CO7160077A2 - Compuestos de pirazol sustituidos como antagonistas de lpar - Google Patents
Compuestos de pirazol sustituidos como antagonistas de lparInfo
- Publication number
- CO7160077A2 CO7160077A2 CO14279332A CO14279332A CO7160077A2 CO 7160077 A2 CO7160077 A2 CO 7160077A2 CO 14279332 A CO14279332 A CO 14279332A CO 14279332 A CO14279332 A CO 14279332A CO 7160077 A2 CO7160077 A2 CO 7160077A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds substituted
- pyrazole compounds
- lpar antagonists
- lpar
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 125000003226 pyrazolyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661958P | 2012-06-20 | 2012-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7160077A2 true CO7160077A2 (es) | 2015-01-15 |
Family
ID=48656033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14279332A CO7160077A2 (es) | 2012-06-20 | 2014-12-19 | Compuestos de pirazol sustituidos como antagonistas de lpar |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20150259295A1 (forum.php) |
| EP (1) | EP2864294A1 (forum.php) |
| JP (1) | JP2015520201A (forum.php) |
| KR (1) | KR20150011003A (forum.php) |
| CN (1) | CN104411690A (forum.php) |
| AU (1) | AU2013279510A1 (forum.php) |
| BR (1) | BR112014031108A2 (forum.php) |
| CA (1) | CA2869602A1 (forum.php) |
| CL (1) | CL2014003242A1 (forum.php) |
| CO (1) | CO7160077A2 (forum.php) |
| CR (1) | CR20140516A (forum.php) |
| EA (1) | EA201492283A1 (forum.php) |
| HK (1) | HK1206341A1 (forum.php) |
| IL (1) | IL236091A0 (forum.php) |
| IN (1) | IN2014DN09347A (forum.php) |
| MA (1) | MA37765A1 (forum.php) |
| MX (1) | MX2014014105A (forum.php) |
| PE (1) | PE20142445A1 (forum.php) |
| PH (1) | PH12014502364A1 (forum.php) |
| SG (1) | SG11201407229UA (forum.php) |
| UA (1) | UA109867C2 (forum.php) |
| WO (1) | WO2013189862A1 (forum.php) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2744807A4 (en) | 2011-08-15 | 2015-03-04 | Intermune Inc | COMPOUNDS AS LYSOPHOSPHIC ACID RECEPTOR ANTAGONISTS |
| MX382748B (es) | 2013-03-15 | 2025-03-13 | Epigen Biosciences Inc | Compuestos heterociclicos utiles para el tratamiento de una enfermedad. |
| RU2689315C2 (ru) | 2014-06-27 | 2019-05-27 | Убе Индастриз, Лтд. | Соль гетероциклического соединения, замещенного галогеном |
| CN111699180B (zh) * | 2017-12-19 | 2024-11-29 | 百时美施贵宝公司 | 作为lpa拮抗剂的吡唑n-连接的氨基甲酰基环己基酸 |
| CN111434655A (zh) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 溶血磷脂酸受体拮抗剂及其制备方法 |
| JP7431961B2 (ja) | 2019-11-15 | 2024-02-15 | ギリアード サイエンシーズ， インコーポレイテッド | Ｌｐａ受容体アンタゴニストとしてのトリアゾールカルバメートピリジルスルホンアミド及びその使用 |
| CN115867556B (zh) | 2020-06-03 | 2025-05-06 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
| TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| KR20240005892A (ko) | 2021-05-11 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| KR20240115978A (ko) | 2021-12-08 | 2024-07-26 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005063241A1 (ja) * | 2003-12-26 | 2005-07-14 | Ono Pharmaceutical Co., Ltd. | ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤 |
| TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| GB2470833B (en) * | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| JP2013501064A (ja) * | 2009-08-04 | 2013-01-10 | アミラ ファーマシューティカルス，インコーポレーテッド | リゾホスファチジン酸受容体アンタゴニストとしての化合物 |
| BR112013014019A2 (pt) * | 2010-12-07 | 2016-09-13 | Amira Pharmaceuticals Inc | antagonistas do receptor do ácido lisofosfatídico e seus usos |
| WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
| EP2744807A4 (en) * | 2011-08-15 | 2015-03-04 | Intermune Inc | COMPOUNDS AS LYSOPHOSPHIC ACID RECEPTOR ANTAGONISTS |
-
2013
- 2013-06-17 PE PE2014002212A patent/PE20142445A1/es not_active Application Discontinuation
- 2013-06-17 UA UAA201500427A patent/UA109867C2/ru unknown
- 2013-06-17 MA MA37765A patent/MA37765A1/fr unknown
- 2013-06-17 BR BR112014031108A patent/BR112014031108A2/pt not_active Application Discontinuation
- 2013-06-17 CA CA2869602A patent/CA2869602A1/en not_active Abandoned
- 2013-06-17 AU AU2013279510A patent/AU2013279510A1/en not_active Abandoned
- 2013-06-17 CN CN201380032266.8A patent/CN104411690A/zh active Pending
- 2013-06-17 IN IN9347DEN2014 patent/IN2014DN09347A/en unknown
- 2013-06-17 EP EP13729940.0A patent/EP2864294A1/en not_active Withdrawn
- 2013-06-17 HK HK15106926.9A patent/HK1206341A1/xx unknown
- 2013-06-17 MX MX2014014105A patent/MX2014014105A/es unknown
- 2013-06-17 SG SG11201407229UA patent/SG11201407229UA/en unknown
- 2013-06-17 WO PCT/EP2013/062458 patent/WO2013189862A1/en active Application Filing
- 2013-06-17 EA EA201492283A patent/EA201492283A1/ru unknown
- 2013-06-17 US US14/402,128 patent/US20150259295A1/en not_active Abandoned
- 2013-06-17 KR KR1020147035552A patent/KR20150011003A/ko not_active Ceased
- 2013-06-17 JP JP2015517702A patent/JP2015520201A/ja active Pending
-
2014
- 2014-10-22 PH PH12014502364A patent/PH12014502364A1/en unknown
- 2014-11-11 CR CR20140516A patent/CR20140516A/es unknown
- 2014-11-28 CL CL2014003242A patent/CL2014003242A1/es unknown
- 2014-12-04 IL IL236091A patent/IL236091A0/en unknown
- 2014-12-19 CO CO14279332A patent/CO7160077A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150259295A1 (en) | 2015-09-17 |
| PH12014502364A1 (en) | 2015-01-12 |
| KR20150011003A (ko) | 2015-01-29 |
| MX2014014105A (es) | 2015-03-05 |
| AU2013279510A1 (en) | 2014-10-16 |
| CA2869602A1 (en) | 2013-12-27 |
| IL236091A0 (en) | 2015-02-01 |
| CL2014003242A1 (es) | 2015-03-20 |
| EP2864294A1 (en) | 2015-04-29 |
| CN104411690A (zh) | 2015-03-11 |
| HK1206341A1 (en) | 2016-01-08 |
| WO2013189862A1 (en) | 2013-12-27 |
| MA37765A1 (fr) | 2017-04-28 |
| JP2015520201A (ja) | 2015-07-16 |
| BR112014031108A2 (pt) | 2017-06-27 |
| SG11201407229UA (en) | 2014-12-30 |
| EA201492283A1 (ru) | 2015-04-30 |
| UA109867C2 (ru) | 2015-10-12 |
| CR20140516A (es) | 2014-12-01 |
| PE20142445A1 (es) | 2015-01-28 |
| IN2014DN09347A (forum.php) | 2015-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO7131357A2 (es) | Compuestos de n-ariltriazol como antagonistas de lpar | |
| CO7131358A2 (es) | Compuestos de n-alquiltriazol como antagonistas de lpar | |
| CO7160077A2 (es) | Compuestos de pirazol sustituidos como antagonistas de lpar | |
| CL2019002103A1 (es) | Derivados de tirosinamida como inhibidores de rho-quinasa. | |
| CO2017004525A2 (es) | Dihidropirrolopiridinas inhibidoras de ror-gamma | |
| CU20160167A7 (es) | Compuestos de pirazolopiridinas y pirazolopirimidinas útiles en el tratamiento de condiciones alérgicas y respiratorias | |
| MX2018009257A (es) | Derivados de benzimidazol como moduladores de ror-gamma. | |
| CO2018011408A2 (es) | Compuestos de pirimidina como inhibidores de la quinasa jak | |
| UY36244A (es) | Derivados de la pirimidinona como inhibidores del factor xia y/o de la calicreína plasmática y composiciones farmacéuticas que los contienen | |
| CL2014001174A1 (es) | Compuestos derivados de [1,2,3]triazolo[4,5-d]pirimidina y sus sales, como agonistas del receptor de canabinoides 2; su proceso de obtencion; composicion farmaceutica que los contiene; y su uso para el tratamiento o profilaxis del dolor, aterosclerosis, inflamacion, glaucoma, ataque isquemico transitorio, entre otras enfermedades. | |
| PE20170502A1 (es) | ACIDO 4-(3-FLUORO-3-(2-(5,6,7,8-TETRAHIDRO-1,8-NAFTIRIDIN-2-IL)ETIL)PIRROLIDIN-1-IL)-3-(3-(2-METOXIETOXI)FENIL)BUTANOICO COMO ANTAGONISTA DE INTEGRINA aVß6 | |
| MX2016009230A (es) | Macrociclicos con grupos p2'heterociclicos como inhibidores del factor xia. | |
| PE20180318A1 (es) | Procedimiento para preparar isoquinolinonas y formas solidas de isoquinolinonas | |
| UY34545A (es) | Novedosas dihidropirimidinoisoquinolinonas y composiciones farmacéuticas de las mismas para el tratamiento de trastornos inflamatorios. | |
| UY34960A (es) | Dihidropiridona p1 como inhibidores del factor xia | |
| UY34917A (es) | Inhibidores de la producción de leucotrieno-a4-hidrolasa (lta4h), composiciones farmacéuticas que los contienen y proceso para su preparación | |
| UY34959A (es) | Dihidropiridona p1 como inhibidores del factor xia | |
| MX2015008233A (es) | Nuevos derivados de quinolona. | |
| CU20150021A7 (es) | Piridinonas bicíclicas novedosas | |
| ECSP16074478A (es) | Compuestos novedosos | |
| CO2017007325A2 (es) | 2,4 diamino-quinolina sustituida como nuevos agentes anti-cancerigenos | |
| UY32755A (es) | Nuevos derivados de (6-oxo-1,6-dihidro-pirimidin-2-il)-amida, su preparación y su utilización farmacéutica como inhibidores de fosforilación de akt (pkb). | |
| CR20130318A (es) | Nuevos compuestos de benzodioxol-piperazina | |
| ECSP10010597A (es) | Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas | |
| BR112015003998A2 (pt) | compostos de cianopirazol lpar-substituídos |