CS227343B2 - Method of preparing substituted n-(4-indolylpiperidinoalkyl)benzimidazolone - Google Patents

Method of preparing substituted n-(4-indolylpiperidinoalkyl)benzimidazolone Download PDF

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Publication number
CS227343B2
CS227343B2 CS821228A CS122882A CS227343B2 CS 227343 B2 CS227343 B2 CS 227343B2 CS 821228 A CS821228 A CS 821228A CS 122882 A CS122882 A CS 122882A CS 227343 B2 CS227343 B2 CS 227343B2
Authority
CS
Czechoslovakia
Prior art keywords
benzimidazolone
hydrogen atom
acid
indolyl
atom
Prior art date
Application number
CS821228A
Other languages
Czech (cs)
English (en)
Inventor
Kurt Dr Freter
Viktor Fuchs
James T Dr Oliver
Original Assignee
Boehringer Ingelheim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ltd filed Critical Boehringer Ingelheim Ltd
Publication of CS227343B2 publication Critical patent/CS227343B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CS821228A 1981-02-25 1982-02-23 Method of preparing substituted n-(4-indolylpiperidinoalkyl)benzimidazolone CS227343B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/237,966 US4359468A (en) 1981-02-25 1981-02-25 Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones

Publications (1)

Publication Number Publication Date
CS227343B2 true CS227343B2 (en) 1984-04-16

Family

ID=22895956

Family Applications (1)

Application Number Title Priority Date Filing Date
CS821228A CS227343B2 (en) 1981-02-25 1982-02-23 Method of preparing substituted n-(4-indolylpiperidinoalkyl)benzimidazolone

Country Status (28)

Country Link
US (1) US4359468A (ru)
EP (1) EP0058975B1 (ru)
JP (1) JPS57156484A (ru)
KR (1) KR890000008B1 (ru)
AR (1) AR228475A1 (ru)
AT (1) ATE10742T1 (ru)
AU (1) AU543948B2 (ru)
CA (1) CA1191137A (ru)
CS (1) CS227343B2 (ru)
DD (1) DD202562A5 (ru)
DE (1) DE3261497D1 (ru)
DK (1) DK151017C (ru)
ES (2) ES509871A0 (ru)
FI (1) FI71558C (ru)
GB (1) GB2093455B (ru)
GR (1) GR74778B (ru)
HU (1) HU187652B (ru)
IE (1) IE52562B1 (ru)
IL (1) IL65097A0 (ru)
NO (1) NO157296C (ru)
NZ (1) NZ199822A (ru)
PH (1) PH17889A (ru)
PL (1) PL135472B1 (ru)
PT (1) PT74481B (ru)
SU (1) SU1088665A3 (ru)
UA (1) UA7228A1 (ru)
YU (1) YU42758B (ru)
ZA (1) ZA821196B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
FR2613222B1 (fr) * 1987-04-03 1991-06-14 Guigon Nadine Composition pour les soins locaux de l'epiderme, notamment du cuir chevelu
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
US5238945A (en) * 1989-04-11 1993-08-24 H. Lundbeck A/S Method of treating psychoses
GB8908085D0 (en) * 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
TW203049B (ru) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
CA2195850A1 (en) * 1994-08-03 1996-02-15 Guillaume Lebaut Substituted indoles
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
WO1996029075A1 (en) * 1995-03-20 1996-09-26 Eli Lilly And Company 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists
GB9825413D0 (en) 1998-11-19 1999-01-13 Lilly Co Eli Pharmaceutical compounds
GB9903784D0 (en) * 1999-02-18 1999-04-14 Lilly Co Eli Pharmaceutical compounds
AU2003297597A1 (en) * 2002-11-26 2004-06-18 Isis Pharmaceuticals, Inc. Benzimidazoles and analogs thereof as antibacterials
US7759365B2 (en) * 2005-04-30 2010-07-20 Boehringer Ingelheim International Gmbh Piperidine-substituted indoles
JP2009515833A (ja) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター
US8462477B2 (en) 2010-09-13 2013-06-11 Analog Devices, Inc. Junction field effect transistor for voltage protection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794333A (fr) * 1972-01-20 1973-07-19 Wyeth John & Brother Ltd Composes heterocycliques azotes therapeutiques
US3954764A (en) * 1973-03-30 1976-05-04 Hoffmann-La Roche Inc. Dibenzo [b,f]thiepins bearing piperazinyl substitution
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
ZA76475B (en) * 1975-03-10 1977-08-31 Ciba Geigy Ag Indolyalkylpiperidines
US4147786A (en) * 1976-02-02 1979-04-03 Ciba-Geigy Corporation 1-Indolylalkyl-3-or 4-trimethyleneurido-piperidines
FR2469411A1 (fr) * 1979-11-15 1981-05-22 Science Union & Cie Nouveaux derives de la piperidylbenzimidazolinone, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
US4254127A (en) * 1980-04-03 1981-03-03 Janssen Pharmaceutica, N.V. 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives

Also Published As

Publication number Publication date
EP0058975A1 (de) 1982-09-01
NO157296B (no) 1987-11-16
ES8401961A1 (es) 1984-01-01
DK79882A (da) 1982-08-26
YU42758B (en) 1988-12-31
CA1191137A (en) 1985-07-30
GB2093455A (en) 1982-09-02
PL135472B1 (en) 1985-10-31
KR890000008B1 (ko) 1989-03-02
AR228475A1 (es) 1983-03-15
DD202562A5 (de) 1983-09-21
NZ199822A (en) 1985-01-31
HU187652B (en) 1986-02-28
NO820583L (no) 1982-08-26
PH17889A (en) 1985-01-21
AU543948B2 (en) 1985-05-09
ES8306142A1 (es) 1983-05-01
GR74778B (ru) 1984-07-12
DE3261497D1 (en) 1985-01-24
EP0058975B1 (de) 1984-12-12
IE52562B1 (en) 1987-12-09
ES509871A0 (es) 1983-05-01
IE820401L (en) 1982-08-25
US4359468A (en) 1982-11-16
SU1088665A3 (ru) 1984-04-23
PT74481A (de) 1982-03-01
YU41082A (en) 1985-03-20
NO157296C (no) 1988-02-24
AU8078382A (en) 1982-09-02
IL65097A0 (en) 1982-04-30
DK151017C (da) 1988-06-13
UA7228A1 (ru) 1995-06-30
PT74481B (de) 1984-10-09
ZA821196B (en) 1983-10-26
KR830009086A (ko) 1983-12-17
PL235187A1 (en) 1984-03-26
ATE10742T1 (de) 1984-12-15
FI71558C (fi) 1987-01-19
ES517988A0 (es) 1984-01-01
FI820594L (fi) 1982-08-26
DK151017B (da) 1987-10-12
JPS57156484A (en) 1982-09-27
FI71558B (fi) 1986-10-10
GB2093455B (en) 1984-06-13
JPH0318637B2 (ru) 1991-03-13

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