CR20190557A - Expansión de linfocitos infiltrantes de tumor a partir de tumores líquidos y usos terapéuticos de los mismos - Google Patents

Expansión de linfocitos infiltrantes de tumor a partir de tumores líquidos y usos terapéuticos de los mismos

Info

Publication number
CR20190557A
CR20190557A CR20190557A CR20190557A CR20190557A CR 20190557 A CR20190557 A CR 20190557A CR 20190557 A CR20190557 A CR 20190557A CR 20190557 A CR20190557 A CR 20190557A CR 20190557 A CR20190557 A CR 20190557A
Authority
CR
Costa Rica
Prior art keywords
expansion
liquid tumors
therapeutic uses
lymphocytes
infiltrating tumor
Prior art date
Application number
CR20190557A
Other languages
English (en)
Spanish (es)
Inventor
María Fardis
Lavakumar Karyampudi
Original Assignee
Iovance Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of CR20190557A publication Critical patent/CR20190557A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/50—Cell markers; Cell surface determinants
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/30—Coculture with; Conditioned medium produced by tumour cells

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CR20190557A 2017-05-10 2018-05-10 Expansión de linfocitos infiltrantes de tumor a partir de tumores líquidos y usos terapéuticos de los mismos CR20190557A (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201762504337P 2017-05-10 2017-05-10
US201762530681P 2017-07-10 2017-07-10
US201762550398P 2017-08-25 2017-08-25
US201762590034P 2017-11-22 2017-11-22
US201862621462P 2018-01-24 2018-01-24
US201862621798P 2018-01-25 2018-01-25
US201862647367P 2018-03-23 2018-03-23
PCT/US2018/032109 WO2018209115A1 (en) 2017-05-10 2018-05-10 Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
CR20190557A true CR20190557A (es) 2020-03-27

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CR20190557A CR20190557A (es) 2017-05-10 2018-05-10 Expansión de linfocitos infiltrantes de tumor a partir de tumores líquidos y usos terapéuticos de los mismos

Country Status (15)

Country Link
US (5) US20200224161A1 (enExample)
EP (1) EP3622055A1 (enExample)
JP (2) JP7349365B2 (enExample)
KR (1) KR20200003913A (enExample)
CN (1) CN110832070B (enExample)
AU (1) AU2018266202C1 (enExample)
BR (1) BR112019023409A2 (enExample)
CA (1) CA3062874A1 (enExample)
CR (1) CR20190557A (enExample)
IL (1) IL270412B2 (enExample)
MA (1) MA50871A (enExample)
MX (1) MX2019013202A (enExample)
PH (1) PH12019502528A1 (enExample)
TW (1) TW201904578A (enExample)
WO (1) WO2018209115A1 (enExample)

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