CS272243B2 - Method of deoxy 9a-allyl-and propargyl-9a-aza-9a homoerythromycin a new derivatives production - Google Patents

Method of deoxy 9a-allyl-and propargyl-9a-aza-9a homoerythromycin a new derivatives production Download PDF

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Publication number
CS272243B2
CS272243B2 CS887402A CS740288A CS272243B2 CS 272243 B2 CS272243 B2 CS 272243B2 CS 887402 A CS887402 A CS 887402A CS 740288 A CS740288 A CS 740288A CS 272243 B2 CS272243 B2 CS 272243B2
Authority
CS
Czechoslovakia
Prior art keywords
aza
allyl
propargyl
formula
homoerythromycin
Prior art date
Application number
CS887402A
Other languages
Czech (cs)
English (en)
Other versions
CS740288A2 (en
Inventor
Gene M Bright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS740288A2 publication Critical patent/CS740288A2/cs
Publication of CS272243B2 publication Critical patent/CS272243B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CS887402A 1987-11-10 1988-11-10 Method of deoxy 9a-allyl-and propargyl-9a-aza-9a homoerythromycin a new derivatives production CS272243B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/002938 WO1989004167A1 (en) 1987-11-10 1987-11-10 Antibacterial 9-deoxo-9a-allyl and propargyl-9a-aza-9a-homoerythromycin a derivatives

Publications (2)

Publication Number Publication Date
CS740288A2 CS740288A2 (en) 1990-03-14
CS272243B2 true CS272243B2 (en) 1991-01-15

Family

ID=22202658

Family Applications (1)

Application Number Title Priority Date Filing Date
CS887402A CS272243B2 (en) 1987-11-10 1988-11-10 Method of deoxy 9a-allyl-and propargyl-9a-aza-9a homoerythromycin a new derivatives production

Country Status (24)

Country Link
EP (1) EP0316128B1 (de)
JP (1) JPH0631301B2 (de)
KR (1) KR900008676B1 (de)
CN (1) CN1018648B (de)
AT (1) ATE86259T1 (de)
AU (1) AU597194B2 (de)
CA (1) CA1323026C (de)
CS (1) CS272243B2 (de)
DD (1) DD275871A5 (de)
DE (1) DE3878835T2 (de)
DK (1) DK623888A (de)
ES (1) ES2053765T3 (de)
GR (1) GR3007218T3 (de)
IE (1) IE61282B1 (de)
IL (1) IL88280A (de)
MX (1) MX13723A (de)
MY (1) MY104109A (de)
NZ (1) NZ226907A (de)
PH (1) PH25188A (de)
PL (1) PL158151B1 (de)
PT (1) PT88957B (de)
WO (1) WO1989004167A1 (de)
YU (1) YU46708B (de)
ZA (1) ZA888364B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
HRP970714B1 (en) * 1997-12-31 2003-08-31 Pliva Pharm & Chem Works Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
CN103072186B (zh) * 2012-12-21 2015-04-01 山东大学 一种高阻尼性机床构件的精密成型方法
CN103669417B (zh) * 2013-12-17 2016-05-11 中国建筑第八工程局有限公司 预制地下室外墙接缝处环氧树脂水泥混凝土及其施工方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor

Also Published As

Publication number Publication date
EP0316128B1 (de) 1993-03-03
CS740288A2 (en) 1990-03-14
KR900008676B1 (ko) 1990-11-26
KR890008136A (ko) 1989-07-10
WO1989004167A1 (en) 1989-05-18
IL88280A0 (en) 1989-06-30
ATE86259T1 (de) 1993-03-15
CN1018648B (zh) 1992-10-14
CA1323026C (en) 1993-10-12
JPH0631301B2 (ja) 1994-04-27
ES2053765T3 (es) 1994-08-01
EP0316128A2 (de) 1989-05-17
DE3878835T2 (de) 1993-06-09
DD275871A5 (de) 1990-02-07
PH25188A (en) 1991-03-27
CN1038453A (zh) 1990-01-03
PT88957A (pt) 1988-12-01
GR3007218T3 (de) 1993-07-30
DK623888D0 (da) 1988-11-09
IL88280A (en) 1993-08-18
IE883365L (en) 1989-05-10
AU597194B2 (en) 1990-05-24
PT88957B (pt) 1993-02-26
PL275690A1 (en) 1989-06-12
DE3878835D1 (de) 1993-04-08
MY104109A (en) 1993-12-31
NZ226907A (en) 1990-09-26
IE61282B1 (en) 1994-10-19
MX13723A (es) 1993-05-01
AU2496888A (en) 1989-05-11
JPH01153632A (ja) 1989-06-15
EP0316128A3 (en) 1989-11-08
PL158151B1 (en) 1992-08-31
DK623888A (da) 1989-07-25
ZA888364B (en) 1990-06-27
YU46708B (sh) 1994-04-05
YU208788A (en) 1990-02-28

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20051110