UY23386A1 - Procedimiento para la preparacion de nuevas amidas carboxilicas - Google Patents

Procedimiento para la preparacion de nuevas amidas carboxilicas

Info

Publication number
UY23386A1
UY23386A1 UY23386A UY23386A UY23386A1 UY 23386 A1 UY23386 A1 UY 23386A1 UY 23386 A UY23386 A UY 23386A UY 23386 A UY23386 A UY 23386A UY 23386 A1 UY23386 A1 UY 23386A1
Authority
UY
Uruguay
Prior art keywords
formula
lower alkyl
preparation
compound
amidas
Prior art date
Application number
UY23386A
Other languages
English (en)
Inventor
Michael Klaus
Peter Mohr
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY23386A1 publication Critical patent/UY23386A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedimiento para la preparación de compuestos de fórmula (I) (figura 1), en donde: M significa -CONH- o -NHCO-; X significa CR3R4 y -CONR5; Z significa CR6R7; R2 es hidrógeno, alquilo inferior, alcoxilo inferior o halógeno; R3, R4, R6 y R7 significan hidrógeno o alquilo inferior; R5 es alquilo; con la salvedad de que se enlaza al anillo de fenilo via el átomo de N, cuyo procedimiento, por ejemplo en una realización particular, comprende hacer reaccionar un compuesto de fórmula (II) (figura 2), con un compuesto de fórmula (III) (figura 3), y monóxido de carbono en presencia de un metal de transición y una amina, donde A es un derivado o un grupo carboxílico y B significa un grupo amino, o viceversa y R11 es un alquilo inferior, y si se desea, saponificar el grupo de éster COOR11 y aislar el ácido formado tal cual o como sal. Ejemplo no limitante: Ácido p-[(1,2,3,4-tetrahidro-1,4,4-trimetil-2-oxo-6-quinolinil)carbamoil]benzoico Los compuestos obtenidos conforme a la invención pueden utilizarse en el tratamiento y profilaxis de neoplasmas, dermatosis y envejecimiento de la piel.
UY23386A 1991-03-21 1992-03-20 Procedimiento para la preparacion de nuevas amidas carboxilicas UY23386A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH86391 1991-03-21

Publications (1)

Publication Number Publication Date
UY23386A1 true UY23386A1 (es) 1992-11-05

Family

ID=4196940

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23386A UY23386A1 (es) 1991-03-21 1992-03-20 Procedimiento para la preparacion de nuevas amidas carboxilicas

Country Status (21)

Country Link
US (1) US5216148A (es)
EP (1) EP0504695A1 (es)
JP (1) JPH07165709A (es)
KR (1) KR920018029A (es)
AU (1) AU649308B2 (es)
BR (1) BR9200951A (es)
CA (1) CA2061662A1 (es)
CS (1) CS83892A3 (es)
FI (1) FI921135A (es)
HU (1) HUT60465A (es)
IE (1) IE920907A1 (es)
IL (1) IL101242A (es)
IS (1) IS3823A (es)
MX (1) MX9201143A (es)
MY (1) MY131268A (es)
NO (1) NO921105L (es)
NZ (1) NZ241953A (es)
TW (1) TW221425B (es)
UY (1) UY23386A1 (es)
YU (1) YU24792A (es)
ZA (1) ZA921889B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599548A (en) * 1995-05-08 1997-02-04 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides and retinol or retinyl ester
ZA9610853B (en) * 1995-12-29 1998-04-06 Smithkline Beecham Corp Processes and intermediates for preparing pharmaceuticals.
US5693330A (en) * 1996-04-25 1997-12-02 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing melinamide and a retinoid
US5716627A (en) * 1996-04-25 1998-02-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester
US5747051A (en) * 1996-09-27 1998-05-05 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid
US5955092A (en) * 1996-09-27 1999-09-21 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing an n-substituted fatty acid amide and retinol or retinyl ester
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
DE60007960T2 (de) * 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
WO2001035964A1 (en) * 1999-11-18 2001-05-25 Antexpharma, Inc. Substituted 1-benzazepines and derivatives thereof
TW200508197A (en) * 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
US20050202055A1 (en) * 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
EP1845996A4 (en) * 2005-01-03 2009-04-29 Univ Michigan COMPOSITIONS AND METHODS RELATING TO NEW COMPOUNDS AND TARGETS
WO2007053193A2 (en) 2005-06-01 2007-05-10 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
AU2006308655B2 (en) 2005-11-01 2010-09-23 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
JP5264716B2 (ja) 2006-06-09 2013-08-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 化合物およびその標的に関連する組成物および方法
WO2008112553A1 (en) 2007-03-09 2008-09-18 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
ES2614498T3 (es) 2007-09-14 2017-05-31 The Regents Of The University Of Michigan Inhibidores de ATPasa F1F0 y métodos relacionados
EP2217576B1 (en) 2007-11-06 2016-05-11 The Regents of the University of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
PT2254873E (pt) 2008-02-22 2014-08-29 Otsuka Pharma Co Ltd Compostos benzodiazepínicos e composições farmacêuticas que os contêm
AU2009291632B2 (en) 2008-09-11 2013-04-04 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
IN2012DN00986A (es) 2009-08-21 2015-04-10 Otsuka Pharma Co Ltd
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
ES2703752T3 (es) 2009-11-17 2019-03-12 Univ Michigan Regents 1,4-Benzodiazepina-2,5-dionas y compuestos relacionados que presentan propiedades terapéuticas
WO2011137089A1 (en) 2010-04-29 2011-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
JP2012184225A (ja) * 2011-02-18 2012-09-27 Otsuka Pharmaceut Co Ltd 医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE3818830A1 (de) * 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
AU626881B2 (en) * 1988-07-14 1992-08-13 F. Hoffmann-La Roche Ag Benzofused heterocyclics used as pharmaceuticals

Also Published As

Publication number Publication date
EP0504695A1 (de) 1992-09-23
HUT60465A (en) 1992-09-28
KR920018029A (ko) 1992-10-21
AU649308B2 (en) 1994-05-19
IS3823A (is) 1992-09-22
BR9200951A (pt) 1992-11-17
FI921135A (fi) 1992-09-22
US5216148A (en) 1993-06-01
IE920907A1 (en) 1992-09-23
FI921135A0 (fi) 1992-03-17
NO921105L (no) 1992-09-22
CS83892A3 (en) 1992-10-14
TW221425B (es) 1994-03-01
YU24792A (sh) 1994-09-09
MY131268A (en) 2007-07-31
MX9201143A (es) 1992-10-01
AU1108992A (en) 1992-09-24
NO921105D0 (no) 1992-03-20
NZ241953A (en) 1994-11-25
IL101242A (en) 1995-12-08
ZA921889B (en) 1992-11-25
CA2061662A1 (en) 1992-09-22
HU9200871D0 (en) 1992-05-28
JPH07165709A (ja) 1995-06-27
IL101242A0 (en) 1992-11-15

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Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20090224