ES2089548T3 - Benzhidrilaminas sustituidas como agentes de conexion para sintesis de peptidos en fase solida. - Google Patents

Benzhidrilaminas sustituidas como agentes de conexion para sintesis de peptidos en fase solida.

Info

Publication number
ES2089548T3
ES2089548T3 ES92917473T ES92917473T ES2089548T3 ES 2089548 T3 ES2089548 T3 ES 2089548T3 ES 92917473 T ES92917473 T ES 92917473T ES 92917473 T ES92917473 T ES 92917473T ES 2089548 T3 ES2089548 T3 ES 2089548T3
Authority
ES
Spain
Prior art keywords
pct
solid phase
substituted
peptide synthesis
benzhidrilamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92917473T
Other languages
English (en)
Inventor
Michal Lebl
Marcel Patek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2089548T3 publication Critical patent/ES2089548T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION ESTA DIRIGIDA A UN NUEVO "CONDUCTOR" DE SINTESIS DE PEPTIDOS EN FASE SOLIDA. LOS CONDUCTORES PUEDEN CONVERTIRSE DE UNA FORMA ESTABLE A UNA NO ESTABLE, PERMITIENDO LA DIVISION DE UN PEPTIDO AMIDA DESDE EL SOPORTE TRAS LA SINTESIS, BAJO CONDICIONES DE CALMA, Y TRAS LA DESPROTECCION DE CADENAS DE AMINOACIDOS. LOS CONDUCTORES SE BASAN EN LA CADENA BENZHIDRILAMINA SUSTITUIDA.
ES92917473T 1991-04-12 1992-04-10 Benzhidrilaminas sustituidas como agentes de conexion para sintesis de peptidos en fase solida. Expired - Lifetime ES2089548T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS911030A CS103091A3 (en) 1991-04-12 1991-04-12 Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Publications (1)

Publication Number Publication Date
ES2089548T3 true ES2089548T3 (es) 1996-10-01

Family

ID=5343649

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92917473T Expired - Lifetime ES2089548T3 (es) 1991-04-12 1992-04-10 Benzhidrilaminas sustituidas como agentes de conexion para sintesis de peptidos en fase solida.

Country Status (12)

Country Link
US (2) US5684131A (es)
EP (1) EP0579785B1 (es)
JP (1) JP3634356B2 (es)
AT (1) ATE139995T1 (es)
CA (1) CA2109433C (es)
CS (1) CS103091A3 (es)
DE (1) DE69211990T2 (es)
DK (1) DK0579785T3 (es)
ES (1) ES2089548T3 (es)
GR (1) GR3020463T3 (es)
HU (1) HU222239B1 (es)
WO (1) WO1992018144A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0751779B1 (en) * 1993-06-21 2001-12-19 Selectide Corporation Selectively cleavable linkers based on iminodiacetic acid ester bonds
ES2115543B1 (es) * 1996-08-06 1999-02-16 Lipotec Sa Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma.
GB9620202D0 (en) * 1996-09-27 1996-11-13 Rhone Poulenc Agriculture New herbicides
GB9621985D0 (en) 1996-10-22 1996-12-18 Peptide Therapeutics Ltd A solid-phase technology for the preparation of libraries of bi-directally functionalised drug-like molecules
AU1589099A (en) * 1997-11-18 1999-06-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Functionalized resin for the synthesis of amides and peptides
EP1034154A1 (en) * 1997-11-26 2000-09-13 Peptide Therapeutics Limited A solid-phase technology for the preparation of combinatorial libraries through amide-bond anchoring
EP2275540B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963701A (en) * 1972-04-17 1976-06-15 Richardson-Merrell Inc. Substituted benzhydryl lactamimide derivatives
FR2595695B1 (fr) * 1986-03-12 1988-12-02 Synthelabo Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
EP0274998A3 (en) * 1986-12-24 1988-12-14 Monsanto Company Resin support for solid phase peptide synthesis
EP0322348B1 (de) * 1987-12-22 1994-02-02 Hoechst Aktiengesellschaft Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法

Also Published As

Publication number Publication date
HUT70198A (en) 1995-09-28
CA2109433C (en) 2006-07-11
CS103091A3 (en) 1992-10-14
CA2109433A1 (en) 1992-10-13
ATE139995T1 (de) 1996-07-15
GR3020463T3 (en) 1996-10-31
JP3634356B2 (ja) 2005-03-30
JPH06506940A (ja) 1994-08-04
DE69211990T2 (de) 1996-11-28
US5684131A (en) 1997-11-04
HU222239B1 (hu) 2003-05-28
EP0579785A4 (en) 1994-07-06
EP0579785B1 (en) 1996-07-03
DK0579785T3 (da) 1996-10-28
HU9302867D0 (en) 1993-12-28
DE69211990D1 (de) 1996-08-08
WO1992018144A1 (en) 1992-10-29
EP0579785A1 (en) 1994-01-26
US5891995A (en) 1999-04-06

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