CY1106370T1 - Επιλεκτικη συνθεση cf3-υποκατεστημενων πυριμιδινων - Google Patents
Επιλεκτικη συνθεση cf3-υποκατεστημενων πυριμιδινωνInfo
- Publication number
- CY1106370T1 CY1106370T1 CY20071100341T CY071100341T CY1106370T1 CY 1106370 T1 CY1106370 T1 CY 1106370T1 CY 20071100341 T CY20071100341 T CY 20071100341T CY 071100341 T CY071100341 T CY 071100341T CY 1106370 T1 CY1106370 T1 CY 1106370T1
- Authority
- CY
- Cyprus
- Prior art keywords
- formula
- substituted pyrimidines
- selective synthesis
- compound
- pyrimidine
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical group NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μια μέθοδο παρασκευής μιας ένωσης του τύπου (I), όπου τα Χ1, Χ2 και R3-R4 είναι όπως ορίστηκε στο παρόν. Η μέθοδος περιλαμβάνει την αντίδραση μιας ένωσης του τύπου (II) με μια αμίνη του τύπου (III) (HNR3R4) παρουσία οξέος του Lewis και μιας μη πυρηνόφιλης βάσης. Η ομάδα 2,4-διαμινο-πυριμιδίνης είναι ένα κοινό συστατικό σε μια ποικιλία βιολογικώς δραστικών μορίων παρόμοιων με φάρμακα και τα παράγωγα πυριμιδίνης βρέθηκαν ότι είναι χρήσιμα στη θεραπεία της μη φυσιολογικής κυτταρικής ανάπτυξης, όπως ο καρκίνος, σε θηλαστικά.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50073303P | 2003-09-05 | 2003-09-05 | |
| PCT/IB2004/002744 WO2005023780A1 (en) | 2003-09-05 | 2004-08-24 | Selective synthesis of cf3-substituted pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106370T1 true CY1106370T1 (el) | 2011-10-12 |
Family
ID=34272990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100341T CY1106370T1 (el) | 2003-09-05 | 2007-03-12 | Επιλεκτικη συνθεση cf3-υποκατεστημενων πυριμιδινων |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7122670B2 (el) |
| EP (1) | EP1663991B1 (el) |
| JP (1) | JP4842816B2 (el) |
| KR (1) | KR100694732B1 (el) |
| CN (1) | CN100465164C (el) |
| AR (1) | AR045557A1 (el) |
| BR (1) | BRPI0414059B8 (el) |
| CA (1) | CA2537373C (el) |
| CO (1) | CO5650237A2 (el) |
| CY (1) | CY1106370T1 (el) |
| DE (1) | DE602004004287T2 (el) |
| DK (1) | DK1663991T3 (el) |
| ES (1) | ES2276344T3 (el) |
| HK (1) | HK1091824A1 (el) |
| IL (1) | IL173363A (el) |
| MX (1) | MXPA06002552A (el) |
| NO (1) | NO334383B1 (el) |
| NZ (1) | NZ544969A (el) |
| PL (1) | PL1663991T3 (el) |
| PT (1) | PT1663991E (el) |
| RU (1) | RU2315759C2 (el) |
| TW (1) | TWI283667B (el) |
| WO (1) | WO2005023780A1 (el) |
| ZA (1) | ZA200600747B (el) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20084357B (en) * | 2002-12-20 | 2008-04-29 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| JP4778717B2 (ja) * | 2005-03-25 | 2011-09-21 | 富士フイルム株式会社 | 複素環式化合物の製造方法 |
| DE102007010801A1 (de) | 2007-03-02 | 2008-09-04 | Bayer Cropscience Ag | Diaminopyrimidine als Fungizide |
| CN101678215B (zh) * | 2007-04-18 | 2014-10-01 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
| KR101294731B1 (ko) * | 2007-06-04 | 2013-08-16 | 삼성디스플레이 주식회사 | 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법 |
| UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| WO2009115583A1 (en) * | 2008-03-20 | 2009-09-24 | Boehringer Ingelheim International Gmbh | Regioselective preparation of substituted pyrimidines |
| DE102009006643A1 (de) | 2009-01-29 | 2010-08-05 | Saltigo Gmbh | Herstellung von halogenierten N-heteroaromatischen Polyhalogenderivaten |
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| WO2011018517A1 (en) | 2009-08-14 | 2011-02-17 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 大環状キナーゼ阻害剤 |
| UY33817A (es) | 2010-12-21 | 2012-07-31 | Boehringer Ingelheim Int | ?nuevas oxindolpirimidinas bencílicas?. |
| EP2675793B1 (en) | 2011-02-17 | 2018-08-08 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
| CN103534240B (zh) | 2011-02-17 | 2015-12-09 | 癌症疗法Crc私人有限公司 | 选择性fak抑制剂 |
| WO2014126954A1 (en) | 2013-02-13 | 2014-08-21 | OSI Pharmaceuticals, LLC | Regioselective synthesis of substituted pyrimidines |
| US9656970B2 (en) | 2014-05-08 | 2017-05-23 | Tosoh F-Tech, Inc. | 5-(trifluoromethyl)pyrimidine derivatives and method for producing same |
| JP6391985B2 (ja) * | 2014-05-16 | 2018-09-19 | 東ソー・ファインケム株式会社 | ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6391988B2 (ja) * | 2014-05-21 | 2018-09-19 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体 |
| CN108440499A (zh) * | 2018-03-22 | 2018-08-24 | 盐城师范学院 | 一种色瑞替尼及其关键中间体的制备方法 |
| CN114213339B (zh) * | 2021-12-20 | 2023-10-31 | 苏州康纯医药科技有限公司 | 一种表皮细胞生长因子受体突变抑制剂的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| ATE407678T1 (de) * | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
-
2004
- 2004-08-24 PT PT04769170T patent/PT1663991E/pt unknown
- 2004-08-24 MX MXPA06002552A patent/MXPA06002552A/es active IP Right Grant
- 2004-08-24 ES ES04769170T patent/ES2276344T3/es active Active
- 2004-08-24 PL PL04769170T patent/PL1663991T3/pl unknown
- 2004-08-24 KR KR1020067004428A patent/KR100694732B1/ko active IP Right Grant
- 2004-08-24 BR BRPI0414059A patent/BRPI0414059B8/pt active IP Right Grant
- 2004-08-24 CN CNB2004800254318A patent/CN100465164C/zh active Active
- 2004-08-24 DK DK04769170T patent/DK1663991T3/da active
- 2004-08-24 CA CA002537373A patent/CA2537373C/en active Active
- 2004-08-24 DE DE602004004287T patent/DE602004004287T2/de active Active
- 2004-08-24 RU RU2006106727/04A patent/RU2315759C2/ru not_active IP Right Cessation
- 2004-08-24 NZ NZ544969A patent/NZ544969A/en unknown
- 2004-08-24 JP JP2006525198A patent/JP4842816B2/ja active Active
- 2004-08-24 WO PCT/IB2004/002744 patent/WO2005023780A1/en active IP Right Grant
- 2004-08-24 EP EP04769170A patent/EP1663991B1/en active Active
- 2004-08-27 US US10/928,954 patent/US7122670B2/en active Active
- 2004-09-02 AR ARP040103140A patent/AR045557A1/es not_active Application Discontinuation
- 2004-09-03 TW TW093126748A patent/TWI283667B/zh active
-
2006
- 2006-01-25 IL IL173363A patent/IL173363A/en active IP Right Grant
- 2006-01-26 ZA ZA200600747A patent/ZA200600747B/xx unknown
- 2006-02-23 CO CO06018320A patent/CO5650237A2/es not_active Application Discontinuation
- 2006-04-03 NO NO20061509A patent/NO334383B1/no unknown
- 2006-11-09 HK HK06112349.7A patent/HK1091824A1/xx unknown
-
2007
- 2007-03-12 CY CY20071100341T patent/CY1106370T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1106370T1 (el) | Επιλεκτικη συνθεση cf3-υποκατεστημενων πυριμιδινων | |
| BR0316056A (pt) | Processo para a preparação de compostos de pirrolotriazina úteis como inibidores de cinase | |
| CY1116119T1 (el) | Παραγωγα ισοξαζολο-πυριδινης | |
| TNSN06074A1 (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| BRPI0415855A (pt) | processo para preparação de ésteres de ácido 2-dihalogenacil-3-amino-acrìlico e ésteres de ácido 3-dihalogeno-metil-pirazol-4-carboxìlico | |
| CY1109227T1 (el) | Παραγωγα της 5-φαινυλο-4-μεθυλο-θειαζολ-2-υλ-αμινης ως αναστολεις των ενζυμων κινασης της φωσφατιδυλινοσιτολης 3 (p13) για την θεραπεια των φλεγμονωδων ασθενειων των αεραγωγων | |
| EA201070874A1 (ru) | Производные индол-2-карбоксамидов и азаиндол-2-карбоксамидов, замещённых силанильной группой, их получение и применение в терапии | |
| EA200601796A1 (ru) | Пиримидиновые производные для лечения аномального клеточного роста | |
| CY1109882T1 (el) | Νεα αλατα ατορβαστατινης και φαρμακευτικες συνθεσεις που τα περιεχουν | |
| ATE347555T1 (de) | 6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung | |
| Gao et al. | Synthesis and evaluation of 10-(3, 5-dimethoxy) benzyl-9 (10H)-acridone derivatives as selective telomeric G-quadruplex DNA ligands | |
| Shanmugam et al. | Synthesis, spectral characterization and antimicrobial studies of novel s-triazine derivatives | |
| JP4389205B2 (ja) | ４−アミノキナゾリン化合物の製法 | |
| Stojković et al. | The phenanthridine biguanides efficiently differentiate between dGdC, dAdT and rArU sequences by two independent, sensitive spectroscopic methods | |
| Xie et al. | An efficient method for the synthesis of substituted 5-aminotetrazoles from selenoureas using PhI (OAc) 2 | |
| EA200600046A1 (ru) | Производные 6-[2-(фосфонометокси)алкокси]пиримидинов (варианты), способ их получения (варианты), фармацевтическая композиция на их основе и способ лечения вирусной инфекции | |
| RU2009133346A (ru) | Способ определения количества коньюгированного таксана в коньюгатах полиглутаминовая кислота-таксан | |
| CY1107805T1 (el) | Στερεοεκλεκτικη μεθοδος παρασκευης νουκλεοζιτικων παραγωγων | |
| Liu et al. | Synthesis of novel amide derivatives with in vitro antiproliferative and cytotoxic activity | |
| Crisp et al. | Intramolecular hydrogen bonding studies for a series of dipurinyl-2, 6-pyridinedicarboxamides | |
| Russell et al. | An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor | |
| KR101457453B1 (ko) | 게피티닙의 제조방법 및 이의 제조에 사용되는 중간체 | |
| Dutta et al. | Synthesis and biological activities of some N6-(nitro-and-aminobenzyl) adenosines | |
| DK1250335T3 (da) | Fremgangsmåde og mellemprodukter til fremstilling af imidazopyridiner | |
| Ristovska et al. | Microwave-assisted Synthesis of Some N-alkylisatin-β-thiocarbohydrazones |