BR112015003998A2 - compostos de cianopirazol lpar-substituídos - Google Patents

compostos de cianopirazol lpar-substituídos

Info

Publication number
BR112015003998A2
BR112015003998A2 BR112015003998A BR112015003998A BR112015003998A2 BR 112015003998 A2 BR112015003998 A2 BR 112015003998A2 BR 112015003998 A BR112015003998 A BR 112015003998A BR 112015003998 A BR112015003998 A BR 112015003998A BR 112015003998 A2 BR112015003998 A2 BR 112015003998A2
Authority
BR
Brazil
Prior art keywords
compounds
lpar
substituted
context
cyanopyrazole
Prior art date
Application number
BR112015003998A
Other languages
English (en)
Inventor
Sidduri Achyutharao
Budd David
Craig Schoenfeld Ryan
Qian Yimin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015003998A2 publication Critical patent/BR112015003998A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1/1 resumo compostos de cianopirazol lpar-substituídos proporcionam-se neste contexto compostos da fórmula (i): r2 n n o n n nh r1 2 (i), bem como os seus sais farmaceuticamente aceitáveis, em que os substituintes são tais como se encontram expostos no relatório. estes compostos, e as composições farmacêuticas que os contêm, são de utilidade para o tratamento de enfermldades e distúrbios inflamatórios tais como, por exemplo, fibrose pulmonar.
BR112015003998A 2012-09-05 2013-09-02 compostos de cianopirazol lpar-substituídos BR112015003998A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261696862P 2012-09-05 2012-09-05
PCT/EP2013/068083 WO2014037303A1 (en) 2012-09-05 2013-09-02 Lpar - substituted cyanopyrazole compounds

Publications (1)

Publication Number Publication Date
BR112015003998A2 true BR112015003998A2 (pt) 2017-07-04

Family

ID=49085036

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015003998A BR112015003998A2 (pt) 2012-09-05 2013-09-02 compostos de cianopirazol lpar-substituídos

Country Status (11)

Country Link
US (1) US9169215B2 (pt)
EP (1) EP2892882A1 (pt)
JP (1) JP2015527378A (pt)
KR (1) KR20150039835A (pt)
CN (1) CN104507914A (pt)
BR (1) BR112015003998A2 (pt)
CA (1) CA2877184A1 (pt)
HK (1) HK1206356A1 (pt)
MX (1) MX2015001657A (pt)
RU (1) RU2015110006A (pt)
WO (1) WO2014037303A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020384883B2 (en) 2019-11-15 2023-11-16 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof
JP2023529369A (ja) 2020-06-03 2023-07-10 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
CR20220609A (es) 2020-06-03 2023-05-04 Gilead Sciences Inc Antagonistas del receptor de lpa y usos de los mismos
US11980609B2 (en) 2021-05-11 2024-05-14 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
US11939318B2 (en) 2021-12-08 2024-03-26 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002023986A1 (fr) * 2000-08-25 2002-03-28 Sankyo Company, Limited Derives de 4-acylaminopyrazole
CA2473740A1 (en) * 2002-01-18 2003-07-31 David Solow-Cordero Methods of treating conditions associated with an edg receptor
MX2013006040A (es) * 2010-12-07 2013-08-26 Amira Pharmaceuticals Inc Antagonistas del receptor de acido lisofosfatidico y su uso en el tratamiento de fibrosis.

Also Published As

Publication number Publication date
KR20150039835A (ko) 2015-04-13
CN104507914A (zh) 2015-04-08
RU2015110006A (ru) 2016-10-27
WO2014037303A1 (en) 2014-03-13
EP2892882A1 (en) 2015-07-15
JP2015527378A (ja) 2015-09-17
CA2877184A1 (en) 2014-03-13
HK1206356A1 (en) 2016-01-08
US9169215B2 (en) 2015-10-27
MX2015001657A (es) 2015-04-08
US20150218106A1 (en) 2015-08-06

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired