CS258483B2 - Method of new thienopyridones production - Google Patents

Method of new thienopyridones production Download PDF

Info

Publication number
CS258483B2
CS258483B2 CS864362A CS436286A CS258483B2 CS 258483 B2 CS258483 B2 CS 258483B2 CS 864362 A CS864362 A CS 864362A CS 436286 A CS436286 A CS 436286A CS 258483 B2 CS258483 B2 CS 258483B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
new
mixture
formula
solution
Prior art date
Application number
CS864362A
Other languages
Czech (cs)
English (en)
Other versions
CS436286A2 (en
Inventor
Roy V Davies
James Frasser
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Priority to CS874060A priority Critical patent/CS258500B2/cs
Publication of CS436286A2 publication Critical patent/CS436286A2/cs
Publication of CS258483B2 publication Critical patent/CS258483B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS864362A 1985-06-15 1986-06-12 Method of new thienopyridones production CS258483B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS874060A CS258500B2 (cs) 1985-06-15 1987-06-03 Způsob výroby 4-methyl-e-methyleulfinyl-thieno[3,2-b]pyrid-7(4K)-onu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858515207A GB8515207D0 (en) 1985-06-15 1985-06-15 Therapeutic agents

Publications (2)

Publication Number Publication Date
CS436286A2 CS436286A2 (en) 1987-12-17
CS258483B2 true CS258483B2 (en) 1988-08-16

Family

ID=10580803

Family Applications (1)

Application Number Title Priority Date Filing Date
CS864362A CS258483B2 (en) 1985-06-15 1986-06-12 Method of new thienopyridones production

Country Status (20)

Country Link
US (1) US4710506A (da)
EP (1) EP0209977A3 (da)
JP (1) JPS6236382A (da)
KR (1) KR870000339A (da)
AU (1) AU581595B2 (da)
CS (1) CS258483B2 (da)
DD (1) DD253823A5 (da)
DK (1) DK272486A (da)
ES (1) ES8707243A1 (da)
FI (1) FI862520A (da)
GB (1) GB8515207D0 (da)
GR (1) GR861527B (da)
HU (1) HU195661B (da)
JO (1) JO1482B1 (da)
NO (1) NO862373L (da)
PH (1) PH22293A (da)
PL (1) PL266392A1 (da)
PT (1) PT82759B (da)
YU (2) YU99386A (da)
ZA (1) ZA864396B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
US4767766A (en) * 1987-01-30 1988-08-30 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
US4904672A (en) * 1987-01-30 1990-02-27 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
AU5509099A (en) * 1998-08-03 2000-02-28 Basf Corporation Pyridinones for the treatment of sexual dysfunction
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
CN101624391A (zh) * 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
US6995171B2 (en) * 2001-06-21 2006-02-07 Agouron Pharmaceuticals, Inc. Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents
CN100413861C (zh) * 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
US7994192B2 (en) * 2006-09-26 2011-08-09 Crestone, Inc. Substituted thienopyridone compounds with antibacterial activity
US8697720B2 (en) 2006-09-26 2014-04-15 Crestone, Inc. Substituted phenylether-thienopyridone compounds with antibacterial activity
US7973050B2 (en) * 2006-09-26 2011-07-05 Crestone, Inc. Enantiomeric compounds with antibacterial activity
US8658670B2 (en) * 2006-09-26 2014-02-25 Crestone, Inc. Methods and compounds for treatment of clostridium based infection
ES2392897T3 (es) * 2006-09-26 2012-12-14 Crestone, Inc. Compuestos tienopiridona sustituidos con actividad antibacteriana
EP2559692A1 (en) 2006-11-15 2013-02-20 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of Flavivirus infections

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997545A (en) * 1973-07-23 1976-12-14 Takeda Chemical Industries, Ltd. Thienopyridine-carboxylic acid derivatives
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
JPS5742690A (en) * 1980-08-28 1982-03-10 Kanebo Ltd Thieno 3,2-b pyridinecarboxylic acid derivative
GB2085441B (en) * 1980-09-26 1984-10-17 Boots The Co Ltd Therapeutic agents
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
DE3412947A1 (de) * 1984-04-06 1985-10-17 Bayer Ag, 5090 Leverkusen Tetrahydothienopyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
CS436286A2 (en) 1987-12-17
DK272486D0 (da) 1986-06-10
JPS6236382A (ja) 1987-02-17
EP0209977A2 (en) 1987-01-28
HUT42775A (en) 1987-08-28
ES8707243A1 (es) 1987-07-16
GB8515207D0 (en) 1985-07-17
ZA864396B (en) 1987-08-26
NO862373L (no) 1986-12-16
FI862520A0 (fi) 1986-06-12
NO862373D0 (no) 1986-06-13
EP0209977A3 (en) 1988-06-08
HU195661B (en) 1988-06-28
AU581595B2 (en) 1989-02-23
DD253823A5 (de) 1988-02-03
FI862520A (fi) 1986-12-16
US4710506A (en) 1987-12-01
PL266392A1 (en) 1988-02-18
GR861527B (en) 1986-10-14
KR870000339A (ko) 1987-02-17
YU99386A (en) 1988-04-30
AU5838386A (en) 1986-12-18
JO1482B1 (en) 1988-03-10
YU121187A (en) 1988-04-30
PT82759A (en) 1986-07-01
PH22293A (en) 1988-07-22
DK272486A (da) 1986-12-16
ES556026A0 (es) 1987-07-16
PT82759B (en) 1988-05-12

Similar Documents

Publication Publication Date Title
CS258483B2 (en) Method of new thienopyridones production
KR900007780B1 (ko) 축합된 피롤리논 유도체의 제조방법
US4353827A (en) Diazepine derivatives
EP0223420B1 (en) Condensed imidazopyridine derivatives
US5001130A (en) Psychotropic heterobicycloalkylpiperazine derivatives
HU218950B (hu) Kondenzált imidazo-piridin-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
US4731358A (en) β-carbolines and their use as tranquilizers
CS277446B6 (en) Novel heteroazepines, process of their preparation and pharmaceutical preparations containing thereof
PL145105B1 (en) Method of obtaining novel concentrated two-ring derivatives of imidazole
CZ17988A3 (en) BENZOPYRAN(4,3-c)PYRAZOLE OR BENZOTHIOPYRAN(4,3-c)PYRAZOLE DERIVATIVES, PROCESSES OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE COMPRISED
NO162414B (no) Fleksibel beholder for transport og lagring av massegods.
EP1446399B1 (en) Piperazine derivatives having sst1 antagonistic activity
DK160762B (da) Analogifremgangsmaade til fremstilling af 2-phenyl- eller 2-pyridyl-pyrazolooe4,3-caaquinolin-3(1 og 5h)-on-forbindelser eller de 3-hydroxytautomere eller salte deraf
FI67550C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 2,10-dihydro-4-piperazinyl-pyrazolo(3,4-b)(1,5)bensodiazepinderivat
FI79319B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tricykliska oxindolkarboxamidderivat.
EP0318682A2 (de) Tricyclische Thiazolderivate
Takada et al. Thienylpyrazoloquinolines: potent agonists and inverse agonists to benzodiazepine receptors
CS259516B2 (en) Method of new heterocyclic compounds production
SE505420C2 (sv) Sulfonylderivat av tieno-triazolo-diazepiner, ett förfarande för framställning därav och terapeutiska kompositioner innehållande dem
CA2061629A1 (en) 5-(substituted amino)-1,2,4- triazolo¬1,5-a|pyrimidine derivatives
DK169721B1 (da) Substituerede spiro-pyridinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til fremstilling af sådanne derivater
SK99794A3 (en) Triazolopyrimidine derivatives as antiotensin ii receptor antagonists, method of their preparation, pharmaceutical agent and use
US5804685A (en) Deazapurine derivatives: a new class of CRF1 specific ligands
US5030646A (en) Novel tricyclic indole compound
US5240918A (en) 2-(substituted imino)-thiazolidines and process for the preparation thereof