CY1106115T1 - Προσδιορισμος κινασης αναπλαστικου λεμφωματος, αντιδραστηρια και συνθεσεις αυτης - Google Patents
Προσδιορισμος κινασης αναπλαστικου λεμφωματος, αντιδραστηρια και συνθεσεις αυτηςInfo
- Publication number
- CY1106115T1 CY1106115T1 CY20061100923T CY061100923T CY1106115T1 CY 1106115 T1 CY1106115 T1 CY 1106115T1 CY 20061100923 T CY20061100923 T CY 20061100923T CY 061100923 T CY061100923 T CY 061100923T CY 1106115 T1 CY1106115 T1 CY 1106115T1
- Authority
- CY
- Cyprus
- Prior art keywords
- reagents
- compositions
- determination
- anaplastic lymphoma
- lymphoma kinase
- Prior art date
Links
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 title abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Παρουσιάζονται μέθοδοι για την ανίχνευση της δράσης της κινάσης τυροσίνης ALK και για την ταυτοποίηση ενώσεων που τροποποιούν τη δράση της ALK, τα πεπτιδικά υποστρώματα, τα αντιδραστήρια και οι συνθέσεις αυτών.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03005186A EP1454992B1 (en) | 2003-03-07 | 2003-03-07 | Anaplastic lymphoma kinase assay, reagents and compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106115T1 true CY1106115T1 (el) | 2011-06-08 |
Family
ID=32798804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100923T CY1106115T1 (el) | 2003-03-07 | 2006-07-04 | Προσδιορισμος κινασης αναπλαστικου λεμφωματος, αντιδραστηρια και συνθεσεις αυτης |
Country Status (15)
Country | Link |
---|---|
US (1) | US20070031907A1 (el) |
EP (1) | EP1454992B1 (el) |
JP (1) | JP2006519800A (el) |
CN (1) | CN100345978C (el) |
AT (1) | ATE328112T1 (el) |
CA (1) | CA2518094A1 (el) |
CY (1) | CY1106115T1 (el) |
DE (1) | DE60305634T2 (el) |
DK (1) | DK1454992T3 (el) |
ES (1) | ES2263862T3 (el) |
HK (1) | HK1068154A1 (el) |
IL (1) | IL170669A0 (el) |
PT (1) | PT1454992E (el) |
SI (1) | SI1454992T1 (el) |
WO (1) | WO2004079326A2 (el) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2561406T3 (es) | 2006-04-14 | 2016-02-26 | Cell Signaling Technology, Inc. | Defectos de genes y quinasa ALK mutante en tumores sólidos humanos |
US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
EP2107054A1 (en) | 2008-04-01 | 2009-10-07 | Università Degli Studi Di Milano - Bicocca | Antiproliferative compounds and therapeutic uses thereof |
EP2274288A2 (en) | 2008-04-24 | 2011-01-19 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
EP2161271A1 (en) | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
WO2010085597A1 (en) | 2009-01-23 | 2010-07-29 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
US9126931B2 (en) * | 2009-06-10 | 2015-09-08 | Chugai Seiyaku Kabushiki Kaisha | Tetracyclic compound |
CN101955995B (zh) * | 2010-06-17 | 2013-06-26 | 江苏迈迪基因生物科技有限公司 | 淋巴瘤相关的融合基因的诊断试剂盒 |
US20120101108A1 (en) | 2010-08-06 | 2012-04-26 | Cell Signaling Technology, Inc. | Anaplastic Lymphoma Kinase In Kidney Cancer |
WO2012023597A1 (ja) | 2010-08-20 | 2012-02-23 | 中外製薬株式会社 | 4環性化合物を含む組成物 |
EP2847353B1 (en) | 2012-05-10 | 2022-01-19 | The General Hospital Corporation | Methods for determining a nucleotide sequence |
TR201815994T4 (tr) | 2012-09-25 | 2018-11-21 | Chugai Pharmaceutical Co Ltd | Ret inhibitörü. |
WO2014128235A1 (en) | 2013-02-22 | 2014-08-28 | F. Hoffmann-La Roche Ag | Methods of treating cancer and preventing drug resistance |
US10450597B2 (en) | 2014-01-27 | 2019-10-22 | The General Hospital Corporation | Methods of preparing nucleic acids for sequencing |
CA2946268A1 (en) | 2014-04-25 | 2015-10-29 | Chugai Seiyaku Kabushiki Kaisha | Crystal of tetracyclic compound |
KR102412321B1 (ko) | 2014-04-25 | 2022-06-22 | 추가이 세이야쿠 가부시키가이샤 | 4환성 화합물을 고용량 함유하는 제제 |
TWI718102B (zh) | 2014-08-08 | 2021-02-11 | 日商中外製藥股份有限公司 | 4環性化合物的非晶質體 |
RU2740261C2 (ru) | 2015-01-16 | 2021-01-12 | Чугаи Сейяку Кабусики Кайся | Комбинированное лекарственное средство |
CN109937254B (zh) | 2016-09-15 | 2023-05-30 | 阿谢尔德克斯有限责任公司 | 核酸样品制备方法 |
CA3037190A1 (en) | 2016-09-15 | 2018-03-22 | ArcherDX, Inc. | Methods of nucleic acid sample preparation for analysis of cell-free dna |
EP4198140A1 (en) | 2016-11-02 | 2023-06-21 | ArcherDX, LLC | Methods of nucleic acid sample preparation for immune repertoire sequencing |
WO2020050241A1 (ja) | 2018-09-04 | 2020-03-12 | 中外製薬株式会社 | 4環性化合物の製造方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05126833A (ja) * | 1991-10-31 | 1993-05-21 | Tosoh Corp | チロシンキナ−ゼ活性の免疫化学的測定法及びそのキツト |
AU4281393A (en) * | 1992-04-10 | 1993-11-18 | Dana-Farber Cancer Institute, Inc. | Activation-state-specific phosphoprotein immunodetection |
ES2136103T3 (es) * | 1992-06-22 | 1999-11-16 | Kyowa Hakko Kogyo Kk | Procedimiento para la preparacion de derivados de estaurosporina. |
GB9314271D0 (en) * | 1993-07-09 | 1993-08-18 | Inst Of Cancer The Research | Cell growth factor receptors |
US6001621A (en) * | 1993-11-23 | 1999-12-14 | Genetech, Inc. | Protein tyrosine kinases |
CA2175892C (en) * | 1993-11-23 | 2000-03-07 | Paul J. Godowski | Kinase receptor activation assay |
US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
US5763198A (en) * | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
US5759787A (en) * | 1996-08-26 | 1998-06-02 | Tularik Inc. | Kinase assay |
CA2288221A1 (en) * | 1997-04-28 | 1998-11-05 | Sugen, Inc. | Diagnosis and treatment of phosphatase 0r kinase-related disorders |
US6806266B1 (en) * | 1999-07-13 | 2004-10-19 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
-
2003
- 2003-03-07 DE DE60305634T patent/DE60305634T2/de not_active Expired - Fee Related
- 2003-03-07 PT PT03005186T patent/PT1454992E/pt unknown
- 2003-03-07 ES ES03005186T patent/ES2263862T3/es not_active Expired - Lifetime
- 2003-03-07 AT AT03005186T patent/ATE328112T1/de not_active IP Right Cessation
- 2003-03-07 DK DK03005186T patent/DK1454992T3/da active
- 2003-03-07 SI SI200330308T patent/SI1454992T1/sl unknown
- 2003-03-07 EP EP03005186A patent/EP1454992B1/en not_active Expired - Lifetime
-
2004
- 2004-03-04 WO PCT/EP2004/002185 patent/WO2004079326A2/en active Application Filing
- 2004-03-04 CN CNB2004800060187A patent/CN100345978C/zh not_active Expired - Fee Related
- 2004-03-04 CA CA002518094A patent/CA2518094A1/en not_active Abandoned
- 2004-03-04 JP JP2006504533A patent/JP2006519800A/ja active Pending
- 2004-03-04 US US10/547,842 patent/US20070031907A1/en not_active Abandoned
-
2005
- 2005-02-17 HK HK05101314A patent/HK1068154A1/xx not_active IP Right Cessation
- 2005-09-05 IL IL170669A patent/IL170669A0/en unknown
-
2006
- 2006-07-04 CY CY20061100923T patent/CY1106115T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2006519800A (ja) | 2006-08-31 |
CN1756850A (zh) | 2006-04-05 |
ATE328112T1 (de) | 2006-06-15 |
WO2004079326A2 (en) | 2004-09-16 |
US20070031907A1 (en) | 2007-02-08 |
DE60305634T2 (de) | 2006-09-21 |
HK1068154A1 (en) | 2005-04-22 |
WO2004079326A3 (en) | 2004-12-09 |
EP1454992B1 (en) | 2006-05-31 |
IL170669A0 (en) | 2011-08-01 |
SI1454992T1 (sl) | 2006-10-31 |
EP1454992A1 (en) | 2004-09-08 |
DK1454992T3 (da) | 2006-10-02 |
ES2263862T3 (es) | 2006-12-16 |
CN100345978C (zh) | 2007-10-31 |
PT1454992E (pt) | 2006-09-29 |
DE60305634D1 (de) | 2006-07-06 |
CA2518094A1 (en) | 2004-09-16 |
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