CR8288A - 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer - Google Patents

6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer

Info

Publication number
CR8288A
CR8288A CR8288A CR8288A CR8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A
Authority
CR
Costa Rica
Prior art keywords
phenyl
replaced
triazolopirimidinas
anticancer agents
compounds
Prior art date
Application number
CR8288A
Other languages
English (en)
Spanish (es)
Inventor
Zhang Nan
Kaloustian Semiramis
Hiep Nguyen Thai
Tong Wei
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8288A publication Critical patent/CR8288A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CR8288A 2003-09-24 2006-03-14 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer CR8288A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
CR8288A true CR8288A (es) 2006-10-04

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8288A CR8288A (es) 2003-09-24 2006-03-14 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer

Country Status (30)

Country Link
US (1) US7507739B2 (cg-RX-API-DMAC7.html)
EP (1) EP1680425B1 (cg-RX-API-DMAC7.html)
JP (1) JP2007506744A (cg-RX-API-DMAC7.html)
KR (1) KR20060098368A (cg-RX-API-DMAC7.html)
CN (1) CN100519559C (cg-RX-API-DMAC7.html)
AR (1) AR045810A1 (cg-RX-API-DMAC7.html)
AU (1) AU2004276240A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0414700A (cg-RX-API-DMAC7.html)
CA (1) CA2539252A1 (cg-RX-API-DMAC7.html)
CO (1) CO5690598A2 (cg-RX-API-DMAC7.html)
CR (1) CR8288A (cg-RX-API-DMAC7.html)
CY (1) CY1106392T1 (cg-RX-API-DMAC7.html)
DE (1) DE602004004295T8 (cg-RX-API-DMAC7.html)
DK (1) DK1680425T3 (cg-RX-API-DMAC7.html)
EC (1) ECSP066458A (cg-RX-API-DMAC7.html)
ES (1) ES2279452T3 (cg-RX-API-DMAC7.html)
GT (1) GT200400190A (cg-RX-API-DMAC7.html)
IL (1) IL174281A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA06003206A (cg-RX-API-DMAC7.html)
NO (1) NO20061318L (cg-RX-API-DMAC7.html)
PA (1) PA8613301A1 (cg-RX-API-DMAC7.html)
PE (1) PE20050433A1 (cg-RX-API-DMAC7.html)
PL (1) PL1680425T3 (cg-RX-API-DMAC7.html)
PT (1) PT1680425E (cg-RX-API-DMAC7.html)
RU (1) RU2006107579A (cg-RX-API-DMAC7.html)
SA (1) SA04250302A (cg-RX-API-DMAC7.html)
SI (1) SI1680425T1 (cg-RX-API-DMAC7.html)
TW (1) TW200512211A (cg-RX-API-DMAC7.html)
WO (1) WO2005030775A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200602387B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
NZ523807A (en) * 2000-06-30 2004-09-24 Wyeth Corp Substituted-triazolopyrimidines as anticancer agents
WO2005030775A1 (en) 2003-09-24 2005-04-07 Wyeth Holdings Corporation 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
WO2006138180A1 (en) * 2005-06-13 2006-12-28 Wyeth Tubulin inhibitor and process for its preparation
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
US20090131708A1 (en) * 2005-06-27 2009-05-21 Basf Aktiengesellschaft Method For Production of Substituted Phenylmalonate Esters, Intermediate Compounds and The Use Thereof for production of 5, 7-dihydroxy-6-(2,4,5-trifluorophenyl)-(1,2,4)triazolo(1,5-A)pyrimidines
JP2009519952A (ja) * 2005-12-16 2009-05-21 ワイス トリアゾロピリミジン化合物の凍結乾燥組成物
CN101370813A (zh) * 2005-12-16 2009-02-18 惠氏公司 用作抗癌药物的6-[(取代的)苯基]三唑并嘧啶类的二聚体和加合物
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
EP3219207A1 (en) * 2012-09-19 2017-09-20 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
US20230167121A1 (en) * 2020-04-14 2023-06-01 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (cg-RX-API-DMAC7.html) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
TW258648B (cg-RX-API-DMAC7.html) 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
DK0984919T3 (da) 1997-03-18 2003-05-12 Basf Ag Fremgangsmåde til fremstilling af arylmalonater
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
CZ292964B6 (cs) 1998-02-11 2004-01-14 Wyeth Holdings Corporation Triazolopyrimidiny, způsob jejich přípravy, fungicidní kompozice s jejich obsahem, způsob potírání hub a použití
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
ATE299505T1 (de) 1998-03-23 2005-07-15 Basf Ag Fungizide 6-(2-halo-4-alkoxyphenyl)- triazolopyrimidine
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
SI0988790T1 (en) 1998-09-25 2003-10-31 Basf Aktiengesellschaft Fungicidal mixtures
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
HUP0103741A3 (en) 1998-09-25 2004-09-28 Basf Ag Non-aqueous suspension concentrate
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US6521628B1 (en) 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
NZ523807A (en) * 2000-06-30 2004-09-24 Wyeth Corp Substituted-triazolopyrimidines as anticancer agents
AR031396A1 (es) 2000-08-25 2003-09-24 Basf Ag Una formulacion fungicida acuosa concentrada para aplicar a las plantas, un metodo de aplicacion de dicha composicion y un kit para la preparacion de una mezcla de aspersion que contiene dicha formulacion
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
AU2002221831A1 (en) 2000-11-13 2002-05-21 Basf Aktiengesellschaft 7-(r)-amino-triazolopyrimidines, the production thereof and use of the same for combating phytopathogenic fungi
ES2226968T3 (es) 2000-12-06 2005-04-01 Wyeth 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas.
DE10063115A1 (de) 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
NZ528745A (en) 2001-04-11 2005-03-24 Basf Ag 5-halogen-6-phenyl-7-fluoralkylamino-triazolopyrimidines as fungicides and their preparation process
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
JP2005504743A (ja) 2001-07-18 2005-02-17 ビーエーエスエフ アクチェンゲゼルシャフト 殺菌薬としての置換された６−（２−メトキシ−フェニル）−トリアゾロピリミジン
WO2005030775A1 (en) 2003-09-24 2005-04-07 Wyeth Holdings Corporation 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents

Also Published As

Publication number Publication date
KR20060098368A (ko) 2006-09-18
AR045810A1 (es) 2005-11-16
MXPA06003206A (es) 2006-06-23
SI1680425T1 (sl) 2007-04-30
PT1680425E (pt) 2007-02-28
IL174281A0 (en) 2006-08-01
DE602004004295D1 (de) 2007-02-22
EP1680425A1 (en) 2006-07-19
CN100519559C (zh) 2009-07-29
PA8613301A1 (es) 2005-11-25
ECSP066458A (es) 2006-09-18
US7507739B2 (en) 2009-03-24
WO2005030775A1 (en) 2005-04-07
EP1680425B1 (en) 2007-01-10
CN1867569A (zh) 2006-11-22
DE602004004295T2 (de) 2007-06-06
CA2539252A1 (en) 2005-04-07
HK1090374A1 (en) 2006-12-22
DK1680425T3 (da) 2007-03-19
CO5690598A2 (es) 2006-10-31
US20050090508A1 (en) 2005-04-28
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
JP2007506744A (ja) 2007-03-22
PE20050433A1 (es) 2005-07-21
AU2004276240A1 (en) 2005-04-07
CY1106392T1 (el) 2011-10-12
GT200400190A (es) 2005-05-02
ES2279452T3 (es) 2007-08-16
DE602004004295T8 (de) 2007-09-20
NO20061318L (no) 2006-04-21
ZA200602387B (en) 2008-11-26
TW200512211A (en) 2005-04-01
BRPI0414700A (pt) 2006-11-14
RU2006107579A (ru) 2007-10-27

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Legal Events

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FA Abandonment or withdrawal (granting procedure)