CS103091A3 - Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use - Google Patents

Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use Download PDF

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Publication number
CS103091A3
CS103091A3 CS911030A CS103091A CS103091A3 CS 103091 A3 CS103091 A3 CS 103091A3 CS 911030 A CS911030 A CS 911030A CS 103091 A CS103091 A CS 103091A CS 103091 A3 CS103091 A3 CS 103091A3
Authority
CS
Czechoslovakia
Prior art keywords
substituted
benzhydrylamines
protected
preparation
peptide
Prior art date
Application number
CS911030A
Other languages
Czech (cs)
English (en)
Inventor
Marcel Ing Patek
Michal Ing Csc Lebl
Original Assignee
Ustav Organicke Chemie A Bioch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ustav Organicke Chemie A Bioch filed Critical Ustav Organicke Chemie A Bioch
Priority to CS911030A priority Critical patent/CS103091A3/cs
Priority to US08/137,048 priority patent/US5684131A/en
Priority to JP51027792A priority patent/JP3634356B2/ja
Priority to ES92917473T priority patent/ES2089548T3/es
Priority to DE69211990T priority patent/DE69211990T2/de
Priority to DK92917473.8T priority patent/DK0579785T3/da
Priority to PCT/US1992/002962 priority patent/WO1992018144A1/en
Priority to EP92917473A priority patent/EP0579785B1/en
Priority to HU9302867A priority patent/HU222239B1/hu
Priority to AT92917473T priority patent/ATE139995T1/de
Priority to CA002109433A priority patent/CA2109433C/en
Publication of CS103091A3 publication Critical patent/CS103091A3/cs
Priority to GR960401664T priority patent/GR3020463T3/el
Priority to US08/960,882 priority patent/US5891995A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS911030A 1991-04-12 1991-04-12 Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use CS103091A3 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CS911030A CS103091A3 (en) 1991-04-12 1991-04-12 Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use
DK92917473.8T DK0579785T3 (da) 1991-04-12 1992-04-10 Substituerede benzhydrylaminer som tlslutningsmolekyler til fastfasepeptidsyntese
JP51027792A JP3634356B2 (ja) 1991-04-12 1992-04-10 固相ペプチド合成用ハンドルとしての置換ベンズヒドリルアミン
ES92917473T ES2089548T3 (es) 1991-04-12 1992-04-10 Benzhidrilaminas sustituidas como agentes de conexion para sintesis de peptidos en fase solida.
DE69211990T DE69211990T2 (de) 1991-04-12 1992-04-10 Substituierte benzhydrylamine als anknüpfungsmoleküle bei der festphasenpeptidsynthese
US08/137,048 US5684131A (en) 1991-04-12 1992-04-10 Substituted benzhydrylamines as handles for solid phase peptide synthesis
PCT/US1992/002962 WO1992018144A1 (en) 1991-04-12 1992-04-10 Substituted benzhydrylamines as handles for solid phase peptide synthesis
EP92917473A EP0579785B1 (en) 1991-04-12 1992-04-10 Substituted benzhydrylamines as handles for solid phase peptide synthesis
HU9302867A HU222239B1 (hu) 1991-04-12 1992-04-10 Eljárás szilárd fázisú peptidszintézisben alkalmazható szubsztituált benzhidril-amin kapcsoló vegyületek és ezeket tartalmazó konjugátumok előállítására, valamint az azokkal végzett peptidszintézisre
AT92917473T ATE139995T1 (de) 1991-04-12 1992-04-10 Substituierte benzhydrylamine als anknüpfungsmoleküle bei der festphasenpeptidsynthese
CA002109433A CA2109433C (en) 1991-04-12 1992-04-10 Substituted benzhydrylamines as handles for solid phase peptide synthesis
GR960401664T GR3020463T3 (en) 1991-04-12 1996-07-04 Substituted benzhydrylamines as handles for solid phase peptide synthesis
US08/960,882 US5891995A (en) 1991-04-12 1997-10-30 Substituted benzhydrylamines as handles for solid phase peptide synthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS911030A CS103091A3 (en) 1991-04-12 1991-04-12 Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Publications (1)

Publication Number Publication Date
CS103091A3 true CS103091A3 (en) 1992-10-14

Family

ID=5343649

Family Applications (1)

Application Number Title Priority Date Filing Date
CS911030A CS103091A3 (en) 1991-04-12 1991-04-12 Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Country Status (12)

Country Link
US (2) US5684131A (da)
EP (1) EP0579785B1 (da)
JP (1) JP3634356B2 (da)
AT (1) ATE139995T1 (da)
CA (1) CA2109433C (da)
CS (1) CS103091A3 (da)
DE (1) DE69211990T2 (da)
DK (1) DK0579785T3 (da)
ES (1) ES2089548T3 (da)
GR (1) GR3020463T3 (da)
HU (1) HU222239B1 (da)
WO (1) WO1992018144A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0751779B1 (en) * 1993-06-21 2001-12-19 Selectide Corporation Selectively cleavable linkers based on iminodiacetic acid ester bonds
ES2115543B1 (es) * 1996-08-06 1999-02-16 Lipotec Sa Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma.
GB9620202D0 (en) * 1996-09-27 1996-11-13 Rhone Poulenc Agriculture New herbicides
GB9621985D0 (en) 1996-10-22 1996-12-18 Peptide Therapeutics Ltd A solid-phase technology for the preparation of libraries of bi-directally functionalised drug-like molecules
AU1589099A (en) * 1997-11-18 1999-06-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Functionalized resin for the synthesis of amides and peptides
EP1034154A1 (en) * 1997-11-26 2000-09-13 Peptide Therapeutics Limited A solid-phase technology for the preparation of combinatorial libraries through amide-bond anchoring
EP2275540B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963701A (en) * 1972-04-17 1976-06-15 Richardson-Merrell Inc. Substituted benzhydryl lactamimide derivatives
FR2595695B1 (fr) * 1986-03-12 1988-12-02 Synthelabo Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
EP0274998A3 (en) * 1986-12-24 1988-12-14 Monsanto Company Resin support for solid phase peptide synthesis
EP0322348B1 (de) * 1987-12-22 1994-02-02 Hoechst Aktiengesellschaft Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法

Also Published As

Publication number Publication date
HUT70198A (en) 1995-09-28
CA2109433C (en) 2006-07-11
CA2109433A1 (en) 1992-10-13
ATE139995T1 (de) 1996-07-15
GR3020463T3 (en) 1996-10-31
JP3634356B2 (ja) 2005-03-30
JPH06506940A (ja) 1994-08-04
DE69211990T2 (de) 1996-11-28
US5684131A (en) 1997-11-04
ES2089548T3 (es) 1996-10-01
HU222239B1 (hu) 2003-05-28
EP0579785A4 (en) 1994-07-06
EP0579785B1 (en) 1996-07-03
DK0579785T3 (da) 1996-10-28
HU9302867D0 (en) 1993-12-28
DE69211990D1 (de) 1996-08-08
WO1992018144A1 (en) 1992-10-29
EP0579785A1 (en) 1994-01-26
US5891995A (en) 1999-04-06

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