DK0466963T3 - Fremgangsmåde til fremstilling af alfa-L-aspartyl-L-phenyl-alaninmethylester, hydroclorid ved anvend else af isoleret N-formyl-asparaginsyreanhydrid - Google Patents
Fremgangsmåde til fremstilling af alfa-L-aspartyl-L-phenyl-alaninmethylester, hydroclorid ved anvend else af isoleret N-formyl-asparaginsyreanhydridInfo
- Publication number
- DK0466963T3 DK0466963T3 DK90113895.8T DK90113895T DK0466963T3 DK 0466963 T3 DK0466963 T3 DK 0466963T3 DK 90113895 T DK90113895 T DK 90113895T DK 0466963 T3 DK0466963 T3 DK 0466963T3
- Authority
- DK
- Denmark
- Prior art keywords
- alpha
- preparation
- aspartyl
- methyl ester
- formyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/219,613 US4946988A (en) | 1988-07-14 | 1988-07-14 | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride |
| CA002021180A CA2021180C (en) | 1988-07-14 | 1990-07-13 | Process for the preparation of .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride |
| DD343152A DD300232A5 (de) | 1988-07-14 | 1990-07-30 | Verfahren zur Herstellung von Alpha-L-Aspartylphenylananin-Methylester-Hydrochlorid durch Verwendung isolierter N-Formyl-L-Asparagin-Anhydride |
| CS903874A CZ283231B6 (cs) | 1988-07-14 | 1990-08-06 | Způsob přípravy hydrochloridu methylesteru alfa-L-asparagyl-L fenylalaninu |
| RO145705A RO108865B1 (ro) | 1988-07-14 | 1990-08-06 | Procedeu pentru prepararea clorhidratului esterului metilic al alfa-l-aspartil-l-fenilalaninei |
| HU904906A HU210688B (en) | 1988-07-14 | 1990-08-06 | Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0466963T3 true DK0466963T3 (da) | 1996-02-05 |
Family
ID=27543426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90113895.8T DK0466963T3 (da) | 1988-07-14 | 1990-07-20 | Fremgangsmåde til fremstilling af alfa-L-aspartyl-L-phenyl-alaninmethylester, hydroclorid ved anvend else af isoleret N-formyl-asparaginsyreanhydrid |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4946988A (cs) |
| EP (1) | EP0466963B1 (cs) |
| JP (1) | JP2609368B2 (cs) |
| KR (1) | KR0185409B1 (cs) |
| CN (1) | CN1035183C (cs) |
| AT (1) | ATE130010T1 (cs) |
| AU (1) | AU648747B2 (cs) |
| BR (1) | BR9007648A (cs) |
| CA (1) | CA2021180C (cs) |
| CZ (1) | CZ283231B6 (cs) |
| DD (1) | DD300232A5 (cs) |
| DK (1) | DK0466963T3 (cs) |
| ES (1) | ES2079402T3 (cs) |
| GR (1) | GR3018046T3 (cs) |
| HU (1) | HU210688B (cs) |
| RO (1) | RO108865B1 (cs) |
| WO (1) | WO1992000950A1 (cs) |
| ZA (1) | ZA905687B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5053532A (en) * | 1988-02-12 | 1991-10-01 | The Nutra Sweet Company | One-pot process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride |
| JPH089584B2 (ja) * | 1988-02-12 | 1996-01-31 | ザ ヌトラスウィート カンパニー | α―Ｌ―アルパルチル―Ｌ―フェニルアラニンメチルエステル塩酸塩のワンポット製造法 |
| US4946988A (en) * | 1988-07-14 | 1990-08-07 | The Nutrasweet Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride |
| DK0471833T3 (da) * | 1990-03-12 | 1995-09-25 | Nutrasweet Co | Fremgangsmåde til forøgelse af alfa/beta-forholdet ved en aspartam-koblingsreaktion |
| ES2253626T3 (es) * | 2000-05-18 | 2006-06-01 | The Nutrasweet Company | Sintesis de n-(n-(3,3-dimetilbutil)-l-alfa-aspartil)-l-fenilalanina 1-metil ester utilizando precursores de l-alfa-aspartil-l-fenilalanina 1-metil ester. |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| CN103130870B (zh) * | 2011-11-30 | 2015-03-18 | 江苏维多股份有限公司 | α-L-天冬氨酸-L-苯丙氨酸甲酯盐酸盐的制备方法 |
| CN102584938B (zh) * | 2012-03-02 | 2014-02-19 | 孟州市华兴生物化工有限责任公司 | 一种阿斯巴甜的结晶方法 |
| CN104628819B (zh) * | 2014-10-23 | 2019-05-21 | 常茂生物化学工程股份有限公司 | 一种偶合反应生成阿斯巴甜的工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5232371B2 (cs) * | 1972-07-20 | 1977-08-20 | ||
| US3933781A (en) * | 1973-11-05 | 1976-01-20 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters |
| JPS5113737A (en) * | 1974-07-23 | 1976-02-03 | Ajinomoto Kk | Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho |
| FR2295015A1 (fr) * | 1974-12-18 | 1976-07-16 | Ajinomoto Kk | Procede de preparation d'esters alkyliques inferieurs d'a-l-aspartyl l-phenylalanine |
| JPH07636B2 (ja) * | 1984-12-17 | 1995-01-11 | 三井東圧化学株式会社 | Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法 |
| JPH0680075B2 (ja) * | 1985-12-24 | 1994-10-12 | 味の素株式会社 | Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法 |
| US4946988A (en) * | 1988-07-14 | 1990-08-07 | The Nutrasweet Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride |
-
1988
- 1988-07-14 US US07/219,613 patent/US4946988A/en not_active Expired - Lifetime
-
1990
- 1990-07-11 KR KR1019910700149A patent/KR0185409B1/ko not_active Expired - Fee Related
- 1990-07-11 AU AU61820/90A patent/AU648747B2/en not_active Ceased
- 1990-07-11 JP JP2511850A patent/JP2609368B2/ja not_active Expired - Lifetime
- 1990-07-11 BR BR909007648A patent/BR9007648A/pt not_active Application Discontinuation
- 1990-07-11 WO PCT/US1990/003899 patent/WO1992000950A1/en unknown
- 1990-07-13 CA CA002021180A patent/CA2021180C/en not_active Expired - Fee Related
- 1990-07-19 ZA ZA905687A patent/ZA905687B/xx unknown
- 1990-07-20 AT AT90113895T patent/ATE130010T1/de not_active IP Right Cessation
- 1990-07-20 EP EP90113895A patent/EP0466963B1/en not_active Expired - Lifetime
- 1990-07-20 ES ES90113895T patent/ES2079402T3/es not_active Expired - Lifetime
- 1990-07-20 DK DK90113895.8T patent/DK0466963T3/da active
- 1990-07-30 DD DD343152A patent/DD300232A5/de unknown
- 1990-08-06 RO RO145705A patent/RO108865B1/ro unknown
- 1990-08-06 CZ CS903874A patent/CZ283231B6/cs not_active IP Right Cessation
- 1990-08-06 HU HU904906A patent/HU210688B/hu not_active IP Right Cessation
- 1990-08-06 CN CN90106906A patent/CN1035183C/zh not_active Expired - Fee Related
-
1995
- 1995-11-09 GR GR950403024T patent/GR3018046T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2079402T3 (es) | 1996-01-16 |
| CZ283231B6 (cs) | 1998-02-18 |
| HU904906D0 (en) | 1991-01-28 |
| ATE130010T1 (de) | 1995-11-15 |
| US4946988A (en) | 1990-08-07 |
| AU6182090A (en) | 1992-02-04 |
| CA2021180A1 (en) | 1992-01-14 |
| AU648747B2 (en) | 1994-05-05 |
| WO1992000950A1 (en) | 1992-01-23 |
| BR9007648A (pt) | 1992-09-15 |
| JPH05500364A (ja) | 1993-01-28 |
| EP0466963B1 (en) | 1995-11-08 |
| CN1035183C (zh) | 1997-06-18 |
| GR3018046T3 (en) | 1996-02-29 |
| EP0466963A1 (en) | 1992-01-22 |
| HUT59658A (en) | 1992-06-29 |
| ZA905687B (en) | 1991-07-31 |
| CA2021180C (en) | 1998-06-23 |
| JP2609368B2 (ja) | 1997-05-14 |
| RO108865B1 (ro) | 1994-09-30 |
| KR0185409B1 (ko) | 1999-06-01 |
| DD300232A5 (de) | 1992-05-27 |
| HU210688B (en) | 1995-06-28 |
| CS387490A3 (en) | 1992-02-19 |
| KR920702341A (ko) | 1992-09-03 |
| CN1058783A (zh) | 1992-02-19 |
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