CY1106985T1 - Γονιδια που σχετιζονται με τη βιοσυνθεση του ml-236b - Google Patents

Γονιδια που σχετιζονται με τη βιοσυνθεση του ml-236b

Info

Publication number
CY1106985T1
CY1106985T1 CY20071101434T CY071101434T CY1106985T1 CY 1106985 T1 CY1106985 T1 CY 1106985T1 CY 20071101434 T CY20071101434 T CY 20071101434T CY 071101434 T CY071101434 T CY 071101434T CY 1106985 T1 CY1106985 T1 CY 1106985T1
Authority
CY
Cyprus
Prior art keywords
biosynthesis
genes related
preparation
inhibitor
pravastatin
Prior art date
Application number
CY20071101434T
Other languages
English (en)
Inventor
Hiroji Yoshikawa
Yuki Abe
Chiho Ono
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of CY1106985T1 publication Critical patent/CY1106985T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/385—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Penicillium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Ο ML-236B είναι αναστολέας της αναγωγάσης HMG-CoA και χρήσιμος για την παρασκευή άλλου αναστολέα, της πραβαστατίνης. Η παρασκευή του ML-236B με τη χρήση κάποιου μικροοργανισμού παραγωγής του ML-236B, ενισχύεται από τη χρήση πολυνουκλεοτιδίου που κωδικοποιεί κάποιο γονίδιο το οποίο σχετίζεται με το σύμπλεγμα της συνθετάσης των πολυκετιδίων που λαμβάνει χώρα στον παραπάνω μικροοργανισμό.
CY20071101434T 2000-04-18 2007-11-08 Γονιδια που σχετιζονται με τη βιοσυνθεση του ml-236b CY1106985T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000116591 2000-04-18
JP2000117458 2000-04-19
EP01303527A EP1149919B1 (en) 2000-04-18 2001-04-18 Genes related to biosynthesis of ML-236B

Publications (1)

Publication Number Publication Date
CY1106985T1 true CY1106985T1 (el) 2012-09-26

Family

ID=26590305

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101434T CY1106985T1 (el) 2000-04-18 2007-11-08 Γονιδια που σχετιζονται με τη βιοσυνθεση του ml-236b

Country Status (24)

Country Link
US (3) US7056710B2 (el)
EP (1) EP1149919B1 (el)
KR (1) KR100632174B1 (el)
CN (1) CN1325959B (el)
AR (1) AR034550A1 (el)
AT (1) ATE373101T1 (el)
AU (1) AU783319B2 (el)
BR (1) BR0101518A (el)
CA (1) CA2342397C (el)
CY (1) CY1106985T1 (el)
CZ (1) CZ20011367A3 (el)
DE (1) DE60130394T2 (el)
DK (1) DK1149919T3 (el)
ES (1) ES2293966T3 (el)
HK (1) HK1037683A1 (el)
HU (1) HUP0101569A3 (el)
IL (1) IL142619A (el)
MX (1) MXPA01003913A (el)
NO (1) NO328653B1 (el)
NZ (1) NZ511166A (el)
PL (1) PL202457B1 (el)
PT (1) PT1149919E (el)
RU (1) RU2236463C2 (el)
TW (1) TWI312807B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2029750T3 (da) * 2006-06-22 2011-10-17 Dsm Ip Assets Bv Fremstilling af pravastatin
EP2334781A1 (en) * 2008-09-24 2011-06-22 DSM IP Assets B.V. Improved statin production
WO2010069914A1 (en) * 2008-12-19 2010-06-24 Dsm Ip Assets B.V. Statin transcription regulators
EP3134098A1 (en) * 2014-04-23 2017-03-01 Danmarks Tekniske Universitet Statin resistance and export

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS572240A (en) 1980-06-06 1982-01-07 Sankyo Co Ltd Ml-236b derivative
US5179013A (en) 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
WO1995012661A1 (en) 1993-11-02 1995-05-11 Merck & Co., Inc. Dna encoding triol polyketide synthase
KR100186758B1 (ko) * 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
AU6475800A (en) 1999-08-11 2001-03-13 Sankyo Company Limited Ml-236b biosynthesis-associated dna
FR2801648B1 (fr) * 1999-11-30 2002-06-21 Commissariat Energie Atomique Injecteur a vapeur haute pression comportant un drain axial

Also Published As

Publication number Publication date
ES2293966T3 (es) 2008-04-01
NZ511166A (en) 2002-11-26
PL202457B1 (pl) 2009-06-30
EP1149919A2 (en) 2001-10-31
HUP0101569A2 (hu) 2002-05-29
US7056710B2 (en) 2006-06-06
ATE373101T1 (de) 2007-09-15
US20070111293A1 (en) 2007-05-17
AR034550A1 (es) 2004-03-03
CN1325959B (zh) 2010-05-05
NO20011890D0 (no) 2001-04-17
HK1037683A1 (en) 2002-02-15
RU2236463C2 (ru) 2004-09-20
US20050214909A1 (en) 2005-09-29
KR20010098713A (ko) 2001-11-08
KR100632174B1 (ko) 2006-10-11
TWI312807B (en) 2009-08-01
HUP0101569A3 (en) 2005-01-28
IL142619A (en) 2008-03-20
CA2342397C (en) 2011-08-23
PL347118A1 (en) 2001-10-22
NO20011890L (no) 2001-10-19
DE60130394D1 (de) 2007-10-25
CZ20011367A3 (cs) 2001-12-12
BR0101518A (pt) 2001-11-13
PT1149919E (pt) 2007-12-17
NO328653B1 (no) 2010-04-19
DE60130394T2 (de) 2008-06-19
MXPA01003913A (es) 2003-08-20
AU3709201A (en) 2001-10-25
HU0101569D0 (en) 2001-06-28
CA2342397A1 (en) 2001-10-18
US20030078395A1 (en) 2003-04-24
EP1149919B1 (en) 2007-09-12
AU783319B2 (en) 2005-10-13
EP1149919A3 (en) 2002-02-06
DK1149919T3 (da) 2007-12-03
CN1325959A (zh) 2001-12-12

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