CS83892A3 - Novel amides of carboxylic acids, process of their preparation andpharmaceutical compositions based thereon - Google Patents

Novel amides of carboxylic acids, process of their preparation andpharmaceutical compositions based thereon Download PDF

Info

Publication number
CS83892A3
CS83892A3 CS92838A CS83892A CS83892A3 CS 83892 A3 CS83892 A3 CS 83892A3 CS 92838 A CS92838 A CS 92838A CS 83892 A CS83892 A CS 83892A CS 83892 A3 CS83892 A3 CS 83892A3
Authority
CS
Czechoslovakia
Prior art keywords
tetrahydro
oxo
benzoic acid
trimethyl
ethyl
Prior art date
Application number
CS92838A
Other languages
Czech (cs)
English (en)
Inventor
Michael Klaus
Petr Mohr
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CS83892A3 publication Critical patent/CS83892A3/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/121,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS92838A 1991-03-21 1992-03-19 Novel amides of carboxylic acids, process of their preparation andpharmaceutical compositions based thereon CS83892A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH86391 1991-03-21

Publications (1)

Publication Number Publication Date
CS83892A3 true CS83892A3 (en) 1992-10-14

Family

ID=4196940

Family Applications (1)

Application Number Title Priority Date Filing Date
CS92838A CS83892A3 (en) 1991-03-21 1992-03-19 Novel amides of carboxylic acids, process of their preparation andpharmaceutical compositions based thereon

Country Status (21)

Country Link
US (1) US5216148A (is)
EP (1) EP0504695A1 (is)
JP (1) JPH07165709A (is)
KR (1) KR920018029A (is)
AU (1) AU649308B2 (is)
BR (1) BR9200951A (is)
CA (1) CA2061662A1 (is)
CS (1) CS83892A3 (is)
FI (1) FI921135A (is)
HU (1) HUT60465A (is)
IE (1) IE920907A1 (is)
IL (1) IL101242A (is)
IS (1) IS3823A (is)
MX (1) MX9201143A (is)
MY (1) MY131268A (is)
NO (1) NO921105L (is)
NZ (1) NZ241953A (is)
TW (1) TW221425B (is)
UY (1) UY23386A1 (is)
YU (1) YU24792A (is)
ZA (1) ZA921889B (is)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599548A (en) * 1995-05-08 1997-02-04 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides and retinol or retinyl ester
ZA9610853B (en) 1995-12-29 1998-04-06 Smithkline Beecham Corp Processes and intermediates for preparing pharmaceuticals.
US5716627A (en) * 1996-04-25 1998-02-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester
US5693330A (en) * 1996-04-25 1997-12-02 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing melinamide and a retinoid
US5955092A (en) * 1996-09-27 1999-09-21 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing an n-substituted fatty acid amide and retinol or retinyl ester
US5747051A (en) * 1996-09-27 1998-05-05 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid
EP1143946B1 (en) * 1999-04-30 2004-01-28 The Regents Of The University Of Michigan Use of benzodiazepines for treating autoimmune diseases induced by apoptosis
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
EP1229913A4 (en) * 1999-11-18 2005-01-19 Antexpharma Inc SUBSTITUTED 1-BENZAZEPINE AND THEIR DERIVATIVES
TW200508197A (en) * 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
US20050202055A1 (en) * 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
AU2006203946B2 (en) * 2005-01-03 2009-07-23 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20070043033A1 (en) 2005-06-01 2007-02-22 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
EP2604269B1 (en) 2005-11-01 2014-09-24 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
AU2007258468B2 (en) 2006-06-09 2011-09-22 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
MX2009009645A (es) 2007-03-09 2009-11-19 Univ Michigan Composiciones y metodos relacionados con nuevos compuestos y objetivos de los mismos.
WO2009036175A2 (en) 2007-09-14 2009-03-19 The Regents Of The University Of Michigan F1f0-atpase inhibitors and related methods
CN101918375A (zh) 2007-11-06 2010-12-15 密歇根大学董事会 在皮肤病症的治疗中有用的苯并二氮杂*酮化合物
AU2009216079B2 (en) 2008-02-22 2013-08-22 Otsuka Pharmaceutical Co., Ltd. Benzodiazepine compound and pharmaceutical composition
JP5567573B2 (ja) 2008-09-11 2014-08-06 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アリールグアニジンf1f0−atpアーゼ阻害剤およびそれと関連する方法
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
EP2468733A4 (en) 2009-08-21 2013-02-06 Otsuka Pharma Co Ltd PROCESS FOR PRODUCING BENZO [B] [1,4] DIAZEPINE-2,4-DIONE COMPOUND
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
JP2013505258A (ja) 2009-09-18 2013-02-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ベンゾジアゼピノン化合物およびそれを使用する治療方法
WO2011062766A2 (en) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
AU2010322286B2 (en) 2009-11-17 2014-06-05 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
JP2012184225A (ja) * 2011-02-18 2012-09-27 Otsuka Pharmaceut Co Ltd 医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE3818830A1 (de) * 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
AU626881B2 (en) * 1988-07-14 1992-08-13 F. Hoffmann-La Roche Ag Benzofused heterocyclics used as pharmaceuticals

Also Published As

Publication number Publication date
FI921135A0 (fi) 1992-03-17
US5216148A (en) 1993-06-01
CA2061662A1 (en) 1992-09-22
ZA921889B (en) 1992-11-25
AU1108992A (en) 1992-09-24
IL101242A (en) 1995-12-08
MX9201143A (es) 1992-10-01
MY131268A (en) 2007-07-31
AU649308B2 (en) 1994-05-19
HU9200871D0 (en) 1992-05-28
NO921105D0 (no) 1992-03-20
YU24792A (sh) 1994-09-09
KR920018029A (ko) 1992-10-21
BR9200951A (pt) 1992-11-17
IL101242A0 (en) 1992-11-15
IE920907A1 (en) 1992-09-23
NO921105L (no) 1992-09-22
JPH07165709A (ja) 1995-06-27
IS3823A (is) 1992-09-22
NZ241953A (en) 1994-11-25
EP0504695A1 (de) 1992-09-23
FI921135A (fi) 1992-09-22
UY23386A1 (es) 1992-11-05
HUT60465A (en) 1992-09-28
TW221425B (is) 1994-03-01

Similar Documents

Publication Publication Date Title
CS83892A3 (en) Novel amides of carboxylic acids, process of their preparation andpharmaceutical compositions based thereon
KR960000852B1 (ko) 퀴놀린형 메발로노락톤
KR19990071542A (ko) 레티노이드형 생리활성을 갖는 테트라히드로나프타렌, 크로만,티오크로만 및 1,2,3,4-테트라히드퀴놀린 카르복실산의 아릴 또는 헤테로아릴 아미드
US3995039A (en) Pyrazolo [1,5-a] [1,3,5] triazines
PL186404B1 (pl) Arylowe i heteroarylowe amidy kwasów karboksylowych posiadające czynność retynopodobną
AU2001249619A1 (en) Carbamate caspase inhibitors and uses thereof
JP2019524699A (ja) イミダゾピリジンアミンフェニル誘導体およびその使用
WO2001072707A2 (en) Carbamate caspase inhibitors and uses thereof
JPH01125322A (ja) アルドース還元酵素阻害剤
US3349088A (en) Therapeutically valuable 1, 2-dihyro-1, 2, 4-benzotriazine derivatives and process for preparation thereof
SU999972A3 (ru) Способ получени производных пиридо-(1,2-а) пиримидина или их фармацевтически приемлемых солей,или их оптически активных изомеров
WO1998022442A2 (en) Pharmaceutical compositions comprising diaryl-cyclomethylenpyrazole compounds and their use as cyclooxygenase i (cox 1) inhibitors
HUT65778A (en) Process for preparing hydroxyamidine derivatives and pharmaceutical comp. containing them
HU200761B (en) Process for producing chromone derivatives and pharmaceutical compositions comprising same as active ingredient
PL166481B1 (en) Method of obtaining novel bezazepine compounds
US4801590A (en) Pyrido(1,8)naphthyridinones, and their use as pharmaceuticals
US4109087A (en) 1,4- AND 4,10-Dihydro-4-oxo-pyrimido[1,2-a]benzimidazole-3-carboxylic acid amides
EP0356673A2 (en) Substituted 5,6,7,8-tetrahydroimidazo[1,5-a]pyridines and process for their preparation
EP0121806B1 (en) Pyrazolo(1,5-a)pyridine derivatives and compositions containing them
JP2686887B2 (ja) ピペリジノ−3,4−ジヒドロカルボスチリル誘導体
US4016267A (en) Sulfacytosine derivatives
EP0089426B1 (en) 2-amino-6-biphenylacetic acids
JPH02196769A (ja) 新規なスルホンアニリド誘導体
SI9210247A (sl) Novi amidi karboksilne kisline
JP3000298B2 (ja) ピロロチアゾール誘導体及びこれを含有する肝疾患予防・治療剤