CY1105423T1 - Παραγωγα ιμιδαζολης μεθοδος παραγωγης και χρηση αυτων - Google Patents
Παραγωγα ιμιδαζολης μεθοδος παραγωγης και χρηση αυτωνInfo
- Publication number
- CY1105423T1 CY1105423T1 CY20061100867T CY061100867T CY1105423T1 CY 1105423 T1 CY1105423 T1 CY 1105423T1 CY 20061100867 T CY20061100867 T CY 20061100867T CY 061100867 T CY061100867 T CY 061100867T CY 1105423 T1 CY1105423 T1 CY 1105423T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compound
- production method
- imidazole derivatives
- mixture
- optically active
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000003287 optical effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ένωση με ανασταλτική δραστικότητα επί στεροειδούς C17,20-λυάσης και η οποία είναι χρήσιμη στη θεραπεία και στην προφύλαξη έναντι όγκων όπως στον προστάτη, στον καρκίνο του μαστού και στα ομοειδή, καθώς παρέχει και μέθοδο επαρκούς διαχωρισμού μίας οπτικώς ενεργής ένωσης από μείγμα οπτικών ισομερών αυτής, παρέχει μία ένωση του τύπου: όπου έκαστο σύμβολο ορίζεται στην προδιαγραφή, ένα άλας αυτής ή ένα προφάρμακο αυτής, καθώς και μέθοδο αποκόμισης μίας οπτικώς ενεργής ένωσης μέσω οπτικής ανάλυσης μείγματος οπτικών ισομερών κάνοντας χρήση ενός παράγοντα ανάλυσης όπως το ταρτρανιλικό οξύ και τα ομοειδή.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000351780 | 2000-11-17 | ||
JP2001247618 | 2001-08-17 | ||
JP2001336880 | 2001-11-01 | ||
PCT/JP2001/010002 WO2002040484A2 (en) | 2000-11-17 | 2001-11-16 | Novel imidazole derivatives, production method thereof and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105423T1 true CY1105423T1 (el) | 2010-04-28 |
Family
ID=27345219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100867T CY1105423T1 (el) | 2000-11-17 | 2006-06-26 | Παραγωγα ιμιδαζολης μεθοδος παραγωγης και χρηση αυτων |
Country Status (27)
Country | Link |
---|---|
US (1) | US7141598B2 (el) |
EP (2) | EP1334106B1 (el) |
JP (2) | JP3753971B2 (el) |
KR (3) | KR100809899B1 (el) |
CN (3) | CN1329394C (el) |
AR (1) | AR034854A1 (el) |
AT (2) | ATE327237T1 (el) |
AU (3) | AU2002214296C1 (el) |
BR (1) | BR0115306B1 (el) |
CA (1) | CA2429133C (el) |
CY (1) | CY1105423T1 (el) |
DE (1) | DE60119963T2 (el) |
DK (1) | DK1334106T3 (el) |
ES (1) | ES2260303T3 (el) |
HK (1) | HK1056168A1 (el) |
HU (1) | HU229408B1 (el) |
IL (2) | IL155624A0 (el) |
MX (1) | MXPA03004347A (el) |
MY (1) | MY134929A (el) |
NO (1) | NO326366B1 (el) |
NZ (1) | NZ526387A (el) |
PE (1) | PE20020596A1 (el) |
PL (1) | PL204934B1 (el) |
PT (1) | PT1334106E (el) |
SI (1) | SI1334106T1 (el) |
TW (1) | TWI306099B (el) |
WO (1) | WO2002040484A2 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100588649C (zh) * | 2002-01-10 | 2010-02-10 | 武田药品工业株式会社 | 制备稠合咪唑化合物的方法、稳定形式的里福马斯基试剂及其制备方法 |
JP4745616B2 (ja) * | 2003-02-26 | 2011-08-10 | 武田薬品工業株式会社 | 安定化されたイミダゾール誘導体含有医薬組成物、イミダゾール誘導体の安定化方法 |
WO2004075890A1 (ja) * | 2003-02-26 | 2004-09-10 | Takeda Pharmaceutical Company | 安定化されたイミダゾール誘導体含有医薬組成物、イミダゾ-ル誘導体の安定化方法 |
CA2519211A1 (en) * | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Release control compositions |
JP4837895B2 (ja) * | 2003-03-17 | 2011-12-14 | 武田薬品工業株式会社 | 放出制御組成物 |
AU2005243240B2 (en) * | 2004-05-03 | 2012-03-15 | Janssen Pharmaceutica N.V. | Novel indole derivatives as selective androgen receptor modulators (SARMS) |
CA2568163A1 (en) * | 2004-05-28 | 2005-12-15 | Speedel Experimenta Ag | Bicyclic, nitrogen-containing heterocycles as aromatase inhibitors |
JP5159303B2 (ja) * | 2005-03-03 | 2013-03-06 | 武田薬品工業株式会社 | 放出制御組成物 |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
TW200804378A (en) * | 2005-12-09 | 2008-01-16 | Speedel Experimenta Ag | Organic compounds |
DE602007007734D1 (de) * | 2006-02-10 | 2010-08-26 | Janssen Pharmaceutica Nv | Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren |
TW200804284A (en) * | 2006-03-31 | 2008-01-16 | Speedel Experimenta Ag | Process for preparing 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one |
WO2009057795A2 (en) * | 2007-10-29 | 2009-05-07 | Takeda Pharmaceutical Company Limited | Pyrrolo [1,2-c] imidazole derivatives for use im the prophylaxis or treatment of cancer which is refractory to known cancer therapies |
JOP20190230A1 (ar) * | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
AR083916A1 (es) * | 2010-11-18 | 2013-04-10 | Takeda Pharmaceutical | Metodo para tratar el cancer de mama y cancer de ovarios |
JP6077459B2 (ja) | 2011-04-01 | 2017-02-08 | 武田薬品工業株式会社 | 固形製剤 |
EA201490019A1 (ru) | 2011-06-15 | 2014-04-30 | Такеда Фармасьютикал Компани Лимитед | Способ получения производных имидазола |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4728645A (en) * | 1982-12-21 | 1988-03-01 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors |
NZ221729A (en) | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
NZ224288A (en) | 1987-04-22 | 1989-12-21 | Merrell Dow Pharma | 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans |
US5057521A (en) * | 1988-10-26 | 1991-10-15 | Ciba-Geigy Corporation | Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism |
US4966898A (en) | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
WO1992015404A1 (en) | 1991-03-01 | 1992-09-17 | S.L. Electrostatic Technology, Inc. | Powder coating method for producing circuit board laminae and the like |
US5457102A (en) | 1994-07-07 | 1995-10-10 | Janssen Pharmaceutica, N.V. | Pyrroloimidazolyl and imidazopyridinyl substituted 1H-benzimidazole derivatives |
CA2127689A1 (en) | 1992-01-27 | 1993-08-05 | Marcel A. C. Janssen | Pyrroloimidazolyl and imidazopyridinyl substituted 1h-benzimidazole derivatives as aromatase inhibitors |
NZ249911A (en) | 1992-03-31 | 1996-06-25 | British Tech Group | 17-(3-pyridyl) substituted steroids and use in pharmaceutical compositions |
GB9310635D0 (en) | 1993-05-21 | 1993-07-07 | Glaxo Group Ltd | Chemical compounds |
CN1131944A (zh) | 1993-09-30 | 1996-09-25 | 山之内制药株式会社 | 唑类衍生物和它的药物组合物 |
AU3846395A (en) | 1994-11-07 | 1996-05-31 | Janssen Pharmaceutica N.V. | Compositions comprising carbazoles and cyclodextrins |
AU6015796A (en) | 1995-06-14 | 1997-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Fused imidazole derivatives and medicinal composition thereof |
AU6229698A (en) | 1997-02-21 | 1998-09-09 | Takeda Chemical Industries Ltd. | Fused ring compounds, process for producing the same and use thereof |
WO1999018075A1 (fr) | 1997-10-02 | 1999-04-15 | Yukijirushi Nyugyo Kabushiki Kaisha | Nouveaux composes a base de dihydronaphtalene et leur procede de production |
ATE293102T1 (de) | 1998-04-23 | 2005-04-15 | Takeda Pharmaceutical | Naphthalene derivate ,ihre herstellung und verwendung |
PE20010781A1 (es) * | 1999-10-22 | 2001-08-08 | Takeda Chemical Industries Ltd | Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion |
-
2001
- 2001-11-16 SI SI200130590T patent/SI1334106T1/sl unknown
- 2001-11-16 AU AU2002214296A patent/AU2002214296C1/en not_active Ceased
- 2001-11-16 NZ NZ526387A patent/NZ526387A/en not_active IP Right Cessation
- 2001-11-16 AT AT01982800T patent/ATE327237T1/de active
- 2001-11-16 KR KR1020057018247A patent/KR100809899B1/ko active IP Right Grant
- 2001-11-16 EP EP01982800A patent/EP1334106B1/en not_active Expired - Lifetime
- 2001-11-16 HU HU0400549A patent/HU229408B1/hu not_active IP Right Cessation
- 2001-11-16 PT PT01982800T patent/PT1334106E/pt unknown
- 2001-11-16 JP JP2001351035A patent/JP3753971B2/ja not_active Expired - Fee Related
- 2001-11-16 KR KR1020037006727A patent/KR100725442B1/ko active IP Right Grant
- 2001-11-16 CN CNB018190251A patent/CN1329394C/zh not_active Expired - Fee Related
- 2001-11-16 MX MXPA03004347A patent/MXPA03004347A/es active IP Right Grant
- 2001-11-16 WO PCT/JP2001/010002 patent/WO2002040484A2/en active IP Right Grant
- 2001-11-16 IL IL15562401A patent/IL155624A0/xx active IP Right Grant
- 2001-11-16 DK DK01982800T patent/DK1334106T3/da active
- 2001-11-16 CA CA002429133A patent/CA2429133C/en not_active Expired - Fee Related
- 2001-11-16 TW TW090128440A patent/TWI306099B/zh not_active IP Right Cessation
- 2001-11-16 AR ARP010105365A patent/AR034854A1/es active IP Right Grant
- 2001-11-16 BR BRPI0115306-4B1A patent/BR0115306B1/pt not_active IP Right Cessation
- 2001-11-16 ES ES01982800T patent/ES2260303T3/es not_active Expired - Lifetime
- 2001-11-16 PL PL362766A patent/PL204934B1/pl unknown
- 2001-11-16 CN CNA200610100666XA patent/CN1900079A/zh active Pending
- 2001-11-16 MY MYPI20015279A patent/MY134929A/en unknown
- 2001-11-16 EP EP05077705.1A patent/EP1681290B9/en not_active Expired - Lifetime
- 2001-11-16 CN CNB2005100640723A patent/CN100572363C/zh not_active Expired - Fee Related
- 2001-11-16 PE PE2001001147A patent/PE20020596A1/es active IP Right Grant
- 2001-11-16 AT AT05077705T patent/ATE533768T1/de active
- 2001-11-16 KR KR1020077025704A patent/KR20080002929A/ko not_active Application Discontinuation
- 2001-11-16 DE DE60119963T patent/DE60119963T2/de not_active Expired - Lifetime
- 2001-11-16 US US10/416,986 patent/US7141598B2/en not_active Expired - Lifetime
- 2001-11-16 AU AU1429602A patent/AU1429602A/xx active Pending
-
2003
- 2003-04-28 IL IL155624A patent/IL155624A/en not_active IP Right Cessation
- 2003-05-16 NO NO20032234A patent/NO326366B1/no not_active IP Right Cessation
- 2003-11-17 HK HK03108376A patent/HK1056168A1/xx not_active IP Right Cessation
-
2005
- 2005-08-31 JP JP2005252651A patent/JP4427496B2/ja not_active Expired - Fee Related
- 2005-10-18 AU AU2005225035A patent/AU2005225035B2/en not_active Ceased
-
2006
- 2006-06-26 CY CY20061100867T patent/CY1105423T1/el unknown
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