CS225850B2 - Process for preparing new r,r-n-(2-phenyl-2-hydroxyethyl)-1-methyl-3-phenylpropylamines - Google Patents

Process for preparing new r,r-n-(2-phenyl-2-hydroxyethyl)-1-methyl-3-phenylpropylamines Download PDF

Info

Publication number
CS225850B2
CS225850B2 CS794629A CS462979A CS225850B2 CS 225850 B2 CS225850 B2 CS 225850B2 CS 794629 A CS794629 A CS 794629A CS 462979 A CS462979 A CS 462979A CS 225850 B2 CS225850 B2 CS 225850B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
hydrogen
compounds
phenyl
hydroxyethyl
Prior art date
Application number
CS794629A
Other languages
Czech (cs)
English (en)
Inventor
Jack Mills
Klaus K Schmiegel
Ronald Ralph Tuttle
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS225850B2 publication Critical patent/CS225850B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
CS794629A 1978-07-03 1979-07-02 Process for preparing new r,r-n-(2-phenyl-2-hydroxyethyl)-1-methyl-3-phenylpropylamines CS225850B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92166778A 1978-07-03 1978-07-03

Publications (1)

Publication Number Publication Date
CS225850B2 true CS225850B2 (en) 1984-02-13

Family

ID=25445784

Family Applications (1)

Application Number Title Priority Date Filing Date
CS794629A CS225850B2 (en) 1978-07-03 1979-07-02 Process for preparing new r,r-n-(2-phenyl-2-hydroxyethyl)-1-methyl-3-phenylpropylamines

Country Status (25)

Country Link
EP (1) EP0007205A1 (fr)
JP (1) JPS559098A (fr)
AR (2) AR221884A1 (fr)
AT (1) ATA463779A (fr)
AU (1) AU4849079A (fr)
BE (1) BE877391A (fr)
BG (4) BG31492A3 (fr)
CA (1) CA1145766A (fr)
CS (1) CS225850B2 (fr)
DD (1) DD145265A5 (fr)
DK (1) DK269079A (fr)
ES (4) ES482154A1 (fr)
FI (1) FI792079A (fr)
FR (1) FR2430408A1 (fr)
GB (1) GB2029407A (fr)
GR (1) GR72939B (fr)
IL (1) IL57673A0 (fr)
LU (1) LU81455A1 (fr)
NZ (1) NZ190860A (fr)
PH (1) PH15040A (fr)
PL (3) PL117514B1 (fr)
PT (1) PT69841A (fr)
RO (1) RO77729A (fr)
SU (1) SU936804A3 (fr)
ZA (1) ZA793298B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
CA1142954A (fr) * 1978-07-03 1983-03-15 Jack Mills Phenethanolamines, compositions qui en renferment, et methode pour faire perdre efficacement du poids
JPS57116300A (en) * 1981-01-12 1982-07-20 Fuji Photo Film Co Ltd Noise elimination in radiation image recording reproduction
CA1219865A (fr) * 1982-05-14 1987-03-31 Leo Alig Derives de phenethanolamine d'aziridine
CA1258454A (fr) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
US5643967A (en) * 1983-01-31 1997-07-01 Eli Lilly And Company Growth promotion
US4690951A (en) * 1983-01-31 1987-09-01 Eli Lilly And Company Growth promotion
US4562206A (en) * 1983-12-23 1985-12-31 Key Pharmaceuticals, Inc. Orally effective inotropic compounds
IT1204416B (it) * 1986-06-27 1989-03-01 Midy Spa Medicamenti a base di analoghi di feniletanolammine per il trattamento di disturbi gastro-intestinali ed uterini
US5108363A (en) * 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
US5135955A (en) * 1988-04-25 1992-08-04 Eli Lilly And Company Propanamine derivatives
AU7863394A (en) * 1993-10-20 1995-05-08 Tokyo Tanabe Company Limited Novel arylethanolamino(aryl)propanol compound
WO2002020821A2 (fr) * 2000-09-08 2002-03-14 Dsm N.V. Procede de preparation d'amines enantiomeriquement enrichies
CA2541398C (fr) * 2003-10-07 2012-08-21 Eli Lilly And Company Preparations liquides de ractopamine
WO2007143336A2 (fr) * 2006-05-30 2007-12-13 Stirling Products Limited Utilisation d'énantiomères de ractopamine
US20070282010A1 (en) 2006-05-30 2007-12-06 Bridge Pharma, Inc. Methods of Accelerating Muscle Growth, Decreasing Fat Deposits and Improving Feed Efficiency in Livestock Animals
AU2008331928B2 (en) 2007-12-03 2012-08-16 Bridge Pharma, Inc. Use of RR/SR-ractopamine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE894396C (de) * 1944-05-21 1953-10-26 Troponwerke Dinklage & Co Verfahren zur Herstellung von 1-(o-, m- oder p-Oxyphenyl)-1-oxy-2-aralkylamino-aethanen
DE1182245B (de) * 1961-01-23 1964-11-26 Philips Nv Verfahren zur Herstellung eines uterospasmolytisch wirksamen linksdrehenden 1-(4'-Hy-droxyphenyl)-2-(1"-methyl-3"phenylpropylamino)-propanols
DE1543918A1 (de) * 1966-01-28 1970-01-08 Troponwerke Dinklage & Co 1-[m-Hydroxyphenyl]-2-[1-methyl-3-phenylpropyl-(1)-amino]-aethanol-(1) und Verfahren zu dessen Herstellung
NL6610530A (fr) * 1966-07-27 1968-01-29
DE2044573A1 (en) * 1970-09-09 1972-03-23 Troponwerke Dinklage & Co, 5000 Köln-Mülheim 1-(hydroxyphenyl)-2-(1-phenyl-2-methylpropyl or 4-methylpentyl - -(2)-amino)-ethanols and their salts - betasympathicomometic
DE2413102C3 (de) * 1974-03-19 1980-09-11 C.H. Boehringer Sohn, 6507 Ingelheim Verfahren zur Herstellung von l-(3,5-Dihydroxyphenyl)-t-hydroxy-2- eckige Klammer auf 1-methyl-2-(4-hydroxyphenyl)- äthyl] -aminoäthan

Also Published As

Publication number Publication date
LU81455A1 (fr) 1979-10-30
GR72939B (fr) 1984-01-16
DK269079A (da) 1980-02-01
ES490213A0 (es) 1981-05-16
ES8105264A1 (es) 1981-05-16
ES490212A0 (es) 1981-05-16
ZA793298B (en) 1981-02-25
DD145265A5 (de) 1980-12-03
PH15040A (en) 1982-05-20
AU4849079A (en) 1980-01-10
PL118755B1 (en) 1981-10-31
IL57673A0 (en) 1979-10-31
ATA463779A (de) 1982-01-15
RO77729A (fr) 1981-11-24
GB2029407A (en) 1980-03-19
BG31491A3 (en) 1982-01-15
EP0007205A1 (fr) 1980-01-23
PL117514B1 (en) 1981-08-31
PT69841A (en) 1979-07-01
BG31493A3 (en) 1982-01-15
PL216812A1 (fr) 1980-03-24
AR221884A1 (es) 1981-03-31
ES8105265A1 (es) 1981-05-16
AR225653A1 (es) 1982-04-15
ES8105263A1 (es) 1981-05-16
BG31492A3 (en) 1982-01-15
ES482154A1 (es) 1980-08-16
NZ190860A (en) 1982-05-25
PL118515B1 (en) 1981-10-31
BE877391A (fr) 1980-01-02
FR2430408A1 (fr) 1980-02-01
FI792079A (fi) 1980-01-04
BG31376A3 (en) 1981-12-15
JPS559098A (en) 1980-01-22
ES490211A0 (es) 1981-05-16
SU936804A3 (ru) 1982-06-15
CA1145766A (fr) 1983-05-03

Similar Documents

Publication Publication Date Title
CS225850B2 (en) Process for preparing new r,r-n-(2-phenyl-2-hydroxyethyl)-1-methyl-3-phenylpropylamines
CS208663B2 (en) Method of making the new r,s-n-/2-phenyl-2-hydroxyethyl0 -1-alkyl-3-/4-substituted phenyl/propylamines
EP0428434A2 (fr) Composés aromatiques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant
WO2002081453A1 (fr) Hiohydantoïnes et leur utilisation dans le traitement du diabete
BE851310A (fr) Nouveaux derives de la tetrahydro-equinocandine b
EP1386908B1 (fr) Derive d'amine a fonction regulatrice des canaux potassiques, sa preparation et son utilisation
JPS59108749A (ja) ５−｛（ｒ）−１−ヒドロキシ−２−〔（ｒ）−（１−メチル−３−フエニルプロピル）アミノ〕エチル｝サルチルアミドまたはその薬理学的に許容される酸付加塩の製造方法
CH617697A5 (fr)
EP0060179A1 (fr) Compositions pharmaceutiques à action anorexigène
EP0024960B1 (fr) Nouvelles phénoxyamines hétérocycliques substituées, procédé pour leur préparation et leur application comme anesthésiques locaux
EP0003445A1 (fr) Dérivés d'aza-1 bicyclo(2,2,2)octane, leur procédé de préparation et produits intermédiaires, et médicaments les contenant
DK166878B (da) Fluorallylaminer og pharmakologisk acceptable syreadditionssalte deraf samt pharmaceutisk praeparat indeholdende disse forbindelser
FR2460947A1 (fr) Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
NO171847B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzenderivater
LU87129A1 (fr) Nouvel acide piperazinecarboxylique,sa preparation et son utilisation comme medicament
CH643243A5 (fr) Cis- et trans-3-aryloxy-4-hydroxypyrrolidines et leurs derives, utiles notamment en medecine veterinaire comme antidepresseurs.
BE1005612A5 (fr) Derive de la dichloroaniline.
EP0005091B1 (fr) Nouvelles pipérazines monosubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant
EP0061406B1 (fr) Dérivés d'acide benzamido-alkyl-hydroxamique, procédé de préparation et composition thérapeutique
JPH11506470A (ja) 新規複素環式化合物
EP0007716A1 (fr) R-N-(2-phényl 2-hydroxyéthyl) 3-phénylpropylamines, leurs compositions, leur utilisation et leur préparation
FR2605008A1 (fr) Derives d'imidazo (4,5-b)pyridinone-2, leur preparation et leur application en therapeutique
CA1190242A (fr) Derives d'acide 2-amino-3-hydroxyphenyl-3- butenoique
WO2000063160A1 (fr) Derives de 2-alcoxy-cyclobutane-3,4-dione leur preparation et leur application en therapeutique
JP3021187B2 (ja) 新規なフェニルアセトアミド誘導体およびその製法