CS215054B2 - Method of making the hydroxyiminosubstituted aminoacetonitriles - Google Patents
Method of making the hydroxyiminosubstituted aminoacetonitriles Download PDFInfo
- Publication number
- CS215054B2 CS215054B2 CS802292A CS229280A CS215054B2 CS 215054 B2 CS215054 B2 CS 215054B2 CS 802292 A CS802292 A CS 802292A CS 229280 A CS229280 A CS 229280A CS 215054 B2 CS215054 B2 CS 215054B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- mol
- chloro
- alpha
- substituted
- preparation
- Prior art date
Links
- 150000008361 aminoacetonitriles Chemical class 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title description 3
- 238000002360 preparation method Methods 0.000 claims abstract description 28
- DFNYGALUNNFWKJ-UHFFFAOYSA-N aminoacetonitrile Chemical compound NCC#N DFNYGALUNNFWKJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 125000005843 halogen group Chemical group 0.000 claims abstract description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 19
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 13
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical group ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- 239000000460 chlorine Substances 0.000 claims description 12
- 229910052801 chlorine Inorganic materials 0.000 claims description 8
- 229910052794 bromium Chemical group 0.000 claims description 7
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 14
- 239000000543 intermediate Substances 0.000 abstract description 12
- 150000001875 compounds Chemical class 0.000 abstract description 11
- XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical class NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 abstract description 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract description 3
- 230000000749 insecticidal effect Effects 0.000 abstract description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 30
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 27
- 239000000047 product Substances 0.000 description 24
- 239000000243 solution Substances 0.000 description 23
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 21
- 239000000203 mixture Substances 0.000 description 19
- -1 3,5-disubstituted 2-aminopyrazine-1-oxides Chemical class 0.000 description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 18
- 239000004157 Nitrosyl chloride Substances 0.000 description 17
- VPCDQGACGWYTMC-UHFFFAOYSA-N nitrosyl chloride Chemical compound ClN=O VPCDQGACGWYTMC-UHFFFAOYSA-N 0.000 description 17
- 235000019392 nitrosyl chloride Nutrition 0.000 description 17
- 229910052799 carbon Inorganic materials 0.000 description 16
- 239000011541 reaction mixture Substances 0.000 description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
- 238000005481 NMR spectroscopy Methods 0.000 description 13
- 229910052757 nitrogen Inorganic materials 0.000 description 13
- 239000002904 solvent Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 150000003440 styrenes Chemical class 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000002274 desiccant Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 238000003786 synthesis reaction Methods 0.000 description 8
- XFKYKTBPRBZDFG-UHFFFAOYSA-N 2-aminoacetonitrile;hydrochloride Chemical compound Cl.NCC#N XFKYKTBPRBZDFG-UHFFFAOYSA-N 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 7
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 7
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 125000001841 imino group Chemical group [H]N=* 0.000 description 4
- 239000012044 organic layer Substances 0.000 description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- 239000000538 analytical sample Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 239000012458 free base Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 229910000033 sodium borohydride Inorganic materials 0.000 description 3
- 239000012279 sodium borohydride Substances 0.000 description 3
- DBASWHONNARUPG-UHFFFAOYSA-N 1,2-dichloro-4-prop-1-enylbenzene Chemical compound CC=CC1=CC=C(Cl)C(Cl)=C1 DBASWHONNARUPG-UHFFFAOYSA-N 0.000 description 2
- PJYGECCAJOYJMK-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)propan-1-ol Chemical compound CCC(O)C1=CC=C(Cl)C(Cl)=C1 PJYGECCAJOYJMK-UHFFFAOYSA-N 0.000 description 2
- KZNLLGVHMGYUAX-UHFFFAOYSA-N 1-bromo-4-prop-1-enylbenzene Chemical compound CC=CC1=CC=C(Br)C=C1 KZNLLGVHMGYUAX-UHFFFAOYSA-N 0.000 description 2
- MKJOTWMWLNTTJM-UHFFFAOYSA-N 1-ethyl-4-prop-1-enylbenzene Chemical compound CCC1=CC=C(C=CC)C=C1 MKJOTWMWLNTTJM-UHFFFAOYSA-N 0.000 description 2
- LYIIBVSRGJSHAV-UHFFFAOYSA-N 2-aminoacetaldehyde Chemical compound NCC=O LYIIBVSRGJSHAV-UHFFFAOYSA-N 0.000 description 2
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 description 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 description 2
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Natural products CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- OCAAIVJYAVLKHY-UHFFFAOYSA-N ON=C(C)C(Cl)C1=CC=C(Br)C=C1 Chemical compound ON=C(C)C(Cl)C1=CC=C(Br)C=C1 OCAAIVJYAVLKHY-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- BCDGQXUMWHRQCB-UHFFFAOYSA-N aminoacetone Chemical compound CC(=O)CN BCDGQXUMWHRQCB-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 2
- 239000001120 potassium sulphate Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- OVGLVOLWBBGQHS-DUXPYHPUSA-N (1e)-1-hydroxyiminopropan-2-one Chemical compound CC(=O)\C=N\O OVGLVOLWBBGQHS-DUXPYHPUSA-N 0.000 description 1
- NTTBDWAXCRRVJY-UHFFFAOYSA-N 1-(4-ethylphenyl)propan-1-ol Chemical compound CCC(O)C1=CC=C(CC)C=C1 NTTBDWAXCRRVJY-UHFFFAOYSA-N 0.000 description 1
- VGQRIILEZYZAOE-UHFFFAOYSA-N 1-(4-ethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(CC)C=C1 VGQRIILEZYZAOE-UHFFFAOYSA-N 0.000 description 1
- IPDBNWOEFLIODE-UHFFFAOYSA-N 1-bromo-2-prop-1-enylbenzene Chemical compound CC=CC1=CC=CC=C1Br IPDBNWOEFLIODE-UHFFFAOYSA-N 0.000 description 1
- CXRVLYOHAQORCT-UHFFFAOYSA-N 1-bromo-3-propylbenzene Chemical compound CCCC1=CC=CC(Br)=C1 CXRVLYOHAQORCT-UHFFFAOYSA-N 0.000 description 1
- ZYNMGEDQWPBZAS-UHFFFAOYSA-N 1-bromo-4-but-1-enylbenzene Chemical compound CCC=CC1=CC=C(Br)C=C1 ZYNMGEDQWPBZAS-UHFFFAOYSA-N 0.000 description 1
- HAZZRKZNTNNBJW-UHFFFAOYSA-N 1-chloro-4-prop-1-enylbenzene Chemical compound CC=CC1=CC=C(Cl)C=C1 HAZZRKZNTNNBJW-UHFFFAOYSA-N 0.000 description 1
- HIAGSPVAYSSKHL-UHFFFAOYSA-N 1-methyl-9h-carbazole Chemical compound N1C2=CC=CC=C2C2=C1C(C)=CC=C2 HIAGSPVAYSSKHL-UHFFFAOYSA-N 0.000 description 1
- OUZWHCIDWBRHFD-UHFFFAOYSA-N 1-prop-1-enyl-3-(trifluoromethyl)benzene Chemical compound CC=CC1=CC=CC(C(F)(F)F)=C1 OUZWHCIDWBRHFD-UHFFFAOYSA-N 0.000 description 1
- BOMOHWDVLAJWEI-UHFFFAOYSA-N 2,4-dimethyl-1-prop-1-enylbenzene Chemical compound CC=CC1=CC=C(C)C=C1C BOMOHWDVLAJWEI-UHFFFAOYSA-N 0.000 description 1
- MNEUEZGHHHVQCY-UHFFFAOYSA-N 2-[[1-(2,4-dimethylphenyl)-2-hydroxyiminopropyl]amino]acetonitrile Chemical compound N#CCNC(C(=NO)C)C1=CC=C(C)C=C1C MNEUEZGHHHVQCY-UHFFFAOYSA-N 0.000 description 1
- XCHPVOMIGFUUPS-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)-2-hydroxyiminopropyl]amino]acetonitrile Chemical compound N#CCNC(C(=NO)C)C1=CC=C(Br)C=C1 XCHPVOMIGFUUPS-UHFFFAOYSA-N 0.000 description 1
- NDOPHXWIAZIXPR-UHFFFAOYSA-N 2-bromobenzaldehyde Chemical compound BrC1=CC=CC=C1C=O NDOPHXWIAZIXPR-UHFFFAOYSA-N 0.000 description 1
- JTNCEQNHURODLX-UHFFFAOYSA-N 2-phenylethanimidamide Chemical compound NC(=N)CC1=CC=CC=C1 JTNCEQNHURODLX-UHFFFAOYSA-N 0.000 description 1
- ZWUSBSHBFFPRNE-UHFFFAOYSA-N 3,4-dichlorobenzaldehyde Chemical compound ClC1=CC=C(C=O)C=C1Cl ZWUSBSHBFFPRNE-UHFFFAOYSA-N 0.000 description 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 description 1
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- YKGPLGQFEQISRN-UHFFFAOYSA-N CCC(=NO)C(Cl)C1=CC=C(Br)C=C1 Chemical compound CCC(=NO)C(Cl)C1=CC=C(Br)C=C1 YKGPLGQFEQISRN-UHFFFAOYSA-N 0.000 description 1
- UODHLFWPXJGIAL-UHFFFAOYSA-N CCOC(=O)C1=NC(C)=C[N+]([O-])=C1N Chemical compound CCOC(=O)C1=NC(C)=C[N+]([O-])=C1N UODHLFWPXJGIAL-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- XHDBQDSIMYOXBU-UHFFFAOYSA-N N-[1-chloro-1-(2,4-dimethylphenyl)propan-2-ylidene]hydroxylamine Chemical compound ON=C(C)C(Cl)C1=CC=C(C)C=C1C XHDBQDSIMYOXBU-UHFFFAOYSA-N 0.000 description 1
- HEHVCMHKHXZXLJ-UHFFFAOYSA-N N-[1-chloro-1-(4-chlorophenyl)propan-2-ylidene]hydroxylamine Chemical compound ON=C(C)C(Cl)C1=CC=C(Cl)C=C1 HEHVCMHKHXZXLJ-UHFFFAOYSA-N 0.000 description 1
- RFBKSILYIMILDS-UHFFFAOYSA-N ON=C(C)C(Cl)C1=CC=CC(C(F)(F)F)=C1 Chemical compound ON=C(C)C(Cl)C1=CC=CC(C(F)(F)F)=C1 RFBKSILYIMILDS-UHFFFAOYSA-N 0.000 description 1
- ZIUMYUZJGDWWAP-UHFFFAOYSA-N ON=C(C)C(Cl)C1=CC=CC=C1Br Chemical compound ON=C(C)C(Cl)C1=CC=CC=C1Br ZIUMYUZJGDWWAP-UHFFFAOYSA-N 0.000 description 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical class CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 1
- 239000007868 Raney catalyst Substances 0.000 description 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 1
- 229910000564 Raney nickel Inorganic materials 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- QROGIFZRVHSFLM-QHHAFSJGSA-N [(e)-prop-1-enyl]benzene Chemical compound C\C=C\C1=CC=CC=C1 QROGIFZRVHSFLM-QHHAFSJGSA-N 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- PXAJQJMDEXJWFB-UHFFFAOYSA-N acetone oxime Chemical compound CC(C)=NO PXAJQJMDEXJWFB-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 125000006269 biphenyl-2-yl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(*)C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 125000004799 bromophenyl group Chemical group 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 229960003887 dichlorophen Drugs 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- FCZCIXQGZOUIDN-UHFFFAOYSA-N ethyl 2-diethoxyphosphinothioyloxyacetate Chemical compound CCOC(=O)COP(=S)(OCC)OCC FCZCIXQGZOUIDN-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- FRIJBUGBVQZNTB-UHFFFAOYSA-M magnesium;ethane;bromide Chemical compound [Mg+2].[Br-].[CH2-]C FRIJBUGBVQZNTB-UHFFFAOYSA-M 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- JIMRVZGQHAUYPJ-UHFFFAOYSA-N n-(1-chloro-1-phenylpropan-2-ylidene)hydroxylamine Chemical compound ON=C(C)C(Cl)C1=CC=CC=C1 JIMRVZGQHAUYPJ-UHFFFAOYSA-N 0.000 description 1
- BMNDJWSIKZECMH-UHFFFAOYSA-N nitrosyl bromide Chemical compound BrN=O BMNDJWSIKZECMH-UHFFFAOYSA-N 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 150000002923 oximes Chemical group 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
- QROGIFZRVHSFLM-UHFFFAOYSA-N prop-1-enylbenzene Chemical compound CC=CC1=CC=CC=C1 QROGIFZRVHSFLM-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- 125000006308 propyl amino group Chemical group 0.000 description 1
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical compound N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 description 1
- 150000003195 pteridines Chemical class 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 102220132006 rs763918203 Human genes 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/40—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
- C07C15/42—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic
- C07C15/44—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic the hydrocarbon substituent containing a carbon-to-carbon double bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/027,627 US4199525A (en) | 1979-04-06 | 1979-04-06 | Hydroxyimino-substituted aminoacetonitriles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS215054B2 true CS215054B2 (en) | 1982-07-30 |
Family
ID=21838822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS802292A CS215054B2 (en) | 1979-04-06 | 1980-04-02 | Method of making the hydroxyiminosubstituted aminoacetonitriles |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4199525A (it) |
| EP (1) | EP0017494A3 (it) |
| JP (1) | JPS55141459A (it) |
| KR (1) | KR830002679A (it) |
| AT (1) | AT365168B (it) |
| AU (1) | AU5710380A (it) |
| BE (1) | BE882607A (it) |
| BR (1) | BR8002078A (it) |
| CA (1) | CA1118788A (it) |
| CS (1) | CS215054B2 (it) |
| DD (1) | DD150053A5 (it) |
| DK (1) | DK143780A (it) |
| ES (1) | ES490286A0 (it) |
| FI (1) | FI801057A7 (it) |
| FR (1) | FR2453144A1 (it) |
| GB (1) | GB2046752A (it) |
| GR (1) | GR68095B (it) |
| HU (1) | HU178852B (it) |
| IL (1) | IL59762A0 (it) |
| IT (1) | IT1147344B (it) |
| LU (1) | LU82341A1 (it) |
| NZ (1) | NZ193346A (it) |
| OA (1) | OA07371A (it) |
| PH (1) | PH15423A (it) |
| PL (1) | PL123696B1 (it) |
| PT (1) | PT71055A (it) |
| RO (1) | RO79499A (it) |
| TR (1) | TR20651A (it) |
| YU (1) | YU90680A (it) |
| ZA (1) | ZA802002B (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD647235S1 (en) | 2010-03-08 | 2011-10-18 | Hubbell Incorporated | Lighting fixture having struts |
| USD689646S1 (en) | 2012-01-25 | 2013-09-10 | Hubbell Incorporated | Wall mounted light fixture having struts |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3144485A (en) * | 1960-01-20 | 1964-08-11 | Boots Pure Drug Co Ltd | Alpha-(nu-aryl, aralkyl) acetamidoxiones |
-
1979
- 1979-04-06 US US06/027,627 patent/US4199525A/en not_active Expired - Lifetime
-
1980
- 1980-04-02 PH PH23856A patent/PH15423A/en unknown
- 1980-04-02 DK DK143780A patent/DK143780A/da not_active IP Right Cessation
- 1980-04-02 FI FI801057A patent/FI801057A7/fi not_active Application Discontinuation
- 1980-04-02 YU YU00906/80A patent/YU90680A/xx unknown
- 1980-04-02 BR BR8002078A patent/BR8002078A/pt unknown
- 1980-04-02 FR FR8007456A patent/FR2453144A1/fr not_active Withdrawn
- 1980-04-02 ES ES490286A patent/ES490286A0/es active Granted
- 1980-04-02 PT PT71055A patent/PT71055A/pt unknown
- 1980-04-02 CS CS802292A patent/CS215054B2/cs unknown
- 1980-04-02 TR TR20651A patent/TR20651A/xx unknown
- 1980-04-02 NZ NZ193346A patent/NZ193346A/xx unknown
- 1980-04-02 CA CA000349062A patent/CA1118788A/en not_active Expired
- 1980-04-02 AU AU57103/80A patent/AU5710380A/en not_active Abandoned
- 1980-04-02 GR GR61608A patent/GR68095B/el unknown
- 1980-04-03 IL IL59762A patent/IL59762A0/xx unknown
- 1980-04-03 BE BE1/9770A patent/BE882607A/fr unknown
- 1980-04-03 HU HU8080816A patent/HU178852B/hu unknown
- 1980-04-03 EP EP80301086A patent/EP0017494A3/en not_active Withdrawn
- 1980-04-03 GB GB8011364A patent/GB2046752A/en not_active Withdrawn
- 1980-04-03 OA OA57076A patent/OA07371A/xx unknown
- 1980-04-03 ZA ZA00802002A patent/ZA802002B/xx unknown
- 1980-04-03 DD DD80220208A patent/DD150053A5/de unknown
- 1980-04-03 AT AT0184580A patent/AT365168B/de not_active IP Right Cessation
- 1980-04-04 IT IT21230/80A patent/IT1147344B/it active
- 1980-04-04 RO RO80100724A patent/RO79499A/ro unknown
- 1980-04-04 KR KR1019800001428A patent/KR830002679A/ko not_active Withdrawn
- 1980-04-04 LU LU82341A patent/LU82341A1/fr unknown
- 1980-04-04 PL PL1980223265A patent/PL123696B1/pl unknown
- 1980-04-05 JP JP4511580A patent/JPS55141459A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55141459A (en) | 1980-11-05 |
| NZ193346A (en) | 1982-11-23 |
| AT365168B (de) | 1981-12-28 |
| DD150053A5 (de) | 1981-08-12 |
| BE882607A (fr) | 1980-10-03 |
| FI801057A7 (fi) | 1981-01-01 |
| PL123696B1 (en) | 1982-11-30 |
| IL59762A0 (en) | 1980-06-30 |
| AU5710380A (en) | 1980-10-09 |
| EP0017494A3 (en) | 1981-06-10 |
| GB2046752A (en) | 1980-11-19 |
| IT1147344B (it) | 1986-11-19 |
| US4199525A (en) | 1980-04-22 |
| RO79499A (ro) | 1982-07-06 |
| LU82341A1 (fr) | 1980-07-02 |
| PH15423A (en) | 1983-01-07 |
| YU90680A (en) | 1983-02-28 |
| PL223265A1 (it) | 1981-01-30 |
| HU178852B (en) | 1982-07-28 |
| BR8002078A (pt) | 1980-11-25 |
| GR68095B (it) | 1981-10-30 |
| ATA184580A (de) | 1981-05-15 |
| ZA802002B (en) | 1981-11-25 |
| ES8105272A1 (es) | 1981-05-16 |
| FR2453144A1 (fr) | 1980-10-31 |
| EP0017494A2 (en) | 1980-10-15 |
| CA1118788A (en) | 1982-02-23 |
| DK143780A (da) | 1980-10-07 |
| KR830002679A (ko) | 1983-05-30 |
| ES490286A0 (es) | 1981-05-16 |
| IT8021230A0 (it) | 1980-04-04 |
| PT71055A (en) | 1980-05-01 |
| OA07371A (fr) | 1984-06-30 |
| TR20651A (tr) | 1982-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0794420B2 (ja) | 置換フェノキシアセトアルデヒドオキシム類の製造方法 | |
| US10618862B2 (en) | Process for preparing (9e, 11z)-9,11-hexadecadienal | |
| KR960000758B1 (ko) | 광학적 활성 히드록시벤질아민 유도체 및 그의 제조방법 | |
| EP1844019B1 (de) | Verfahren zur herstellung von losartan | |
| CS215054B2 (en) | Method of making the hydroxyiminosubstituted aminoacetonitriles | |
| TAMURA et al. | β-Arylaminoacrolein Derivatives. I. The Investigation of Combes Reaction and the Syntheses of β-Arylaminoacrolein Derivatives as the Possible Reactant | |
| JPH05509319A (ja) | １―アザ―１，３―ブタジエンを経ての置換されたピリジン類の製造方法および１―アザ―１，３―ブタジエン中間体 | |
| US4231962A (en) | 3-Phenoxybenzylideneamines and 3-benzylbenzylideneamines | |
| HU190628B (en) | Process for preparing 3-vinyl-substituted 2,2-dimethyl-cyclopropane-1-carboxylic acids and and their esters | |
| EP0872466B1 (en) | Process for the synthesis of 1,7-diaryl or 1,7-heteroarylheptan-4-ols and synthetic intermediates | |
| JPS643177B2 (it) | ||
| HU217663B (hu) | Javított eljárás cikloalkil- és halogén-alkil-2-amino-fenil-keton-származékok előállítására | |
| EP0790251A2 (de) | Herstellung und Verwendung von (3-Alkoxyphenyl)magnesiumchloriden | |
| KR950013099B1 (ko) | 광학적 활성 화합물의 제조방법. | |
| US4983768A (en) | Process of preparation of phosphinamides applications and new products | |
| EP3704116B1 (en) | Process for the synthesis of 2-benzhydryl-3 quinuclidinone | |
| HU186423B (en) | Process for producing pyrazole | |
| JPH05230026A (ja) | ２−クロロ−５−メチルピリジン誘導体の製造方法 | |
| JP3855686B2 (ja) | ３，３−ジアルコキシ−２−ヒドロキシイミノ誘導体及びその製造法 | |
| JP3804078B2 (ja) | β−ニトロエナミンの製造方法 | |
| CS215055B2 (en) | Method of making the substituted 2-aminopyrazines | |
| JPH07252205A (ja) | オキシアミン類の製造方法 | |
| JPH0558419B2 (it) | ||
| JPS5923314B2 (ja) | 新規ピロ−ル誘導体 | |
| JPH04346991A (ja) | 求核反応受容性化合物のシアノ化方法及び不斉合成用触媒 |