NO20044051L - Analyse for ACTRIIB-kinase aktivitet - Google Patents

Analyse for ACTRIIB-kinase aktivitet

Info

Publication number
NO20044051L
NO20044051L NO20044051A NO20044051A NO20044051L NO 20044051 L NO20044051 L NO 20044051L NO 20044051 A NO20044051 A NO 20044051A NO 20044051 A NO20044051 A NO 20044051A NO 20044051 L NO20044051 L NO 20044051L
Authority
NO
Norway
Prior art keywords
assay
kinase activity
actriib
activity
actriib kinase
Prior art date
Application number
NO20044051A
Other languages
English (en)
Inventor
Philip Albert Krasney
Michael Norcia
Barbara Ann O'connor
Robin Whitney Spencer
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20044051L publication Critical patent/NO20044051L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Foreliggende oppfinnelse angår kinase analyser, og spesielt nye kinase analysemetoder som anvender et nytt mål-peptid for måling av aktiviteten og/eller modulering av aktiviteten av ActRliB-kinaseproteinet.
NO20044051A 2002-02-28 2004-09-24 Analyse for ACTRIIB-kinase aktivitet NO20044051L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36060702P 2002-02-28 2002-02-28
PCT/IB2003/000638 WO2003072808A1 (en) 2002-02-28 2003-02-17 Assay for activity of the actriib kinase

Publications (1)

Publication Number Publication Date
NO20044051L true NO20044051L (no) 2004-09-24

Family

ID=27734775

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044051A NO20044051L (no) 2002-02-28 2004-09-24 Analyse for ACTRIIB-kinase aktivitet

Country Status (12)

Country Link
US (1) US20030219846A1 (no)
EP (1) EP1340817A1 (no)
JP (1) JP2003250537A (no)
KR (1) KR20040084942A (no)
CN (1) CN1643161A (no)
AU (1) AU2003206033A1 (no)
CA (1) CA2476942A1 (no)
HR (1) HRP20040786A2 (no)
IL (1) IL163658A0 (no)
NO (1) NO20044051L (no)
RU (1) RU2004126254A (no)
WO (1) WO2003072808A1 (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007515422A (ja) * 2003-12-22 2007-06-14 アルコン，インコーポレイテッド 糖尿病性網膜症および黄斑変性における結晶腔形成の処置のための薬剤
PT1803468E (pt) * 2003-12-22 2011-11-23 Novartis Ag Agentes para tratar a retinopatia glaucomatosa e a neuropatia óptica
TW200526224A (en) * 2003-12-22 2005-08-16 Alcon Inc Short form c-Maf transcription factor antagonists for treatment of glaucoma
US20080096238A1 (en) * 2004-03-30 2008-04-24 Alcon, Inc. High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio
WO2005102345A1 (en) * 2004-03-30 2005-11-03 Alcon, Inc. Use of rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance
US20060115870A1 (en) * 2004-03-30 2006-06-01 Alcon, Inc. High throughput assay for human Rho kinase activity
DK2332977T3 (en) 2004-07-23 2016-02-29 Acceleron Pharma Inc ActRII receptor polypeptides
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
EP3811965A1 (en) 2005-11-23 2021-04-28 Acceleron Pharma, Inc. Activin-actriia antagonists in use for promoting bone growth
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
ME02335B (me) 2006-12-18 2013-04-30 Acceleron Pharma Inc Activin-actrii antagonisti i upotreba za liječenje anemije
ES2415666T3 (es) 2007-02-01 2013-07-26 Acceleron Pharma, Inc. Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIa para uso en la prevención o el tratamiento de metástasis de cáncer de mama o pérdida ósea relacionada con el cáncer de mama
TW202104248A (zh) 2007-02-02 2021-02-01 美商艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
TW201934141A (zh) 2007-02-09 2019-09-01 美商艾瑟勒朗法瑪公司 包含ＡｃｔＲＩＩａ-Ｆｃ融合蛋白的醫藥組合物；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防與癌症相關的骨質流失之用途；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防多發性骨髓瘤之用途
EP2207562B1 (en) 2007-09-18 2017-05-31 Acceleron Pharma, Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
PL2340031T4 (pl) 2008-08-14 2020-12-28 Acceleron Pharma Inc. Zastosowanie pułapek GDF do leczenia niedokrwistości
WO2010083034A1 (en) * 2009-01-13 2010-07-22 Acceleron Pharma Inc. Methods for increasing adiponectin
MX355042B (es) 2009-06-08 2018-04-02 Acceleon Pharma Inc Metodos para aumentar adipositos termogenicos.
EP2440577A4 (en) 2009-06-12 2013-01-23 Acceleron Pharma Inc SHORTEN ACTRIIB FC FUSION PROTEINS
CA2781152A1 (en) 2009-11-17 2011-05-26 Acceleron Pharma Inc. Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
WO2012064771A1 (en) 2010-11-08 2012-05-18 Acceleron Pharma, Inc. Actriia binding agents and uses thereof
WO2014030683A1 (ja) * 2012-08-21 2014-02-27 国立大学法人九州大学 貧血患者の貧血の要因を検出するためのバイオマーカー
ES2884095T3 (es) 2012-11-02 2021-12-10 Celgene Corp Antagonistas de activina-actrii y usos para el tratamiento de trastornos óseos y otros trastornos
CN114699529A (zh) 2014-06-13 2022-07-05 阿塞勒隆制药公司 用于治疗溃疡的方法和组合物
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
SI3227675T1 (sl) 2014-12-03 2023-07-31 Celgene Corporation Antagonisti aktivin-actrii in uporaba za zdravljenje mielodisplastičnega sindroma

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2343934A1 (en) * 1998-09-25 2000-04-06 The Children's Medical Center Corporation Short peptides which selectively modulate the activity of protein kinases
GB9923208D0 (en) * 1999-10-01 1999-12-08 Cambridge Drug Discovery Ltd Assay
US20020115173A1 (en) * 2000-12-11 2002-08-22 Children's Medical Center Corporation Short peptides from the 'A-region' of protein kinases which selectively modulate protein kinase activity
AUPR638101A0 (en) * 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor

Also Published As

Publication number Publication date
IL163658A0 (en) 2005-12-18
JP2003250537A (ja) 2003-09-09
AU2003206033A1 (en) 2003-09-09
US20030219846A1 (en) 2003-11-27
KR20040084942A (ko) 2004-10-06
HRP20040786A2 (en) 2004-12-31
CA2476942A1 (en) 2003-09-04
WO2003072808A1 (en) 2003-09-04
EP1340817A1 (en) 2003-09-03
CN1643161A (zh) 2005-07-20
RU2004126254A (ru) 2005-04-10

Similar Documents

Publication Publication Date Title
NO20044051L (no) Analyse for ACTRIIB-kinase aktivitet
HUP0200400A2 (hu) Fehérjék izolálása és elemzése
ATE530644T1 (de) Protease-screening-verfahren und dadurch identifizierte proteasen
DK1454992T3 (da) Anaplastisk lymfomakinaseassay, reagenser og sammensætninger deraf
ATE464374T1 (de) Assay zum schnellen nachweis vom humanen aktivierten protein c und hochspezifischer monoklonaler antikörper dagegen
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
DE60330376D1 (de) Defructosylierungsverfahren
BRPI0617788A2 (pt) processos isolados estaticamente verificáveis com comunicação interprocessos
WO2005010215A3 (en) Methods for identifying tolerance modulatory compounds and uses therefor
EA200702193A1 (ru) Гликозилирование белков
WO2007067983A3 (en) Sulfotyrosine specific antibodies and uses therefor
NO20064715L (no) Deteksjon, isolering og anvendelse av renalase (monoamin aksidase C)
BR0314155A (pt) Métodos para diagnosticar câncer cervical
WO2003008635A8 (en) η-SECRETASE IN VITRO SCREENING ASSAY
ATE458816T1 (de) Fluoreszierendes protein aus aequorea coerulescens und ihre verwendungen
ES2185652T3 (es) Oligopeptidos derivados de fragmentos de proteinas c-reactiva.
ATE498018T1 (de) Nachweis von salmonella-lactose+
ATE412187T1 (de) Screening test
DE502006005985D1 (de) Testsystem zum nachweis von salmonellen
ATE434761T1 (de) Methode für die analyse von substanzen gegen flaviviren unter verwendung eines persistent virus-infizierten zellsystems
FR2840409B1 (fr) Dispositif de presentation de peptides ou de proteines, son procede de preparation et ses utilisations
WO2005001133A3 (en) Compositions and methods for high throughput construction and functional analysis of expression libraries
WO2007048830A3 (en) Assays for histone deacetylase 1/2 selective inhibitors
NO20043330L (no) Assay for deteksjon av faktorer som modulerer ekspresjon av INGAP
DE60302764D1 (de) Test auf phosphoamidase

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application