CU20110163A7 - Un complejo de haluro de hidrógeno de agomelatina y la preparación del mismo - Google Patents

Un complejo de haluro de hidrógeno de agomelatina y la preparación del mismo

Info

Publication number
CU20110163A7
CU20110163A7 CU20110163A CU20110163A CU20110163A7 CU 20110163 A7 CU20110163 A7 CU 20110163A7 CU 20110163 A CU20110163 A CU 20110163A CU 20110163 A CU20110163 A CU 20110163A CU 20110163 A7 CU20110163 A7 CU 20110163A7
Authority
CU
Cuba
Prior art keywords
preparation
agomelatine
hydrogen halide
same
halide complex
Prior art date
Application number
CU20110163A
Other languages
English (en)
Inventor
Hongiuan Pan
Xiong Yu
Xingdong Cheng
Xufeng Cao
Hubo Wang
Yu Huang
Xudong Jiang
Zhedong Yuan
Peng Zhang
Hanbin Shan
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40878634&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20110163(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of CU20110163A7 publication Critical patent/CU20110163A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B7/00—Halogens; Halogen acids
    • C01B7/01—Chlorine; Hydrogen chloride
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B7/00—Halogens; Halogen acids
    • C01B7/09—Bromine; Hydrogen bromide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un complejo de agomelatina y la preparación de éste. El complejo de haluro de hidrógeno de agomelatina obtenido mediante el presente método es más soluble, más estable y tiene mayor pureza que la agomelatina en sí misma, lo que le hace más adecuado para usarse en preparación farmacéutica. Usando este método, puede obtenerse un producto de gran pureza mediante un proceso sencillo, sin tener que incurrir en etapas complicadas adicionales.
CU20110163A 2009-02-27 2011-08-23 Un complejo de haluro de hidrógeno de agomelatina y la preparación del mismo CU20110163A7 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2009100467821A CN101481321B (zh) 2009-02-27 2009-02-27 阿戈美拉汀卤化氢复合物及其制备方法

Publications (1)

Publication Number Publication Date
CU20110163A7 true CU20110163A7 (es) 2012-02-15

Family

ID=40878634

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20110163A CU20110163A7 (es) 2009-02-27 2011-08-23 Un complejo de haluro de hidrógeno de agomelatina y la preparación del mismo

Country Status (36)

Country Link
US (1) US8524949B2 (es)
EP (1) EP2418195B1 (es)
JP (1) JP5426693B2 (es)
KR (1) KR101284202B1 (es)
CN (1) CN101481321B (es)
AP (1) AP3048A (es)
AU (1) AU2010217082B2 (es)
BR (1) BRPI1008767B1 (es)
CA (1) CA2753449C (es)
CL (1) CL2011002090A1 (es)
CO (1) CO6420335A2 (es)
CR (1) CR20110446A (es)
CU (1) CU20110163A7 (es)
CY (1) CY1117100T1 (es)
DK (1) DK2418195T3 (es)
EA (1) EA021939B1 (es)
EC (1) ECSP11011290A (es)
ES (1) ES2530730T3 (es)
GE (1) GEP20156221B (es)
HN (1) HN2011002291A (es)
HR (1) HRP20150072T1 (es)
IL (1) IL214682A (es)
MA (1) MA33063B1 (es)
MX (1) MX2011008946A (es)
MY (1) MY154015A (es)
NI (1) NI201100163A (es)
NZ (1) NZ594773A (es)
PE (1) PE20120652A1 (es)
PL (1) PL2418195T3 (es)
PT (1) PT2418195E (es)
RS (1) RS53751B1 (es)
SG (1) SG173691A1 (es)
SI (1) SI2418195T1 (es)
UA (1) UA97619C2 (es)
WO (1) WO2010097052A1 (es)
ZA (1) ZA201106048B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102106806B (zh) * 2009-12-29 2013-04-17 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
CN102190595A (zh) * 2010-03-17 2011-09-21 上海医药工业研究院 阿戈美拉汀溴化氢水合物及其制备方法
CN102190594A (zh) * 2010-03-17 2011-09-21 上海医药工业研究院 阿戈美拉汀氯化氢水合物及其制备方法
CN101870662B (zh) * 2010-05-21 2013-03-20 中山大学 结晶型阿戈美拉汀溶剂化物及其制备方法
WO2012046253A2 (en) * 2010-10-08 2012-04-12 Msn Laboratories Limited Process for the preparation of n-[2- (7-methoxy-l-naphthyl) ethyl] acetamide and its novel crystalline forms
PT2517700E (pt) * 2011-04-28 2013-10-14 Zentiva Ks Cocristais farmaceuticamente aceitáveis de n-[2-(7-metoxi- 1-naftil)etil]acetamida e métodos para a sua preparação
EP2551257A1 (en) * 2011-07-28 2013-01-30 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of agomelatine with co-crystal-formers
FR2978916B1 (fr) 2011-08-10 2013-07-26 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
EP2851363B1 (en) * 2012-05-14 2018-01-03 Shanghai Righthand Pharmtech. Co., Ltd. Agomelatine acid radical composite, and preparation method and application thereof
CN102702041B (zh) * 2012-05-14 2013-08-14 上海右手医药科技开发有限公司 阿戈美拉汀苯磺酸类复合物及其制备方法
CN102702008B (zh) * 2012-06-03 2014-05-28 上海右手医药科技开发有限公司 阿戈美拉汀硫酸复合物及其制备方法
CN102718675B (zh) * 2012-06-07 2015-03-25 上海右手医药科技开发有限公司 阿戈美拉汀甲磺酸复合物及其制备方法
EP2743255B1 (en) * 2012-12-17 2016-06-22 Dr. Reddy's Laboratories Ltd. Cocrystal of agomelatine with phosphoric acid
EP2934502A1 (en) 2012-12-21 2015-10-28 Laboratorios Lesvi S.L. Process for prepararing n-(2-(7-methoxy-1-naphthalenyl)ethyl) acetamide and solid forms thereof
FR3001894A1 (fr) 2013-02-08 2014-08-15 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
DK3027588T3 (da) * 2013-07-29 2020-07-06 Servier Lab Komplekser af agomelatin og sulfonsyre, fremgangsmåde til deres fremstilling og lægemiddelsammensætninger som indeholder dem
EA031053B1 (ru) * 2013-07-31 2018-11-30 Ле Лаборатуар Сервье Новые формы сокристаллов агомелатина и п-толуолсульфоновой кислоты, способ их получения и фармацевтические композиции, которые их содержат

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2795326B1 (fr) * 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
CN100475789C (zh) 2002-05-24 2009-04-08 拜尔农作物科学股份公司 制备烷硫基胺衍生物的方法
EP1752440A4 (en) * 2004-01-15 2007-04-18 Tosoh Corp AMINO COMPOUND COMPRISING A FLUORENE GROUP AS A STRUCTURE, PROCESS FOR PRODUCTION OF SAID AMINO COMPOUND, AND USE THEREOF
FR2866335B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2889523B1 (fr) * 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2899472B1 (fr) * 2006-04-07 2008-09-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee

Also Published As

Publication number Publication date
DK2418195T3 (en) 2015-03-02
MY154015A (en) 2015-04-30
PL2418195T3 (pl) 2015-04-30
IL214682A (en) 2015-10-29
EA201101208A1 (ru) 2012-04-30
ECSP11011290A (es) 2011-09-30
HN2011002291A (es) 2014-04-07
PT2418195E (pt) 2014-12-26
PE20120652A1 (es) 2012-06-14
ES2530730T3 (es) 2015-03-05
AU2010217082B2 (en) 2012-05-03
CR20110446A (es) 2011-10-18
BRPI1008767B1 (pt) 2021-06-15
EP2418195A4 (en) 2013-01-16
EP2418195B1 (en) 2014-11-19
KR20110117721A (ko) 2011-10-27
MA33063B1 (fr) 2012-02-01
CN101481321B (zh) 2012-04-18
MX2011008946A (es) 2011-09-27
KR101284202B1 (ko) 2013-07-09
HRP20150072T1 (en) 2015-03-13
UA97619C2 (ru) 2012-02-27
AP3048A (en) 2014-11-30
GEP20156221B (en) 2015-01-26
NI201100163A (es) 2011-12-12
EA021939B1 (ru) 2015-10-30
CY1117100T1 (el) 2017-04-05
AU2010217082A1 (en) 2011-09-08
SI2418195T1 (sl) 2015-03-31
EP2418195A1 (en) 2012-02-15
WO2010097052A1 (zh) 2010-09-02
US20110313198A1 (en) 2011-12-22
US8524949B2 (en) 2013-09-03
BRPI1008767A2 (pt) 2016-06-28
ZA201106048B (en) 2012-10-31
NZ594773A (en) 2013-03-28
SG173691A1 (en) 2011-09-29
CN101481321A (zh) 2009-07-15
CL2011002090A1 (es) 2012-02-03
CO6420335A2 (es) 2012-04-16
JP5426693B2 (ja) 2014-02-26
JP2012519155A (ja) 2012-08-23
CA2753449C (en) 2014-01-07
CA2753449A1 (en) 2010-09-02
RS53751B1 (en) 2015-06-30
IL214682A0 (en) 2011-11-30
AP2011005845A0 (en) 2011-08-31

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