CS387490A3 - Process for preparing hydrochloride of alpha-l-asparagyl-l-phenylalanine methyl ester - Google Patents

Process for preparing hydrochloride of alpha-l-asparagyl-l-phenylalanine methyl ester

Info

Publication number
CS387490A3
CS387490A3 CS903874A CS387490A CS387490A3 CS 387490 A3 CS387490 A3 CS 387490A3 CS 903874 A CS903874 A CS 903874A CS 387490 A CS387490 A CS 387490A CS 387490 A3 CS387490 A3 CS 387490A3
Authority
CS
Czechoslovakia
Prior art keywords
alpha
methyl ester
asparagyl
phenylalanine methyl
preparing hydrochloride
Prior art date
Application number
CS903874A
Other languages
English (en)
Inventor
John B Hill
Yefim Gelman
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/219,613 priority Critical patent/US4946988A/en
Priority to JP2511850A priority patent/JP2609368B2/ja
Priority to AU61820/90A priority patent/AU648747B2/en
Priority to PCT/US1990/003899 priority patent/WO1992000950A1/en
Priority to KR1019910700149A priority patent/KR0185409B1/ko
Priority to BR909007648A priority patent/BR9007648A/pt
Priority to CA002021180A priority patent/CA2021180C/en
Priority to ZA905687A priority patent/ZA905687B/xx
Priority to ES90113895T priority patent/ES2079402T3/es
Priority to EP90113895A priority patent/EP0466963B1/en
Priority to AT90113895T priority patent/ATE130010T1/de
Priority to DK90113895.8T priority patent/DK0466963T3/da
Priority to DD343152A priority patent/DD300232A5/de
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Priority to CS903874A priority patent/CZ283231B6/cs
Priority to RO145705A priority patent/RO108865B1/ro
Priority to HU904906A priority patent/HU210688B/hu
Priority to CN90106906A priority patent/CN1035183C/zh
Publication of CS387490A3 publication Critical patent/CS387490A3/cs
Priority to GR950403024T priority patent/GR3018046T3/el
Publication of CZ283231B6 publication Critical patent/CZ283231B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS903874A 1988-07-14 1990-08-06 Způsob přípravy hydrochloridu methylesteru alfa-L-asparagyl-L fenylalaninu CZ283231B6 (cs)

Priority Applications (18)

Application Number Priority Date Filing Date Title
US07/219,613 US4946988A (en) 1988-07-14 1988-07-14 Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
JP2511850A JP2609368B2 (ja) 1988-07-14 1990-07-11 単離したＮ―ホルミル―Ｌ―アスパラギン酸無水物を使用するα―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステル塩酸塩の製造方法
AU61820/90A AU648747B2 (en) 1988-07-14 1990-07-11 A process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
PCT/US1990/003899 WO1992000950A1 (en) 1988-07-14 1990-07-11 A process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl l-aspartic anhydride
KR1019910700149A KR0185409B1 (ko) 1988-07-14 1990-07-11 순수분리된 n-포밀-l-아스파라틱 무수물을 사용하여 알파-l-아스파르틸-l-페닐알라닌 메틸에스테르 염산 제조공정
BR909007648A BR9007648A (pt) 1988-07-14 1990-07-11 Processos para preparar hidrocloreto de -apm,e anidrido n-formil-l-aspartico
CA002021180A CA2021180C (en) 1988-07-14 1990-07-13 Process for the preparation of .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride
ZA905687A ZA905687B (en) 1988-07-14 1990-07-19 Process for the preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride
EP90113895A EP0466963B1 (en) 1988-07-14 1990-07-20 A process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl-aspartic anhydride
ES90113895T ES2079402T3 (es) 1988-07-14 1990-07-20 Un proceso para la preparacion de hidrocloruro de ester metilico de alfa-l-aspartil-l-fenilalanina mediante el uso de anhidrido n-formil-aspartico aislado.
AT90113895T ATE130010T1 (de) 1988-07-14 1990-07-20 Verfahren zur herstellung des alpha-l-aspartyl-l- phenylalaninmethylesters mittels isolierten n- formyl-aspartylanhydrids.
DK90113895.8T DK0466963T3 (da) 1988-07-14 1990-07-20 Fremgangsmåde til fremstilling af alfa-L-aspartyl-L-phenyl-alaninmethylester, hydroclorid ved anvend else af isoleret N-formyl-asparaginsyreanhydrid
DD343152A DD300232A5 (de) 1988-07-14 1990-07-30 Verfahren zur Herstellung von Alpha-L-Aspartylphenylananin-Methylester-Hydrochlorid durch Verwendung isolierter N-Formyl-L-Asparagin-Anhydride
CS903874A CZ283231B6 (cs) 1988-07-14 1990-08-06 Způsob přípravy hydrochloridu methylesteru alfa-L-asparagyl-L fenylalaninu
RO145705A RO108865B1 (ro) 1988-07-14 1990-08-06 Procedeu pentru prepararea clorhidratului esterului metilic al alfa-l-aspartil-l-fenilalaninei
HU904906A HU210688B (en) 1988-07-14 1990-08-06 Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride
CN90106906A CN1035183C (zh) 1988-07-14 1990-08-06 制备α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐的方法
GR950403024T GR3018046T3 (en) 1988-07-14 1995-11-09 A process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl-aspartic anhydride.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/219,613 US4946988A (en) 1988-07-14 1988-07-14 Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
CA002021180A CA2021180C (en) 1988-07-14 1990-07-13 Process for the preparation of .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride
DD343152A DD300232A5 (de) 1988-07-14 1990-07-30 Verfahren zur Herstellung von Alpha-L-Aspartylphenylananin-Methylester-Hydrochlorid durch Verwendung isolierter N-Formyl-L-Asparagin-Anhydride
HU904906A HU210688B (en) 1988-07-14 1990-08-06 Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride
CS903874A CZ283231B6 (cs) 1988-07-14 1990-08-06 Způsob přípravy hydrochloridu methylesteru alfa-L-asparagyl-L fenylalaninu
RO145705A RO108865B1 (ro) 1988-07-14 1990-08-06 Procedeu pentru prepararea clorhidratului esterului metilic al alfa-l-aspartil-l-fenilalaninei

Publications (2)

Publication Number Publication Date
CS387490A3 true CS387490A3 (en) 1992-02-19
CZ283231B6 CZ283231B6 (cs) 1998-02-18

Family

ID=27543426

Country Status (18)

Country Link
US (1) US4946988A (cs)
EP (1) EP0466963B1 (cs)
JP (1) JP2609368B2 (cs)
KR (1) KR0185409B1 (cs)
CN (1) CN1035183C (cs)
AT (1) ATE130010T1 (cs)
AU (1) AU648747B2 (cs)
BR (1) BR9007648A (cs)
CA (1) CA2021180C (cs)
CZ (1) CZ283231B6 (cs)
DD (1) DD300232A5 (cs)
DK (1) DK0466963T3 (cs)
ES (1) ES2079402T3 (cs)
GR (1) GR3018046T3 (cs)
HU (1) HU210688B (cs)
RO (1) RO108865B1 (cs)
WO (1) WO1992000950A1 (cs)
ZA (1) ZA905687B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053532A (en) * 1988-02-12 1991-10-01 The Nutra Sweet Company One-pot process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride
JPH089584B2 (ja) * 1988-02-12 1996-01-31 ザ ヌトラスウィート カンパニー α―Ｌ―アルパルチル―Ｌ―フェニルアラニンメチルエステル塩酸塩のワンポット製造法
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
EP0471833B1 (en) * 1990-03-12 1995-06-14 The Nutrasweet Company Method for increasing the alpha to beta ratio in an aspartame coupling reaction
US6642406B2 (en) * 2000-05-18 2003-11-04 The Nutrasweet Company Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using L-α-aspartyl-L-phenylalanine 1-methyl ester precursors
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CN103130870B (zh) * 2011-11-30 2015-03-18 江苏维多股份有限公司 α-L-天冬氨酸-L-苯丙氨酸甲酯盐酸盐的制备方法
CN102584938B (zh) * 2012-03-02 2014-02-19 孟州市华兴生物化工有限责任公司 一种阿斯巴甜的结晶方法
CN104628819B (zh) * 2014-10-23 2019-05-21 常茂生物化学工程股份有限公司 一种偶合反应生成阿斯巴甜的工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5232371B2 (cs) * 1972-07-20 1977-08-20
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
FR2295015A1 (fr) * 1974-12-18 1976-07-16 Ajinomoto Kk Procede de preparation d'esters alkyliques inferieurs d'a-l-aspartyl l-phenylalanine
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride

Also Published As

Publication number Publication date
AU648747B2 (en) 1994-05-05
CN1035183C (zh) 1997-06-18
ZA905687B (en) 1991-07-31
CA2021180A1 (en) 1992-01-14
CA2021180C (en) 1998-06-23
EP0466963A1 (en) 1992-01-22
DD300232A5 (de) 1992-05-27
CZ283231B6 (cs) 1998-02-18
US4946988A (en) 1990-08-07
CN1058783A (zh) 1992-02-19
JPH05500364A (ja) 1993-01-28
JP2609368B2 (ja) 1997-05-14
WO1992000950A1 (en) 1992-01-23
BR9007648A (pt) 1992-09-15
ES2079402T3 (es) 1996-01-16
RO108865B1 (ro) 1994-09-30
AU6182090A (en) 1992-02-04
EP0466963B1 (en) 1995-11-08
KR920702341A (ko) 1992-09-03
GR3018046T3 (en) 1996-02-29
HU904906D0 (en) 1991-01-28
DK0466963T3 (da) 1996-02-05
HUT59658A (en) 1992-06-29
KR0185409B1 (ko) 1999-06-01
ATE130010T1 (de) 1995-11-15
HU210688B (en) 1995-06-28

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20010806