DK1664093T3 - Antitumorforbindelser baseret på kahalalid F - Google Patents
Antitumorforbindelser baseret på kahalalid FInfo
- Publication number
- DK1664093T3 DK1664093T3 DK04768394T DK04768394T DK1664093T3 DK 1664093 T3 DK1664093 T3 DK 1664093T3 DK 04768394 T DK04768394 T DK 04768394T DK 04768394 T DK04768394 T DK 04768394T DK 1664093 T3 DK1664093 T3 DK 1664093T3
- Authority
- DK
- Denmark
- Prior art keywords
- kahalalide
- compounds based
- tumor compounds
- tumor
- new analogues
- Prior art date
Links
- RCGXNDQKCXNWLO-WLEIXIPESA-N (2r)-n-[(2s)-5-amino-1-[[(2r,3r)-1-[[(3s,6z,9s,12r,15r,18r,19s)-9-benzyl-15-[(2r)-butan-2-yl]-6-ethylidene-19-methyl-2,5,8,11,14,17-hexaoxo-3,12-di(propan-2-yl)-1-oxa-4,7,10,13,16-pentazacyclononadec-18-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent Chemical compound N([C@@H](CCCN)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H]1C(N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NC(/C(=O)N[C@H](C(=O)O[C@H]1C)C(C)C)=C\C)C(C)C)[C@H](C)CC)=O)C(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C RCGXNDQKCXNWLO-WLEIXIPESA-N 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 108010091711 kahalalide F Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0321066.3A GB0321066D0 (en) | 2003-09-09 | 2003-09-09 | New antitumoral compounds |
| PCT/GB2004/003847 WO2005023846A1 (en) | 2003-09-09 | 2004-09-09 | New antitumoral compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1664093T3 true DK1664093T3 (da) | 2008-08-18 |
Family
ID=29226738
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13180582.2T DK2664623T3 (da) | 2003-09-09 | 2004-09-09 | Nye antitumorale forbindelser |
| DK04768394T DK1664093T3 (da) | 2003-09-09 | 2004-09-09 | Antitumorforbindelser baseret på kahalalid F |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13180582.2T DK2664623T3 (da) | 2003-09-09 | 2004-09-09 | Nye antitumorale forbindelser |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20070117743A1 (da) |
| EP (6) | EP2280027A3 (da) |
| JP (4) | JP4874796B2 (da) |
| KR (1) | KR20060073618A (da) |
| CN (2) | CN101531707A (da) |
| AT (1) | ATE393776T1 (da) |
| AU (2) | AU2004270471B2 (da) |
| CA (1) | CA2537128A1 (da) |
| CY (1) | CY1108226T1 (da) |
| DE (1) | DE602004013454T2 (da) |
| DK (2) | DK2664623T3 (da) |
| ES (2) | ES2305843T3 (da) |
| GB (1) | GB0321066D0 (da) |
| HR (1) | HRP20080330T3 (da) |
| HU (1) | HUE025308T2 (da) |
| IL (1) | IL173929A (da) |
| MX (1) | MXPA06002741A (da) |
| NZ (4) | NZ580124A (da) |
| PL (1) | PL1664093T3 (da) |
| PT (1) | PT1664093E (da) |
| RU (2) | RU2395520C2 (da) |
| SI (1) | SI1664093T1 (da) |
| WO (1) | WO2005023846A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0002952D0 (en) * | 2000-02-09 | 2000-03-29 | Pharma Mar Sa | Process for producing kahalalide F compounds |
| GB0304367D0 (en) | 2003-02-26 | 2003-04-02 | Pharma Mar Sau | Methods for treating psoriasis |
| US7507708B2 (en) | 2003-02-26 | 2009-03-24 | Pharma Mar, S.A.U. | Antitumoral compounds |
| WO2009052379A2 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
| EP2252315A1 (en) * | 2008-01-30 | 2010-11-24 | Pharma Mar, S.A. | Improved antitumoral treatments |
| EP2262522A1 (en) * | 2008-03-07 | 2010-12-22 | Pharma Mar, S.A. | Improved antitumoral treatments |
| CN101519437B (zh) * | 2009-04-09 | 2012-05-02 | 中国人民解放军第二军医大学 | 西沙海绵中一种环七肽类化合物及其用途 |
| CN104725266B (zh) * | 2014-04-10 | 2016-08-10 | 申俊 | 酰亚胺类化合物的合成方法 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) * | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| JPS6178719A (ja) * | 1984-09-25 | 1986-04-22 | Tanabe Seiyaku Co Ltd | 総合輸液剤 |
| DK0531472T3 (da) * | 1991-03-06 | 2003-12-01 | Merck Patent Gmbh | Humaniserede monoklonale antistoffer |
| GB9300059D0 (en) * | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| GB9302046D0 (en) | 1993-02-03 | 1993-03-24 | Pharma Mar Sa | Antiumoral compound-v |
| US6274551B1 (en) * | 1994-02-03 | 2001-08-14 | Pharmamar, S.A. | Cytotoxic and antiviral compound |
| US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| EP0912559B1 (en) * | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| GB9800569D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| US6200598B1 (en) * | 1998-06-18 | 2001-03-13 | Duke University | Temperature-sensitive liposomal formulation |
| WO2000031048A1 (en) * | 1998-11-19 | 2000-06-02 | Warner-Lambert Company | N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases |
| US7311924B2 (en) * | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| UA74803C2 (uk) * | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| GB0002952D0 (en) * | 2000-02-09 | 2000-03-29 | Pharma Mar Sa | Process for producing kahalalide F compounds |
| MXPA03003704A (es) | 2000-10-31 | 2004-05-04 | Pharma Mar Sa | Formulacion de kahalalide f. |
| AU2002334203C1 (en) | 2001-10-19 | 2008-10-09 | Pharma Mar, S.A. | Kahalalide compounds for use in cancer therapy |
| CN100591691C (zh) | 2002-10-18 | 2010-02-24 | 马尔药品公司 | 新型抗肿瘤化合物 |
| GB0304367D0 (en) * | 2003-02-26 | 2003-04-02 | Pharma Mar Sau | Methods for treating psoriasis |
| SI1572726T1 (sl) * | 2002-10-18 | 2011-04-29 | Pharma Mar Sau | 4-metilheksanoiäśna kahalalid f spojina |
| US7507708B2 (en) * | 2003-02-26 | 2009-03-24 | Pharma Mar, S.A.U. | Antitumoral compounds |
-
2003
- 2003-09-09 GB GBGB0321066.3A patent/GB0321066D0/en not_active Ceased
-
2004
- 2004-09-09 WO PCT/GB2004/003847 patent/WO2005023846A1/en not_active Ceased
- 2004-09-09 AU AU2004270471A patent/AU2004270471B2/en not_active Ceased
- 2004-09-09 CN CN200910001891A patent/CN101531707A/zh active Pending
- 2004-09-09 CN CNB2004800258906A patent/CN100467482C/zh not_active Expired - Fee Related
- 2004-09-09 EP EP10179452A patent/EP2280027A3/en not_active Withdrawn
- 2004-09-09 AT AT04768394T patent/ATE393776T1/de active
- 2004-09-09 HU HUE13180582A patent/HUE025308T2/en unknown
- 2004-09-09 ES ES04768394T patent/ES2305843T3/es not_active Expired - Lifetime
- 2004-09-09 NZ NZ580124A patent/NZ580124A/en not_active IP Right Cessation
- 2004-09-09 JP JP2006525886A patent/JP4874796B2/ja not_active Expired - Fee Related
- 2004-09-09 RU RU2006111491/04A patent/RU2395520C2/ru not_active IP Right Cessation
- 2004-09-09 DE DE602004013454T patent/DE602004013454T2/de not_active Expired - Lifetime
- 2004-09-09 ES ES13180582.2T patent/ES2536285T3/es not_active Expired - Lifetime
- 2004-09-09 NZ NZ595490A patent/NZ595490A/xx not_active IP Right Cessation
- 2004-09-09 SI SI200430765T patent/SI1664093T1/sl unknown
- 2004-09-09 DK DK13180582.2T patent/DK2664623T3/da active
- 2004-09-09 DK DK04768394T patent/DK1664093T3/da active
- 2004-09-09 EP EP08100973A patent/EP1918296B1/en not_active Expired - Lifetime
- 2004-09-09 PL PL04768394T patent/PL1664093T3/pl unknown
- 2004-09-09 KR KR1020067004786A patent/KR20060073618A/ko not_active Abandoned
- 2004-09-09 HR HR20080330T patent/HRP20080330T3/xx unknown
- 2004-09-09 EP EP10179442A patent/EP2280026A3/en not_active Withdrawn
- 2004-09-09 EP EP10179425A patent/EP2280025A3/en not_active Withdrawn
- 2004-09-09 EP EP13180582.2A patent/EP2664623B1/en not_active Expired - Lifetime
- 2004-09-09 NZ NZ589890A patent/NZ589890A/en not_active IP Right Cessation
- 2004-09-09 PT PT04768394T patent/PT1664093E/pt unknown
- 2004-09-09 NZ NZ545700A patent/NZ545700A/en not_active IP Right Cessation
- 2004-09-09 US US10/570,734 patent/US20070117743A1/en not_active Abandoned
- 2004-09-09 EP EP04768394A patent/EP1664093B8/en not_active Expired - Lifetime
- 2004-09-09 MX MXPA06002741A patent/MXPA06002741A/es active IP Right Grant
- 2004-09-09 CA CA002537128A patent/CA2537128A1/en not_active Abandoned
-
2006
- 2006-02-26 IL IL173929A patent/IL173929A/en not_active IP Right Cessation
-
2008
- 2008-07-30 CY CY20081100794T patent/CY1108226T1/el unknown
-
2009
- 2009-12-18 RU RU2009147217/04A patent/RU2009147217A/ru not_active Application Discontinuation
-
2011
- 2011-05-17 AU AU2011202286A patent/AU2011202286B2/en not_active Ceased
- 2011-09-29 JP JP2011214681A patent/JP2012031187A/ja active Pending
- 2011-09-29 JP JP2011214682A patent/JP5372096B2/ja not_active Expired - Fee Related
- 2011-09-29 JP JP2011214680A patent/JP2012051899A/ja active Pending
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