL16598903A patent/IL165989A0/xx unknown
- 2003-07-07 AU AU2003244858A patent/AU2003244858B2/en not_active Expired
- 2003-07-07 AT AT03738334T patent/ATE354648T1/de active
- 2003-07-07 MX MXPA05000393A patent/MXPA05000393A/es active IP Right Grant
- 2003-07-07 DE DE60311990T patent/DE60311990T2/de not_active Expired - Lifetime
- 2003-07-07 WO PCT/GB2003/002942 patent/WO2004007707A1/en active Application Filing
- 2003-07-07 ES ES03738334T patent/ES2282644T3/es not_active Expired - Lifetime
- 2003-07-07 PT PT03738334T patent/PT1520018E/pt unknown
- 2003-07-07 EP EP03738334A patent/EP1520018B1/en not_active Expired - Lifetime
- 2003-07-07 JP JP2004520823A patent/JP4445386B2/ja not_active Expired - Lifetime
- 2003-07-07 US US10/520,457 patent/US8435779B2/en active Active
-
2004
- 2004-12-26 IL IL165989A patent/IL165989A/en active IP Right Grant
-
2005
- 2005-01-06 NO NO20050090A patent/NO20050090L/no unknown
- 2005-02-02 EC EC2005005586A patent/ECSP055586A/es unknown
-
2007
- 2007-05-18 CY CY20071100677T patent/CY1107632T1/el unknown
-
2009
- 2009-09-23 IL IL201146A patent/IL201146A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE60311990T2 (de) | 2007-11-08 |
BR0312522A (pt) | 2005-04-19 |
IL165989A (en) | 2010-11-30 |
DE60311990D1 (de) | 2007-04-05 |
GB0216002D0 (en) | 2002-08-21 |
IL165989A0 (en) | 2006-01-15 |
NZ537502A (en) | 2007-12-21 |
WO2004007707A1 (en) | 2004-01-22 |
IL201146A (en) | 2011-05-31 |
BRPI0312522B1 (pt) | 2019-01-02 |
EP1520018A1 (en) | 2005-04-06 |
PT1520018E (pt) | 2007-04-30 |
BRPI0312522B8 (pt) | 2021-05-25 |
AU2003244858A1 (en) | 2004-02-02 |
US20060134769A1 (en) | 2006-06-22 |
CA2491718C (en) | 2013-10-22 |
ATE354648T1 (de) | 2007-03-15 |
CA2491718A1 (en) | 2004-01-22 |
US8435779B2 (en) | 2013-05-07 |
AU2003244858B2 (en) | 2008-01-31 |
ES2282644T3 (es) | 2007-10-16 |
MXPA05000393A (es) | 2005-07-22 |
JP2005532073A (ja) | 2005-10-27 |
EP1520018B1 (en) | 2007-02-21 |
NO20050090L (no) | 2005-04-08 |
JP4445386B2 (ja) | 2010-04-07 |
PL374747A1 (en) | 2005-10-31 |
ECSP055586A (es) | 2005-07-06 |
PL208219B1 (pl) | 2011-03-31 |
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