ATE328112T1 - Anaplastisches lymphoma kinase testverfahren, reagenzien und kompositionen davon - Google Patents

Anaplastisches lymphoma kinase testverfahren, reagenzien und kompositionen davon

Info

Publication number
ATE328112T1
ATE328112T1 AT03005186T AT03005186T ATE328112T1 AT E328112 T1 ATE328112 T1 AT E328112T1 AT 03005186 T AT03005186 T AT 03005186T AT 03005186 T AT03005186 T AT 03005186T AT E328112 T1 ATE328112 T1 AT E328112T1
Authority
AT
Austria
Prior art keywords
reagents
compositions
testing methods
anaplastic lymphoma
lymphoma kinase
Prior art date
Application number
AT03005186T
Other languages
English (en)
Inventor
Lorenzo A Pinna
Arianna Donella-Deana
Oriano Marin
Luca Mologni
Rosalind Gunby
Passerini Carlo Gambacorti
Leonardo Scapozza
Original Assignee
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Naz Stud Cura Dei Tumori filed Critical Ist Naz Stud Cura Dei Tumori
Application granted granted Critical
Publication of ATE328112T1 publication Critical patent/ATE328112T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
AT03005186T 2003-03-07 2003-03-07 Anaplastisches lymphoma kinase testverfahren, reagenzien und kompositionen davon ATE328112T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03005186A EP1454992B1 (de) 2003-03-07 2003-03-07 Anaplastisches Lymphoma Kinase Testverfahren, Reagenzien und Kompositionen davon

Publications (1)

Publication Number Publication Date
ATE328112T1 true ATE328112T1 (de) 2006-06-15

Family

ID=32798804

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03005186T ATE328112T1 (de) 2003-03-07 2003-03-07 Anaplastisches lymphoma kinase testverfahren, reagenzien und kompositionen davon

Country Status (15)

Country Link
US (1) US20070031907A1 (de)
EP (1) EP1454992B1 (de)
JP (1) JP2006519800A (de)
CN (1) CN100345978C (de)
AT (1) ATE328112T1 (de)
CA (1) CA2518094A1 (de)
CY (1) CY1106115T1 (de)
DE (1) DE60305634T2 (de)
DK (1) DK1454992T3 (de)
ES (1) ES2263862T3 (de)
HK (1) HK1068154A1 (de)
IL (1) IL170669A0 (de)
PT (1) PT1454992E (de)
SI (1) SI1454992T1 (de)
WO (1) WO2004079326A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168383B2 (en) 2006-04-14 2012-05-01 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
EP2447360A1 (de) 2006-04-14 2012-05-02 Cell Signaling Technology, Inc. Gendefekte und Mutante ALK-Kinase in festen menschlichen Tumoren
EP2107054A1 (de) 2008-04-01 2009-10-07 Università Degli Studi Di Milano - Bicocca Antiproliferative Verbindungen und therapeutische Verwendungen dafür
CA2722326A1 (en) 2008-04-24 2009-10-29 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
EP2161271A1 (de) 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-Carbolin-Hemmer von NMP-ALK, RET und Bcr-Abl
WO2010085597A1 (en) 2009-01-23 2010-07-29 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
CA2764653C (en) 2009-06-10 2018-01-02 Chugai Seiyaku Kabushiki Kaisha Tetracyclic compounds
CN101955995B (zh) * 2010-06-17 2013-06-26 江苏迈迪基因生物科技有限公司 淋巴瘤相关的融合基因的诊断试剂盒
US20120101108A1 (en) 2010-08-06 2012-04-26 Cell Signaling Technology, Inc. Anaplastic Lymphoma Kinase In Kidney Cancer
EP2606886B1 (de) 2010-08-20 2020-01-08 Chugai Seiyaku Kabushiki Kaisha Zusammensetzung umfassend eine tetrazyklische verbindung
WO2013169339A1 (en) 2012-05-10 2013-11-14 The General Hospital Corporation Methods for determining a nucleotide sequence
CA3077553C (en) 2012-09-25 2022-08-02 Chugai Seiyaku Kabushiki Kaisha Ret inhibitor
JP2016509045A (ja) 2013-02-22 2016-03-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト がんを治療し、薬剤耐性を防止する方法
AU2015209079B2 (en) 2014-01-27 2021-07-15 Archerdx, Llc Methods of preparing nucleic acids for sequencing
AU2015250574B2 (en) 2014-04-25 2020-07-16 Chugai Seiyaku Kabushiki Kaisha Preparation containing tetracyclic compound at high dose
CA2946268A1 (en) 2014-04-25 2015-10-29 Chugai Seiyaku Kabushiki Kaisha Crystal of tetracyclic compound
TWI718102B (zh) 2014-08-08 2021-02-11 日商中外製藥股份有限公司 4環性化合物的非晶質體
US11077093B2 (en) 2015-01-16 2021-08-03 Chugai Seiyaku Kabushiki Kaisha Combination drug
JP6997773B2 (ja) 2016-09-15 2022-01-18 アーチャーディーエックス, エルエルシー 無細胞dnaの分析用の核酸サンプル調製の方法
US10704082B2 (en) 2016-09-15 2020-07-07 ArcherDX, Inc. Methods of nucleic acid sample preparation
JP7161991B2 (ja) 2016-11-02 2022-10-27 アーチャーディーエックス, エルエルシー 免疫レパートリーシーケンシングのための核酸サンプル調製の方法
AR116113A1 (es) 2018-09-04 2021-03-31 Chugai Pharmaceutical Co Ltd Método para fabricar un compuesto tetracíclico

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05126833A (ja) * 1991-10-31 1993-05-21 Tosoh Corp チロシンキナ−ゼ活性の免疫化学的測定法及びそのキツト
DE69334053T2 (de) * 1992-04-10 2007-01-04 Dana-Farber Cancer Institute, Inc., Boston Immunnachweis eines aktivierungszustandsspezifischen phosphoproteins
ES2136103T3 (es) * 1992-06-22 1999-11-16 Kyowa Hakko Kogyo Kk Procedimiento para la preparacion de derivados de estaurosporina.
GB9314271D0 (en) * 1993-07-09 1993-08-18 Inst Of Cancer The Research Cell growth factor receptors
US6001621A (en) * 1993-11-23 1999-12-14 Genetech, Inc. Protein tyrosine kinases
ATE163231T1 (de) * 1993-11-23 1998-02-15 Genentech Inc Kinaserezeptoraktivierungstest
US5529925A (en) * 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US5763198A (en) * 1994-07-22 1998-06-09 Sugen, Inc. Screening assays for compounds
US5759787A (en) * 1996-08-26 1998-06-02 Tularik Inc. Kinase assay
JP2002513289A (ja) * 1997-04-28 2002-05-08 スージェン・インコーポレーテッド チロシンホスファターゼ関連疾患の診断および治療および関連する方法
CA2379035A1 (en) * 1999-07-13 2001-01-18 Shiro Akinaga Staurosporin derivatives

Also Published As

Publication number Publication date
EP1454992A1 (de) 2004-09-08
EP1454992B1 (de) 2006-05-31
JP2006519800A (ja) 2006-08-31
ES2263862T3 (es) 2006-12-16
SI1454992T1 (sl) 2006-10-31
CN1756850A (zh) 2006-04-05
WO2004079326A3 (en) 2004-12-09
WO2004079326A2 (en) 2004-09-16
DE60305634T2 (de) 2006-09-21
CN100345978C (zh) 2007-10-31
DK1454992T3 (da) 2006-10-02
CA2518094A1 (en) 2004-09-16
PT1454992E (pt) 2006-09-29
CY1106115T1 (el) 2011-06-08
HK1068154A1 (en) 2005-04-22
DE60305634D1 (de) 2006-07-06
US20070031907A1 (en) 2007-02-08
IL170669A0 (en) 2011-08-01

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