CU24400B1 - Una composición que comprende 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas - Google Patents

Una composición que comprende 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas

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Publication number
CU24400B1
CU24400B1 CU2015000140A CU20150140A CU24400B1 CU 24400 B1 CU24400 B1 CU 24400B1 CU 2015000140 A CU2015000140 A CU 2015000140A CU 20150140 A CU20150140 A CU 20150140A CU 24400 B1 CU24400 B1 CU 24400B1
Authority
CU
Cuba
Prior art keywords
dihydroimidazo
composition
inhibitor
kinazolins
substituted
Prior art date
Application number
CU2015000140A
Other languages
English (en)
Other versions
CU20150140A7 (es
Inventor
Katja Haike
Dr Ningshu Liu
Juliane Paul
Dr Antje Margret Wengner
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CU20150140A7 publication Critical patent/CU20150140A7/es
Publication of CU24400B1 publication Critical patent/CU24400B1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

<p>La presente invención está relacionada  con una composición, que comprende una combinación de: a) un compuesto del tipo 2,3-dihidroimidazo [1,2-c]quinazolinas de fórmula general:</p> <p>ESPACIO PARA FÓRMULA</p> <p>, o composiciones farmacéuticas que lo contienen, como único agente activo, y b) un agente activo adicional que se selecciona del grupo que consiste en el inhibidor selectivo de la PI3K DELTA GS-1101, el inhibidor de las BTK ibrutinib, el compuesto inhibidor de las IKK BAY B y el refametinib (BAY 86-9766, RDEA-119).</p>
CU2015000140A 2013-04-08 2014-04-04 Una composición que comprende 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas CU24400B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13162710 2013-04-08
EP13184240 2013-09-13
PCT/EP2014/056768 WO2014166820A1 (en) 2013-04-08 2014-04-04 Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for treating lymphomas

Publications (2)

Publication Number Publication Date
CU20150140A7 CU20150140A7 (es) 2016-10-28
CU24400B1 true CU24400B1 (es) 2019-04-04

Family

ID=50439383

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2015000140A CU24400B1 (es) 2013-04-08 2014-04-04 Una composición que comprende 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas

Country Status (27)

Country Link
US (2) US9999623B2 (es)
EP (1) EP2983669B1 (es)
JP (1) JP6368353B2 (es)
KR (1) KR102304108B1 (es)
CN (1) CN105263497B (es)
AP (1) AP2015008750A0 (es)
AU (1) AU2014253348B2 (es)
BR (1) BR112015025304B1 (es)
CA (1) CA2908776C (es)
CL (1) CL2015002978A1 (es)
CR (1) CR20150523A (es)
CU (1) CU24400B1 (es)
DO (1) DOP2015000256A (es)
EA (2) EA031493B9 (es)
ES (1) ES2708350T3 (es)
IL (1) IL241543B (es)
JO (1) JOP20140141B1 (es)
MX (1) MX2015014171A (es)
MY (1) MY192626A (es)
NI (1) NI201500148A (es)
PE (1) PE20151780A1 (es)
PH (1) PH12015502317A1 (es)
SG (2) SG11201507265XA (es)
TN (1) TN2015000452A1 (es)
TW (2) TWI675663B (es)
UA (2) UA119537C2 (es)
WO (1) WO2014166820A1 (es)

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Publication number Publication date
PE20151780A1 (es) 2015-12-20
CN105263497B (zh) 2019-04-30
EP2983669B1 (en) 2018-10-24
CL2015002978A1 (es) 2016-04-15
JOP20140141B1 (ar) 2021-08-17
MY192626A (en) 2022-08-29
AU2014253348A1 (en) 2015-10-08
EA031493B1 (ru) 2019-01-31
KR20150138858A (ko) 2015-12-10
UA119537C2 (uk) 2019-07-10
TW201517909A (zh) 2015-05-16
TW201924690A (zh) 2019-07-01
CA2908776C (en) 2021-08-10
AU2014253348B2 (en) 2019-05-23
NZ712033A (en) 2021-03-26
CA2908776A1 (en) 2014-10-16
TWI689307B (zh) 2020-04-01
WO2014166820A1 (en) 2014-10-16
TWI675663B (zh) 2019-11-01
EA037577B1 (ru) 2021-04-16
CU20150140A7 (es) 2016-10-28
KR102304108B1 (ko) 2021-09-23
IL241543B (en) 2019-08-29
CR20150523A (es) 2016-01-29
US20180193349A1 (en) 2018-07-12
CN105263497A (zh) 2016-01-20
BR112015025304A2 (pt) 2017-07-18
US10226469B2 (en) 2019-03-12
PH12015502317A1 (en) 2016-02-10
EA201792650A1 (ru) 2018-04-30
AP2015008750A0 (en) 2015-09-30
TN2015000452A1 (en) 2017-04-06
EP2983669A1 (en) 2016-02-17
EA201591932A1 (ru) 2016-04-29
JP6368353B2 (ja) 2018-08-01
US20160058770A1 (en) 2016-03-03
EA031493B9 (ru) 2019-12-18
HK1220121A1 (zh) 2017-04-28
NI201500148A (es) 2015-11-30
DOP2015000256A (es) 2015-12-31
UA122822C2 (uk) 2021-01-06
SG10201710539QA (en) 2018-01-30
SG11201507265XA (en) 2015-10-29
ES2708350T3 (es) 2019-04-09
JP2016515601A (ja) 2016-05-30
MX2015014171A (es) 2015-12-16
BR112015025304B1 (pt) 2022-09-27
US9999623B2 (en) 2018-06-19

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