CR6774A - Sustitutos arilicos de piridinas, pirimidinas, pirazinas, triazinas y el uso de estos - Google Patents
Sustitutos arilicos de piridinas, pirimidinas, pirazinas, triazinas y el uso de estosInfo
- Publication number
- CR6774A CR6774A CR6774A CR6774A CR6774A CR 6774 A CR6774 A CR 6774A CR 6774 A CR6774 A CR 6774A CR 6774 A CR6774 A CR 6774A CR 6774 A CR6774 A CR 6774A
- Authority
- CR
- Costa Rica
- Prior art keywords
- treatment
- pyridines
- prevention
- substitutes
- pirazins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/24—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to three ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Luminescent Compositions (AREA)
Abstract
Consiste en sustitutos arilicos de piridinas, pirimidinas, pirazinas y triazinas de la formula I o una sal farmaceuticamente aceptable, prodroga o solvato de esta, donde A1, A2, A3, R1-R4, X y Y se colocan en la especificacion. El invento tambien esta dirigido al uso de compuestos de la formula I para el tratamiento de dano neuronal despues de isquemias focales y globales, para el tratamiento o la prevencion de condiciones neurodegenerativas tales como esclerosis amiotrofica lateral (EAL), y para el tratamiento, prevencion o disminucion del dolor tanto agudo como cronico, como agentes antitinnitus, como anticonvulsivos, y como depresores antimaniacos, como anestesicos locales, como antiarritmicos y para el tratamiento de la prevencion de nueropatia diabetica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18818800P | 2000-03-10 | 2000-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR6774A true CR6774A (es) | 2003-09-16 |
Family
ID=22692096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR6774A CR6774A (es) | 2000-03-10 | 2002-10-09 | Sustitutos arilicos de piridinas, pirimidinas, pirazinas, triazinas y el uso de estos |
Country Status (34)
Country | Link |
---|---|
US (3) | US6867210B2 (es) |
EP (1) | EP1265866B1 (es) |
JP (2) | JP4359016B2 (es) |
KR (1) | KR20030011792A (es) |
CN (1) | CN1422254A (es) |
AP (1) | AP1404A (es) |
AR (1) | AR029489A1 (es) |
AT (1) | ATE474828T1 (es) |
AU (2) | AU4562001A (es) |
BR (1) | BR0108918A (es) |
CA (1) | CA2400945C (es) |
CR (1) | CR6774A (es) |
CY (1) | CY1110809T1 (es) |
CZ (1) | CZ20032228A3 (es) |
DE (1) | DE60142613D1 (es) |
DK (1) | DK1265866T3 (es) |
EA (1) | EA005770B1 (es) |
ES (1) | ES2348974T3 (es) |
HR (1) | HRP20020805A2 (es) |
HU (1) | HUP0300466A3 (es) |
IL (2) | IL151417A0 (es) |
IS (1) | IS6518A (es) |
MA (1) | MA26893A1 (es) |
MX (1) | MXPA02008733A (es) |
NO (1) | NO20024308L (es) |
NZ (1) | NZ521866A (es) |
OA (1) | OA12677A (es) |
PL (1) | PL357272A1 (es) |
PT (1) | PT1265866E (es) |
SI (1) | SI1265866T1 (es) |
SK (1) | SK10692003A3 (es) |
WO (1) | WO2001068612A2 (es) |
YU (1) | YU67902A (es) |
ZA (1) | ZA200207069B (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
CA2453633A1 (en) * | 2001-07-16 | 2003-01-30 | Euro-Celtique S.A. | Aryl substituted thiazolidinones and the use thereof |
AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
US20030124174A1 (en) * | 2001-10-25 | 2003-07-03 | Endo Pharmaceuticals, Inc | Method for treating non-neuropathic pain |
ATE434610T1 (de) * | 2002-03-13 | 2009-07-15 | Euro Celtique Sa | Aryl substituierte pyrimidine und deren verwendung |
BR0313352A (pt) * | 2002-07-31 | 2005-07-12 | Euro Celtique Sa | Composto, composições farmacêuticas, método para a produção de um composto, método para o tratamento, prevenção ou a melhora de um distúrbio e método para o tratamento de um mamìfero |
US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
US20040152696A1 (en) * | 2002-08-01 | 2004-08-05 | Euro-Celtique S.A. | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
SE0203752D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
EP1594439A2 (en) * | 2003-02-13 | 2005-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LEVELS IN THE HYPOTHALAMUS |
MY142651A (en) | 2003-03-18 | 2010-12-15 | Merck Sharp & Dohme | Biaryl substituted triazoles as sodium channel blockers |
CN1798738A (zh) | 2003-04-03 | 2006-07-05 | 麦克公司 | 作为钠通道阻滞剂的联芳基取代吡唑 |
WO2004111011A2 (en) * | 2003-05-30 | 2004-12-23 | Euro-Celtique S.A. | Synthesis of 2-aryl pyrimidine 4-carboxylic acid amides |
BRPI0416319A (pt) | 2003-11-10 | 2007-01-09 | Merck & Co Inc | composto, composição farmacêutica, métodos de tratamento ou prevenção da dor, das sìndromes, e de doença, e, métodos de administrar anestesia local, e para a neuroproteção sob condições isquêmicas |
US20050112183A1 (en) * | 2003-11-25 | 2005-05-26 | Galer Bradley S. | Compositions and methods for treating neuropathic sensory loss |
CA2574600C (en) | 2004-07-23 | 2010-08-31 | Pfizer Inc. | Pyridine derivatives |
WO2006041922A2 (en) * | 2004-10-08 | 2006-04-20 | Dara Biosciences, Inc. | Agents and methods for administration to the central nervous system |
US20060178388A1 (en) * | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
US20070026079A1 (en) * | 2005-02-14 | 2007-02-01 | Louis Herlands | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels |
US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
EP2183241B1 (en) | 2007-05-03 | 2012-12-19 | Pfizer Limited | 2-pyridine carboxamide derivatives as sodium channel modulators |
CN102300862B (zh) | 2008-12-19 | 2016-11-23 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的化合物 |
EP2582666B1 (en) | 2010-06-16 | 2014-08-13 | Purdue Pharma L.P. | Aryl substituted indoles and their use as blockers of sodium channels |
US9120752B2 (en) | 2010-07-16 | 2015-09-01 | Purdue Pharma, L.P. | Pyridine compounds as sodium channel blockers |
EP2616441B1 (en) | 2010-09-17 | 2019-08-07 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
US9045435B2 (en) | 2010-10-05 | 2015-06-02 | Purdue Pharma, L.P. | Quinazoline compounds as sodium channel blockers |
CN103429571A (zh) | 2010-12-22 | 2013-12-04 | 普渡制药公司 | 作为钠通道阻断剂的取代吡啶 |
SI2753606T1 (sl) * | 2011-09-02 | 2017-10-30 | Purdue Pharma Lp | Pirimidini kot blokatorji natrijevih kanalov |
AU2012321111A1 (en) | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
AU2012324010A1 (en) | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
WO2013072758A1 (en) * | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
AU2013203824A1 (en) | 2012-03-16 | 2013-10-03 | Purdue Pharma L.P. | Substituted pyridines and pryimidines as sodium channel blockers |
US9714252B2 (en) | 2012-12-20 | 2017-07-25 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
ES2859148T3 (es) | 2013-03-04 | 2021-10-01 | Purdue Pharma Lp | Carboxamidas de pirimidina como bloqueantes de los canales de sodio |
US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
EP2968307A4 (en) * | 2013-03-15 | 2017-01-04 | Purdue Pharma LP | Carboxamide derivatives and use thereof |
US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
WO2015031036A1 (en) | 2013-08-26 | 2015-03-05 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
EP3083606B1 (en) | 2013-12-20 | 2020-10-28 | Purdue Pharma LP | Pyrimidines and use thereof |
US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
EP3087059B1 (en) | 2013-12-23 | 2020-04-29 | Purdue Pharma L.P. | Indazoles and use thereof |
EP3089978B1 (en) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
US10047075B2 (en) | 2014-01-24 | 2018-08-14 | Purdue Pharma L.P. | Pyridines and pyrimidines and use thereof |
AU2015217185B2 (en) | 2014-02-12 | 2018-04-05 | Purdue Pharma L.P. | Isoquinoline derivatives and use thereof |
US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
CA2948144A1 (en) | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
WO2015177367A1 (en) | 2014-05-23 | 2015-11-26 | Active Biotech Ab | Novel compounds useful as s100-inhibitors |
EP3154972A4 (en) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
CA2952124A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
CN104387331A (zh) * | 2014-10-27 | 2015-03-04 | 湖南华腾制药有限公司 | 一种吡嗪衍生物的制备方法 |
JP6762308B2 (ja) | 2015-02-19 | 2020-09-30 | パーデュー、ファーマ、リミテッド、パートナーシップ | 胃排出の減少方法及び組成物 |
WO2017059357A1 (en) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna damaging agents and atr inhibitors |
WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3149109A (en) * | 1962-02-20 | 1964-09-15 | Searle & Co | Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines |
FR1477021A (fr) | 1965-04-21 | 1967-04-14 | Ilford Ltd | Matières photographiques |
GB1121922A (en) * | 1966-06-17 | 1968-07-31 | Ici Ltd | Pyrimidine derivatives |
FR1536093A (fr) | 1966-09-10 | 1968-08-09 | Basf Ag | Nouvelles amino-4-alcoylmercapto-6-triazines-s |
US3631036A (en) * | 1969-11-04 | 1971-12-28 | American Home Prod | 5-amino-2 6-substituted-7h-pyrrolo(2 3-d) pyrimidines and related compounds |
US3660414A (en) | 1970-06-01 | 1972-05-02 | Sandoz Ag | Certain 5-aryl-2-amino-nicotinonitriles |
US3709888A (en) | 1970-06-01 | 1973-01-09 | Sandoz Ag | Aryl-substituted-pyrido(2,3-d)pyrimidin-2-ones |
US3940404A (en) | 1974-03-06 | 1976-02-24 | The United States Of America As Represented By The Secretary Of The Army | 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines |
US3886167A (en) | 1974-03-06 | 1975-05-27 | Us Army | 2-Aryl-6-trifluoromethyl-4-pyridylcarbinolamine antimalarials |
US4133956A (en) | 1977-07-27 | 1979-01-09 | Eli Lilly And Company | Preparation of benzoylureas |
US4293552A (en) | 1978-02-27 | 1981-10-06 | Eli Lilly And Company | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas |
IL59748A (en) | 1979-04-05 | 1983-11-30 | Lilly Industries Ltd | 5-substituted pyranone derivatives,their production and pharmaceutical compositions containing them |
JPS56104883A (en) * | 1980-01-25 | 1981-08-20 | Tanabe Seiyaku Co Ltd | Novel pyridinecarboxamide derivative and its preparation |
JPS56115784A (en) | 1980-02-15 | 1981-09-11 | Tanabe Seiyaku Co Ltd | Novel pyridinecarboxamide derivative and its preparation |
US4332552A (en) * | 1980-10-03 | 1982-06-01 | General Signal Corporation | Moldatherm insulated pacemaker furnace and method of manufacture |
GB2095240A (en) * | 1981-03-05 | 1982-09-29 | Fujisawa Pharmaceutical Co | Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
DE3239573A1 (de) | 1981-10-28 | 1983-05-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Substituierte picolinsaeuren, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel |
DE3245950A1 (de) | 1981-12-24 | 1983-07-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Verfahren zur herstellung substituierter pyridine |
FR2527206B1 (fr) | 1982-05-18 | 1986-12-05 | Sandoz Sa | Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments |
DE3379544D1 (en) | 1982-06-08 | 1989-05-11 | Ciba Geigy Ag | 2-phenyl-2-naphthyl and 2-heterocyclic pyrimidines as antidotes for protecting cultured plants before phytotoxic damages caused by herbicides |
EP0123700A1 (de) | 1983-04-27 | 1984-11-07 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituierte Picolinsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel |
US4701208A (en) | 1983-08-02 | 1987-10-20 | American Cyanamid Company | Dihydroimidazopyrrolopyridine, quinoline, thieno- and furo[2,3-b]pyridine, dihydrothieno- and furo[2,3-b]-pyridine, thieno- and furo[3,2-b]pyridine and dihydrothieno- and furo[3,2-b]pyridine herbicides and method for preparation thereof |
EP0200024B1 (de) | 1985-04-30 | 1992-07-01 | ARZNEIMITTELWERK DRESDEN GmbH | 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
GB8531637D0 (en) * | 1985-12-23 | 1986-02-05 | Ici Plc | Pyrimidine derivatives |
US4962109A (en) * | 1985-12-23 | 1990-10-09 | Imperial Chemical Industries Plc | Insecticidally and acaricidally active pyrimidine esters and intermediates therefor |
JPS6320234A (ja) | 1986-07-11 | 1988-01-27 | Daihatsu Motor Co Ltd | 自動車の2輪・4輪駆動切換装置 |
GB8627059D0 (en) | 1986-11-12 | 1986-12-10 | Cookson Group Plc | Substituted trialine derivatives |
ZW21687A1 (en) | 1986-12-12 | 1988-07-20 | Hoffmann La Roche | Triazine derivatives |
US5116989A (en) | 1987-11-06 | 1992-05-26 | Baxter Diagnostics Inc. | Fluorescent poly(arylpyridine) rare earth chelates |
US5084462A (en) | 1988-04-26 | 1992-01-28 | The Du Pont Merck Pharmaceutical Company | 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents |
EP0356672B1 (en) * | 1988-07-13 | 1993-04-07 | Canon Kabushiki Kaisha | Ferroelectric chiral smectic liquid crystal composition and liquid crystal device using same |
JPH0252360A (ja) | 1988-08-15 | 1990-02-21 | Fujitsu Ltd | 電子写真感光体 |
EP0362578A1 (en) | 1988-09-14 | 1990-04-11 | E.I. Du Pont De Nemours And Company | Treatment of cancer in mammals by concurrent administration of 4-quinoline carboxylic acid derivatives and interleukin-2 |
FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
US4968702A (en) | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
GB8906470D0 (en) | 1989-03-21 | 1989-05-04 | Cookson Group Plc | Photopolymerisable composition |
DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3940476A1 (de) | 1989-12-07 | 1991-06-13 | Bayer Ag | Pyridinylpyrimidin-derivate |
GB8923131D0 (en) | 1989-10-13 | 1989-11-29 | Smith Kline French Lab | Chemical compounds |
US5136080A (en) * | 1989-12-04 | 1992-08-04 | Burroughs Wellcome Co. | Nitrile compounds |
US5403934A (en) | 1990-03-12 | 1995-04-04 | Burroughs Wellcome Co. | Heterocyclic compounds |
EP0446604A3 (en) | 1990-03-16 | 1992-02-19 | American Cyanamid Company | Pyridine and related aza heterocycle derivatives as cardiovascular agents |
AU644016B2 (en) | 1990-09-28 | 1993-12-02 | Smith Kline & French Laboratories Limited | Phenylpyridinol derivatives as medicaments |
DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
WO1992007846A1 (en) * | 1990-10-25 | 1992-05-14 | Kumiai Chemical Industry Co., Ltd. | Picolinic acid derivative, production thereof, and herbicide |
JPH0597706A (ja) | 1991-04-09 | 1993-04-20 | Chemex Block Drug Jv | アフタ性潰瘍および他の粘膜皮膚障害の処置方法 |
DE4200323A1 (de) | 1992-01-09 | 1993-07-15 | Bayer Ag | Herbizide und pflanzennematizide mittel auf basis von mercaptonicotinsaeurederivaten |
US5389632A (en) | 1992-02-24 | 1995-02-14 | Laboratoires Upsa | Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists |
TW237456B (es) | 1992-04-09 | 1995-01-01 | Ciba Geigy | |
JPH0776542A (ja) | 1993-09-06 | 1995-03-20 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
US5744492A (en) | 1993-09-17 | 1998-04-28 | United States Of America | Method for inhibiting angiogenesis |
US5602156A (en) | 1993-09-17 | 1997-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | Method for inhibiting metalloproteinase expression |
IL112290A (en) | 1994-01-12 | 1999-01-26 | Novartis Ag | Transformed aryl and the troiryl pyrimidines and herbicides containing them |
US5563143A (en) | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
US6057346A (en) | 1994-12-12 | 2000-05-02 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of retroviral LTR promoters by calcium response modifiers |
CZ290330B6 (cs) * | 1995-01-26 | 2002-07-17 | American Cyanamid Company | 2,6-Disubstituované pyridinové a 2,4-disubstituované pyrimidinové deriváty, způsob a meziprodukty pro jejich výrobu, jejich pouľití a herbicidní prostředky na jejich bázi a způsob potlačování růstu neľádoucích rostlin |
US5849758A (en) * | 1995-05-30 | 1998-12-15 | American Cyanamid Company | Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines |
US6008161A (en) * | 1995-05-30 | 1999-12-28 | American Cyanamid Company | Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero) aryloxypyrimidines |
US5741818A (en) | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
JP2002515854A (ja) | 1995-08-02 | 2002-05-28 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗薬 |
AU6320998A (en) | 1997-02-21 | 1998-09-09 | Bristol-Myers Squibb Company | Benzoic acid derivatives and related compounds as antiarrhythmic agents |
ATE289295T1 (de) | 1997-04-22 | 2005-03-15 | Euro Celtique Sa | Die verwendung von durch carbozyklische und heterozyklische reste substituierte semicarbazonen und thiosemicarbazonen als natriumkanalblocker |
EP1037886B1 (en) * | 1997-12-12 | 2003-05-02 | Abbott Laboratories | Triazine angiogenesis inhibitors |
AU1504599A (en) | 1997-12-17 | 1999-07-05 | Shionogi & Co., Ltd. | Novel pyridine compounds |
ZA9811576B (en) | 1997-12-19 | 2000-06-19 | Takeda Chemical Industries Ltd | Anilide derivative, production and use thereof. |
CN1231440C (zh) | 1998-01-28 | 2005-12-14 | 盐野义制药株式会社 | 新的三环化合物 |
TR200102790T2 (tr) | 1999-03-26 | 2002-06-21 | Euro-Celtique S.A. | Aril İkameli Pirazoller, İmidazoller, Oksazoller, Tiazoller ve Piroller Ve Bunların Kullanımı. |
AU770600B2 (en) * | 1999-10-07 | 2004-02-26 | Amgen, Inc. | Triazine kinase inhibitors |
AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
-
2001
- 2001-03-09 AR ARP010101117A patent/AR029489A1/es not_active Application Discontinuation
- 2001-03-12 PT PT01918558T patent/PT1265866E/pt unknown
- 2001-03-12 NZ NZ521866A patent/NZ521866A/en not_active Application Discontinuation
- 2001-03-12 SI SI200130975T patent/SI1265866T1/sl unknown
- 2001-03-12 CZ CZ20032228A patent/CZ20032228A3/cs unknown
- 2001-03-12 HU HU0300466A patent/HUP0300466A3/hu unknown
- 2001-03-12 JP JP2001567706A patent/JP4359016B2/ja not_active Expired - Fee Related
- 2001-03-12 AP APAP/P/2002/002629A patent/AP1404A/en active
- 2001-03-12 AU AU4562001A patent/AU4562001A/xx active Pending
- 2001-03-12 EP EP01918558A patent/EP1265866B1/en not_active Expired - Lifetime
- 2001-03-12 WO PCT/US2001/007797 patent/WO2001068612A2/en not_active Application Discontinuation
- 2001-03-12 CN CN01807553A patent/CN1422254A/zh active Pending
- 2001-03-12 ES ES01918558T patent/ES2348974T3/es not_active Expired - Lifetime
- 2001-03-12 DE DE60142613T patent/DE60142613D1/de not_active Expired - Lifetime
- 2001-03-12 MX MXPA02008733A patent/MXPA02008733A/es active IP Right Grant
- 2001-03-12 AT AT01918558T patent/ATE474828T1/de active
- 2001-03-12 OA OA1200200283A patent/OA12677A/en unknown
- 2001-03-12 DK DK01918558.6T patent/DK1265866T3/da active
- 2001-03-12 IL IL15141701A patent/IL151417A0/xx active IP Right Grant
- 2001-03-12 CA CA002400945A patent/CA2400945C/en not_active Expired - Fee Related
- 2001-03-12 YU YU67902A patent/YU67902A/sh unknown
- 2001-03-12 PL PL01357272A patent/PL357272A1/xx not_active Application Discontinuation
- 2001-03-12 KR KR1020027011841A patent/KR20030011792A/ko not_active Application Discontinuation
- 2001-03-12 US US09/803,659 patent/US6867210B2/en not_active Expired - Lifetime
- 2001-03-12 BR BR0108918-8A patent/BR0108918A/pt not_active IP Right Cessation
- 2001-03-12 SK SK1069-2003A patent/SK10692003A3/sk unknown
- 2001-03-12 AU AU2001245620A patent/AU2001245620B2/en not_active Ceased
- 2001-03-12 EA EA200200966A patent/EA005770B1/ru not_active IP Right Cessation
-
2002
- 2002-08-21 IS IS6518A patent/IS6518A/is unknown
- 2002-08-22 IL IL151417A patent/IL151417A/en unknown
- 2002-09-03 ZA ZA200207069A patent/ZA200207069B/en unknown
- 2002-09-09 NO NO20024308A patent/NO20024308L/no not_active Application Discontinuation
- 2002-10-07 MA MA26852A patent/MA26893A1/fr unknown
- 2002-10-09 CR CR6774A patent/CR6774A/es not_active Application Discontinuation
- 2002-10-09 HR HRP20020805 patent/HRP20020805A2/hr not_active Application Discontinuation
-
2003
- 2003-12-19 US US10/738,989 patent/US20040192691A1/en not_active Abandoned
-
2004
- 2004-09-29 US US10/951,861 patent/US20050043305A1/en not_active Abandoned
-
2008
- 2008-10-24 JP JP2008274840A patent/JP2009062390A/ja not_active Withdrawn
-
2010
- 2010-09-28 CY CY20101100873T patent/CY1110809T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR6774A (es) | Sustitutos arilicos de piridinas, pirimidinas, pirazinas, triazinas y el uso de estos | |
MXPA05000812A (es) | Bencimidazoles aril sustituidos y su uso como bloqueadores del canal de sodio. | |
MXPA02009279A (es) | Pirazoles, triazoles y tetrazoles sustituidos con arilo como bloqueadores del canal de sodio. | |
MXPA02009619A (es) | Aminopiridinas y su uso como anticonvulsivos y bloqueadores del canal de sodio. | |
MXPA04002171A (es) | Piridicarboxamidas aril sustituidas y su uso como bloqueadores del canal de sodio. | |
MXPA01009655A (es) | Pirazoles, imidazoles, oxazoles, tiazoles y pirroles substituidos con arilo y uso de los mismos. | |
DE602004008098T8 (de) | Substituierte 2h-[1,2,4]triazolo[4,3-a]pyrazine als gsk-3-inhibitoren | |
MXPA05000813A (es) | Compuestos hidrantoina aril sustituidos y su uso como bloqueadores del canal de sodio. | |
TR200201505T2 (tr) | Terapötik maddeler olarak pirazolopirimidinler | |
WO2008094909A3 (en) | Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions | |
ECSP088283A (es) | Compuestos de piridina 5- (fenilisoxazoliletoxi) -triazol- 3-ilo substituidos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor | |
BR0308451A (pt) | Composto, composição farmacêutica, métodos para o tratamento, prevenção ou melhoria de disfunção e método de fabricação de composto | |
BRPI0412257A (pt) | compostos para inflamação e usos imuno-relacionados | |
CO5580767A2 (es) | Compuestos de indazol y composiciones farmaceuticas para inhibir proteinquinasas y procedimientos para su uso | |
SV1999000147A (es) | Derivados de 4, 4-biarilpiperidina ref. pc10083/82759/bb | |
SV1999000251A (es) | Derivados de 3,3-biarilpiperidina y 2,2-biarilmorfolina ref. pcl0085/82805/bb | |
BR9710737A (pt) | Pentafluorobenzenosulfonamidas e análogos. | |
SV2008002958A (es) | Uso de derivados de sulfamida heterociclo benzo-fusionado para el tratamiento del trastorno bipolar y mania referencia cruzada ref. prd2592sv | |
PT1080726E (pt) | Agentes para atenuacao de efeitos colaterais | |
PA8487701A1 (es) | Derivados de 3,3-biarilpiperidina y 2,2-biarilmorfolina | |
UY27275A1 (es) | Composiciones y metodos para aumentar la biodisponibilidad de agentes farmacéuticos | |
BR0017120A (pt) | Composição farmacêutica | |
BRPI0414778A (pt) | 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer | |
PA8471901A1 (es) | Derivados de 2"-desoxi higromicina | |
SV2002000474A (es) | Derivados de higromicina a ref.pc11o32abcz/bb |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal (granting procedure) |