CS270593B2 - Method of 7 beta-/2-(r)-2-(p-hydroxyphenyl)-2-aminoacetamido/-3-chloro-3-(carbadethiacephem)-4-carboxylic acid's crystalline monohydrate form preparation - Google Patents
Method of 7 beta-/2-(r)-2-(p-hydroxyphenyl)-2-aminoacetamido/-3-chloro-3-(carbadethiacephem)-4-carboxylic acid's crystalline monohydrate form preparation Download PDFInfo
- Publication number
- CS270593B2 CS270593B2 CS886665A CS666588A CS270593B2 CS 270593 B2 CS270593 B2 CS 270593B2 CS 886665 A CS886665 A CS 886665A CS 666588 A CS666588 A CS 666588A CS 270593 B2 CS270593 B2 CS 270593B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- dmf
- suspension
- solvate
- solution
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10576287A | 1987-10-07 | 1987-10-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS666588A2 CS666588A2 (en) | 1989-11-14 |
| CS270593B2 true CS270593B2 (en) | 1990-07-12 |
Family
ID=22307652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS886665A CS270593B2 (en) | 1987-10-07 | 1988-10-06 | Method of 7 beta-/2-(r)-2-(p-hydroxyphenyl)-2-aminoacetamido/-3-chloro-3-(carbadethiacephem)-4-carboxylic acid's crystalline monohydrate form preparation |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0311365A1 (da) |
| JP (1) | JPH02270871A (da) |
| KR (1) | KR890006643A (da) |
| CN (1) | CN1032442A (da) |
| AU (1) | AU605635B2 (da) |
| BG (1) | BG47035A3 (da) |
| CS (1) | CS270593B2 (da) |
| DD (1) | DD280112A5 (da) |
| DK (1) | DK553888A (da) |
| FI (1) | FI884555A (da) |
| HU (1) | HU205112B (da) |
| IL (1) | IL87904A0 (da) |
| MX (1) | MX13276A (da) |
| MY (1) | MY103554A (da) |
| NO (1) | NO884417L (da) |
| NZ (1) | NZ226451A (da) |
| OA (1) | OA09017A (da) |
| PH (1) | PH26811A (da) |
| PL (2) | PL163113B1 (da) |
| PT (1) | PT88663B (da) |
| RO (2) | RO102423B1 (da) |
| RU (1) | RU1776260C (da) |
| YU (1) | YU46700B (da) |
| ZA (1) | ZA887408B (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA887409B (en) * | 1987-10-06 | 1990-06-27 | Lilly Co Eli | Crystalline beta-lactam hydrate |
| CS133392A3 (en) * | 1991-05-10 | 1992-11-18 | Lilly Co Eli | Process for preparing twice blocked1-carba(1-dithia)-3-cephem-4-carboxylic acids |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1472746A (en) * | 1973-07-05 | 1977-05-04 | Glaxo Lab Ltd | Cephalosporin compounds |
| US4160863A (en) * | 1977-04-07 | 1979-07-10 | Bristol-Myers Company | Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid |
| JPS5672698A (en) * | 1979-11-14 | 1981-06-16 | Kyowa Hakko Kogyo Co Ltd | Preparation of optically active cephalosporin analogue |
| ZA887409B (en) * | 1987-10-06 | 1990-06-27 | Lilly Co Eli | Crystalline beta-lactam hydrate |
-
1988
- 1988-10-03 YU YU184688A patent/YU46700B/sh unknown
- 1988-10-03 ZA ZA887408A patent/ZA887408B/xx unknown
- 1988-10-03 MY MYPI88001104A patent/MY103554A/en unknown
- 1988-10-03 DD DD88320416A patent/DD280112A5/de not_active IP Right Cessation
- 1988-10-04 IL IL87904A patent/IL87904A0/xx unknown
- 1988-10-04 PT PT88663A patent/PT88663B/pt not_active IP Right Cessation
- 1988-10-04 AU AU23371/88A patent/AU605635B2/en not_active Ceased
- 1988-10-04 DK DK553888A patent/DK553888A/da not_active Application Discontinuation
- 1988-10-04 RO RO1988135393A patent/RO102423B1/ro unknown
- 1988-10-04 JP JP63251713A patent/JPH02270871A/ja active Pending
- 1988-10-04 PH PH37637A patent/PH26811A/en unknown
- 1988-10-04 BG BG085593A patent/BG47035A3/xx unknown
- 1988-10-04 FI FI884555A patent/FI884555A/fi not_active Application Discontinuation
- 1988-10-04 RO RO145635A patent/RO105809B1/ro unknown
- 1988-10-04 NZ NZ226451A patent/NZ226451A/xx unknown
- 1988-10-04 MX MX1327688A patent/MX13276A/es unknown
- 1988-10-05 EP EP88309260A patent/EP0311365A1/en not_active Withdrawn
- 1988-10-05 CN CN88109139A patent/CN1032442A/zh active Pending
- 1988-10-05 HU HU885170A patent/HU205112B/hu not_active IP Right Cessation
- 1988-10-05 KR KR1019880012960A patent/KR890006643A/ko not_active Application Discontinuation
- 1988-10-05 PL PL88294911A patent/PL163113B1/pl unknown
- 1988-10-05 OA OA59443A patent/OA09017A/xx unknown
- 1988-10-05 NO NO88884417A patent/NO884417L/no unknown
- 1988-10-05 RU SU884356612A patent/RU1776260C/ru active
- 1988-10-05 PL PL1988275092A patent/PL159766B1/pl unknown
- 1988-10-06 CS CS886665A patent/CS270593B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02270871A (ja) | 1990-11-05 |
| PL159766B1 (pl) | 1993-01-29 |
| HUT48883A (en) | 1989-07-28 |
| CN1032442A (zh) | 1989-04-19 |
| AU2337188A (en) | 1989-04-13 |
| MY103554A (en) | 1993-07-31 |
| NO884417L (no) | 1989-04-10 |
| AU605635B2 (en) | 1991-01-17 |
| MX13276A (es) | 1993-11-01 |
| IL87904A0 (en) | 1989-03-31 |
| HU205112B (en) | 1992-03-30 |
| RO102423B1 (en) | 1992-08-01 |
| BG47035A3 (en) | 1990-04-16 |
| DD280112A5 (de) | 1990-06-27 |
| DK553888A (da) | 1989-04-08 |
| YU46700B (sh) | 1994-04-05 |
| PT88663A (pt) | 1989-07-31 |
| PL163113B1 (pl) | 1994-02-28 |
| KR890006643A (ko) | 1989-06-15 |
| RU1776260C (ru) | 1992-11-15 |
| FI884555A (fi) | 1989-04-08 |
| PT88663B (pt) | 1993-10-29 |
| OA09017A (fr) | 1991-03-31 |
| EP0311365A1 (en) | 1989-04-12 |
| NO884417D0 (no) | 1988-10-05 |
| DK553888D0 (da) | 1988-10-04 |
| RO105809B1 (ro) | 1992-12-30 |
| PH26811A (en) | 1992-11-05 |
| CS666588A2 (en) | 1989-11-14 |
| PL275092A1 (en) | 1989-05-16 |
| YU184688A (en) | 1990-04-30 |
| FI884555A0 (fi) | 1988-10-04 |
| NZ226451A (en) | 1990-10-26 |
| ZA887408B (en) | 1990-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5091525A (en) | Monohydrate and DMF solvates of a new carbacephem antibiotic | |
| RU2125571C1 (ru) | СОЛЬ 7-([1α,5α,6α]-6-АМИНО-3-АЗАБИЦИКЛО [3.1.0] ГЕКС-3-ИЛ)-6-ФТОР-1-(2,4-ДИФТОРФЕНИЛ)-1,4- ДИГИДРО-4-ОКСО-1,8-НАФТИРИДИН-3-КАРБОНОВОЙ И МЕТАНСУЛЬФОНОВОЙ КИСЛОТ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ | |
| EP0311366B1 (en) | Crystalline beta-lactam hydrate | |
| AU620659B2 (en) | Hydrate forms of 1-carbacephalosporin derivatives | |
| SU845789A3 (ru) | Способ получени -7- -(4-окси-6-метил-НиКОТиНАМидО)- -(4-ОКСифЕНил)АцЕТАМидО -3- (1-МЕТилТЕТРАзОл-5-ил)ТиОМЕТил-3-цЕфЕМ-4-КАРбО-НОВОй КиСлОТы | |
| AU615026B2 (en) | Crystalline beta-lactam solvate | |
| EP0266896B1 (en) | 7-( (meta-substituted) phenylglycine) 1-carba-1-dethiacephalosporins | |
| CS270593B2 (en) | Method of 7 beta-/2-(r)-2-(p-hydroxyphenyl)-2-aminoacetamido/-3-chloro-3-(carbadethiacephem)-4-carboxylic acid's crystalline monohydrate form preparation | |
| JP2842640B2 (ja) | β―ラクタム抗生物質の溶媒和物 | |
| EP0439353B1 (en) | Crystalline hydrochloride of new beta-lactam antibiotic and process therefor | |
| KR100274736B1 (ko) | 6-엔-(엘-에이엘에이-엘-에이엘에이)-트로바플록사신 전구약물의 폴리모프 |