CS850584A2 - Zpusob vyroby erythro diolu - Google Patents
Zpusob vyroby erythro dioluInfo
- Publication number
- CS850584A2 CS850584A2 CS848505A CS850584A CS850584A2 CS 850584 A2 CS850584 A2 CS 850584A2 CS 848505 A CS848505 A CS 848505A CS 850584 A CS850584 A CS 850584A CS 850584 A2 CS850584 A2 CS 850584A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- formula
- trans
- erythro
- polymethylene
- aryl
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- -1 polymethylene Polymers 0.000 abstract 2
- PSZDOEIIIJFCFE-UHFFFAOYSA-N Oleanolic alcohol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C)(C)CC5C4=CCC3C21C PSZDOEIIIJFCFE-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000002012 dioxanes Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- PSZDOEIIIJFCFE-OSQDELBUSA-N erythrodiol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PSZDOEIIIJFCFE-OSQDELBUSA-N 0.000 abstract 1
- HTZRWCSRPTWJCT-UHFFFAOYSA-N erythrodiol Natural products CC1(C)CCC2(CO)CCC3C(CCC4C3(C)CCC5C(C)(C)C(O)CCC45C)C2C1 HTZRWCSRPTWJCT-UHFFFAOYSA-N 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000009467 reduction Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pyrane Compounds (AREA)
- Television Signal Processing For Recording (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicinal Preparation (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838330120A GB8330120D0 (en) | 1983-11-11 | 1983-11-11 | Chemical process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS850584A2 true CS850584A2 (en) | 1986-12-18 |
| CS251777B2 CS251777B2 (en) | 1987-08-13 |
Family
ID=10551607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS848505A CS251777B2 (en) | 1983-11-11 | 1984-11-08 | Method of erytmo-dioles production |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US4723037A (cs) |
| EP (3) | EP0304138B1 (cs) |
| JP (1) | JPS60123444A (cs) |
| KR (1) | KR920010180B1 (cs) |
| AT (3) | ATE50772T1 (cs) |
| AU (1) | AU587962B2 (cs) |
| CA (1) | CA1283926C (cs) |
| CS (1) | CS251777B2 (cs) |
| DD (1) | DD231351A5 (cs) |
| DE (3) | DE3481513D1 (cs) |
| DK (1) | DK535584A (cs) |
| ES (2) | ES8607897A1 (cs) |
| FI (1) | FI88029C (cs) |
| GB (1) | GB8330120D0 (cs) |
| GR (1) | GR80833B (cs) |
| HU (2) | HU196162B (cs) |
| IE (1) | IE57771B1 (cs) |
| IL (1) | IL73373A (cs) |
| NO (1) | NO158671C (cs) |
| NZ (1) | NZ210160A (cs) |
| PL (1) | PL144623B1 (cs) |
| PT (1) | PT79477B (cs) |
| SU (1) | SU1480760A3 (cs) |
| ZA (1) | ZA848472B (cs) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8511890D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Benzene derivatives |
| GB8511894D0 (en) | 1985-05-10 | 1985-06-19 | Ici Plc | Phenol derivatives |
| DE3685775T2 (de) * | 1985-05-10 | 1993-01-21 | Ici Plc | Alkenderivate. |
| GB8511891D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Alkenoic acids |
| HU198706B (en) * | 1985-05-10 | 1989-11-28 | Ici Plc | Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them |
| GB8611174D0 (en) * | 1986-05-08 | 1986-06-18 | Ici Plc | Amide derivatives |
| GB8626296D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Therapeutic agents |
| GB8626297D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Pharmaceutical compositions |
| GB8709794D0 (en) * | 1987-04-24 | 1987-05-28 | Ici Plc | Heterocyclic acids |
| GB8901201D0 (en) * | 1988-02-16 | 1989-03-15 | Ici Plc | Pyridine derivatives |
| US5248780A (en) * | 1988-02-16 | 1993-09-28 | Imperial Chemical Industries, Plc | Pyridyl substituted alkenoic acid derivatives |
| GB8814340D0 (en) * | 1988-06-16 | 1988-07-20 | Ici Plc | Process |
| GB9021571D0 (en) * | 1990-10-04 | 1990-11-21 | Ici Plc | Heterocyclic acids |
| WO2002085833A1 (en) * | 2001-04-18 | 2002-10-31 | Kuraray Co., Ltd. | Processes for preparation of optically active 2-benzyl- succinic acid and optically active 2-benzylsuccinic acid monoamides |
| US20110178112A1 (en) * | 2006-01-18 | 2011-07-21 | Evolva Sa | PPAR Modulators |
| CA2676444C (en) * | 2007-01-18 | 2013-07-30 | Evolva Sa | Prodrugs of substituted 1,3-dioxanes and their uses |
| WO2008089462A2 (en) * | 2007-01-18 | 2008-07-24 | Evolva Sa | Substituted 1,3-dioxanes and their uses |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8310407D0 (en) * | 1982-05-12 | 1983-05-25 | Ici Plc | 1 3 - dioxan -5- ylalkenoic acids |
-
1983
- 1983-11-11 GB GB838330120A patent/GB8330120D0/en active Pending
-
1984
- 1984-10-22 IE IE2718/84A patent/IE57771B1/en not_active IP Right Cessation
- 1984-10-30 ZA ZA848472A patent/ZA848472B/xx unknown
- 1984-10-30 IL IL73373A patent/IL73373A/xx unknown
- 1984-11-05 GR GR80833A patent/GR80833B/el unknown
- 1984-11-05 CA CA000467020A patent/CA1283926C/en not_active Expired - Lifetime
- 1984-11-06 EP EP88201967A patent/EP0304138B1/en not_active Expired - Lifetime
- 1984-11-06 DE DE8484307659T patent/DE3481513D1/de not_active Expired - Lifetime
- 1984-11-06 DE DE8888201967T patent/DE3485550D1/de not_active Expired - Lifetime
- 1984-11-06 AT AT84307659T patent/ATE50772T1/de not_active IP Right Cessation
- 1984-11-06 AT AT88201968T patent/ATE67195T1/de not_active IP Right Cessation
- 1984-11-06 EP EP84307659A patent/EP0142323B1/en not_active Expired - Lifetime
- 1984-11-06 DE DE8888201968T patent/DE3485065D1/de not_active Expired - Lifetime
- 1984-11-06 AT AT88201967T patent/ATE73134T1/de not_active IP Right Cessation
- 1984-11-06 EP EP88201968A patent/EP0304139B1/en not_active Expired - Lifetime
- 1984-11-08 CS CS848505A patent/CS251777B2/cs unknown
- 1984-11-08 DD DD84269266A patent/DD231351A5/de not_active IP Right Cessation
- 1984-11-08 ES ES537543A patent/ES8607897A1/es not_active Expired
- 1984-11-08 FI FI844394A patent/FI88029C/fi not_active IP Right Cessation
- 1984-11-09 AU AU35266/84A patent/AU587962B2/en not_active Ceased
- 1984-11-09 HU HU844175A patent/HU196162B/hu not_active IP Right Cessation
- 1984-11-09 DK DK535584A patent/DK535584A/da not_active Application Discontinuation
- 1984-11-09 US US06/670,016 patent/US4723037A/en not_active Expired - Fee Related
- 1984-11-09 NZ NZ210160A patent/NZ210160A/xx unknown
- 1984-11-09 NO NO844481A patent/NO158671C/no unknown
- 1984-11-09 HU HU84116A patent/HU196595B/hu not_active IP Right Cessation
- 1984-11-09 SU SU843818449A patent/SU1480760A3/ru active
- 1984-11-09 PT PT79477A patent/PT79477B/pt not_active IP Right Cessation
- 1984-11-09 PL PL1984250365A patent/PL144623B1/pl unknown
- 1984-11-10 KR KR1019840007065A patent/KR920010180B1/ko not_active Expired
- 1984-11-12 JP JP59236882A patent/JPS60123444A/ja active Pending
-
1986
- 1986-01-16 ES ES550952A patent/ES8703447A1/es not_active Expired
-
1987
- 1987-10-27 US US07/113,153 patent/US4900846A/en not_active Expired - Fee Related
Also Published As
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