DK1925333T3 - Intradermal indgivelse af stoffer - Google Patents

Intradermal indgivelse af stoffer

Info

Publication number
DK1925333T3
DK1925333T3 DK08101174.4T DK08101174T DK1925333T3 DK 1925333 T3 DK1925333 T3 DK 1925333T3 DK 08101174 T DK08101174 T DK 08101174T DK 1925333 T3 DK1925333 T3 DK 1925333T3
Authority
DK
Denmark
Prior art keywords
delivery
methods
substance
needle outlet
similar
Prior art date
Application number
DK08101174.4T
Other languages
English (en)
Inventor
Ronald J Pettis
James A Down
Noel Harvey
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24430006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1925333(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Application granted granted Critical
Publication of DK1925333T3 publication Critical patent/DK1925333T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3286—Needle tip design, e.g. for improved penetration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A61M5/3291—Shafts with additional lateral openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
DK08101174.4T 2000-06-29 2001-06-29 Intradermal indgivelse af stoffer DK1925333T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/606,909 US8465468B1 (en) 2000-06-29 2000-06-29 Intradermal delivery of substances
EP05021412A EP1625870B1 (en) 2000-06-29 2001-06-29 Needle for intradermal delivery of substances having penetration limiting means

Publications (1)

Publication Number Publication Date
DK1925333T3 true DK1925333T3 (da) 2012-02-20

Family

ID=24430006

Family Applications (4)

Application Number Title Priority Date Filing Date
DK08101174.4T DK1925333T3 (da) 2000-06-29 2001-06-29 Intradermal indgivelse af stoffer
DK01953399T DK1296742T3 (da) 2000-06-29 2001-06-29 Intradermal afgivelse af stoffet
DK01948832T DK1296740T3 (da) 2000-06-29 2001-06-29 Administration af en substans i dermis
DK05021412T DK1625870T3 (da) 2000-06-29 2001-06-29 Kanyle til intradermal administration af stoffer med penetrationsbegrænsende organer

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK01953399T DK1296742T3 (da) 2000-06-29 2001-06-29 Intradermal afgivelse af stoffet
DK01948832T DK1296740T3 (da) 2000-06-29 2001-06-29 Administration af en substans i dermis
DK05021412T DK1625870T3 (da) 2000-06-29 2001-06-29 Kanyle til intradermal administration af stoffer med penetrationsbegrænsende organer

Country Status (16)

Country Link
US (13) US8465468B1 (da)
EP (5) EP1925333B1 (da)
JP (2) JP2004501725A (da)
KR (2) KR100870345B1 (da)
CN (2) CN1454104A (da)
AT (4) ATE536906T1 (da)
AU (6) AU2001275853B2 (da)
BR (2) BR0112313A (da)
CA (2) CA2413769C (da)
CY (3) CY1107458T1 (da)
DE (3) DE60131401T2 (da)
DK (4) DK1925333T3 (da)
ES (4) ES2250437T3 (da)
MX (2) MXPA03000134A (da)
PT (3) PT1625870E (da)
WO (2) WO2002002179A1 (da)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US8465468B1 (en) * 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
JP2005504002A (ja) 2001-02-13 2005-02-10 ガバメント オブ ザ ユナイテッド ステイツ、 アズ リプリゼンティッド バイ ザ セクレタリィ オブ ジ アーミイ 経皮免疫感作のためのワクチン
ATE503493T1 (de) 2001-02-23 2011-04-15 Glaxosmithkline Biolog Sa Influenza vakzinzusammensetzungen zur intradermaler verabreichung
JP2004525713A (ja) * 2001-04-13 2004-08-26 ベクトン・ディキンソン・アンド・カンパニー 全身吸収のために皮膚の皮内層中に物質を投与するための方法および装置
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
CN100349629C (zh) 2001-09-12 2007-11-21 贝克顿迪肯森公司 用于药物传送的微针为基础的笔装置和使用该装置的方法
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
EP1476210B1 (en) 2002-02-11 2008-09-24 Antares Pharma, Inc. Intradermal injector
CN2772162Y (zh) * 2002-02-19 2006-04-12 交互数字技术公司 无线通信中为二元判定提供偏置准则以加强防护的用户设备
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
US7722595B2 (en) * 2002-05-06 2010-05-25 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US7338465B2 (en) * 2002-07-02 2008-03-04 Patton Medical Devices, Lp Infusion device and method thereof
US9955994B2 (en) 2002-08-02 2018-05-01 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
BR0313890A (pt) * 2002-08-30 2005-07-26 Becton Dickinson Co Método de controle da farmacocinética de compostos imunomoduladores
US9486581B2 (en) 2002-09-11 2016-11-08 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
CN1859943B (zh) * 2002-10-11 2010-09-29 贝克顿·迪金森公司 用于控制患者体内葡萄糖的浓度的系统
US20050163711A1 (en) * 2003-06-13 2005-07-28 Becton, Dickinson And Company, Inc. Intra-dermal delivery of biologically active agents
DE10330094B4 (de) * 2003-07-03 2008-04-17 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines flüssigen Produkts
EP1658078A4 (en) * 2003-08-26 2009-05-06 Becton Dickinson Co PROCESS FOR THE INTRADERMAL DISTRIBUTION OF THERAPEUTIC AGENTS
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US8029454B2 (en) 2003-11-05 2011-10-04 Baxter International Inc. High convection home hemodialysis/hemofiltration and sorbent system
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
WO2005115360A2 (en) * 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same
EP1744683B1 (en) 2004-05-13 2016-03-16 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
DE602005025138D1 (de) 2004-08-16 2011-01-13 Fuctional Microstructures Ltd Verfahren zur herstellung einer mikronadel oder eines mikroimplantats
CN101132820B (zh) 2005-01-24 2010-05-19 安塔雷斯制药公司 预充式针辅助喷射注入器
US7645264B2 (en) 2005-04-11 2010-01-12 Becton, Dickinson And Company Injection device with secondary reservoir
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
AU2006297601A1 (en) * 2005-08-22 2007-04-12 Patton Medical Devices, Lp Fluid delivery devices, systems and methods
AU2006311708A1 (en) 2005-11-03 2007-05-18 Patton Medical Devices, Lp Fluid delivery devices, systems and methods
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
EP2005990B1 (en) 2006-04-07 2013-08-28 Hisamitsu Pharmaceutical Co., Inc. Microneedle device and transdermal administration device provided with microneedles
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
JP2009543902A (ja) 2006-07-10 2009-12-10 メディパックス インコーポレイテッド 超弾性エポキシヒドロゲル
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
HRP20120825T1 (hr) * 2007-06-14 2012-11-30 Crucell Switzerland Ag Intradermalno cjepivo protiv influence
US9995295B2 (en) 2007-12-03 2018-06-12 Medipacs, Inc. Fluid metering device
ES2752152T3 (es) 2008-03-10 2020-04-03 Antares Pharma Inc Dispositivo de seguridad para inyector
WO2010017285A2 (en) 2008-08-05 2010-02-11 Antares Pharma, Inc. Multiple dosage injector
US8702677B2 (en) 2008-10-31 2014-04-22 Warsaw Orthopedic, Inc. Device and method for directional delivery of a drug depot
WO2010062768A1 (en) * 2008-11-03 2010-06-03 Bayer Healthcare Llc Method for the treatment of hemophilia
EP2355887B1 (en) * 2008-11-18 2017-08-02 3M Innovative Properties Company Hollow microneedle array
AU2010226442A1 (en) 2009-03-20 2011-10-13 Antares Pharma, Inc. Hazardous agent injection system
US8715223B2 (en) 2009-07-22 2014-05-06 Warsaw Orthopedic, Inc. Device and method for delivery of a drug depot near the nerve
WO2011032011A1 (en) 2009-09-10 2011-03-17 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
US9199034B2 (en) * 2009-11-09 2015-12-01 Becton, Dickinson And Company Drug delivery devices, systems, and methods
US8454975B1 (en) 2010-01-11 2013-06-04 Elizabeth VanderVeer Method for enhancing skin appearance
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
EP2701508A4 (en) 2011-04-26 2015-01-07 Univ Leland Stanford Junior MANUFACTURE AND DELIVERY OF A STABLE COLLAGEN
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9216252B2 (en) 2011-07-27 2015-12-22 Hisamitsu Pharmaceutical Co., Inc. Applicator
WO2013112877A1 (en) * 2012-01-25 2013-08-01 Tasso, Inc. Handheld device for drawing, collecting, and analyzing bodily fluid
US9486583B2 (en) 2012-03-06 2016-11-08 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
EP2847249A4 (en) 2012-03-14 2016-12-28 Medipacs Inc Smart polymer materials with excess reactive molecules
US20150080844A1 (en) * 2012-04-02 2015-03-19 Medtronic, Inc. Therapy for kidney disease and/or heart failure by intradermal infusion
EP2833944A4 (en) 2012-04-06 2016-05-25 Antares Pharma Inc ADMINISTRATION OF TESTOSTERONE COMPOSITIONS BY NEEDLE-SUPPORTED NOZZLE INJECTION
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
EP2879596A2 (en) 2012-08-02 2015-06-10 Flowcardia, Inc. Ultrasound catheter system
WO2014124427A1 (en) 2013-02-11 2014-08-14 Travanty Michael Needle assisted jet injection device having reduced trigger force
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
CN105073180B (zh) * 2013-03-22 2016-08-10 3M创新有限公司 包括计数器组件的微针施用装置
DK3682920T3 (da) 2013-06-18 2022-10-03 Enable Injections Inc Indretning og fremgangsmåde til hætteglasoverførsel og injektion
JP2017514810A (ja) * 2014-04-25 2017-06-08 サノフイ インスリン、インスリン類似体またはインスリンの誘導体の新規な投与経路
US10080877B2 (en) 2014-07-25 2018-09-25 Warsaw Orthopedic, Inc. Drug delivery device and methods having a drug cartridge
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
EP3248634B1 (en) * 2015-01-20 2021-10-27 Terumo Kabushiki Kaisha Injection needle assembly and injector provided therewith for injecting drug solution into upper layer of skin
US10765361B2 (en) * 2015-03-02 2020-09-08 Verily Life Sciences Llc Automated sequential injection and blood draw
MA54623A (fr) * 2015-04-21 2021-11-03 Univ North Carolina State Système d'administration d'insuline répondant au glucose utilisant des nanocomposites sensibles à l'hypoxie
EP3352814B1 (en) * 2015-09-22 2024-04-10 Thomas Jefferson University Continuous subcutaneous insulin infusion catheter
US11065381B2 (en) 2015-10-05 2021-07-20 E3D A.C.A.L. Infusion pump device and method for use thereof
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
EP3832661A1 (en) * 2015-12-03 2021-06-09 UNL Holdings LLC Systems and methods for controlled drug delivery pumps
US11200298B2 (en) * 2016-03-15 2021-12-14 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
US9827369B2 (en) 2016-03-16 2017-11-28 Baxter International Inc. Percutaneous administration device and method for injecting medicinal substances
USD802755S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
US11278665B2 (en) 2016-11-22 2022-03-22 Eitan Medical Ltd. Method for delivering a therapeutic substance
US20180140321A1 (en) 2016-11-23 2018-05-24 C. R. Bard, Inc. Catheter With Retractable Sheath And Methods Thereof
US11596726B2 (en) 2016-12-17 2023-03-07 C.R. Bard, Inc. Ultrasound devices for removing clots from catheters and related methods
US10582983B2 (en) 2017-02-06 2020-03-10 C. R. Bard, Inc. Ultrasonic endovascular catheter with a controllable sheath
US10413658B2 (en) 2017-03-31 2019-09-17 Capillary Biomedical, Inc. Helical insertion infusion device
CN109972116B (zh) * 2017-12-28 2021-03-23 深圳先进技术研究院 金刚石管及其制备方法
US11357909B2 (en) 2018-10-05 2022-06-14 Eitan Medical Ltd. Triggering sequence
US12357751B2 (en) 2018-11-08 2025-07-15 Tandem Diabetes Care, Inc. Linear insertion device with rotational drive
GB202011055D0 (en) * 2020-07-17 2020-09-02 Ipsen Bioinnovation Ltd Treatment of post-operative pain
US12214159B2 (en) 2020-08-28 2025-02-04 Tandem Diabetes Care, Inc Insulin infusion set
US20220401355A1 (en) * 2021-05-13 2022-12-22 University Of Washington Transdural Drug Delivery System
CN114281448A (zh) * 2021-12-07 2022-04-05 维沃移动通信有限公司 应用程序控制方法、装置及电子设备

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US394482A (en) * 1888-12-11 Triple-expansion engine
US2619962A (en) 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4655762A (en) 1980-06-09 1987-04-07 Rogers Phillip P Ambulatory dialysis system and connector
FR2524321A1 (fr) 1982-03-30 1983-10-07 Denance Raymond Dispositif d'injection " manuelle ou mecanique " a usage medical et veterinaire
US4440207A (en) 1982-05-14 1984-04-03 Baxter Travenol Laboratories, Inc. Antibacterial protective cap for connectors
IE53703B1 (en) 1982-12-13 1989-01-18 Elan Corp Plc Drug delivery device
CA1248832A (en) 1985-07-22 1989-01-17 Francesco Peluso Antibacterial closure system
CA1283827C (en) * 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
AU614092B2 (en) 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
US5007501A (en) 1989-09-01 1991-04-16 Baston Peter J Apparatus for facilitating the internal inspection and repair of large pressure vessels
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5098389A (en) 1990-06-28 1992-03-24 Becton, Dickinson And Company Hypodermic needle assembly
US5505694A (en) 1990-08-22 1996-04-09 Tcnl Technologies, Inc. Apparatus and method for raising a skin wheal
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
TW279133B (da) * 1990-12-13 1996-06-21 Elan Med Tech
ES2027923A6 (es) 1991-01-30 1992-06-16 Segura Badia Marcelo Conexion desinfectante para tubos de cateteres y similares.
US5484417A (en) * 1991-04-19 1996-01-16 Biotime, Inc. Microcannula
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5242425A (en) 1991-11-14 1993-09-07 Gish Biomedical, Inc. Antiseptic catheter coupling septum
US5328483A (en) * 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
US5567495A (en) 1993-08-06 1996-10-22 The Trustees Of Columbia University In The City Of New York Infection resistant medical devices
CA2132277C (en) * 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5536258A (en) 1994-02-14 1996-07-16 Fresenius Usa, Inc. Antibacterial medical tubing connector
IL113010A (en) 1994-03-31 1999-10-28 Pharmacia & Upjohn Ab Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
JPH07299143A (ja) * 1994-05-09 1995-11-14 Kenji Tsubota 医科用注射針
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5540657A (en) * 1994-07-15 1996-07-30 Collagen Corporation Delivery device for injectable materials
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
IE72524B1 (en) * 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
CA2205444A1 (en) 1994-12-09 1996-06-13 Novartis Ag Transdermal system
US5554135A (en) 1995-02-17 1996-09-10 Menyhay; Steve Z. Sterile medical injection port and cover method and apparatus
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
US5858001A (en) 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
US5801057A (en) 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
US5741224A (en) 1996-04-16 1998-04-21 Implemed, Inc. Iontophoretic material
FR2749172B1 (fr) * 1996-05-31 1998-11-06 Multipropulseurs Seringue hypodermique
IL127328A (en) 1996-06-10 2003-07-31 Elan Corp Plc Needle for subcutaneous delivery of fluids
ATE231015T1 (de) 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
GB2321014A (en) * 1997-01-14 1998-07-15 Nigel John Middleton Hypodermic needle with retractable needle guard
US5871158A (en) 1997-01-27 1999-02-16 The University Of Utah Research Foundation Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces
DE19717253A1 (de) * 1997-04-24 1998-10-29 Edwin Dr Med Klaus Universal-Ideal-Nadel
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
JP2003514587A (ja) 1997-07-14 2003-04-22 ノボ ノルディスク アクティーゼルスカブ 射出部品
US6007821A (en) * 1997-10-16 1999-12-28 Fordham University Method and compositions for the treatment of autoimmune disease using heat shock proteins
IE970782A1 (en) 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US6482176B1 (en) 1997-11-27 2002-11-19 Disetronic Licensing Ag Method and device for controlling the introduction depth of an injection needle
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
DE69936355T2 (de) 1998-02-25 2008-02-21 The Government Of The United States, As Represented By The Secretary Of The Army Verwendung von Hautpenetrationsförderern und für die Zerstörung der oberen Hautschichten geeigneten Mitteln zur Erhöhung der transkutanen Immunantwort
JP2002517300A (ja) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP4118399B2 (ja) * 1998-07-21 2008-07-16 テルモ株式会社 注射針用穿刺調整具およびそれを備えた注射針組立体
US6428528B2 (en) 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
WO2000016833A1 (en) 1998-09-18 2000-03-30 The University Of Utah Research Foundation Surface micromachined microneedles
US6159472A (en) 1998-11-16 2000-12-12 Akzo Nobel N.V. Intradermal Avian immunization with inactivated vaccines
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
ATE462468T1 (de) 1999-06-04 2010-04-15 Georgia Tech Res Inst Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6056176A (en) * 1999-06-09 2000-05-02 Jac Products, Inc. Vehicle article carrier having clamping cross bar
DE19934433A1 (de) 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
US6679870B1 (en) 1999-07-23 2004-01-20 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US6569123B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6569143B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
CA2392810A1 (en) 1999-12-01 2001-06-07 Natco Pharma Limited A rapid acting freeze dired oral pharmaceutical composition for treating migraine
GB9928578D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Pharmaceutical formulations
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US20050181033A1 (en) * 2000-06-29 2005-08-18 Dekker John P.Iii Method for delivering interferons to the intradermal compartment
US20040175360A1 (en) 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
AU2001277961A1 (en) 2000-08-07 2002-02-18 Antigenics, Llc Compositions comprising heat shock proteins or alpha(2)macroglobulin, antigenic molecules and saponins, and methods of use thereof
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
JP2004525713A (ja) 2001-04-13 2004-08-26 ベクトン・ディキンソン・アンド・カンパニー 全身吸収のために皮膚の皮内層中に物質を投与するための方法および装置
US20050245594A1 (en) * 2001-06-29 2005-11-03 Sutter Diane E Dermal delivery of anti-pain agents and methods useful thereof
US20050010193A1 (en) 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US20030073609A1 (en) 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
DE10139410A1 (de) 2001-08-17 2003-02-27 Boehringer Ingelheim Pharma Verwendung von BIBN4096 in Kombination mit anderen Arzneistoffen gegen Migräne für die Behandlung von Migräne
AU2002346399A1 (en) * 2001-11-14 2003-05-26 Medical Instill Technologies, Inc. Intradermal delivery device and method
AU2002348829A1 (en) 2001-12-21 2003-07-09 Dr. Reddy's Laboratories Ltd. Novel compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
DE60328361D1 (de) 2002-02-04 2009-08-27 Becton Dickinson Co Vorrichtung und verfahren zur abgabe oder entnahme einer substanz durch die haut
US7722595B2 (en) * 2002-05-06 2010-05-25 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
BR0313890A (pt) 2002-08-30 2005-07-26 Becton Dickinson Co Método de controle da farmacocinética de compostos imunomoduladores
JP2007517768A (ja) 2003-05-06 2007-07-05 ベクトン・ディキンソン・アンド・カンパニー インスリンの薬物動態を変化させる方法
US20050096332A1 (en) 2003-10-30 2005-05-05 Boehringer Ingelheim International Gmbh Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
US20050147525A1 (en) 2004-01-06 2005-07-07 Bousquet Gerald G. Sanitized tubing termination method and assembly
US20050256499A1 (en) 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
US20050196380A1 (en) * 2004-03-08 2005-09-08 Mikszta John A. Method for delivering therapeutic proteins to the intradermal compartment
WO2005115360A2 (en) 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same

Also Published As

Publication number Publication date
US9005182B2 (en) 2015-04-14
CN1438905A (zh) 2003-08-27
EP1296742B1 (en) 2005-12-14
EP1880743A1 (en) 2008-01-23
KR20030019464A (ko) 2003-03-06
US20050096630A1 (en) 2005-05-05
JP2004501724A (ja) 2004-01-22
CY1107458T1 (el) 2012-12-19
US20040073160A1 (en) 2004-04-15
US8986280B2 (en) 2015-03-24
ATE396763T1 (de) 2008-06-15
ES2292601T3 (es) 2008-03-16
EP1925333A1 (en) 2008-05-28
ATE536906T1 (de) 2011-12-15
US20080234656A1 (en) 2008-09-25
US20050096631A1 (en) 2005-05-05
CA2413798C (en) 2009-10-27
KR20030017567A (ko) 2003-03-03
JP5614911B2 (ja) 2014-10-29
DE60134286D1 (de) 2008-07-10
EP1296740A1 (en) 2003-04-02
JP2004501725A (ja) 2004-01-22
CY1108530T1 (el) 2014-04-09
CA2413769C (en) 2010-03-16
US20160331911A1 (en) 2016-11-17
ES2250437T3 (es) 2006-04-16
US20130237960A1 (en) 2013-09-12
ES2374755T3 (es) 2012-02-21
US20150182705A1 (en) 2015-07-02
AU2010201340A1 (en) 2010-04-29
CN1454104A (zh) 2003-11-05
AU2001275853B2 (en) 2006-06-08
DK1296742T3 (da) 2006-04-18
EP1625870B1 (en) 2008-05-28
BR0112313A (pt) 2003-06-24
EP1925333B1 (en) 2011-12-14
DK1625870T3 (da) 2008-06-23
BR0112314A (pt) 2003-06-24
US20050096632A1 (en) 2005-05-05
EP1625870A2 (en) 2006-02-15
PT1296742E (pt) 2006-05-31
PT1296740E (pt) 2008-02-25
US8708994B2 (en) 2014-04-29
AU7026201A (en) 2002-01-14
US20140200547A1 (en) 2014-07-17
MXPA03000134A (es) 2004-09-13
KR100870345B1 (ko) 2008-11-25
MXPA03000228A (es) 2004-11-01
WO2002002178A1 (en) 2002-01-10
EP1296740B1 (en) 2007-11-14
AU7585301A (en) 2002-01-14
AU2010201340B2 (en) 2011-09-08
US20130245601A1 (en) 2013-09-19
DK1296740T3 (da) 2008-01-07
ATE312644T1 (de) 2005-12-15
DE60115897T2 (de) 2006-08-24
AU2001270262B2 (en) 2005-07-21
DE60131401D1 (de) 2007-12-27
US8465468B1 (en) 2013-06-18
AU2006203511A1 (en) 2006-09-07
CA2413798A1 (en) 2002-01-10
US9242052B2 (en) 2016-01-26
KR100897148B1 (ko) 2009-05-14
CA2413769A1 (en) 2002-01-10
EP1296742A1 (en) 2003-04-02
WO2002002179A1 (en) 2002-01-10
PT1625870E (pt) 2008-08-29
DE60131401T2 (de) 2008-05-15
US9339613B2 (en) 2016-05-17
ES2303169T3 (es) 2008-08-01
US20130237961A1 (en) 2013-09-12
EP1625870A3 (en) 2006-04-19
ATE378087T1 (de) 2007-11-15
US20110190725A1 (en) 2011-08-04
CY1107847T1 (el) 2013-06-19
DE60115897D1 (de) 2006-01-19
US8998877B2 (en) 2015-04-07

Similar Documents

Publication Publication Date Title
DK1925333T3 (da) Intradermal indgivelse af stoffer
JP2004525712A (ja) 高分子量物質の送出のための方法および装置
AU2001275853A1 (en) Needle for intradermal delivery of substances having penetration limiting means
CA2471493A1 (en) A method and device for reducing therapeutic dosage
Guarnieri et al. Flexible versus rigid catheters for chronic administration of exogenous agents into central nervous system tissues
Wright et al. Long-term controlled delivery of therapeutic agents by the osmotically driven DUROS® implant