CO7101193A2 - Anticuerpo anti-epirregulina humanizado y agente terapéutico con el cancer que comprende dicho anticuerpo como ingrediente activo - Google Patents
Anticuerpo anti-epirregulina humanizado y agente terapéutico con el cancer que comprende dicho anticuerpo como ingrediente activoInfo
- Publication number
- CO7101193A2 CO7101193A2 CO14161083A CO14161083A CO7101193A2 CO 7101193 A2 CO7101193 A2 CO 7101193A2 CO 14161083 A CO14161083 A CO 14161083A CO 14161083 A CO14161083 A CO 14161083A CO 7101193 A2 CO7101193 A2 CO 7101193A2
- Authority
- CO
- Colombia
- Prior art keywords
- epirregulin
- antibodies
- antibody
- cancer
- active ingredient
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Los inventores produjeron con éxito anticuerpos anti-Epirregulina que muestran reactividad cruzada entre las especies de mono cynomolgus (animales no humanos) y humana, anticuerpos anti-Epirregulina con degradación química suprimida, anticuerpos anti-Epirregulina con punto isoeléctrico disminuido, anticuerpos anti-pirregulina con temperatura de punto medio de desnaturalización térmica aumentada, y anticuerpos anti-Epirregulina con cantidad de agregado reducida; mediante la realización de sustituciones apropiadas de residuos de aminoácidos en las secuencias de la región variable del anticuerpo EP27 humanizado el que inhibe el crecimiento de las células cancerosas al exhibir actividad citotóxica y actividad neutralizante contra células cancerosas que expresan anti-Epirregulina humana.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011287654 | 2011-12-28 | ||
JP2012133394 | 2012-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO7101193A2 true CO7101193A2 (es) | 2014-10-31 |
Family
ID=48697597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO14161083A CO7101193A2 (es) | 2011-12-28 | 2014-07-24 | Anticuerpo anti-epirregulina humanizado y agente terapéutico con el cancer que comprende dicho anticuerpo como ingrediente activo |
Country Status (23)
Country | Link |
---|---|
US (2) | US9556264B2 (es) |
EP (1) | EP2799543A4 (es) |
JP (2) | JP6010551B2 (es) |
KR (1) | KR20140107610A (es) |
CN (1) | CN104136610B (es) |
AU (1) | AU2012361510B8 (es) |
BR (1) | BR112014015581A2 (es) |
CA (1) | CA2862254A1 (es) |
CL (1) | CL2014001730A1 (es) |
CO (1) | CO7101193A2 (es) |
CR (1) | CR20140352A (es) |
HK (1) | HK1200187A1 (es) |
IL (1) | IL233368A0 (es) |
MX (1) | MX350044B (es) |
MY (1) | MY172428A (es) |
PE (1) | PE20141560A1 (es) |
PH (1) | PH12014501468A1 (es) |
RU (1) | RU2634383C2 (es) |
SG (2) | SG10201508095UA (es) |
TW (1) | TWI593705B (es) |
UA (1) | UA115046C2 (es) |
WO (1) | WO2013100120A1 (es) |
ZA (1) | ZA201405405B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007312367B2 (en) | 2006-10-12 | 2012-09-06 | Chugai Seiyaku Kabushiki Kaisha | Diagnosis and treatment of cancer using anti-EREG antibody |
EP2436397B1 (en) | 2009-05-29 | 2017-05-10 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition containing antagonist of egf family ligand as component |
DK2728002T3 (da) | 2011-06-30 | 2022-04-04 | Chugai Pharmaceutical Co Ltd | Heterodimeriseret polypeptid |
JP6291254B2 (ja) | 2011-10-28 | 2018-03-14 | 中外製薬株式会社 | 癌幹細胞特異的分子 |
TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
EP2940135B9 (en) | 2012-12-27 | 2021-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
RU2016101716A (ru) * | 2013-06-24 | 2017-07-27 | Чугаи Сейяку Кабусики Кайся | Терапевтический агент, содержащий гуманизированное антиэпирегулиновое антитело в качестве действующего ингредиента для немелкоклеточной карциномы легкого, за исключением аденокарциномы |
BR112016014824A2 (pt) * | 2013-12-27 | 2017-09-19 | Chugai Pharmaceutical Co Ltd | Método para purificar anticorpo que tem ponto isoelétrico baixo |
EA201692109A1 (ru) * | 2014-05-01 | 2017-03-31 | Дженентек, Инк. | Варианты антител к фактору d и их применение |
WO2016027859A1 (ja) | 2014-08-20 | 2016-02-25 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
JP2019202936A (ja) * | 2016-08-17 | 2019-11-28 | 中外製薬株式会社 | 抗Epiregulin抗体と抗EGFR抗体との併用医薬 |
WO2018155611A1 (ja) | 2017-02-24 | 2018-08-30 | 中外製薬株式会社 | 薬学的組成物、抗原結合分子、治療方法、およびスクリーニング方法 |
CN110753703B (zh) * | 2017-05-23 | 2024-04-09 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | 新的cd73抗体、其制备和用途 |
GB201803892D0 (en) * | 2018-03-12 | 2018-04-25 | Ultrahuman Six Ltd | C-met binding agents |
JPWO2020045545A1 (ja) | 2018-08-29 | 2021-08-12 | 中外製薬株式会社 | 抗体半分子、および抗体半分子のホモ二量体形成を抑制する方法 |
EP3915581A4 (en) * | 2019-01-24 | 2023-03-22 | Chugai Seiyaku Kabushiki Kaisha | NOVEL CANCER ANTIGENS AND ANTIBODIES OF THESE ANTIGENS |
JP7232707B2 (ja) | 2019-05-21 | 2023-03-03 | トーソー株式会社 | ブラケット構造 |
CN112574308A (zh) | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 靶向bcma的抗体、双特异性抗体及其用途 |
CN113150155B (zh) * | 2021-04-22 | 2022-04-08 | 安徽瀚海博兴生物技术有限公司 | 一种抗pd-l1人源化单克隆抗体及其应用 |
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DK2728002T3 (da) * | 2011-06-30 | 2022-04-04 | Chugai Pharmaceutical Co Ltd | Heterodimeriseret polypeptid |
TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
RU2016101716A (ru) | 2013-06-24 | 2017-07-27 | Чугаи Сейяку Кабусики Кайся | Терапевтический агент, содержащий гуманизированное антиэпирегулиновое антитело в качестве действующего ингредиента для немелкоклеточной карциномы легкого, за исключением аденокарциномы |
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2012
- 2012-12-26 TW TW101150028A patent/TWI593705B/zh not_active IP Right Cessation
- 2012-12-28 AU AU2012361510A patent/AU2012361510B8/en not_active Ceased
- 2012-12-28 JP JP2013551852A patent/JP6010551B2/ja not_active Expired - Fee Related
- 2012-12-28 WO PCT/JP2012/084042 patent/WO2013100120A1/ja active Application Filing
- 2012-12-28 SG SG10201508095UA patent/SG10201508095UA/en unknown
- 2012-12-28 UA UAA201408353A patent/UA115046C2/uk unknown
- 2012-12-28 MX MX2014008009A patent/MX350044B/es active IP Right Grant
- 2012-12-28 MY MYPI2014701733A patent/MY172428A/en unknown
- 2012-12-28 KR KR20147020786A patent/KR20140107610A/ko not_active Application Discontinuation
- 2012-12-28 CN CN201280070788.2A patent/CN104136610B/zh not_active Expired - Fee Related
- 2012-12-28 CA CA2862254A patent/CA2862254A1/en not_active Abandoned
- 2012-12-28 RU RU2014130766A patent/RU2634383C2/ru not_active IP Right Cessation
- 2012-12-28 PE PE2014001036A patent/PE20141560A1/es not_active Application Discontinuation
- 2012-12-28 EP EP12863154.6A patent/EP2799543A4/en not_active Withdrawn
- 2012-12-28 SG SG11201403565XA patent/SG11201403565XA/en unknown
- 2012-12-28 BR BR112014015581-0A patent/BR112014015581A2/pt not_active IP Right Cessation
- 2012-12-28 US US14/369,539 patent/US9556264B2/en not_active Expired - Fee Related
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2014
- 2014-06-25 IL IL233368A patent/IL233368A0/en unknown
- 2014-06-25 PH PH12014501468A patent/PH12014501468A1/en unknown
- 2014-06-26 CL CL2014001730A patent/CL2014001730A1/es unknown
- 2014-07-22 CR CR20140352A patent/CR20140352A/es unknown
- 2014-07-22 ZA ZA2014/05405A patent/ZA201405405B/en unknown
- 2014-07-24 CO CO14161083A patent/CO7101193A2/es unknown
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2015
- 2015-01-16 HK HK15100507.9A patent/HK1200187A1/xx not_active IP Right Cessation
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2016
- 2016-09-15 US US15/266,829 patent/US20170129950A1/en not_active Abandoned
- 2016-09-16 JP JP2016181435A patent/JP6329601B2/ja not_active Expired - Fee Related
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