CR11741A - Antagonistas de la trayectoria hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Info

Publication number
CR11741A
CR11741A CR11741A CR11741A CR11741A CR 11741 A CR11741 A CR 11741A CR 11741 A CR11741 A CR 11741A CR 11741 A CR11741 A CR 11741A CR 11741 A CR11741 A CR 11741A
Authority
CR
Costa Rica
Prior art keywords
antagonists
hedgehog
ftalazina
disttituted
trajectory
Prior art date
Application number
CR11741A
Other languages
English (en)
Spanish (es)
Inventor
Arthur Hipskind Philip
Wilson Takako
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR11741A publication Critical patent/CR11741A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CR11741A 2008-04-29 2010-10-15 Antagonistas de la trayectoria hedgehog de ftalazina disustituida CR11741A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4872908P 2008-04-29 2008-04-29

Publications (1)

Publication Number Publication Date
CR11741A true CR11741A (es) 2011-01-05

Family

ID=40846962

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11741A CR11741A (es) 2008-04-29 2010-10-15 Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Country Status (22)

Country Link
US (1) US7981892B2 (OSRAM)
EP (1) EP2294061A2 (OSRAM)
JP (1) JP5442717B2 (OSRAM)
KR (1) KR101260116B1 (OSRAM)
CN (1) CN102066353B (OSRAM)
AU (1) AU2009241561B2 (OSRAM)
BR (1) BRPI0911618A2 (OSRAM)
CA (1) CA2723042A1 (OSRAM)
CO (1) CO6300945A2 (OSRAM)
CR (1) CR11741A (OSRAM)
DO (1) DOP2010000302A (OSRAM)
EA (1) EA201071248A1 (OSRAM)
EC (1) ECSP10010577A (OSRAM)
HN (1) HN2010002157A (OSRAM)
IL (1) IL208211A0 (OSRAM)
MA (1) MA32349B1 (OSRAM)
MX (1) MX2010011948A (OSRAM)
MY (1) MY159491A (OSRAM)
NZ (1) NZ588001A (OSRAM)
UA (1) UA102250C2 (OSRAM)
WO (1) WO2009134574A2 (OSRAM)
ZA (1) ZA201006695B (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2723042A1 (en) 2008-04-29 2009-11-05 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
HRP20130527T1 (en) * 2008-11-03 2013-07-31 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
HRP20120762T1 (hr) 2008-11-17 2012-10-31 Eli Lilly And Company Tetrasupstituirani piridazini kao inhibitori hedgehog puta
ES2446307T3 (es) * 2008-11-17 2014-03-07 Eli Lilly And Company Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US20120232087A1 (en) * 2009-11-18 2012-09-13 Silvia Buonamici Methods and compositions for treating solid tumors and other malignancies
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
US9512106B2 (en) 2012-09-17 2016-12-06 Duke University Smoothened modulators and methods of use thereof
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用
CA3198661A1 (en) 2020-10-13 2022-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
AU2023347443A1 (en) * 2022-09-23 2025-04-03 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
JP4169368B2 (ja) 1996-01-15 2008-10-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 脈管形成阻害性ピリダジンアミン
EP1067939B1 (en) 1998-04-09 2015-09-16 The Johns Hopkins University Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP2003501395A (ja) 1999-06-08 2003-01-14 ローランティス・リミテッド 治療的使用
CA2483311A1 (en) 2002-04-22 2003-10-30 Philip A. Beachy Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
WO2006004589A2 (en) 2004-05-08 2006-01-12 Neurogen Corporation 3-aryl-5,6-disubstituted pyridazines
PT1789390E (pt) * 2004-09-02 2012-02-08 Genentech Inc Inibidores de piridilo da sinalização de hedgehog
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
SG182205A1 (en) * 2007-03-15 2012-07-30 Novartis Ag Organic compounds and their uses
WO2009002469A1 (en) 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
AU2008300019A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
CA2723042A1 (en) 2008-04-29 2009-11-05 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
HRP20130527T1 (en) 2008-11-03 2013-07-31 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
HRP20120762T1 (hr) 2008-11-17 2012-10-31 Eli Lilly And Company Tetrasupstituirani piridazini kao inhibitori hedgehog puta
ES2446307T3 (es) 2008-11-17 2014-03-07 Eli Lilly And Company Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
EP2294061A2 (en) 2011-03-16
HN2010002157A (es) 2014-09-08
KR20100126580A (ko) 2010-12-01
AU2009241561A1 (en) 2009-11-05
AU2009241561B2 (en) 2013-05-16
KR101260116B1 (ko) 2013-05-02
CN102066353B (zh) 2013-12-11
MA32349B1 (fr) 2011-06-01
BRPI0911618A2 (pt) 2019-09-24
JP5442717B2 (ja) 2014-03-12
EA201071248A1 (ru) 2011-06-30
US20110046143A1 (en) 2011-02-24
ZA201006695B (en) 2012-09-26
UA102250C2 (ru) 2013-06-25
US7981892B2 (en) 2011-07-19
MX2010011948A (es) 2010-12-14
MY159491A (en) 2017-01-13
DOP2010000302A (es) 2010-11-15
WO2009134574A3 (en) 2014-09-04
JP2011527666A (ja) 2011-11-04
CO6300945A2 (es) 2011-07-21
NZ588001A (en) 2012-06-29
IL208211A0 (en) 2010-12-30
CA2723042A1 (en) 2009-11-05
CN102066353A (zh) 2011-05-18
ECSP10010577A (es) 2010-11-30
WO2009134574A2 (en) 2009-11-05

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