AU2013279510A1 - Substituted pyrazole compounds as LPAR antagonists - Google Patents
Substituted pyrazole compounds as LPAR antagonists Download PDFInfo
- Publication number
- AU2013279510A1 AU2013279510A1 AU2013279510A AU2013279510A AU2013279510A1 AU 2013279510 A1 AU2013279510 A1 AU 2013279510A1 AU 2013279510 A AU2013279510 A AU 2013279510A AU 2013279510 A AU2013279510 A AU 2013279510A AU 2013279510 A1 AU2013279510 A1 AU 2013279510A1
- Authority
- AU
- Australia
- Prior art keywords
- phenyl
- methyl
- pyrazol
- biphenyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000642 Lysophosphatidic Acid Receptors Proteins 0.000 title description 8
- 102000004137 Lysophosphatidic Acid Receptors Human genes 0.000 title description 8
- 239000005557 antagonist Substances 0.000 title description 6
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
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- SSMIBGPOHRVNGJ-UHFFFAOYSA-N 1-(2-chlorophenyl)ethyl n-[4-(2-fluorophenyl)-2-methylpyrazol-3-yl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C(C)OC(=O)NC(N(N=C1)C)=C1C1=CC=CC=C1F SSMIBGPOHRVNGJ-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661958P | 2012-06-20 | 2012-06-20 | |
| US61/661,958 | 2012-06-20 | ||
| PCT/EP2013/062458 WO2013189862A1 (en) | 2012-06-20 | 2013-06-17 | Substituted pyrazole compounds as lpar antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2013279510A1 true AU2013279510A1 (en) | 2014-10-16 |
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|---|---|---|---|
| AU2013279510A Abandoned AU2013279510A1 (en) | 2012-06-20 | 2013-06-17 | Substituted pyrazole compounds as LPAR antagonists |
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| EP (1) | EP2864294A1 (forum.php) |
| JP (1) | JP2015520201A (forum.php) |
| KR (1) | KR20150011003A (forum.php) |
| CN (1) | CN104411690A (forum.php) |
| AU (1) | AU2013279510A1 (forum.php) |
| BR (1) | BR112014031108A2 (forum.php) |
| CA (1) | CA2869602A1 (forum.php) |
| CL (1) | CL2014003242A1 (forum.php) |
| CO (1) | CO7160077A2 (forum.php) |
| CR (1) | CR20140516A (forum.php) |
| EA (1) | EA201492283A1 (forum.php) |
| HK (1) | HK1206341A1 (forum.php) |
| IL (1) | IL236091A0 (forum.php) |
| IN (1) | IN2014DN09347A (forum.php) |
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| PE (1) | PE20142445A1 (forum.php) |
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| UA (1) | UA109867C2 (forum.php) |
| WO (1) | WO2013189862A1 (forum.php) |
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| JP2014525932A (ja) | 2011-08-15 | 2014-10-02 | インターミューン， インコーポレイテッド | リゾホスファチド酸レセプターアンタゴニスト |
| MX382748B (es) | 2013-03-15 | 2025-03-13 | Epigen Biosciences Inc | Compuestos heterociclicos utiles para el tratamiento de una enfermedad. |
| KR102433588B1 (ko) | 2014-06-27 | 2022-08-19 | 우베 가부시키가이샤 | 할로겐 치환 헤테로환 화합물의 염 |
| EP3728216B1 (en) * | 2017-12-19 | 2023-09-06 | Bristol-Myers Squibb Company | Pyrazole n-linked carbamoyl cyclohexyl acids as lpa antagonists |
| CN111434655A (zh) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 溶血磷脂酸受体拮抗剂及其制备方法 |
| CA3158743A1 (en) | 2019-11-15 | 2021-05-20 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
| WO2021247215A1 (en) | 2020-06-03 | 2021-12-09 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| JP7701473B2 (ja) * | 2021-05-11 | 2025-07-01 | ギリアード サイエンシーズ， インコーポレイテッド | Ｌｐａ受容体アンタゴニスト及びそれらの使用 |
| JP7709612B2 (ja) | 2021-12-08 | 2025-07-16 | ギリアード サイエンシーズ， インコーポレイテッド | Ｌｐａ受容体アンタゴニスト及びそれらの使用 |
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| WO2005063241A1 (ja) * | 2003-12-26 | 2005-07-14 | Ono Pharmaceutical Co., Ltd. | ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤 |
| TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| GB2470833B (en) * | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| CN102574822A (zh) * | 2009-08-04 | 2012-07-11 | 阿米拉制药公司 | 作为溶血磷脂酸受体拮抗剂的化合物 |
| PH12013501136A1 (en) * | 2010-12-07 | 2013-07-08 | Amira Pharmaceuticals Inc | Lysophosphatidic acid receptor antagonists and uses thereof |
| WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
| JP2014525932A (ja) * | 2011-08-15 | 2014-10-02 | インターミューン， インコーポレイテッド | リゾホスファチド酸レセプターアンタゴニスト |
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2013
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- 2013-06-17 CN CN201380032266.8A patent/CN104411690A/zh active Pending
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- 2013-06-17 MA MA37765A patent/MA37765A1/fr unknown
- 2013-06-17 JP JP2015517702A patent/JP2015520201A/ja active Pending
- 2013-06-17 CA CA2869602A patent/CA2869602A1/en not_active Abandoned
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- 2014-12-04 IL IL236091A patent/IL236091A0/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| MA37765A1 (fr) | 2017-04-28 |
| PH12014502364A1 (en) | 2015-01-12 |
| CA2869602A1 (en) | 2013-12-27 |
| PE20142445A1 (es) | 2015-01-28 |
| IN2014DN09347A (forum.php) | 2015-07-17 |
| CL2014003242A1 (es) | 2015-03-20 |
| MX2014014105A (es) | 2015-03-05 |
| CR20140516A (es) | 2014-12-01 |
| IL236091A0 (en) | 2015-02-01 |
| EA201492283A1 (ru) | 2015-04-30 |
| HK1206341A1 (en) | 2016-01-08 |
| UA109867C2 (ru) | 2015-10-12 |
| US20150259295A1 (en) | 2015-09-17 |
| CO7160077A2 (es) | 2015-01-15 |
| BR112014031108A2 (pt) | 2017-06-27 |
| WO2013189862A1 (en) | 2013-12-27 |
| SG11201407229UA (en) | 2014-12-30 |
| CN104411690A (zh) | 2015-03-11 |
| KR20150011003A (ko) | 2015-01-29 |
| EP2864294A1 (en) | 2015-04-29 |
| JP2015520201A (ja) | 2015-07-16 |
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