IL163658A0 - Assay for activity of the actriib kinase - Google Patents
Assay for activity of the actriib kinaseInfo
- Publication number
- IL163658A0 IL163658A0 IL16365803A IL16365803A IL163658A0 IL 163658 A0 IL163658 A0 IL 163658A0 IL 16365803 A IL16365803 A IL 16365803A IL 16365803 A IL16365803 A IL 16365803A IL 163658 A0 IL163658 A0 IL 163658A0
- Authority
- IL
- Israel
- Prior art keywords
- assay
- activity
- actriib
- kinase
- actriib kinase
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36060702P | 2002-02-28 | 2002-02-28 | |
PCT/IB2003/000638 WO2003072808A1 (en) | 2002-02-28 | 2003-02-17 | Assay for activity of the actriib kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
IL163658A0 true IL163658A0 (en) | 2005-12-18 |
Family
ID=27734775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16365803A IL163658A0 (en) | 2002-02-28 | 2003-02-17 | Assay for activity of the actriib kinase |
Country Status (12)
Country | Link |
---|---|
US (1) | US20030219846A1 (xx) |
EP (1) | EP1340817A1 (xx) |
JP (1) | JP2003250537A (xx) |
KR (1) | KR20040084942A (xx) |
CN (1) | CN1643161A (xx) |
AU (1) | AU2003206033A1 (xx) |
CA (1) | CA2476942A1 (xx) |
HR (1) | HRP20040786A2 (xx) |
IL (1) | IL163658A0 (xx) |
NO (1) | NO20044051L (xx) |
RU (1) | RU2004126254A (xx) |
WO (1) | WO2003072808A1 (xx) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE357932T1 (de) * | 2003-12-22 | 2007-04-15 | Alcon Inc | Mittel zur behandlung von glaukomatöser retinopathie und optischer neuropathie |
TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
CA2548146A1 (en) * | 2003-12-22 | 2005-07-14 | Alcon, Inc. | Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration |
US20080096238A1 (en) * | 2004-03-30 | 2008-04-24 | Alcon, Inc. | High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio |
US20050222127A1 (en) * | 2004-03-30 | 2005-10-06 | Alcon, Inc. | Use of Rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance |
US20060115870A1 (en) * | 2004-03-30 | 2006-06-01 | Alcon, Inc. | High throughput assay for human Rho kinase activity |
EP3489257A1 (en) | 2004-07-23 | 2019-05-29 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
RS58231B1 (sr) | 2005-11-23 | 2019-03-29 | Acceleron Pharma Inc | Antagonisti aktivin-actriia i primene za stimulaciju rasta kostiju |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
DK2124999T3 (da) | 2006-12-18 | 2013-01-14 | Acceleron Pharma Inc | Activin-actrii antagonister og anvendelser til behandling af anæmi |
TWI584815B (zh) | 2007-02-01 | 2017-06-01 | 艾瑟勒朗法瑪公司 | 活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途 |
TW201907946A (zh) * | 2007-02-02 | 2019-03-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
EA018221B1 (ru) | 2007-02-09 | 2013-06-28 | Акселерон Фарма Инк. | АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ |
CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
PL3494986T3 (pl) | 2008-08-14 | 2020-11-16 | Acceleron Pharma Inc. | Pułapki GDF |
EP2387412A4 (en) * | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | METHODS FOR INCREASING ADIPONECTIN |
AU2010258931B2 (en) | 2009-06-08 | 2015-04-23 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
WO2010151426A1 (en) | 2009-06-12 | 2010-12-29 | Acceleron Pharma Inc. | Truncated actriib-fc fusion proteins |
EP2501400B1 (en) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
EP2638065A4 (en) | 2010-11-08 | 2014-04-09 | Acceleron Pharma Inc | ACTRIIA BINDING AGENTS AND USES THEREOF |
JP6214537B2 (ja) * | 2012-08-21 | 2017-10-25 | 国立大学法人九州大学 | 貧血患者の貧血の要因を検出するためのバイオマーカー |
AU2013337677B2 (en) | 2012-11-02 | 2018-06-28 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
US9850298B2 (en) | 2014-06-13 | 2017-12-26 | Acceleron Pharma Inc. | Methods for treating ulcers in thalassemia syndrome with an ActRIIB polypeptide |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
RS64214B1 (sr) | 2014-12-03 | 2023-06-30 | Celgene Corp | Antagonisti aktivin-actrii i njihova primena u lečenju mijelodisplastičnog sindroma |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000018895A1 (en) * | 1998-09-25 | 2000-04-06 | The Children's Medical Center Corporation | Short peptides which selectively modulate the activity of protein kinases |
GB9923208D0 (en) * | 1999-10-01 | 1999-12-08 | Cambridge Drug Discovery Ltd | Assay |
US20020115173A1 (en) * | 2000-12-11 | 2002-08-22 | Children's Medical Center Corporation | Short peptides from the 'A-region' of protein kinases which selectively modulate protein kinase activity |
AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
-
2003
- 2003-02-14 US US10/367,241 patent/US20030219846A1/en not_active Abandoned
- 2003-02-17 WO PCT/IB2003/000638 patent/WO2003072808A1/en not_active Application Discontinuation
- 2003-02-17 AU AU2003206033A patent/AU2003206033A1/en not_active Abandoned
- 2003-02-17 KR KR10-2004-7013380A patent/KR20040084942A/ko not_active Application Discontinuation
- 2003-02-17 CA CA002476942A patent/CA2476942A1/en not_active Abandoned
- 2003-02-17 CN CNA038065827A patent/CN1643161A/zh active Pending
- 2003-02-17 IL IL16365803A patent/IL163658A0/xx unknown
- 2003-02-17 RU RU2004126254/13A patent/RU2004126254A/ru not_active Application Discontinuation
- 2003-02-19 EP EP03251012A patent/EP1340817A1/en not_active Withdrawn
- 2003-02-28 JP JP2003052729A patent/JP2003250537A/ja not_active Withdrawn
-
2004
- 2004-08-27 HR HRP20040786 patent/HRP20040786A2/hr not_active Application Discontinuation
- 2004-09-24 NO NO20044051A patent/NO20044051L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20040786A2 (en) | 2004-12-31 |
AU2003206033A1 (en) | 2003-09-09 |
KR20040084942A (ko) | 2004-10-06 |
JP2003250537A (ja) | 2003-09-09 |
CN1643161A (zh) | 2005-07-20 |
EP1340817A1 (en) | 2003-09-03 |
CA2476942A1 (en) | 2003-09-04 |
RU2004126254A (ru) | 2005-04-10 |
US20030219846A1 (en) | 2003-11-27 |
WO2003072808A1 (en) | 2003-09-04 |
NO20044051L (no) | 2004-09-24 |
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