CY1107458T1 - Ενδοδepμικh μεταφορa ουσιων - Google Patents
Ενδοδepμικh μεταφορa ουσιωνInfo
- Publication number
- CY1107458T1 CY1107458T1 CY20061100325T CY061100325T CY1107458T1 CY 1107458 T1 CY1107458 T1 CY 1107458T1 CY 20061100325 T CY20061100325 T CY 20061100325T CY 061100325 T CY061100325 T CY 061100325T CY 1107458 T1 CY1107458 T1 CY 1107458T1
- Authority
- CY
- Cyprus
- Prior art keywords
- delivery
- methods
- substance
- needle outlet
- similar
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3286—Needle tip design, e.g. for improved penetration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
- A61M5/3291—Shafts with additional lateral openings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Extraction Or Liquid Replacement (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει βελτιωμένες μεθόδους για ΕΔ (ενδοδερμική-intradermal) μεταφορά φαρμάκων και άλλων ουσιών σε ανθρώπους ή σε ζώα. Οι μέθοδοι χρησιμοποιούν βελόνες μικρού διαμετρήματος, ειδικότερα μικροβελόνες, που τοποθετούνται στον ενδοδερματικό χώρο για να μεταφέρουν την ουσία στον ενδοδερματικό χώρο ως ώση (bolus) ή με έγχυση. Έχει βρεθεί ότι η τοποθέτηση του στομίου εκροής της βελόνας εντός του δέρματος και το εκτιθέμενο ύψος του στομίου εκροής της βελόνας είναι κρίσιμα για την αποτελεσματική μεταφορά δραστικών ουσιών μέσω βελόνων μικρού διαμετρήματος προκειμένου να παρεμποδιστεί η διαρροή της ουσίας έξω από το δέρμα και να βελτιωθεί η απορρόφηση εντός του ενδοδερματικού χώρου. Η φάρμακοκινητική των φαρμάκων ορμόνης που μεταφέρονται σύμφωνα με τις μεθόδους της εφεύρεσης βρέθηκε να είναι αρκετά παρόμοια με την φαρμακοκινητική της συμβατικής ΥΔ (υποδόριας-subcutaneous) μεταφοράς, υποδεικνύοντας ότι η ΕΔ χορήγηση σύμφωνα με τις μεθόδους της εφεύρεσης είναι πιθανόν να παράγει ένα παρόμοιο κλινικό αποτέλεσμα (δηλ. παρόμοια αποτελεσματικότητα) με το πλεονέκτημα της μείωσης ή εξάλειψης του πόνου για τον ασθενή. Οι συσκευές μεταφοράς που τοποθετούν το στόμιο εκροής της βελόνας σε κατάλληλο βάθος στο ενδοδερματικό χώρο και ελέγχουν τον όγκο και τον ρυθμό μεταφοράς του ρευστού, παρέχουν ακριβή μεταφορά των ουσιών στην επιθυμητή θέση χωρίς διαρροή.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/606,909 US8465468B1 (en) | 2000-06-29 | 2000-06-29 | Intradermal delivery of substances |
EP01953399A EP1296742B1 (en) | 2000-06-29 | 2001-06-29 | Intradermal delivery of substances |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107458T1 true CY1107458T1 (el) | 2012-12-19 |
Family
ID=24430006
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100325T CY1107458T1 (el) | 2000-06-29 | 2006-03-08 | Ενδοδepμικh μεταφορa ουσιων |
CY20081100016T CY1107847T1 (el) | 2000-06-29 | 2008-01-04 | Απελευθερωση μιας ουσιας εντος του δερματος |
CY20081100581T CY1108530T1 (el) | 2000-06-29 | 2008-06-03 | Βελονα για ενδοδερμικη μεταφορα ουσιων η οποια διαθετει περιοριστικα μεσα διεισδυσης |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100016T CY1107847T1 (el) | 2000-06-29 | 2008-01-04 | Απελευθερωση μιας ουσιας εντος του δερματος |
CY20081100581T CY1108530T1 (el) | 2000-06-29 | 2008-06-03 | Βελονα για ενδοδερμικη μεταφορα ουσιων η οποια διαθετει περιοριστικα μεσα διεισδυσης |
Country Status (16)
Country | Link |
---|---|
US (13) | US8465468B1 (el) |
EP (5) | EP1296740B1 (el) |
JP (2) | JP5614911B2 (el) |
KR (2) | KR100897148B1 (el) |
CN (2) | CN1438905A (el) |
AT (4) | ATE312644T1 (el) |
AU (6) | AU2001270262B2 (el) |
BR (2) | BR0112313A (el) |
CA (2) | CA2413769C (el) |
CY (3) | CY1107458T1 (el) |
DE (3) | DE60134286D1 (el) |
DK (4) | DK1296742T3 (el) |
ES (4) | ES2292601T3 (el) |
MX (2) | MXPA03000228A (el) |
PT (3) | PT1296742E (el) |
WO (2) | WO2002002178A1 (el) |
Families Citing this family (99)
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US8465468B1 (en) | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
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US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
US20040175360A1 (en) * | 2000-06-29 | 2004-09-09 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
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CA2444391A1 (en) * | 2001-04-13 | 2002-10-24 | Becton Dickinson And Company | Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption |
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- 2013-04-19 US US13/866,425 patent/US8986280B2/en not_active Expired - Fee Related
- 2013-04-19 US US13/866,381 patent/US9005182B2/en not_active Expired - Fee Related
- 2013-04-19 US US13/866,446 patent/US8998877B2/en not_active Expired - Fee Related
-
2014
- 2014-03-17 US US14/215,271 patent/US9242052B2/en not_active Expired - Fee Related
-
2015
- 2015-03-13 US US14/657,746 patent/US9339613B2/en not_active Expired - Fee Related
-
2016
- 2016-05-16 US US15/155,921 patent/US20160331911A1/en not_active Abandoned
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