CY1106704T1 - Αλογονουχος συνθεση, η μεθοδος παρασκευης της και οι χρησεις της - Google Patents
Αλογονουχος συνθεση, η μεθοδος παρασκευης της και οι χρησεις τηςInfo
- Publication number
- CY1106704T1 CY1106704T1 CY20071100893T CY071100893T CY1106704T1 CY 1106704 T1 CY1106704 T1 CY 1106704T1 CY 20071100893 T CY20071100893 T CY 20071100893T CY 071100893 T CY071100893 T CY 071100893T CY 1106704 T1 CY1106704 T1 CY 1106704T1
- Authority
- CY
- Cyprus
- Prior art keywords
- taurine
- derivative
- halide
- preparation
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract 3
- -1 alkali metal hypochlorite salt Chemical class 0.000 abstract 2
- 229960003080 taurine Drugs 0.000 abstract 2
- 102000003896 Myeloperoxidases Human genes 0.000 abstract 1
- 108090000235 Myeloperoxidases Proteins 0.000 abstract 1
- 239000005708 Sodium hypochlorite Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 229940064004 antiseptic throat preparations Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Glass Compositions (AREA)
Abstract
Η παρούσα εφεύρεση πραγματεύεται τις φαρμακευτικές συνθέσεις που αποτελούνται (i) το λιγότερο από μία αλογονούχο σύνθεση και (ii) το λιγότερο από ένα Ν-αλογονούχο παράγωγο ενός τουλάχιστον επιλεγμένου μείγματος από τα μείγματα των διπολικών ιόντων και / ή αμινοξέων. Η αλογονούχος σύνθεση είναι ευνοϊκά ένα υποχλωριώδες άλας αλκαλικού μετάλλου και κατά προτίμηση το υποχλωριώδες νάτριο, και το παράγωγο Ν-αλογονούχο είναι κατά προτίμηση ένα Ν-αλογονούχο παράγωγο ταυρίνης και συγκεκριμένα μία Ν-αλοαμινούχο ταυρίνη και ακόμα προτιμότερο η Ν-χλωραμινούχος ταυρίνη. Η εφεύρεση αφορά επίσης την προετοιμασία των προαναφερθεισών συνθέσεων και την χρήση τους ως αντισηπτικά μεγάλου φάσματος, ως αντιφλεγμονώδη και ως διαμορφωτές του ανοσοποιητικού χωρίς να διεγείρουν τη δράση της μυελοϋπεροξειδάσης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0100862A FR2819723B1 (fr) | 2001-01-23 | 2001-01-23 | Composition halogene, son procede de preparation et ses utilisations |
PCT/FR2002/000151 WO2002058692A2 (fr) | 2001-01-23 | 2002-01-16 | Composition halogenee de hypohalites avec n-chloramine taurine, procede de preparation et ses utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106704T1 true CY1106704T1 (el) | 2012-05-23 |
Family
ID=8859119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100893T CY1106704T1 (el) | 2001-01-23 | 2007-07-04 | Αλογονουχος συνθεση, η μεθοδος παρασκευης της και οι χρησεις της |
Country Status (13)
Country | Link |
---|---|
US (3) | US20040022871A1 (el) |
EP (1) | EP1401422B1 (el) |
JP (3) | JP2004519462A (el) |
AT (1) | ATE358474T1 (el) |
AU (1) | AU2002231889A1 (el) |
CA (1) | CA2435419C (el) |
CY (1) | CY1106704T1 (el) |
DE (1) | DE60219314T2 (el) |
DK (1) | DK1401422T3 (el) |
ES (1) | ES2284837T3 (el) |
FR (1) | FR2819723B1 (el) |
PT (1) | PT1401422E (el) |
WO (1) | WO2002058692A2 (el) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2819723B1 (fr) * | 2001-01-23 | 2006-11-17 | Arnaud Mainnemare | Composition halogene, son procede de preparation et ses utilisations |
SE0103766D0 (sv) * | 2001-11-09 | 2001-11-09 | Astrazeneca Ab | Novel assay |
AR039385A1 (es) * | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
CA2535926C (en) | 2003-08-18 | 2012-10-09 | Novacal Pharmaceuticals, Inc. | N,n-dihalogenated amino acids and derivatives |
SE0302756D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel Compounds |
SE0402591D0 (sv) * | 2004-10-25 | 2004-10-25 | Astrazeneca Ab | Novel use |
MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
TWI386201B (zh) * | 2005-01-25 | 2013-02-21 | Novabay Pharmaceuticals Inc | N-鹵化胺基酸、n,n-二鹵化胺基酸與其衍生物;以及使用其之組合物與方法 |
US20070244449A1 (en) * | 2005-10-06 | 2007-10-18 | Novacal Pharmaceuticals, Inc. | System and method for the prevention of bacterial and fungal infections including Urinary Tract Infections (UTI) using N-halogenated amino acids |
TW200804383A (en) * | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
US20080288019A1 (en) * | 2007-01-31 | 2008-11-20 | Adam Heller | Electrochemical management of pain |
ES2608047T3 (es) * | 2008-04-10 | 2017-04-05 | Waldemar Gottardi | Composiciones que comprenden amina N-halogenada o N,N-dihalogenada para el tratamiento y profilaxis de infecciones broncopulmonares |
WO2009127924A1 (en) * | 2008-04-15 | 2009-10-22 | Waldemar Gottardi | Compositions and devices for antisepsis and anticoagulation |
US8945540B2 (en) * | 2008-05-09 | 2015-02-03 | Exoxemis, Inc. | Compositions for enhancing the antibacterial activity of myeloperoxidase and methods of use thereof |
US9642780B2 (en) | 2011-06-15 | 2017-05-09 | Rls Global Ab | Detection and removal of carious dentin tissue |
SE536581C2 (sv) | 2012-07-24 | 2014-03-11 | Rls Global Ab | Ett kit för behandling av sår eller liknande och ett preparat och metoder därav |
JP6295274B2 (ja) * | 2013-01-30 | 2018-03-14 | ストラウマン ホールディング アーゲー | 歯周病の処置 |
FR3009196B1 (fr) * | 2013-08-02 | 2015-10-02 | Arnaud Mainnemare | Nouvelle composition pour le traitement de l'inflammation |
CA3026576A1 (en) | 2016-06-09 | 2017-12-14 | Johnson Matthey Public Limited Company | Electrolytic production of organic chloramine solutions |
RU2624166C1 (ru) * | 2016-07-29 | 2017-06-30 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) | Способ лечения деструктивных форм хронических верхушечных периодонтитов |
LU101842B1 (en) | 2020-06-08 | 2021-12-08 | Arnaud Mainnemare | Pharmaceutical Composition for treating or preventing lesions and infections in a mammal |
IT202000028082A1 (it) | 2020-11-23 | 2022-05-23 | Md Italy Srl | Composizione, preparazione ed impiego di una miscela a base di bromo per l’igiene perioculare, il trattamento e la prevenzione delle blefariti |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4012842A (en) * | 1972-06-12 | 1977-03-22 | National Patent Development Corporation | Dental treatment method and apparatus |
CA1025705A (en) | 1972-06-12 | 1978-02-07 | Jaroslav Vit | Method and apparatus for removal of dental plaque and caries by means of high velocity pulsating jet of liquid |
US3998945A (en) * | 1972-06-12 | 1976-12-21 | National Patent Development Corporation | Dental treatment |
US4035483A (en) * | 1973-05-29 | 1977-07-12 | John Bunyan | Antiseptic and non-toxic substance and a method of making the same |
DE4041703C2 (de) * | 1990-12-24 | 1993-10-21 | Waldemar Dr Gottardi | Alkalimetallsalze des N-Chlortaurins in kristalliner Form, Verfahren zu deren Herstellung und deren Verwendung |
JP3759757B2 (ja) * | 1994-01-13 | 2006-03-29 | 相互薬工株式会社 | 殺菌剤 |
DE19712565A1 (de) * | 1997-03-25 | 1998-10-01 | Thomas W Dr Stief | Arzneimittel auf der Basis eines Singulett-Sauerstoff erzeugenden Agenzes |
JPH11279057A (ja) | 1998-03-30 | 1999-10-12 | Arimasa Miyamoto | NFκB活性化阻害剤 |
DE19816102C1 (de) * | 1998-04-10 | 1999-09-16 | Waldemar Gottardi | Verfahren zum Inaktivieren von Viren in Proteinlösungen, Verwendung von N-Chlortaurin in dem Verfahren sowie nach dem Verfahren hergestellte Proteinlösungen |
DE60037657T2 (de) * | 1999-06-04 | 2009-01-08 | Oxibio, Inc., Portland | Infektionsmittel enthaltendes medizinisches gerät und verfahren zu ihrer darstellung |
FR2819723B1 (fr) * | 2001-01-23 | 2006-11-17 | Arnaud Mainnemare | Composition halogene, son procede de preparation et ses utilisations |
JP4948846B2 (ja) | 2006-02-08 | 2012-06-06 | 株式会社東芝 | 突入電流抑制回路を備えた電源装置 |
-
2001
- 2001-01-23 FR FR0100862A patent/FR2819723B1/fr not_active Expired - Lifetime
-
2002
- 2002-01-16 JP JP2002559026A patent/JP2004519462A/ja active Pending
- 2002-01-16 ES ES02711967T patent/ES2284837T3/es not_active Expired - Lifetime
- 2002-01-16 CA CA2435419A patent/CA2435419C/fr not_active Expired - Lifetime
- 2002-01-16 PT PT02711967T patent/PT1401422E/pt unknown
- 2002-01-16 DE DE60219314T patent/DE60219314T2/de not_active Expired - Lifetime
- 2002-01-16 WO PCT/FR2002/000151 patent/WO2002058692A2/fr active IP Right Grant
- 2002-01-16 AU AU2002231889A patent/AU2002231889A1/en not_active Abandoned
- 2002-01-16 EP EP02711967A patent/EP1401422B1/fr not_active Expired - Lifetime
- 2002-01-16 DK DK02711967T patent/DK1401422T3/da active
- 2002-01-16 AT AT02711967T patent/ATE358474T1/de active
-
2003
- 2003-07-18 US US10/622,262 patent/US20040022871A1/en not_active Abandoned
-
2007
- 2007-07-04 CY CY20071100893T patent/CY1106704T1/el unknown
-
2008
- 2008-09-24 US US12/236,613 patent/US7879366B2/en not_active Expired - Fee Related
-
2010
- 2010-05-21 JP JP2010117839A patent/JP2010174050A/ja active Pending
- 2010-12-22 US US12/976,414 patent/US8709498B2/en not_active Expired - Lifetime
-
2013
- 2013-07-01 JP JP2013137996A patent/JP2013189477A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1401422B1 (fr) | 2007-04-04 |
ES2284837T3 (es) | 2007-11-16 |
DE60219314T2 (de) | 2008-01-03 |
DK1401422T3 (da) | 2007-08-06 |
ATE358474T1 (de) | 2007-04-15 |
PT1401422E (pt) | 2007-07-09 |
JP2004519462A (ja) | 2004-07-02 |
WO2002058692A2 (fr) | 2002-08-01 |
WO2002058692A9 (fr) | 2003-03-06 |
US20040022871A1 (en) | 2004-02-05 |
US8709498B2 (en) | 2014-04-29 |
US20110091578A1 (en) | 2011-04-21 |
JP2013189477A (ja) | 2013-09-26 |
FR2819723A1 (fr) | 2002-07-26 |
CA2435419C (fr) | 2012-06-05 |
WO2002058692A3 (fr) | 2003-12-24 |
JP2010174050A (ja) | 2010-08-12 |
US20090022815A1 (en) | 2009-01-22 |
FR2819723B1 (fr) | 2006-11-17 |
US7879366B2 (en) | 2011-02-01 |
DE60219314D1 (de) | 2007-05-16 |
AU2002231889A1 (en) | 2002-08-06 |
CA2435419A1 (fr) | 2002-08-01 |
EP1401422A2 (fr) | 2004-03-31 |
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