PE20200291A1 - Glicosidos de esteviol de alta pureza - Google Patents
Glicosidos de esteviol de alta purezaInfo
- Publication number
- PE20200291A1 PE20200291A1 PE2019002422A PE2019002422A PE20200291A1 PE 20200291 A1 PE20200291 A1 PE 20200291A1 PE 2019002422 A PE2019002422 A PE 2019002422A PE 2019002422 A PE2019002422 A PE 2019002422A PE 20200291 A1 PE20200291 A1 PE 20200291A1
- Authority
- PE
- Peru
- Prior art keywords
- microorganism
- steviol glycosides
- high purity
- udp
- providing
- Prior art date
Links
- 239000004383 Steviol glycoside Substances 0.000 title abstract 3
- 229930182488 steviol glycoside Natural products 0.000 title abstract 3
- 150000008144 steviol glycosides Chemical class 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 3
- 235000019411 steviol glycoside Nutrition 0.000 abstract 2
- 235000019202 steviosides Nutrition 0.000 abstract 2
- 241000228257 Aspergillus sp. Species 0.000 abstract 1
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 241000235061 Pichia sp. Species 0.000 abstract 1
- 241000235088 Saccharomyces sp. Species 0.000 abstract 1
- QFVOYBUQQBFCRH-UHFFFAOYSA-N Steviol Natural products C1CC2(C3)CC(=C)C3(O)CCC2C2(C)C1C(C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-UHFFFAOYSA-N 0.000 abstract 1
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 abstract 1
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000490645 Yarrowia sp. Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- QFVOYBUQQBFCRH-VQSWZGCSSA-N steviol Chemical compound C([C@@]1(O)C(=C)C[C@@]2(C1)CC1)C[C@H]2[C@@]2(C)[C@H]1[C@](C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-VQSWZGCSSA-N 0.000 abstract 1
- 229940032084 steviol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1062—Sucrose synthase (2.4.1.13)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Referida a un metodo para producir glucosidos de esteviol, el cual comprende los pasos de: a) proporcionar una composicion inicial que comprenda un compuesto organico con al menos un atomo de carbono, b) proporcionar una preparacion enzimatica o microorganismo que contenga al menos una enzima seleccionada de enzimas de biosintesis de esteviol, UDP-glicosiltransferasas, y opcionalmente, enzimas de reciclaje de UDP-glucosa, c) poner en contacto la preparacion enzimatica o microorganismo con un medio que contenga la composicion de partida para producir un medio que comprenda al menos un glucosido de esteviol. El microorganismo se selecciona de E. coli, Saccharomyces sp., Aspergillus sp., Pichia sp., Bacillus sp. y Yarrowia sp.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762506357P | 2017-05-15 | 2017-05-15 | |
| US201762581880P | 2017-11-06 | 2017-11-06 | |
| PCT/US2018/032720 WO2018213279A1 (en) | 2017-05-15 | 2018-05-15 | High-purity steviol glycosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20200291A1 true PE20200291A1 (es) | 2020-02-05 |
Family
ID=64274895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019002422A PE20200291A1 (es) | 2017-05-15 | 2018-05-15 | Glicosidos de esteviol de alta pureza |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20200157594A1 (es) |
| EP (1) | EP3624599A4 (es) |
| CN (1) | CN111093390A (es) |
| AU (1) | AU2018269962B2 (es) |
| CA (1) | CA3063742A1 (es) |
| CO (1) | CO2019014105A2 (es) |
| PE (1) | PE20200291A1 (es) |
| PH (1) | PH12019550239A1 (es) |
| SG (1) | SG10202112698PA (es) |
| WO (1) | WO2018213279A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3497222T (pt) | 2016-08-12 | 2022-02-09 | Amyris Inc | Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos |
| WO2022002918A1 (en) | 2020-07-03 | 2022-01-06 | C-Lecta Gmbh | One-pot cell-free glycosylation process |
| CN113151316B (zh) * | 2021-04-21 | 2022-06-24 | 湖北大学 | 一种通过控制HDS22基因来调控MEcPP含量从而改善植物耐热性的方法 |
| CN114921431B (zh) * | 2022-05-05 | 2023-04-25 | 湖北大学 | 糖基转移酶突变体及其在发酵生产芳香醇糖苷中的应用 |
| WO2024121721A1 (en) | 2022-12-05 | 2024-06-13 | Tate & Lyle Solutions Usa Llc | Methods for obtaining steviol glycosides |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3176307A1 (en) * | 2010-06-02 | 2011-12-08 | Evolva Nutrition, Inc. | Recombinant production of steviol glycosides |
| WO2012006742A1 (en) * | 2010-07-16 | 2012-01-19 | Justbio Inc. | Extraction method for providing an organic certifiable stevia rebaudiana extract |
| US9752174B2 (en) * | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| CN103397064B (zh) * | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| EP3063286B1 (en) * | 2013-11-01 | 2018-12-05 | Conagen Inc. | Recombinant production of steviol glycosides |
| EP4166010A1 (en) * | 2014-09-19 | 2023-04-19 | PureCircle SDN BHD | High-purity steviol glycosides |
| EP3331373A4 (en) * | 2015-08-06 | 2019-07-10 | Cargill, Incorporated | FERMENTATION PROCESS FOR THE PREPARATION OF STEVIOL GLYCOSIDES |
| PT3497222T (pt) * | 2016-08-12 | 2022-02-09 | Amyris Inc | Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos |
-
2018
- 2018-05-15 CN CN201880041862.5A patent/CN111093390A/zh active Pending
- 2018-05-15 EP EP18803270.0A patent/EP3624599A4/en active Pending
- 2018-05-15 AU AU2018269962A patent/AU2018269962B2/en active Active
- 2018-05-15 SG SG10202112698PA patent/SG10202112698PA/en unknown
- 2018-05-15 PE PE2019002422A patent/PE20200291A1/es unknown
- 2018-05-15 CA CA3063742A patent/CA3063742A1/en active Pending
- 2018-05-15 WO PCT/US2018/032720 patent/WO2018213279A1/en unknown
- 2018-05-15 US US16/614,218 patent/US20200157594A1/en active Pending
-
2019
- 2019-11-15 PH PH12019550239A patent/PH12019550239A1/en unknown
- 2019-12-13 CO CONC2019/0014105A patent/CO2019014105A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN111093390A (zh) | 2020-05-01 |
| BR112019024080A2 (pt) | 2020-06-16 |
| WO2018213279A1 (en) | 2018-11-22 |
| AU2018269962A1 (en) | 2020-01-02 |
| US20200157594A1 (en) | 2020-05-21 |
| PH12019550239A1 (en) | 2020-12-07 |
| CO2019014105A2 (es) | 2020-04-01 |
| SG10202112698PA (en) | 2021-12-30 |
| CA3063742A1 (en) | 2018-11-22 |
| EP3624599A1 (en) | 2020-03-25 |
| AU2018269962B2 (en) | 2023-02-02 |
| BR112019024080A8 (pt) | 2023-03-07 |
| EP3624599A4 (en) | 2020-11-18 |
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