CS225823B2 - The production of the pyridine derivates - Google Patents

The production of the pyridine derivates Download PDF

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Publication number
CS225823B2
CS225823B2 CS806875A CS687580A CS225823B2 CS 225823 B2 CS225823 B2 CS 225823B2 CS 806875 A CS806875 A CS 806875A CS 687580 A CS687580 A CS 687580A CS 225823 B2 CS225823 B2 CS 225823B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
pyridine
carbon atoms
nitrile
cyclohexyl group
Prior art date
Application number
CS806875A
Other languages
Czech (cs)
English (en)
Inventor
Henri Demarne
Claude Bernhart
Jacqueline Lansen
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CS225823B2 publication Critical patent/CS225823B2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56Amides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS806875A 1979-10-11 1980-10-10 The production of the pyridine derivates CS225823B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7925370A FR2467200A1 (fr) 1979-10-11 1979-10-11 Derives du pyrrole actifs sur les troubles du rythme cardiovasculaire

Publications (1)

Publication Number Publication Date
CS225823B2 true CS225823B2 (en) 1984-02-13

Family

ID=9230594

Family Applications (2)

Application Number Title Priority Date Filing Date
CS814303A CS225840B2 (en) 1979-10-11 1980-10-10 The manufacturing process of the pyridine derivates
CS806875A CS225823B2 (en) 1979-10-11 1980-10-10 The production of the pyridine derivates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS814303A CS225840B2 (en) 1979-10-11 1980-10-10 The manufacturing process of the pyridine derivates

Country Status (26)

Country Link
US (1) US4356177A (xx)
EP (1) EP0027412B1 (xx)
JP (1) JPS5661355A (xx)
AR (2) AR231129A1 (xx)
AT (1) ATE5561T1 (xx)
AU (1) AU540556B2 (xx)
BR (1) BR8006547A (xx)
CA (1) CA1156653A (xx)
CS (2) CS225840B2 (xx)
DD (1) DD153549A5 (xx)
DE (1) DE3065906D1 (xx)
DK (1) DK156650C (xx)
ES (1) ES8200347A1 (xx)
FI (1) FI75339C (xx)
FR (1) FR2467200A1 (xx)
GR (1) GR69616B (xx)
HU (1) HU184330B (xx)
IE (1) IE50827B1 (xx)
IL (1) IL61250A (xx)
NO (1) NO153849C (xx)
NZ (1) NZ195233A (xx)
PH (1) PH18748A (xx)
PT (1) PT71888B (xx)
SU (2) SU1011048A3 (xx)
YU (2) YU42537B (xx)
ZA (1) ZA806180B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2535722B1 (fr) * 1982-11-08 1985-06-28 Sanofi Sa Derives de la g-butyrolactone protecteurs du myocarde presentant une activite antiarythmique, procede pour leur preparation et medicaments en contenant
FR2535721A1 (fr) * 1982-11-08 1984-05-11 Sanofi Sa Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives
US4847301A (en) * 1985-11-13 1989-07-11 Pennwalt Corporation Methods of use of α-(aminoalkyl)-arylacetic acid derivatives
US4783537A (en) * 1985-11-13 1988-11-08 Pennwalt Corporation α-(aminoalkyl)-arylacetic acid derivatives
FR2856061A1 (fr) * 2003-06-11 2004-12-17 Chrysalon Derives polycycliques ortho-condenses de l'aminopyrrole a substituant electroattracteur chimiotheques combinatoires desdits derives et leur procede d'obtention

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL70757C (xx) * 1947-10-13
GB915804A (en) * 1958-04-12 1963-01-16 Degussa Process for the production of basically substituted carboxylic acid amides
FR2485M (fr) * 1961-05-17 1964-04-27 Searle & Co Nouveaux régulateurs cardiaques.
CA1073892A (en) * 1976-08-03 1980-03-18 John M. Holmes Mixed metal amide catalysts for h-d exchange in amines

Also Published As

Publication number Publication date
FI75339C (fi) 1988-06-09
ES495745A0 (es) 1981-11-16
AR231129A1 (es) 1984-09-28
AR231975A1 (es) 1985-04-30
NO803051L (no) 1981-04-13
CA1156653A (en) 1983-11-08
DD153549A5 (de) 1982-01-13
JPH0115501B2 (xx) 1989-03-17
CS225840B2 (en) 1984-02-13
US4356177A (en) 1982-10-26
ZA806180B (en) 1981-11-25
DK156650B (da) 1989-09-18
FR2467200B1 (xx) 1982-07-02
YU261180A (en) 1983-09-30
YU21283A (en) 1983-09-30
PH18748A (en) 1985-09-19
SU1127529A3 (ru) 1984-11-30
PT71888B (fr) 1981-08-14
IE802112L (en) 1981-04-11
ATE5561T1 (de) 1983-12-15
IE50827B1 (en) 1986-07-23
IL61250A (en) 1983-11-30
PT71888A (fr) 1980-11-01
YU42537B (en) 1988-10-31
FI803221L (fi) 1981-04-12
NZ195233A (en) 1983-05-10
BR8006547A (pt) 1981-04-14
FR2467200A1 (fr) 1981-04-17
SU1011048A3 (ru) 1983-04-07
ES8200347A1 (es) 1981-11-16
FI75339B (fi) 1988-02-29
IL61250A0 (en) 1980-12-31
EP0027412A1 (fr) 1981-04-22
EP0027412B1 (fr) 1983-12-14
GR69616B (xx) 1982-07-05
AU6328380A (en) 1981-04-30
HU184330B (en) 1984-08-28
JPS5661355A (en) 1981-05-26
NO153849B (no) 1986-02-24
NO153849C (no) 1986-06-04
DK156650C (da) 1990-02-12
AU540556B2 (en) 1984-11-22
DK428280A (da) 1981-04-12
DE3065906D1 (en) 1984-01-19

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