CS195343B2 - Method of producing derivatives of dimere indol-dihydro-indoldiones - Google Patents

Method of producing derivatives of dimere indol-dihydro-indoldiones Download PDF

Info

Publication number
CS195343B2
CS195343B2 CS777939A CS793977A CS195343B2 CS 195343 B2 CS195343 B2 CS 195343B2 CS 777939 A CS777939 A CS 777939A CS 793977 A CS793977 A CS 793977A CS 195343 B2 CS195343 B2 CS 195343B2
Authority
CS
Czechoslovakia
Prior art keywords
vlb
formula
methyl
isocyanate
apos
Prior art date
Application number
CS777939A
Other languages
Czech (cs)
English (en)
Inventor
Jean C Miller
Gerald E Gutowski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS195343B2 publication Critical patent/CS195343B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
CS777939A 1976-12-06 1977-11-30 Method of producing derivatives of dimere indol-dihydro-indoldiones CS195343B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/747,575 US4096148A (en) 1976-12-06 1976-12-06 Oxazolidinedione derivatives of Vinca alkaloids

Publications (1)

Publication Number Publication Date
CS195343B2 true CS195343B2 (en) 1980-01-31

Family

ID=25005690

Family Applications (2)

Application Number Title Priority Date Filing Date
CS777940A CS195344B2 (en) 1976-12-06 1977-11-30 Method of producing spirooxazolidindiones
CS777939A CS195343B2 (en) 1976-12-06 1977-11-30 Method of producing derivatives of dimere indol-dihydro-indoldiones

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS777940A CS195344B2 (en) 1976-12-06 1977-11-30 Method of producing spirooxazolidindiones

Country Status (31)

Country Link
US (1) US4096148A (pl)
JP (1) JPS5371100A (pl)
AR (1) AR218467A1 (pl)
AT (2) AT353987B (pl)
AU (1) AU513936B2 (pl)
BE (1) BE861417A (pl)
BG (2) BG33437A3 (pl)
CA (2) CA1082180A (pl)
CH (2) CH632516A5 (pl)
CS (2) CS195344B2 (pl)
DD (2) DD134228A5 (pl)
DE (1) DE2753791A1 (pl)
DK (2) DK145001C (pl)
ES (2) ES464765A1 (pl)
FR (1) FR2372839A1 (pl)
GB (1) GB1590649A (pl)
GR (2) GR67244B (pl)
HK (1) HK57281A (pl)
HU (2) HU180724B (pl)
IE (1) IE46105B1 (pl)
IL (1) IL53506A (pl)
MX (1) MX4326E (pl)
MY (1) MY8200176A (pl)
NL (1) NL7713336A (pl)
NZ (1) NZ185818A (pl)
PL (2) PL110671B1 (pl)
PT (2) PT67342B (pl)
RO (2) RO75391A (pl)
SE (2) SE436036B (pl)
SU (2) SU865127A3 (pl)
ZA (1) ZA777237B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
US4357334A (en) * 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
GR81790B (pl) * 1983-04-29 1984-12-12 Omnichem Sa
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT649883A (pl) * 1960-05-24
HU165986B (pl) * 1973-02-16 1974-12-28
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid

Also Published As

Publication number Publication date
GR67243B (pl) 1981-06-25
SU843753A3 (ru) 1981-06-30
BE861417A (fr) 1978-06-02
ATA868877A (de) 1979-05-15
CH634076A5 (de) 1983-01-14
ES464765A1 (es) 1979-01-01
MX4326E (es) 1982-03-24
DK541177A (da) 1978-06-07
IL53506A (en) 1981-09-13
SU865127A3 (ru) 1981-09-15
NL7713336A (nl) 1978-06-08
AU513936B2 (en) 1981-01-15
RO75391A (ro) 1980-11-30
BG33436A3 (en) 1983-02-15
PL110671B1 (en) 1980-07-31
CA1082180A (en) 1980-07-22
HK57281A (en) 1981-11-27
SE7713586L (sv) 1978-06-07
GR67244B (pl) 1981-06-25
AU3123077A (en) 1979-06-14
HU180725B (en) 1983-04-29
IE46105B1 (en) 1983-02-23
PL106522B1 (pl) 1979-12-31
IL53506A0 (en) 1978-03-10
DD134228A5 (de) 1979-02-14
SE436036B (sv) 1984-11-05
DK541077A (da) 1978-06-07
DK144916B (da) 1982-07-05
ZA777237B (en) 1979-07-25
PL202660A1 (pl) 1978-08-28
RO74137A (ro) 1981-08-30
PL202659A1 (pl) 1978-12-04
IE46105L (en) 1978-06-06
GB1590649A (en) 1981-06-03
PT67343A (en) 1977-12-01
DE2753791A1 (de) 1978-06-08
DK145001B (da) 1982-07-26
PT67342B (en) 1979-04-26
SE435930B (sv) 1984-10-29
NZ185818A (en) 1979-12-11
JPS625160B2 (pl) 1987-02-03
SE7713587L (sv) 1978-06-07
US4096148A (en) 1978-06-20
HU180724B (en) 1983-04-29
PT67342A (en) 1977-12-01
JPS5371100A (en) 1978-06-24
BG33437A3 (bg) 1983-02-15
CS195344B2 (en) 1980-01-31
ES464764A1 (es) 1979-01-01
FR2372839A1 (fr) 1978-06-30
DD134227A5 (de) 1979-02-14
DK145001C (da) 1982-12-27
CA1103664A (en) 1981-06-23
DK144916C (da) 1982-12-06
FR2372839B1 (pl) 1981-11-06
PT67343B (en) 1979-04-26
ATA868777A (de) 1980-08-15
DE2753791C2 (pl) 1990-08-02
AR218467A1 (es) 1980-06-13
AT353987B (de) 1979-12-10
AT361638B (de) 1981-03-25
MY8200176A (en) 1982-12-31
CH632516A5 (de) 1982-10-15

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