CL2014003242A1 - Compuestos de pirazol sustituidos como antagonistas del receptor del acido lisofosfatidico (lpar); usos contra la fibrosis pulmonar. - Google Patents
Compuestos de pirazol sustituidos como antagonistas del receptor del acido lisofosfatidico (lpar); usos contra la fibrosis pulmonar.Info
- Publication number
- CL2014003242A1 CL2014003242A1 CL2014003242A CL2014003242A CL2014003242A1 CL 2014003242 A1 CL2014003242 A1 CL 2014003242A1 CL 2014003242 A CL2014003242 A CL 2014003242A CL 2014003242 A CL2014003242 A CL 2014003242A CL 2014003242 A1 CL2014003242 A1 CL 2014003242A1
- Authority
- CL
- Chile
- Prior art keywords
- lpar
- receptor antagonists
- pulmonary fibrosis
- acid receptor
- lysophosphatidic acid
- Prior art date
Links
- NOIXNOMHHWGUTG-UHFFFAOYSA-N 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline Chemical class C=1C=C(OCC=2N=C3C=CC=CC3=CC=2)C=CC=1C1=NN(CC(F)(F)F)C=C1C1=CC=NC=C1 NOIXNOMHHWGUTG-UHFFFAOYSA-N 0.000 title 1
- 229940123977 Lysophosphatidic acid receptor antagonist Drugs 0.000 title 1
- 208000005069 pulmonary fibrosis Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661958P | 2012-06-20 | 2012-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014003242A1 true CL2014003242A1 (es) | 2015-03-20 |
Family
ID=48656033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014003242A CL2014003242A1 (es) | 2012-06-20 | 2014-11-28 | Compuestos de pirazol sustituidos como antagonistas del receptor del acido lisofosfatidico (lpar); usos contra la fibrosis pulmonar. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20150259295A1 (forum.php) |
| EP (1) | EP2864294A1 (forum.php) |
| JP (1) | JP2015520201A (forum.php) |
| KR (1) | KR20150011003A (forum.php) |
| CN (1) | CN104411690A (forum.php) |
| AU (1) | AU2013279510A1 (forum.php) |
| BR (1) | BR112014031108A2 (forum.php) |
| CA (1) | CA2869602A1 (forum.php) |
| CL (1) | CL2014003242A1 (forum.php) |
| CO (1) | CO7160077A2 (forum.php) |
| CR (1) | CR20140516A (forum.php) |
| EA (1) | EA201492283A1 (forum.php) |
| HK (1) | HK1206341A1 (forum.php) |
| IL (1) | IL236091A0 (forum.php) |
| IN (1) | IN2014DN09347A (forum.php) |
| MA (1) | MA37765A1 (forum.php) |
| MX (1) | MX2014014105A (forum.php) |
| PE (1) | PE20142445A1 (forum.php) |
| PH (1) | PH12014502364A1 (forum.php) |
| SG (1) | SG11201407229UA (forum.php) |
| UA (1) | UA109867C2 (forum.php) |
| WO (1) | WO2013189862A1 (forum.php) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12014500355A1 (en) | 2011-08-15 | 2014-03-31 | Intermune Inc | Lysophosphatidic acid receptor antagonists |
| PT2988743T (pt) | 2013-03-15 | 2021-03-03 | Epigen Biosciences Inc | Compostos heterocíclicos úteis no tratamento da doença |
| CA2953472C (en) | 2014-06-27 | 2022-08-02 | Ube Industries, Ltd. | Halogen-substituted heterocyclic compound salt |
| CA3085347A1 (en) * | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Pyrazole n-linked carbamoyl cyclohexyl acids as lpa antagonists |
| CN111434655A (zh) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 溶血磷脂酸受体拮抗剂及其制备方法 |
| EP4058144A1 (en) | 2019-11-15 | 2022-09-21 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
| TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| CN115867556B (zh) | 2020-06-03 | 2025-05-06 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
| US11980609B2 (en) | 2021-05-11 | 2024-05-14 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
| CN118541360A (zh) | 2021-12-08 | 2024-08-23 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1698335A4 (en) * | 2003-12-26 | 2007-08-01 | Ono Pharmaceutical Co | AGENT FOR PREVENTING AND / OR TREATING DISEASES INVOLVING A MITOCHONDRIAL BENZODIAZEPINE RECEPTOR |
| TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| GB2470833B (en) * | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| CN102574822A (zh) * | 2009-08-04 | 2012-07-11 | 阿米拉制药公司 | 作为溶血磷脂酸受体拮抗剂的化合物 |
| AU2011338561A1 (en) * | 2010-12-07 | 2013-07-25 | Amira Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonists and their use in the treatment of fibrosis |
| WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
| PH12014500355A1 (en) * | 2011-08-15 | 2014-03-31 | Intermune Inc | Lysophosphatidic acid receptor antagonists |
-
2013
- 2013-06-17 BR BR112014031108A patent/BR112014031108A2/pt not_active Application Discontinuation
- 2013-06-17 UA UAA201500427A patent/UA109867C2/ru unknown
- 2013-06-17 HK HK15106926.9A patent/HK1206341A1/xx unknown
- 2013-06-17 CA CA2869602A patent/CA2869602A1/en not_active Abandoned
- 2013-06-17 EA EA201492283A patent/EA201492283A1/ru unknown
- 2013-06-17 US US14/402,128 patent/US20150259295A1/en not_active Abandoned
- 2013-06-17 MA MA37765A patent/MA37765A1/fr unknown
- 2013-06-17 KR KR1020147035552A patent/KR20150011003A/ko not_active Ceased
- 2013-06-17 MX MX2014014105A patent/MX2014014105A/es unknown
- 2013-06-17 SG SG11201407229UA patent/SG11201407229UA/en unknown
- 2013-06-17 JP JP2015517702A patent/JP2015520201A/ja active Pending
- 2013-06-17 CN CN201380032266.8A patent/CN104411690A/zh active Pending
- 2013-06-17 WO PCT/EP2013/062458 patent/WO2013189862A1/en not_active Ceased
- 2013-06-17 IN IN9347DEN2014 patent/IN2014DN09347A/en unknown
- 2013-06-17 EP EP13729940.0A patent/EP2864294A1/en not_active Withdrawn
- 2013-06-17 AU AU2013279510A patent/AU2013279510A1/en not_active Abandoned
- 2013-06-17 PE PE2014002212A patent/PE20142445A1/es not_active Application Discontinuation
-
2014
- 2014-10-22 PH PH12014502364A patent/PH12014502364A1/en unknown
- 2014-11-11 CR CR20140516A patent/CR20140516A/es unknown
- 2014-11-28 CL CL2014003242A patent/CL2014003242A1/es unknown
- 2014-12-04 IL IL236091A patent/IL236091A0/en unknown
- 2014-12-19 CO CO14279332A patent/CO7160077A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2864294A1 (en) | 2015-04-29 |
| PH12014502364A1 (en) | 2015-01-12 |
| AU2013279510A1 (en) | 2014-10-16 |
| PE20142445A1 (es) | 2015-01-28 |
| KR20150011003A (ko) | 2015-01-29 |
| CA2869602A1 (en) | 2013-12-27 |
| JP2015520201A (ja) | 2015-07-16 |
| HK1206341A1 (en) | 2016-01-08 |
| CO7160077A2 (es) | 2015-01-15 |
| US20150259295A1 (en) | 2015-09-17 |
| IN2014DN09347A (forum.php) | 2015-07-17 |
| MA37765A1 (fr) | 2017-04-28 |
| EA201492283A1 (ru) | 2015-04-30 |
| BR112014031108A2 (pt) | 2017-06-27 |
| UA109867C2 (ru) | 2015-10-12 |
| IL236091A0 (en) | 2015-02-01 |
| SG11201407229UA (en) | 2014-12-30 |
| CN104411690A (zh) | 2015-03-11 |
| CR20140516A (es) | 2014-12-01 |
| WO2013189862A1 (en) | 2013-12-27 |
| MX2014014105A (es) | 2015-03-05 |
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