EA201792650A1 - ПРИМЕНЕНИЕ ЗАМЕЩЕННЫХ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНОВ ДЛЯ ЛЕЧЕНИЯ ЛИМФОМ - Google Patents
ПРИМЕНЕНИЕ ЗАМЕЩЕННЫХ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНОВ ДЛЯ ЛЕЧЕНИЯ ЛИМФОМInfo
- Publication number
- EA201792650A1 EA201792650A1 EA201792650A EA201792650A EA201792650A1 EA 201792650 A1 EA201792650 A1 EA 201792650A1 EA 201792650 A EA201792650 A EA 201792650A EA 201792650 A EA201792650 A EA 201792650A EA 201792650 A1 EA201792650 A1 EA 201792650A1
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- Eurasian Patent Office
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- lymphoma
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- pharmaceutical composition
- hodgkin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Настоящее изобретение относится к применению соединения 2,3-дигидроимидазо[1,2-c]хиназолина или к применению фармацевтической композиции, содержащей такое соединение, в виде отдельного активного агента или в комбинации a) указанного соединения или фармацевтической композиции, содержащей такое соединение, и b) одного или нескольких дополнительных активных агентов для получения лекарственного средства для лечения или профилактики неходжкинской лимфомы (НХЛ), в частности рецидивов лимфомы или рефрактерной лимфомы после терапии первой линии, второй линии, индолентной или агрессивной неходжкинской лимфомы (НХЛ), в частности фолликулярной лимфомы (ФЛ), хронической лимфоцитарной лейкемии (ХЛЛ), лимфомы маргинальной зоны (ЛМЗ), диффузной В-крупноклеточной лимфомы (ДВККЛ), мантийноклеточной лимфомы (МКЛ), трансформированной лимфомы (ТЛ) или периферической Т-клеточной лимфомы (ПТКЛ); к комбинациям a) указанного соединения и b) одного или нескольких дополнительных активных агентов; к фармацевтической композиции, содержащей такое соединение, в виде отдельного активного агента для лечения неходжкинской лимфомы (НХЛ), в частности рецидивов лимфомы или рефрактерной лимфомы после терапии первой линии, второй линии, индолентной или агрессивной неходжкинской лимфомы (НХЛ), в частности фолликулярной лимфомы (ФЛ), хронической лимфоцитарной лейкемии (ХЛЛ), лимфомы маргинальной зоны (ЛМЗ), диффузной B-крупноклеточной лимфомы (ДВККЛ), мантийноклеточной лимфомы (МКЛ), трансформированной лимфомы (ТЛ) или периферической T-клеточной лимфомы (ПТКЛ); к фармацевтической композиции, содержащей комбинацию a) указанного соединения и b) одного или нескольких дополнительных активных агентов; к применению биомаркеров, участвующих в модификации экспрессии изоформ PI3K, BTK, IKK, BCR активации, BCR активации далее по ходу транскрипции пути NFκB, c-Myc, EZH2, для прогноза чувствительности и/или резистентности пациента с раком к указанному соединению и предоставления синергической комбинации на рациональной основе согласно определению в настоящем документе для увеличения чувствительности и/или для преодоления резистентности; и к способу определения уровня одного или нескольких следующих компонентов: экспрессия изоформ PI3K, BTK и IKK, BCR активация, BCR активация далее по ходу транскрипции пути NFκB, c-Myc, EZH2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13162710 | 2013-04-08 | ||
| EP13184240 | 2013-09-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201792650A1 true EA201792650A1 (ru) | 2018-04-30 |
| EA037577B1 EA037577B1 (ru) | 2021-04-16 |
Family
ID=50439383
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201792650A EA037577B1 (ru) | 2013-04-08 | 2014-04-04 | ПРИМЕНЕНИЕ 2-АМИНО-N-[7-МЕТОКСИ-8-(3-МОРФОЛИН-4-ИЛПРОПОКСИ)-2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИН-5-ИЛ]ПИРИМИДИН-5-КАРБОКСАМИДА ИЛИ ЕГО ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМОЙ СОЛИ ИЛИ ГИДРАТА И ФАРМАЦЕВТИЧЕСКОЙ КОМПОЗИЦИИ, СОДЕРЖАЩЕЙ УКАЗАННОЕ СОЕДИНЕНИЕ, ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ НЕХОДЖКИНСКОЙ ЛИМФОМЫ (НХЛ) |
| EA201591932A EA031493B9 (ru) | 2013-04-08 | 2014-04-04 | Комбинация и фармацевтическая композиция для лечения или профилактики неходжкинской лимфомы (нхл) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591932A EA031493B9 (ru) | 2013-04-08 | 2014-04-04 | Комбинация и фармацевтическая композиция для лечения или профилактики неходжкинской лимфомы (нхл) |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US9999623B2 (ru) |
| EP (1) | EP2983669B1 (ru) |
| JP (1) | JP6368353B2 (ru) |
| KR (1) | KR102304108B1 (ru) |
| CN (1) | CN105263497B (ru) |
| AP (1) | AP2015008750A0 (ru) |
| AU (1) | AU2014253348B2 (ru) |
| BR (1) | BR112015025304B1 (ru) |
| CA (1) | CA2908776C (ru) |
| CL (1) | CL2015002978A1 (ru) |
| CR (1) | CR20150523A (ru) |
| CU (1) | CU24400B1 (ru) |
| DO (1) | DOP2015000256A (ru) |
| EA (2) | EA037577B1 (ru) |
| ES (1) | ES2708350T3 (ru) |
| HK (1) | HK1220121A1 (ru) |
| IL (1) | IL241543B (ru) |
| JO (1) | JOP20140141B1 (ru) |
| MX (1) | MX2015014171A (ru) |
| MY (1) | MY192626A (ru) |
| NI (1) | NI201500148A (ru) |
| PE (1) | PE20151780A1 (ru) |
| PH (1) | PH12015502317A1 (ru) |
| SG (2) | SG10201710539QA (ru) |
| TN (1) | TN2015000452A1 (ru) |
| TW (2) | TWI689307B (ru) |
| UA (2) | UA122822C2 (ru) |
| WO (1) | WO2014166820A1 (ru) |
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| EP2508525A1 (en) * | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts |
| EP3077003A1 (en) | 2013-12-03 | 2016-10-12 | Bayer Pharma Aktiengesellschaft | Combination of pi3k-inhibitors |
| WO2015082376A2 (en) * | 2013-12-03 | 2015-06-11 | Bayer Pharma Aktiengesellschaft | Use of pi3k-inhibitors |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| EP3018127A1 (en) | 2014-11-07 | 2016-05-11 | Bayer Pharma Aktiengesellschaft | Synthesis of copanlisib and its dihydrochloride salt |
| WO2016087488A1 (en) * | 2014-12-03 | 2016-06-09 | Bayer Pharma Aktiengesellschaft | Administration regime for aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives |
| WO2016087490A1 (en) * | 2014-12-03 | 2016-06-09 | Bayer Pharma Aktiengesellschaft | Combination of pi3k-inhibitors |
| EP3268490B1 (en) | 2015-03-09 | 2020-07-08 | Bayer Pharma Aktiengesellschaft | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| PL3317281T3 (pl) | 2015-07-02 | 2020-11-02 | Acerta Pharma B.V. | Postacie stałe i formulacje (s)-4-(8-amino-3-(1-(but-2-ynoilo)pirolidyn-2-ylo)imidazo[1,5-a]-pirazyn-1-ylo)-n-(pirydyn-2-ylo)benzamidu |
| CA3012951A1 (en) * | 2016-02-01 | 2017-08-10 | Bayer Pharma Aktiengesellschaft | Copanlisib biomarkers |
| KR20180101603A (ko) * | 2016-02-01 | 2018-09-12 | 바이엘 파마 악티엔게젤샤프트 | 코판리십 바이오마커 |
| CN108884098B (zh) | 2016-03-08 | 2021-09-14 | 拜耳制药股份公司 | 2-氨基-N-[7-甲氧基-2,3-二氢咪唑并[1,2-c]喹唑啉-5-基]嘧啶-5-甲酰胺类 |
| EP3219329A1 (en) * | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib |
| WO2017221100A1 (en) * | 2016-06-20 | 2017-12-28 | Novartis Ag | Imidazopyrimidine compounds useful for the treatment of cancer |
| EP3472161B1 (en) * | 2016-06-20 | 2020-03-25 | Novartis AG | Triazolopyridine compounds and uses thereof |
| WO2018054782A1 (en) * | 2016-09-23 | 2018-03-29 | Bayer Pharma Aktiengesellschaft | Combination of pi3k-inhibitors |
| BR112019023632A2 (pt) | 2017-05-18 | 2020-08-18 | Jiangsu Hengrui Medicine Co., Ltd. | uso do inibidor de ezh2 combinado com o inibidor de btk na preparação de fármacos para tratamento de tumor |
| EP3645005A1 (en) | 2017-06-28 | 2020-05-06 | Bayer Consumer Care AG | Combination of a pi3k-inhibitor with an androgen receptor antagonist |
| KR20200052901A (ko) | 2017-09-13 | 2020-05-15 | 광동 오포 모바일 텔레커뮤니케이션즈 코포레이션 리미티드 | 데이터 처리 방법, 단말기 디바이스 및 네트워크 디바이스 |
| TW201922256A (zh) | 2017-10-27 | 2019-06-16 | 中國大陸商浙江導明醫藥科技有限公司 | 治療淋巴樣惡性疾病之方法 |
| EP4045505A1 (en) * | 2019-10-15 | 2022-08-24 | Bayer Aktiengesellschaft | 2-methyl-aza-quinazolines |
| JP7440360B2 (ja) | 2020-06-30 | 2024-02-28 | 東日本旅客鉄道株式会社 | 山形鋼材の研磨装置 |
| CN115120596A (zh) * | 2021-03-26 | 2022-09-30 | 上海璎黎药业有限公司 | 一种喹唑啉化合物及药物组合物的应用 |
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