CS201015B2 - Method of producing 1,2-dihydoro-3h-pyrrolo/1,2-/pyrrol--1-carboxylic acids substituted in position 5 - Google Patents

Method of producing 1,2-dihydoro-3h-pyrrolo/1,2-/pyrrol--1-carboxylic acids substituted in position 5 Download PDF

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Publication number
CS201015B2
CS201015B2 CS784851A CS485178A CS201015B2 CS 201015 B2 CS201015 B2 CS 201015B2 CS 784851 A CS784851 A CS 784851A CS 485178 A CS485178 A CS 485178A CS 201015 B2 CS201015 B2 CS 201015B2
Authority
CS
Czechoslovakia
Prior art keywords
pyrrolo
pyrrole
dihydro
added
mixture
Prior art date
Application number
CS784851A
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Czech (cs)
English (en)
Inventor
Horn Van
Pasquale G Gallegra
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25225403&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS201015(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of CS201015B2 publication Critical patent/CS201015B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CS784851A 1977-07-25 1978-07-20 Method of producing 1,2-dihydoro-3h-pyrrolo/1,2-/pyrrol--1-carboxylic acids substituted in position 5 CS201015B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81837777A 1977-07-25 1977-07-25

Publications (1)

Publication Number Publication Date
CS201015B2 true CS201015B2 (en) 1980-10-31

Family

ID=25225403

Family Applications (1)

Application Number Title Priority Date Filing Date
CS784851A CS201015B2 (en) 1977-07-25 1978-07-20 Method of producing 1,2-dihydoro-3h-pyrrolo/1,2-/pyrrol--1-carboxylic acids substituted in position 5

Country Status (27)

Country Link
US (1) US4140698A (es)
EP (1) EP0000649B1 (es)
JP (1) JPS5424889A (es)
AT (1) AT364843B (es)
AU (1) AU515352B2 (es)
CA (1) CA1111431A (es)
CS (1) CS201015B2 (es)
DD (1) DD137229A5 (es)
DE (1) DE2860560D1 (es)
DK (1) DK146720C (es)
ES (1) ES472002A1 (es)
FI (1) FI64597C (es)
GR (1) GR63733B (es)
HK (1) HK17186A (es)
HU (1) HU178354B (es)
IE (1) IE47138B1 (es)
IL (1) IL55181A (es)
IT (1) IT1160443B (es)
MY (1) MY8800142A (es)
NO (2) NO166863C (es)
NZ (1) NZ187924A (es)
PL (1) PL111419B1 (es)
PT (1) PT68328A (es)
SG (1) SG31884G (es)
SU (1) SU1138029A3 (es)
YU (1) YU40717B (es)
ZA (1) ZA784216B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
EP0034481B1 (en) * 1980-02-14 1984-05-30 Grigg, Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4397862A (en) * 1981-10-13 1983-08-09 Syntex (U.S.A.) Inc. Gastrointestinal sparing thioester drugs
WO1983001382A1 (en) * 1981-10-13 1983-04-28 Mroszczak, Edward Gastrointestinal sparing thioester pro-drugs
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
EP0117675B1 (en) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran and benzothiophene-carboxylic-acid derivatives
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
JPH09503997A (ja) * 1993-07-08 1997-04-22 シグナス，インコーポレイテッド モノリシックなマトリックス経皮送達システム
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
JP2002520313A (ja) * 1998-07-10 2002-07-09 マリンクロッド・インコーポレイテッド ケトロラクの製造に有用な化合物の合成

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539789A (en) * 1976-07-14 1978-01-28 Syntex Inc Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative
US4087539A (en) * 1976-07-14 1978-05-02 Syntex (U.S.A.) Inc. 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof

Also Published As

Publication number Publication date
YU174178A (en) 1983-01-21
FI64597C (fi) 1983-12-12
FI64597B (fi) 1983-08-31
GR63733B (en) 1979-12-04
CA1111431A (en) 1981-10-27
AU515352B2 (en) 1981-04-02
HK17186A (en) 1986-03-21
NO155244B (no) 1986-11-24
ES472002A1 (es) 1984-07-16
EP0000649B1 (en) 1981-03-25
DD137229A5 (de) 1979-08-22
AT364843B (de) 1981-11-25
DE2860560D1 (en) 1981-04-16
FI782307A (fi) 1979-01-26
DK146720C (da) 1984-08-20
ATA528978A (de) 1981-04-15
NO851935L (no) 1979-01-26
IL55181A0 (en) 1978-09-29
NO782545L (no) 1979-01-26
AU3826978A (en) 1980-01-31
US4140698A (en) 1979-02-20
MY8800142A (en) 1988-12-31
JPS6337793B2 (es) 1988-07-27
NO166863C (no) 1991-09-11
NZ187924A (en) 1980-03-05
PL111419B1 (en) 1980-08-30
IT1160443B (it) 1987-03-11
ZA784216B (en) 1980-02-27
HU178354B (en) 1982-04-28
IL55181A (en) 1981-12-31
NO166863B (no) 1991-06-03
YU40717B (en) 1986-04-30
DK325078A (da) 1979-01-26
IE781473L (en) 1979-01-25
IE47138B1 (en) 1983-12-28
IT7868765A0 (it) 1978-07-24
PL208576A1 (pl) 1979-05-07
EP0000649A1 (en) 1979-02-07
SU1138029A3 (ru) 1985-01-30
NO155244C (no) 1987-03-04
SG31884G (en) 1985-09-13
JPS5424889A (en) 1979-02-24
PT68328A (en) 1978-08-01
DK146720B (da) 1983-12-12

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